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21.发明授权公开(公告)号：US11232939B2
公开(公告)日：2022-01-25
申请号：US16765958
申请日：2018-11-20
Applicant: DH Technologies Development Pte. Ltd.
Inventor： Don W Arnold , Thomas R. Covey , Chang Liu , Bogdan Morosan
Abstract: Mass spectrometer based analytical systems and methods in which a feedback control system can be utilized to control the flow of liquid within a sampling probe to adjust and/or maintain the surface profile (e.g., shape) of the liquid-air interface within an open sampling port of the sampling probe. The feedback control systems can automatically monitor and/or detect the surface profile of the liquid-air interface and adjust the flow rate of the sampling liquid to ensure that experimental conditions remain consistent at the time of sample introduction during serial samplings. These can provide stable and reproducible analyte flows of consistent dilution to the ion source, increasing reproducibility and/or accuracy of data generated by MS analysis. Can be used with a change in the desired set point according to the particular experimental workflow (e.g., automated adjustment between an interface corresponding to a sampling set point and a cleaning set point).
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22.发明申请公开(公告)号：US20220011327A1
公开(公告)日：2022-01-13
申请号：US17261811
申请日：2019-07-19
Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
Inventor： Don W. Arnold , Thomas R. Covey , Chang Liu , Stanislaw Potyrala , Alex Tsipirovich
Abstract: Electromagnetic systems and corresponding methods for assembling the electromagnetic systems are described. The electromagnetic systems can be used in fluid processing systems that include a plurality of fluid containers, each configured to define a fluid chamber that receives a fluid and a plurality of magnetic particles, and a plurality of electromagnets configured to generate a magnetic field within at least one of the plurality of the fluid containers. The fluid processing system can also include a PCB board that supplies the electromagnets with electrical current by establishing an electrical connection between electrical contact terminals included on the PCB board and spring loaded connections included on each electromagnet. A control component controls the electromagnetic field generated by each electromagnet to generate a plurality of magnetic field gradients within the at least one fluid container sufficient to magnetically influence the plurality of magnetic particles within the fluid in each fluid container.
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23.发明申请公开(公告)号：US20210270774A1
公开(公告)日：2021-09-02
申请号：US17325483
申请日：2021-05-20
Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
Inventor： Bradley B. Schneider , Erkinjon Nazarov , Thomas R. Covey
IPC: G01N27/624 , H01J49/00 , H01J49/16
Abstract: An apparatus includes a first electrode and a second electrode. The second electrode is placed in parallel with the first electrode to provide constant gap distance. The gap between the first electrode and the second electrode is at atmospheric pressure. Ions are introduced into the center of the gap and travel through the apparatus in a direction parallel to the first electrode and the second electrode. The apparatus is configured as a high-field symmetric-waveform apparatus for filtering high mobility ions or for fragmenting ions. The apparatus is also configured for three modes of operation: as a conventional DMS; as a filter high mobility ions; and as fragmentation device. A symmetric electric field is produced in the gap with a maximum density normalized field strength greater than 10 Td to filter high mobility ions and with a maximum density normalized field strength greater than 100 Td to fragment ions.
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24.发明申请公开(公告)号：US20210225631A1
公开(公告)日：2021-07-22
申请号：US17225622
申请日：2021-04-08
Applicant: DH Technologies Development Pte. Ltd.
Inventor： Don W. Arnold , Thomas R. Covey , Chang Liu
Abstract: Methods and systems for delivering a liquid sample to an ion source for the generation of ions and subsequent analysis by mass spectrometry are provided herein. In accordance with various aspects of the present teachings, MS-based systems and methods are provided in which the flow of desorption solvent within a sampling probe fluidly coupled to an ion source can be selectively controlled such that one or more analyte species can be desorbed from a sample substrate inserted within the sampling probe within a decreased volume of desorption solvent for subsequently delivery to the ion source. In various aspects, sensitivity can be increased due to higher desorption efficiency (e.g., due to increased desorption time) and/or decreased dilution of the desorbed analytes. The methods and systems described herein can additionally or alternatively provide for the selective control of the flow rate of the desorption solvent within the sampling interface so as to enable additional processing steps to occur within the sampling probe (e.g., multiple samplings, reactions).
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25.发明授权公开(公告)号：US10998179B2
公开(公告)日：2021-05-04
申请号：US16341718
申请日：2017-10-12
Applicant: DH Technologies Development Pte. Ltd.
Inventor： Don W. Arnold , Thomas R. Covey , Chang Liu
Abstract: Methods and systems for delivering a liquid sample to an ion source for the generation of ions and subsequent analysis by mass spectrometry are provided herein. In accordance with various aspects of the present teachings, MS-based systems and methods are provided in which the flow of desorption solvent within a sampling probe fluidly coupled to an ion source can be selectively controlled such that one or more analyte species can be desorbed from a sample substrate inserted within the sampling probe within a decreased volume of desorption solvent for subsequently delivery to the ion source. In various aspects, sensitivity can be increased due to higher desorption efficiency (e.g., due to increased desorption time) and/or decreased dilution of the desorbed analytes. The methods and systems described herein can additionally or alternatively provide for the selective control of the flow rate of the desorption solvent within the sampling interface so as to enable additional processing steps to occur within the sampling probe (e.g., multiple samplings, reactions).
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Patent Agency Ranking
公开(公告)号：US09564302B2
公开(公告)日：2017-02-07
申请号：US14894494
申请日：2014-06-20
Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
Inventor： Thomas R. Covey , Bradley B. Schneider
CPC classification number: G01N27/624 , H01J49/0031 , H01J49/004 , H01J49/0422 , H01J49/145 , H01J49/165
Abstract: Methods and systems for performing mass spectrometry are provided herein. In accordance with various aspects of the applicants' teachings, the methods and systems can utilize an ion mobility spectrometer operating at atmospheric or low-vacuum pressure to remove the major contributors to the contamination and degradation of critical downstream components of a mass spectrometer located within a high-vacuum system (e.g., ion optics, mass filters, detectors), with limited signal loss.
Abstract translation: 本文提供了用于进行质谱分析的方法和系统。 根据申请人的教导的各个方面，所述方法和系统可以利用在大气压或低真空压力下操作的离子迁移谱仪来除去主要贡献者对位于一个或多个内部的质谱仪的关键下游组分的污染和降解 高真空系统（例如离子光学，质量过滤器，检测器），信号损失有限。
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公开(公告)号：US20160320342A1
公开(公告)日：2016-11-03
申请号：US15104954
申请日：2014-12-06
Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
Inventor： Bradley B. Schneider , Hassan Javaheri , Thomas R. Covey
CPC classification number: G01N27/624 , H01J49/0031 , H01J49/063 , H01J49/066 , H01J49/24
Abstract: Differential mobility spectrometry is performed under vacuum. Ions generated in a high pressure region are received from the inlet orifice of a vacuum chamber using a first ion guide located in the vacuum chamber. The first ion guide focuses the generated ions on a DMS device inlet end using a plurality of tapered electrodes. The DMS device is coaxial and adjacent to the first ion guide. The DMS device separates the focused ions using a plurality of electrodes. The inscribed diameter at the DMS device inlet end is larger than the inscribed diameter at the first ion guide exit end to maximize ion transfer. The separated ions are received from the DMS device using a second ion guide coaxial and adjacent to the DMS device. The second ion guide focuses the separated ions on an exit orifice of the vacuum chamber using a plurality of tapered electrodes.
Abstract translation: 差示运动光谱法在真空下进行。 在真空室中使用位于真空室中的第一离子导向器从真空室的入口孔接收在高压区域中产生的离子。 第一离子导向器使用多个锥形电极将产生的离子聚焦在DMS器件入口端上。 DMS装置是同轴的并且与第一离子导向件相邻。 DMS装置使用多个电极分离聚焦的离子。 DMS设备入口端处的内接螺纹直径大于第一离子导出口端的内接直径，以最大化离子转移。 使用第二离子导向器从DMS装置接收分离的离子，并且与DMS装置相邻。 第二离子导向器使用多个锥形电极将分离的离子聚焦在真空室的出口上。
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28.发明申请公开(公告)号：US20130092834A1
公开(公告)日：2013-04-18
申请号：US13693837
申请日：2012-12-04
Applicant: DH Technologies Development Pte. Ltd.
Inventor： Thomas R. Covey , Bradley B. Schneider
IPC: H01J49/26
CPC classification number: H01J49/26 , G01N27/624 , H01J49/004 , Y10T436/24
Abstract: A mass analysis system including a low pressure dissociation region and a differential mobility spectrometer. The differential mobility spectrometer including at least one pair of filter electrodes defining an ion flow path where the filter electrodes generate an electric field for passing through a selected portion of the sample ions based on the mobility characteristics of the sample ions. The differential mobility spectrometer also includes a voltage source that provides DC and RF voltages to at least one of the filter electrodes to generate the electric field, an ion inlet that receives sample ions that have passed through the low pressure dissociation region, and an ion outlet that outputs the selected portion of the sample ions. A mass spectrometer receives some or all of the selected portion of the sample ions.
Abstract translation: 质量分析系统，包括低压解离区域和差动迁移谱仪。 差动迁移谱仪包括至少一对限定离子流动路径的过滤电极对，其中过滤电极基于样品离子的迁移率特性产生用于通过选定部分样品离子的电场。 差分迁移率光谱仪还包括电压源，其向至少一个滤光器电极提供DC和RF电压以产生电场;接收经过低压解离区域的样品离子的离子入口和离子出口 其输出所选择的样本离子部分。 质谱仪接收样品离子的部分或全部选定部分。
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公开(公告)号：US20250018412A1
公开(公告)日：2025-01-16
申请号：US18774553
申请日：2024-07-16
Applicant: DH Technologies Development Pte. Ltd.
Inventor： Thomas R. Covey , Chang Liu
Abstract: Improvements in acoustically dispensed samples that are injected into an open port probe (OPP) are described. Apparatus and method are described that calibrate the volume dispensing determination and mechanisms in the acoustic dispenser to produce accurate and precise volumetric delivery.
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30.发明公开公开(公告)号：US20240347333A1
公开(公告)日：2024-10-17
申请号：US18507940
申请日：2023-11-13
Applicant: DH Technologies Development Pte. Ltd.
Inventor： Don W. Arnold , Thomas R. Covey , Chang Liu
CPC classification number: H01J49/0495 , G01N1/405 , H01J49/0404 , H01J49/165 , G01N2030/009
Abstract: Methods and systems for delivering a liquid sample to an ion source for the generation of ions and subsequent analysis by mass spectrometry are provided herein. In accordance with various aspects of the present teachings, MS-based systems and methods are provided in which the flow of desorption solvent within a sampling probe fluidly coupled to an ion source can be selectively controlled such that one or more analyte species can be desorbed from a sample substrate inserted within the sampling probe within a decreased volume of desorption solvent for subsequently delivery to the ion source. In various aspects, sensitivity can be increased due to higher desorption efficiency (e.g., due to increased desorption time) and/or decreased dilution of the desorbed analytes. The methods and systems described herein can additionally or alternatively provide for the selective control of the flow rate of the desorption solvent within the sampling interface so as to enable additional processing steps to occur within the sampling probe (e.g., multiple samplings, reactions).
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