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    Sample measurement system
    21.
    发明授权
    Sample measurement system 有权
    样品测量系统

    公开(公告)号：US09006684B2

    公开(公告)日：2015-04-14

    申请号：US12738843

    申请日：2008-10-08

    Applicant: Jyrki Laitinen ,  Petri Kivelä

    Inventor： Jyrki Laitinen ,  Petri Kivelä

    IPC: G01J1/58 ,  G01N21/64 ,  G01J3/02 ,  G01J3/10 ,  G01J3/18 ,  G01J3/44 ,  G01N21/25

    CPC classification number: G01N21/6452 ,  G01J3/02 ,  G01J3/0218 ,  G01J3/0297 ,  G01J3/10 ,  G01J3/18 ,  G01J3/4406 ,  G01N21/253 ,  G01N21/6428 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6471 ,  G01N2021/6484 ,  G01N2201/0627 ,  G01N2201/0806

    Abstract: The invention relates to an apparatus and method for optically analyzing samples contained in sample sites of a sample holder by means of fluorescence. The apparatus comprises a first light source comprising a plurality of individual light sources having narrow wavelength bands, means for further limiting wavelength bands of the light emitted by the individual light sources, means for guiding the reduced-wavelength light to the sample sites of the sample holder, and a detector for detecting light from the sample sites. According to the invention said means for further reducing the wavelength bands emitted by the individual light sources comprise a wavelength-tunable single monochromator. The invention allows manufacturing of a microplate reader having the capability for fluorescence measurements at a continuous wavelength range, while maintaining the cost of the device at a reasonable level.

    Abstract translation: 本发明涉及一种用于通过荧光光学分析样品保持器的样品位点中包含的样品的装置和方法。 该装置包括：第一光源，其包括具有窄波长带的多个单独的光源;用于进一步限制由各个光源发射的光的波长带的装置;用于将所述还原波长的光引导到所述样品的样品位置的装置 支架和用于检测来自样品位点的光的检测器。 根据本发明，用于进一步减少由各个光源发射的波长带的装置包括波长可调单色器。 本发明允许制造具有在连续波长范围内的荧光测量能力的酶标仪，同时将装置的成本保持在合理的水平。

    Fault inspection device and fault inspection method
    22.
    发明授权
    Fault inspection device and fault inspection method 有权
    故障检查装置及故障检查方法

    公开(公告)号：US08804110B2

    公开(公告)日：2014-08-12

    申请号：US13703414

    申请日：2011-05-20

    Applicant: Yuta Urano ,  Shigenobu Maruyama ,  Toshiyuki Nakao ,  Toshifumi Honda ,  Yukihiro Shibata

    Inventor： Yuta Urano ,  Shigenobu Maruyama ,  Toshiyuki Nakao ,  Toshifumi Honda ,  Yukihiro Shibata

    IPC: G01N21/00 ,  G01N21/95 ,  G01N21/94 ,  G01N21/956

    CPC classification number: G01N21/94 ,  G01N21/47 ,  G01N21/8806 ,  G01N21/9501 ,  G01N21/956 ,  G01N2021/4711 ,  G01N2021/8867 ,  G01N2021/8874 ,  G01N2201/0806 ,  G01N2201/10

    Abstract: Proposed is a defect inspection method whereby: illuminating light having a substantially uniform illumination intensity distribution in one direction of a sample surface irradiated on the sample surface; multiple scattered light components, which are output in multiple independent directions, are detected among the scattered light from the sample surface and multiple corresponding scattered light detection signals are obtained; at least one of the multiple scattered light detection signals is processed and the presence of defects is determined; at least one of the multiple scattered light detection signals that correspond to each of the points determined by the processing as a defect is processed and the dimensions of the defect are determined; and the position and dimensions of the defect on the sample surface, at each of the points determined as a defect, are displayed.

    Abstract translation: 提出了一种缺陷检查方法，其中：照射在样品表面上的样品表面的一个方向具有基本上均匀的照明强度分布的光; 在来自样品表面的散射光中检测多个独立方向输出的多个散射光分量，并获得多个相应的散射光检测信号; 处理多个散射光检测信号中的至少一个并确定缺陷的存在; 处理与通过处理确定的每个点对应的多个散射光检测信号中的至少一个作为缺陷，并确定缺陷的尺寸; 并且显示在被确定为缺陷的每个点处的样品表面上的缺陷的位置和尺寸。

    Method and apparatus for measuring purity of noble gases
    24.
    发明授权
    Method and apparatus for measuring purity of noble gases 失效
    用于测量稀有气体纯度的方法和装置

    公开(公告)号：US07351981B2

    公开(公告)日：2008-04-01

    申请号：US11350240

    申请日：2006-02-08

    Applicant: Robert Austin

    Inventor： Robert Austin

    IPC: G01J1/42

    CPC classification number: G01N21/03 ,  G01N21/33 ,  G01N23/227 ,  G01N2201/0806

    Abstract: A device for detecting impurities in a noble gas includes a detection chamber and a source of pulsed ultraviolet light. The pulse of the ultraviolet light is transferred into the detection chamber and onto a photocathode, thereby emitting a cloud of free electrons into the noble gas within the detection chamber. The cloud of electrons is attracted to the opposite end of the detection chamber by a high positive voltage potential at that end and focused onto a sensing anode. If there are impurities in the noble gas, some or all of the electrons within the cloud will bond with the impurity molecules and not reach the sensing anode. Therefore, measuring a lower signal at the sensing anode indicates a higher level of impurities while sensing a higher signal indicates fewer impurities. Impurities in the range of one part per billion can be measured by this device.

    Abstract translation: 用于检测惰性气体中的杂质的装置包括检测室和脉冲紫外光源。 紫外光的脉冲被传送到检测室和光电阴极上，从而将自由电子云发射到检测室内的惰性气体中。 电子云被吸收到检测室的另一端，在该端处具有高的正电压电位并聚焦到感测阳极上。 如果稀有气体中存在杂质，云中的部分或全部电子将与杂质分子结合，而不会到达感应阳极。 因此，在感测阳极处测量较低的信号指示较高水平的杂质，同时感测较高的信号表示较少的杂质。 该装置可以测量十亿分之一的杂质。

    Spectrophotometric image scrambler for full aperture microspectroscopy
    26.
    发明授权
    Spectrophotometric image scrambler for full aperture microspectroscopy 失效
    分光光度图像加扰器，用于全孔径显微光谱

    公开(公告)号：US4712912A

    公开(公告)日：1987-12-15

    申请号：US837672

    申请日：1986-03-10

    Applicant: Robert G. Messerschmidt

    Inventor： Robert G. Messerschmidt

    IPC: G01J3/02 ,  G01N21/25 ,  G01N21/55 ,  G01N21/59

    CPC classification number: G01N21/255 ,  G01J3/02 ,  G01N21/474 ,  G01N2201/0806

    Abstract: The optical system of the present invention comtemplates directing a beam of radiant energy to either an aperture beam splitter or polarizing beam splitter. Radiant energy from the beam splitter forms a first remote image at an entrance to an image scrambler so that any image information which the beam contains is destroyed. The output of the scrambler fills the full aperture of a focusing objective that reproduces the image of the output of the scrambler onto a sample. A mask, positioned at a remote image between the output of the scrambler and focusing objective, determines the geometrical shape of the sample image. The focusing objective images the radiant energy that is reflected from the sample to a second remote image at the scrambler so that the scrambler destroys image information while retaining spectroscopic information. The beam splitter reflects a portion of the radiant energy from the scrambler to the detector. The absence of image information in the radiant energy from the sample reduces measurement errors by producing a predictable dispersion of radiant energy at the detector.

    Abstract translation: 本发明的光学系统旨在将辐射能束照射到孔径分束器或偏振分束器。 来自分束器的辐射能量在图像加扰器的入口处形成第一远程图像，使得束包含的任何图像信息被破坏。 加扰器的输出填充聚焦目标的全孔径，其将扰频器的输出的图像再现到样本上。 位于加扰器的输出端和聚焦目标之间的远程图像处的掩模确定样本图像的几何形状。 聚焦目标将从样本反射的辐射能量图像化成加扰器处的第二远程图像，使得加扰器在保留光谱信息的同时破坏图像信息。 分束器将辐射能量的一部分从扰频器反射到检测器。 来自样品的辐射能中不存在图像信息通过在检测器处产生可预测的辐射能的色散来降低测量误差。

    Ultraviolet absorption hygrometer
    27.
    发明授权
    Ultraviolet absorption hygrometer 失效
    紫外线吸收式湿度计

    公开(公告)号：US4627284A

    公开(公告)日：1986-12-09

    申请号：US757165

    申请日：1985-07-22

    Applicant: Michael E. Gersh ,  Fritz Bien ,  Lawrence S. Bernstein

    Inventor： Michael E. Gersh ,  Fritz Bien ,  Lawrence S. Bernstein

    IPC: G01J1/16 ,  G01N21/31 ,  G01N21/33 ,  G01W1/00

    CPC classification number: G01N21/33 ,  G01W1/00 ,  G01J1/1626 ,  G01N21/314 ,  G01N2201/0696 ,  G01N2201/0806

    Abstract: An ultraviolet absorption hygrometer is provided including a source of pulsed ultraviolet radiation for providing radiation in a first wavelength region where water absorbs significantly and in a second proximate wavelength region where water absorbs weakly. Ultraviolet radiation in the first and second regions which has been transmitted through a sample path of atmosphere is detected. The intensity of the radiation transmitted in each of the first and second regions is compared and from this comparison the amount of water in the sample path is determined.

    Abstract translation: 提供一种紫外线吸收式湿度计，其包括用于在水吸收显着的第一波长区域中提供辐射的脉冲紫外线辐射源，以及在弱吸收水的第二接近波长区域。 检测已经透过大气样本路径的第一和第二区域中的紫外线辐射。 比较在第一和第二区域中的每一个中发射的辐射的强度，并从该比较中确定样品路径中的水量。

    Multi-channel optical time-sharing apparatus having a rotating filter wheel with position-encoding means
    28.
    发明授权
    Multi-channel optical time-sharing apparatus having a rotating filter wheel with position-encoding means 失效
    具有带位置编码装置的旋转滤光轮的多通道光时分装置

    公开(公告)号：US3963351A

    公开(公告)日：1976-06-15

    申请号：US567946

    申请日：1975-04-14

    Applicant: Britton Chance ,  Victor Legallais ,  John R. Sorge ,  Norman C. Graham, Jr.

    Inventor： Britton Chance ,  Victor Legallais ,  John R. Sorge ,  Norman C. Graham, Jr.

    IPC: G01J1/44 ,  G01J3/12 ,  G01N21/31 ,  G01J3/30 ,  G01J3/48

    CPC classification number: G01N21/314 ,  G01J2001/444 ,  G01J2003/123 ,  G01N2021/3162 ,  G01N2021/3174 ,  G01N2021/4742 ,  G01N2021/6421 ,  G01N21/6408 ,  G01N2201/0621 ,  G01N2201/0806

    Abstract: A multi-wavelength time-sharing apparatus usable in various different configurations of optical measuring equipment to provide a plurality of time-shared optical channels and including appropriate circuitry. The apparatus employs a turbine-driven filter wheel having a shaft position-encoding arrangement consisting of a hollow shaft portion which is internally illuminated. The hollow shaft portion has two sets of spaced apertures cyclically communicating with respective angularly spaced pairs of externally fixedly mounted phototransistors which are sequentially illuminated as the shaft portion rotates and which produce timing pulses which drive Schmitt triggers, which, in a typical embodiment, in turn produce pulses compatible with a logic circuit employed to decode the phototransistor signals into triggers for driving a 4-channel switched gain equalizer, a dark current clamp, and detector gates. Appropriate selection of the signals enables the instrument to function as a fluorometer or a spectrophotometer.

    Abstract translation: 一种可用于各种不同配置的光学测量设备以提供多个时间共享的光学信道并且包括适当的电路的多波长时间共享装置。 该装置采用具有轴位置编码装置的涡轮驱动滤光轮，该轴位置编码装置由内部照明的中空轴部分组成。 空心轴部分具有两组间隔开的孔，这些孔与相应的有角度地间隔开的外部固定安装的光电晶体管对循环连通，随着轴部分旋转，该光电晶体管依次被照亮，并且产生驱动施密特触发器的定时脉冲，在典型的实施例中， 产生与用于将光电晶体管信号解码为用于驱动4通道开关增益均衡器，暗电流钳和检测器门的触发器的逻辑电路兼容的脉冲。 信号的适当选择使得仪器能够用作荧光计或分光光度计。

    Multi-channel fluorescence detecting system and method of using the same
    30.
    发明授权
    Multi-channel fluorescence detecting system and method of using the same 有权

    公开(公告)号：US09989465B2

    公开(公告)日：2018-06-05

    申请号：US15598236

    申请日：2017-05-17

    Applicant: TAIGEN BIOSCIENCE CORPORATION

    Inventor： Hung-Jen Kao

    IPC: F21V9/16 ,  G01N21/64 ,  C12Q1/68

    CPC classification number: G01N21/6428 ,  C12Q1/686 ,  G01N21/645 ,  G01N2021/6419 ,  G01N2021/6439 ,  G01N2021/6441 ,  G01N2201/0627 ,  G01N2201/0806

    Abstract: The present invention provides a multi-channel fluorescence detecting system for detecting a plurality of fluorescence labeled analytes. The multi-channel fluorescence detecting system comprises a light source, a light filter device, a dual branch light guide tube, and a detector. The light source comprises a plurality of sub light sources for respectively providing an excitation light. The plurality of sub light sources are a plurality of single color Light emitting diodes (LEDs) which can be selectively turned on or off. The light source generates a plurality of lights with full width at half maximum (FWHM) wavelengths formed in a non-overlap manner. With the disposition of the plurality of sub light sources, the accuracy for detecting the specific analytes is raised, the light flux with a specific wavelength band is effectively raised (without raising the light flux of the full wavelength band), the structure is simplified, and the manufacturing cost is decreased.

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