公开(公告)号：US09360365B2

公开(公告)日：2016-06-07

申请号：US14083904

申请日：2013-11-19

Applicant: MURATA MANUFACTURING CO., LTD.

Inventor： Hirofumi Tsuchimoto ,  Toru Shimuta

IPC: H03F3/08 ,  G01J1/44 ,  G01J3/427 ,  G01N21/25 ,  G01N21/31 ,  A61B5/1455 ,  A61B5/00

CPC classification number: G01J1/44 ,  A61B5/02433 ,  A61B5/14552 ,  A61B5/6826 ,  A61B5/6829 ,  A61B5/7203 ,  G01J3/427 ,  G01J2001/444 ,  G01N21/256 ,  G01N21/3151

Abstract: An optical sensor device includes a light emitter for emitting, to a living body, lights having two wavelengths and blinking at a predetermined frequency, and a light receiver for receiving the lights from the living body. The light receiver outputs first and second detection signals corresponding to the respective wavelengths. A filter circuit extracts, from the first and second detection signals, modulation signals that are obtained with amplitude modulation of signals of the predetermined frequency. The modulation signals are amplified by a post-amplifier and are taken into an arithmetic processing unit after being converted to digital signals by an AD converter. The arithmetic processing unit calculates DC components and AC components of the first and second detection signals by employing the modulation signals converted the digital signals.

Abstract translation: 光传感器装置包括：发光体，用于向生物体发射具有两个波长并以预定频率闪烁的光;以及光接收器，用于从生物体接收光。 光接收器输出对应于各个波长的第一和第二检测信号。 滤波器电路从第一和第二检测信号中提取通过预定频率的信号的幅度调制获得的调制信号。 调制信号由后置放大器放大，并通过AD转换器转换成数字信号后被送入运算处理单元。 算术处理单元通过采用转换数字信号的调制信号来计算第一和第二检测信号的直流分量和交流分量。

公开(公告)号：US09341515B2

公开(公告)日：2016-05-17

申请号：US13370969

申请日：2012-02-10

Applicant: Alfons Schulte ,  Silki Arora

Inventor： Alfons Schulte ,  Silki Arora

IPC: G01J3/42 ,  G02B21/00 ,  G01J3/02 ,  G01J3/427 ,  G01N21/03 ,  G01N21/31 ,  G02B21/26 ,  G02B21/36 ,  G01N21/05 ,  G01N21/65

CPC classification number: G01J3/42 ,  G01J3/0208 ,  G01J3/0229 ,  G01J3/0289 ,  G01J3/427 ,  G01N21/03 ,  G01N21/31 ,  G01N21/314 ,  G01N21/3151 ,  G01N2021/0346 ,  G01N2021/058 ,  G01N2021/651 ,  G01N2021/656 ,  G01N2201/0627 ,  G01N2201/0846 ,  G02B21/0028 ,  G02B21/0032 ,  G02B21/26 ,  G02B21/367

Abstract: Apparatus and method to measure optical absorption spectra with spatial resolution on the micron scale. An exemplary setup combines a continuous white light excitation beam in transmission geometry with a confocal microscope. Spatial resolution better than 1.4 μm in the lateral and 3.6 μm in the axial, directions was obtained. The detection and measurement of the absorption spectrum of hemoglobin in a single red blood cell under physiological conditions on the timescale of seconds was realized. The apparatus and method enables the investigation of spatial variations in the optical density of small samples on the micron scale and the study of biological assemblies at the single cell level, leading to applications in optical diagnostics, microfluidics, and other areas.

Abstract translation: 用微米尺度测量空间分辨率的光吸收光谱的装置和方法。 示例性设置将透射几何中的连续白光激发光束与共聚焦显微镜组合。 获得横向分辨率优于1.4μm，轴向方向为3.6μm。 实现了在生理条件下单次红细胞血红蛋白吸收光谱在秒的时间刻度上的检测和测量。 该装置和方法能够调查微尺度上小样品的光密度的空间变化以及在单细胞水平上对生物组装的研究，导致在光学诊断，微流体等领域的应用。

公开(公告)号：US09329123B2

公开(公告)日：2016-05-03

申请号：US14424850

申请日：2013-08-06

Applicant: NewSouth Innovations Pty Limited

Inventor： Charles Charbel Harb

IPC: G01N21/39 ,  G01J3/42 ,  H01S3/08 ,  G01N21/3504 ,  G01N21/03 ,  G01J3/02 ,  G01J3/10 ,  G01J3/427 ,  G01J3/433 ,  H01S3/105

CPC classification number: G01N21/39 ,  G01J3/021 ,  G01J3/10 ,  G01J3/42 ,  G01J3/427 ,  G01J3/433 ,  G01J2003/102 ,  G01N21/031 ,  G01N21/3504 ,  G01N2201/06113 ,  H01S3/08063 ,  H01S3/105

Abstract: Methods and optical detection systems (200, 300, 800, 900) for generating and processing a real-time time-domain cavity ringdown spectroscopy (CRDS) signal (831, 931) from an absorbing species in an optical detection system (200, 300, 800, 900) having an optical ringdown cavity (200, 300) are disclosed. The optical ringdown cavity (200, 300) is adapted for accepting a sample of an absorbing species. One or more modulated light signals (241,243,245,341) are generated using one or more light sources (240, 242, 244, 340). The light source(s) (240, 242, 244, 340) is pulsed at a specified pulse rate(s). The modulated light signal(s) (241,243,245, 341) is resonated using the optical ringdown cavity (200, 300) comprising a plurality of mirrors (220, 230), or sets of mirrors (320, 330), to produce the CRDS signal (831, 931). The reflectivity of the mirrors (220, 230), or sets of mirrors (320, 330), is dependent upon the pulse rate of the modulated light signals (241,243,245,341). Different beamlines (212, 214, 216, 312, 314, 316) are established by the modulated light signal(s) (241,243,245, 341) and the mirrors (220, 230, 320, 330) interacting with the absorbing species sample.

Abstract translation: 用于从光学检测系统（200,300）中的吸收物质生成和处理实时时域衰减光谱（CRDS）信号（831,931）的方法和光学检测系统（200,300,800,900） ，800,900），其具有光学衰减腔（200,300）。 光学衰减腔（200,300）适于接收吸收物质的样品。 使用一个或多个光源（240,242,244,340）产生一个或多个调制光信号（241,243,245,341）。 光源（240,242,244,340）以指定的脉冲速率脉冲。 调制光信号（241,243,245,341）使用包括多个反射镜（220,230）或一组反射镜（320,330）的光学环形空腔（200,300）进行谐振，以产生CRDS信号 （831,931）。 反射镜（220,230）或反射镜组（320,330）的反射率取决于调制光信号的脉冲速率（241,243,245,341）。 通过调制光信号（241,243,245,341）和与吸收物质样品相互作用的反射镜（220,230,320,330）建立不同的光束线（212,214,216,312,314,316）。

公开(公告)号：US09329121B2

公开(公告)日：2016-05-03

申请号：US13264419

申请日：2010-04-16

Applicant: Jens Moeller Jensen ,  Arun Krishna ,  Lars Munch ,  Rainer Buchner ,  Thomine Stolberg-Rohr ,  Henrik Gedde Moos

Inventor： Jens Moeller Jensen ,  Arun Krishna ,  Lars Munch ,  Rainer Buchner ,  Thomine Stolberg-Rohr ,  Henrik Gedde Moos

IPC: G01J1/00 ,  G01J1/10 ,  G01J5/02 ,  G01J5/10 ,  G01N21/3504 ,  G01J3/02 ,  G01J3/36 ,  G01N21/31 ,  G01J3/427 ,  G01J3/12

CPC classification number: G01N21/3504 ,  G01J1/00 ,  G01J1/10 ,  G01J3/02 ,  G01J3/027 ,  G01J3/36 ,  G01J3/427 ,  G01J5/02 ,  G01J5/10 ,  G01J2003/1213 ,  G01N21/314

Abstract: The invention relates to a sensor having a filter arrangement, downstream of which there is arranged a detector arrangement, and an evaluating device connected to the detector arrangement. The filter arrangement has at least a first filter, the suspect filter, and at least one second filter, the reference filter(s). The first filter is configured as a band pass filter allowing the passage of a first predetermined band, the suspect band. The at least one second filter is configured as a band pass filter allowing the passage of a second predetermined band(s), the reference band(s). The detector arrangement has at least one detector associated with at least one of the filters. The band passes reference filters are distributed above and below the band pass of the suspect filter. The sensor with advantage could be utilized within the IR band, and could advantageously be used to detect CO2.

Abstract translation: 本发明涉及一种具有滤波器装置的传感器，其下游设置有检测器装置，以及连接到检测器装置的评估装置。 过滤器装置至少具有第一过滤器，可疑过滤器和至少一个第二过滤器，参考过滤器。 第一滤波器被配置为允许第一预定频带（可疑频带）通过的带通滤波器。 至少一个第二滤波器被配置为带通滤波器，允许通过第二预定带（参考频带）。 检测器装置具有至少一个与至少一个滤波器相关的检测器。 带通过参考滤波器分布在可疑滤波器的带通上方和下方。 有利的传感器可以在IR带内使用，并且可以有利地用于检测CO 2。

公开(公告)号：US08957377B2

公开(公告)日：2015-02-17

申请号：US14054599

申请日：2013-10-15

Applicant: Ronald T. Logan ,  Joseph R. Demers

Inventor： Ronald T. Logan ,  Joseph R. Demers

IPC: G01N21/39 ,  G01J3/427 ,  A61B5/05 ,  G01J3/10 ,  G01J3/42 ,  G01J3/453 ,  G01N21/3581 ,  G01N21/3586

CPC classification number: G01J3/427 ,  A61B5/0507 ,  G01J3/10 ,  G01J3/42 ,  G01J3/4531 ,  G01N21/3581 ,  G01N21/3586 ,  G01N21/39

Abstract: An apparatus for analyzing, identifying or imaging an target including first and second laser beams coupled to a pair of photoconductive switches to produce CW signals in one or more bands in a range of frequencies greater than 100 GHz focused on and transmitted through or reflected from the target; and a detector for acquiring spectral information from signals received from the target and using a multi-spectral heterodyne process to generate an electrical signal representative of some characteristics of the target. The lasers are tuned to different frequencies and a frequency shifter in the path of one laser beam allows the terahertz beam to be finely adjusted in one or more selected frequency bands.

Abstract translation: 一种用于分析，识别或成像目标的装置，包括耦合到一对光电导开关的第一和第二激光束，以在大于100GHz的频率的范围内的一个或多个频带中产生CW信号，该信号集中于并经由 目标; 以及检测器，用于从从目标接收的信号中获取光谱信息，并使用多光谱外差处理产生表示目标的某些特性的电信号。 将激光器调谐到不同的频率，并且在一个激光束的路径中的频移器允许在一个或多个所选频带中微调太赫兹波束。

公开(公告)号：US08137993B2

公开(公告)日：2012-03-20

申请号：US13066255

申请日：2011-04-11

Applicant: Anthony H. Cincotta

Inventor： Anthony H. Cincotta

IPC: G01N33/53 ,  C12Q1/00 ,  A01N61/00 ,  A01N43/58 ,  A01N43/60 ,  A61K31/00 ,  A61K31/50 ,  A61K31/495 ,  G01J3/42 ,  G01J3/427 ,  G01N13/00 ,  G01N30/84

CPC classification number: A61K31/498 ,  G01N33/6896 ,  G01N33/9413 ,  G01N2800/52 ,  Y10S436/815 ,  Y10T436/145555 ,  Y10T436/173845

Abstract: The present invention is directed to a method of identifying patients to be treated by dopamine agonist therapy comprising the step of analyzing a plasma or urine sample from said patient for concentrations of norepinephrine (NE), norepinephrine metabolites (NE metabolites), dopamine, dopamine metabolites, serotonin, serotonin metabolites, or fasting triglycerides, wherein one or more of: (a) NE metabolites, (b) NE/NE metabolites: dopamine/dopamine metabolites, (c) NE and serotonin, (d) NE/NE metabolites and serotonin, (e) NE and serotonin metabolites, (f) NE/NE metabolites and serotonin metabolites, or (g) NE is/are greater than about 30% over normal level; or dopamine/dopamine metabolites are less than about 30% below normal; or fasting triglycerides are greater than about 150 mg/dl and/or said patient has hypertension. The present invention is also directed to treating identified patients with dopamine agonist therapy.

Abstract translation: 本发明涉及一种通过多巴胺激动剂治疗来鉴定待治疗患者的方法，包括以下步骤：从去甲肾上腺素（NE），去甲肾上腺素代谢物（NE代谢物），多巴胺，多巴胺代谢物的浓度分析来自所述患者的血浆或尿样品 （a）NE代谢产物，（b）NE / NE代谢产物：多巴胺/多巴胺代谢产物，（c）NE和5-羟色胺，（d）NE / NE代谢产物和 5-羟色胺，（e）NE和5-羟色胺代谢物，（f）NE / NE代谢物和5-羟色胺代谢物，或（g）NE比正常水平高大约30％ 或多巴胺/多巴胺代谢物低于正常值的约30％ 或空腹甘油三酸酯大于约150mg / dl和/或所述患者具有高血压。 本发明还涉及治疗多巴胺激动剂治疗的鉴定患者。

公开(公告)号：US20110317150A1

公开(公告)日：2011-12-29

申请号：US13172445

申请日：2011-06-29

Applicant: Eric DECOUX ,  Xavier Schwab

Inventor： Eric DECOUX ,  Xavier Schwab

IPC: G01N21/31 ,  G01J3/427

CPC classification number: G07D7/121 ,  G06K7/10722 ,  G06K7/10792 ,  G06K7/10831

Abstract: A method for measuring optical properties of an optically variable marking applied on an object, the method including the steps of illuminating the optically variable marking so as to form a first light reflected by the marking at a first view angle and a second light reflected by the marking at a second view angle, the first and second lights having different spectral compositions as a result of the optically variable marking, refracting the second reflected light through a optical unit so as to redirect the second reflected light toward an optical sensor, capturing the first light and the second refracted light with the optical sensor simultaneously; and determining optical properties of the optical variable marking based on the captured first and second lights.

Abstract translation: 一种用于测量施加在物体上的光学可变标记的光学性质的方法，所述方法包括以下步骤：照亮所述光学可变标记，以便形成由所述标记以第一视角反射的第一光和由所述光学标记反射的第二光 以第二视角标记，作为光学可变标记的结果，第一和第二光具有不同的光谱组成，通过光学单元折射第二反射光，以将第二反射光重定向到光学传感器，捕获第一 光和第二折射光同时与光学传感器; 以及基于所捕获的第一和第二光来确定所述光学变量标记的光学特性。

公开(公告)号：US07782460B2

公开(公告)日：2010-08-24

申请号：US11837753

申请日：2007-08-13

Applicant: Rocco DiFoggio ,  Sebastian Csutak

Inventor： Rocco DiFoggio ,  Sebastian Csutak

IPC: G01N21/25 ,  G01N21/00 ,  G01J3/42 ,  G01J3/427 ,  G01J3/433 ,  G01J3/447 ,  G01V5/08 ,  G01V5/00 ,  G01V5/04

CPC classification number: G01N21/31 ,  G01N21/39 ,  G01N21/65 ,  G01N21/658 ,  G01N2021/651 ,  G01V8/02

Abstract: Apparatus and method for downhole formation testing using a spectrometer includes a carrier conveyable into a well borehole that traverses a subterranean formation of interest, a plurality of semiconductor light sources disposed on the carrier, a fluid sample cell that receives light emitted from the plurality of semiconductor light sources, and at least one photodetector that detects light emitted from the plurality of semiconductor light sources and after the light interacts with a fluid in the fluid sample cell.

Abstract translation: 用于使用光谱仪进行井下成形测试的装置和方法包括可输送到穿过感兴趣地下地层的井眼中的载体，设置在载体上的多个半导体光源，接收从多个半导体发射的光的流体样品池 光源，以及至少一个光检测器，其检测从多个半导体光源发射的光，并且在光与流体样品池中的流体相互作用之后。

公开(公告)号：US07732217B2

公开(公告)日：2010-06-08

申请号：US11440082

申请日：2006-05-25

Applicant: Hiroshi Kishida ,  Masaomi Uchida

Inventor： Hiroshi Kishida ,  Masaomi Uchida

IPC: G01N21/76 ,  G01B9/00 ,  G01J1/00 ,  G01J3/427 ,  G02B26/08 ,  G02B26/10 ,  G02B26/12 ,  G06K9/00

CPC classification number: G01N21/6458 ,  G01N21/55 ,  G01N21/6452 ,  G01N2021/174 ,  G01N2021/6439 ,  G01N2021/646 ,  G01N2021/6471 ,  G01N2021/6478

Abstract: When detecting fluorescence of a bead chip array, reflected light from a bead is detected at the same time, so as to recognize the bead position. The reflected light can be detected in a similar manner for all beads, regardless of the presence or absence of a fluorescent substance. If the positions of all beads are detected, accurate detection can be achieved by quantifying only the fluorescence at the detected positions. The fluorescence wavelength alone is detected by a first detector using a wavelength selection filter. Other wavelengths are detected by a second detector, thereby obtaining the reflected light. Data on the reflected light is processed into an image for obtaining the bead profile, the bead position is recognized by detecting the center position based on the profile, and the fluorescence is quantified based on the bead position.

Abstract translation: 当检测珠芯片阵列的荧光时，同时检测来自珠粒的反射光，以便识别珠粒位置。 不管荧光物质的存在或不存在，都可以以类似的方式检测所有珠子的反射光。 如果检测到所有珠粒的位置，则可以通过仅在所检测的位置定量荧光来实现准确的检测。 仅使用波长选择滤光片的第一检测器检测荧光波长。 其他波长由第二检测器检测，从而获得反射光。 将反射光的数据处理成用于获得珠粒轮廓的图像，通过基于轮廓检测中心位置来识别珠粒位置，并且基于珠粒位置来量化荧光。

公开(公告)号：US07292335B2

公开(公告)日：2007-11-06

申请号：US10513035

申请日：2003-03-04

Applicant: Boaz Brill ,  Shachar Gov

Inventor： Boaz Brill ,  Shachar Gov

IPC: G01J3/427

CPC classification number: G03F7/70625 ,  G01B11/306

Abstract: A method and a system for optical measuring in a structure having a pattern in the form of spaced-apart parallel elongated regions of optical properties different from that of spaces between said regions. The system comprises a broadband illuminator (8) for generating incident radiation, a spectrophotometer arrangement (30) for detecting a spectral response of the structure to the incident radiation, and an optical arrangement (2) for directing the incident light to the structure and collecting the response of the structure, said optical arrangement (2) comprising a numerical aperture (32) selectively limiting the range of at least one of light incidence or collecting angles in direction substantially perpendicular to longitudinal axes of said elongated regions of the pattern.

Abstract translation: 一种在结构中进行光学测量的方法和系统，其具有与所述区域之间的空间不同的光学性质的间隔开的平行细长区域形式的图案。 该系统包括用于产生入射辐射的宽带照明器（8），用于检测结构对入射辐射的光谱响应的分光光度计装置（30），以及用于将入射光引导到结构并收集 所述结构的响应，所述光学装置（2）包括数值孔径（32），其选择性地限制在基本上垂直于所述图案的所述细长区域的纵向轴线的方向上的入射光或收集角中的至少一个的范围。