公开(公告)号：US07995202B2

公开(公告)日：2011-08-09

申请号：US11704689

申请日：2007-02-09

Applicant: Paul Lundquist ,  Denis Zaccarin ,  Yves Lacroix ,  Mark Maxham ,  Mathieu Foquet ,  Stephen Turner

Inventor： Paul Lundquist ,  Denis Zaccarin ,  Yves Lacroix ,  Mark Maxham ,  Mathieu Foquet ,  Stephen Turner

IPC: G01J3/30

CPC classification number: G01N21/6452 ,  G01J3/02 ,  G01J3/0224 ,  G01J3/10 ,  G01J3/14 ,  G01J3/2803 ,  G01N21/6445 ,  G01N21/6456 ,  G01N21/648 ,  G01N2021/6417 ,  G01N2201/126

Abstract: Methods and systems for real-time monitoring of optical signals from arrays of signal sources, and particularly optical signal sources that have spectrally different signal components. Systems include signal source arrays in optical communication with optical trains that direct excitation radiation to and emitted signals from such arrays and image the signals onto detector arrays, from which such signals may be subjected to additional processing.

公开(公告)号：US07990533B2

公开(公告)日：2011-08-02

申请号：US12834370

申请日：2010-07-12

Applicant: John Maier ,  Shona Stewart ,  Jeffrey Cohen

Inventor： John Maier ,  Shona Stewart ,  Jeffrey Cohen

IPC: G01J3/44 ,  G01N21/65

CPC classification number: G01J3/10 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/417 ,  A61B5/7264 ,  G01J3/02 ,  G01J3/0291 ,  G01J3/0294 ,  G01J3/2823 ,  G01J3/32 ,  G01J3/44 ,  G01J2003/2826 ,  G01N21/65 ,  G01N21/658 ,  G01N2021/656 ,  G01N2201/1293 ,  G01N2201/1296 ,  G02B21/365 ,  G06F19/00 ,  G16H50/70

Abstract: A system and method for determining at least one of: a disease state, a metabolic state, a clinical outcome, and a disease progression of a test renal or prostate sample. A test Raman data set is obtained from the sample wherein said test Raman data set may comprise at least one of a plurality of Raman spectra and a plurality of spatially accurate wavelength resolved Raman images. The test Raman data set is compared to a plurality of reference Raman data sets using a chemometric technique. For analysis of renal samples, each of these reference Raman data sets may have an associated known renal sample and an associated known metabolic state, clinical outcome, and/or disease progression. For analysis of prostate samples, each of these reference Raman data sets may have an associated known prostate sample and an associated known disease state, metabolic state, clinical outcome, and/or disease progression.

Abstract translation: 用于确定测试的肾或前列腺样品的疾病状态，代谢状态，临床结果和疾病进展中的至少一个的系统和方法。 从样品获得测试拉曼数据集，其中所述测试拉曼数据集可以包括多个拉曼光谱和多个空间上准确的波长分辨拉曼图像中的至少一个。 使用化学计量技术将测试拉曼数据集与多个参考拉曼数据集进行比较。 对于肾样品的分析，这些参考拉曼数据集中的每一个可以具有相关联的已知肾样品和相关联的已知代谢状态，临床结果和/或疾病进展。 对于前列腺样品的分析，这些参考拉曼数据集中的每一个可以具有相关联的已知前列腺样品和相关的已知疾病状态，代谢状态，临床结果和/或疾病进展。

公开(公告)号：US07988315B1

公开(公告)日：2011-08-02

申请号：US12982936

申请日：2010-12-31

Applicant: Frederic McCurdy ,  Raymond J Kallio ,  Louis N Chappo

Inventor： Frederic McCurdy ,  Raymond J Kallio ,  Louis N Chappo

IPC: A47F11/10

CPC classification number: G01J3/10 ,  G01J3/46 ,  G01J3/463 ,  G01J3/465

Abstract: A device for simultaneously illuminating objects with light from more than one light source for improved color matching and comparison that includes more than one light source, baffles for separating the light sources and for forming viewing slots, and a platform area in which samples can be simultaneously illuminated on separate portions by each light source.

Abstract translation: 一种用于同时用来自多于一个光源的光照射物体的设备，用于改进的颜色匹配和比较，其包括多于一个光源，用于分离光源和形成观察槽的挡板以及可同时测量样品的平台区域 在每个光源的独立部分上照亮。

公开(公告)号：US20110134421A1

公开(公告)日：2011-06-09

申请号：US12997506

申请日：2009-06-03

Applicant: Kurt Baldwin ,  Simon Webster

Inventor： Kurt Baldwin ,  Simon Webster

IPC: G01J3/44 ,  G01J3/10

CPC classification number: G01J3/44 ,  G01J3/10 ,  G01J2001/4242 ,  G01J2003/4424

Abstract: Raman band detection apparatus illuminates a sample using an illumination source that oscillates in wavelength over a range. The source might for example switch between two wavelengths or might traverse the wavelength range. A wavelength sensitive detector detects radiation emitted by the sample at a series of different wavelengths and a signal processor extracts signals that have a temporal correspondence to the wavelength variation of the illumination at the different wavelengths. One or more Raman bands that might be present will produce a distinctive characteristic of the extracted signals plotted against a spectral axis and relatively simple processing of these spectrally-related time-varying components can then enhance the appearance of the Raman band in a spectral representation based on the processed components. For example, such processing might comprise numerical integration across a spectral plot of the components, or the selection and shifting of certain components, for instance negative components, to overlie others within portions of the spectral representation showing the presence of the Raman band.

Abstract translation: 拉曼带检测装置使用在一定范围内波长振荡的照明源照射样品。 源可以例如在两个波长之间切换或者可以遍历波长范围。 波长敏感检测器以一系列不同波长检测由样本发射的辐射，并且信号处理器提取与不同波长的照明的波长变化具有时间对应关系的信号。 可能存在的一个或多个拉曼带将产生针对光谱轴绘制的提取的信号的独特特性，并且这些光谱相关时变分量的相对简单的处理可以在基于光谱表示的基础上增强拉曼带的出现 对加工组件。 例如，这样的处理可以包括在分量的谱图上的数值积分，或者某些分量（例如负分量）的选择和移位，以覆盖表示拉曼谱带存在的频谱表示的部分内的其他分量。

公开(公告)号：US20110109909A1

公开(公告)日：2011-05-12

申请号：US12939606

申请日：2010-11-04

Applicant: Qi Wu

Inventor： Qi Wu

IPC: G01N21/55 ,  F21V9/00 ,  F21V11/00 ,  F21V9/14

CPC classification number: G01N21/774 ,  G01J3/10 ,  G01J3/12 ,  G01J3/26 ,  G01N2021/7776 ,  G01N2201/062

Abstract: A tunable light source for interrogating at least one resonant waveguide grating (RWG) biosensor having a resonance linewidth. The tunable light source includes a broadband light source that emits a light beam having a first spectral bandwidth greater than the RWG biosensor resonance linewidth. The broadband light source may be substantially spatially incoherent. A tunable optical filter having a tunable spectral linewidth is arranged to receive and filter the light beam to cause the light beam to have a second spectral bandwidth substantially the same as the RWG biosensor resonance linewidth. Label-independent optical readers that employ the tunable light source are also disclosed.

Abstract translation: 一种用于询问至少一个具有谐振线宽度的谐振波导光栅（RWG）生物传感器的可调谐光源。 可调谐光源包括宽带光源，其发射具有大于RWG生物传感器谐振线宽的第一光谱带宽的光束。 宽带光源可能基本上在空间上不相干。 具有可调谐谱线宽度的可调谐滤光器被布置成接收和过滤光束以使得光束具有与RWG生物传感器谐振线宽基本相同的第二光谱带宽。 还公开了采用可调谐光源的标签无关光学读取器。

公开(公告)号：US07936453B2

公开(公告)日：2011-05-03

申请号：US12062772

申请日：2008-04-04

Applicant: Ronald T. Logan, Jr. ,  Joseph R. Demers ,  Bryon L. Kasper

Inventor： Ronald T. Logan, Jr. ,  Joseph R. Demers ,  Bryon L. Kasper

IPC: G01N21/21

CPC classification number: G01J3/42 ,  G01J3/10 ,  G01N21/3581

Abstract: An apparatus for analyzing, identifying or imaging a target including an integrated dual laser module coupled to a pair of photoconductive switches to produce CW signals in the range of frequencies from 100 GHz to over 2 THz focused on and transmitted through or reflected from the target; and a detector for acquiring spectral information from signals received from the target and using a multi-spectral homodyne process to generate an electrical signal representative of some characteristics of the target with resolution less than 250 MHz. The photoconductive switches are activated by laser beams from the dual laser module. The lasers in the module are tuned to different frequencies and have two distinct low frequency identification tones respectively that are used in conjunction with a stable optical filter element to permit precise determination of the offset frequency of the lasers.

Abstract translation: 一种用于分析，识别或成像目标的装置，所述目标包括耦合到一对光电导开关的集成双激光模块，以产生在从100GHz到超过2THz的频率范围内的CW信号，其聚焦并经由目标传送或反射; 以及检测器，用于从从目标接收的信号中获取光谱信息，并使用多光谱零差处理来产生表示具有小于250MHz的分辨率的目标的某些特性的电信号。 光导开关由来自双激光模块的激光束激活。 模块中的激光器被调谐到不同的频率，并且具有分别与稳定的光学滤波器元件结合使用的两个不同的低频识别音，以允许精确地确定激光器的偏移频率。

公开(公告)号：US20110090499A1

公开(公告)日：2011-04-21

申请号：US12997627

申请日：2009-06-12

Applicant: Martinus Bernardus Van Der Mark

Inventor： Martinus Bernardus Van Der Mark

IPC: G01J3/447 ,  G01J3/28

CPC classification number: G01N21/4795 ,  A61B5/0059 ,  G01J3/02 ,  G01J3/0229 ,  G01J3/027 ,  G01J3/10 ,  G01J3/42 ,  G01N21/49

Abstract: A method for optically examining the interior of turbid media is provided. The method comprises the steps: providing broad-band light (2); spatially separating a plurality of wavelength bands (2a, 2b, . . . , 2n) contained in the broad-band light; separately modulating the plurality of wavelength bands (2a, 2b, . . . , 2n); recombining the plurality of modulated wavelength bands to a beam (11) of spectrally encoded broad-band light; illuminating a turbid medium (8) with the beam (11) of spectrally encoded broad-band light; detecting light emanating from the turbid medium (8) with a detector (9) and demodulating the detected light with a demodulator (10) to provide spectroscopic information.

Abstract translation: 提供了一种用于光学检查混浊介质内部的方法。 该方法包括以下步骤：提供宽带光（2）; 空间上分离宽带光中包含的多个波长带（2a，2b，...，2n）; 分别调制多个波长带（2a，2b，...，2n）; 将所述多个调制波长带重新组合成光谱编码的宽带光的波束（11）; 用频谱编码的宽带光束（11）照射混浊介质（8）; 用检测器（9）检测从混浊介质（8）发出的光，并用解调器（10）解调检测到的光，以提供光谱信息。

公开(公告)号：US20110080576A1

公开(公告)日：2011-04-07

申请号：US12896435

申请日：2010-10-01

Applicant: Frank Thiel ,  Peter Fornoff

Inventor： Frank Thiel ,  Peter Fornoff

IPC: G01N21/00

CPC classification number: G01B11/026 ,  A61C9/0053 ,  G01B11/24 ,  G01B2210/50 ,  G01J3/02 ,  G01J3/0208 ,  G01J3/021 ,  G01J3/0229 ,  G01J3/0235 ,  G01J3/0237 ,  G01J3/10 ,  G01J3/50 ,  G01J3/508 ,  G01N21/255 ,  G02B21/0028 ,  G02B21/0032 ,  G02B21/0064

Abstract: The invention relates to a device and a method for optical 3D measurement, wherein said device can be switched between a first mode for optical 3D measurement using a chromatic confocal measurement method or the triangulation measurement method and a second mode for colorimetric measurement. In the first mode, a broad-band illuminating beam is focused onto a first plane and in the second mode the broad-band illuminating beam is focused onto a second plane other than the first plane at a distance d from the surface of the object to be measured.

Abstract translation: 本发明涉及一种用于光学3D测量的装置和方法，其中所述装置可以在使用彩色共焦测量方法或三角测量方法的光学3D测量的第一模式和用于比色测量的第二模式之间切换。 在第一模式中，宽带照明光束被聚焦到第一平面上，而在第二模式中，宽带照明光束被聚焦到距物体表面距离d处的第一平面以外的第二平面上 被测量。

公开(公告)号：US07918779B2

公开(公告)日：2011-04-05

申请号：US11975665

申请日：2007-10-19

Applicant: Constance Haber ,  Allan Gardiner

Inventor： Constance Haber ,  Allan Gardiner

IPC: A61N2/00

CPC classification number: G01J3/02 ,  A61B5/0488 ,  A61B5/0531 ,  A61B5/4519 ,  A61B5/4528 ,  A61N5/0619 ,  A61N2005/0663 ,  G01J3/0229 ,  G01J3/0232 ,  G01J3/10 ,  G01J2003/1213

Abstract: This invention provides methods for treating a variety of disorders using localized electromagnetic radiation directed at excitable tissues, including nerves, muscles and blood vessels. By controlling the wavelength, the wavelength bandpass, pulse duration, intensity, pulse frequency, and/or variations of those characteristics over time, and by selecting sites of exposure to electromagnetic radiation, improvements in the function of different tissues and organs can be provided. By monitoring physiological variables such as muscle tone and activity, temperature gradients, surface electromyography, blood flow and others, the practitioner can optimize a therapeutic regimen suited for the individual patient.

Abstract translation: 本发明提供了使用针对可兴奋组织（包括神经，肌肉和血管）的局部电磁辐射来治疗多种疾病的方法。 通过控制波长，波长带通，脉冲持续时间，强度，脉冲频率和/或这些特性随时间的变化，并且通过选择暴露于电磁辐射的部位，可以提供不同组织和器官的功能的改善。 通过监测诸如肌肉紧张度和活动，温度梯度，表面肌电描记术，血流量等生理变量，医师可以优化适合于个体患者的治疗方案。

公开(公告)号：US20110066014A1

公开(公告)日：2011-03-17

申请号：US12875925

申请日：2010-09-03

Applicant: Kate Leeann Bechtel ,  Tobias Funk ,  Brian Patrick Wilfley ,  Joseph Anthony Heanue

Inventor： Kate Leeann Bechtel ,  Tobias Funk ,  Brian Patrick Wilfley ,  Joseph Anthony Heanue

IPC: A61B5/1455

CPC classification number: A61B5/0059 ,  A61B5/0091 ,  A61B5/14552 ,  A61B5/14553 ,  A61B5/415 ,  A61B5/418 ,  G01J3/02 ,  G01J3/0205 ,  G01J3/0218 ,  G01J3/10 ,  G01J3/2823 ,  G01J3/4406 ,  G01N21/6408 ,  G01N2201/0826 ,  G01N2201/0833

Abstract: The present invention pertains to a method and apparatus for cerebral oximetry. A modulated optical signal based on a digital code sequence is transmitted to the human brain. A temporal transfer characteristic is derived from the modulated optical signal. Oxygen level in the brain is determined based on the temporal transfer characteristic.

Abstract translation: 本发明涉及脑血氧测定法的方法和装置。 基于数字码序列的调制光信号被传送到人脑。 从调制光信号导出时间传递特性。 基于时间转移特征确定脑中的氧水平。