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    Atmospheric Interface for Electrically Grounded Electrospray
    22.
    发明申请
    Atmospheric Interface for Electrically Grounded Electrospray 审中-公开
    电接地电喷雾的大气界面

    公开(公告)号：US20160307744A1

    公开(公告)日：2016-10-20

    申请号：US15102910

    申请日：2014-12-22

    Applicant: WATERS TECHNOLOGIES CORPORATION

    Inventor： Joseph A. Jarrell

    IPC: H01J49/04 ,  H01J49/16

    CPC classification number: H01J49/0404 ,  H01J49/044 ,  H01J49/165

    Abstract: An interface for a mass spectrometer system is provided. The interface can include an inner ceramic tube fabricated from a first ceramic material and an outer tube fabricated from a second ceramic material surrounding the inner ceramic tube. The inner ceramic tube can have high electrical resistivity and high thermal conductivity and the intermediate ceramic tube can have an electrical resistivity that is at least an order of magnitude higher than the electrical resistivity of the first ceramic material and a thermal conductivity that is at least an order of magnitude higher than the thermal conductivity of the first ceramic material.

    Abstract translation: 提供了用于质谱仪系统的界面。 界面可以包括由第一陶瓷材料制成的内陶瓷管和由围绕内陶瓷管的第二陶瓷材料制成的外管。 内部陶瓷管可以具有高电阻率和高导热性，并且中间陶瓷管可以具有比第一陶瓷材料的电阻率高至少一个数量级的电阻率和至少为 数量级高于第一陶瓷材料的热导率。

    Sample Inlet and Vacuum System for Portable Mass Spectrometer
    23.
    发明申请
    Sample Inlet and Vacuum System for Portable Mass Spectrometer 审中-公开
    便携式质谱仪样品入口和真空系统

    公开(公告)号：US20160260594A1

    公开(公告)日：2016-09-08

    申请号：US14677996

    申请日：2015-04-03

    Applicant: Paul I. Hendricks

    Inventor： Paul I. Hendricks

    IPC: H01J49/00 ,  H01J49/04 ,  H01J49/06 ,  H01J49/24

    CPC classification number: H01J49/0022 ,  H01J49/044 ,  H01J49/066 ,  H01J49/24

    Abstract: An inlet and vacuum system for a portable, or handheld, mass spectrometer. The mass spectrometer comprises three vacuum chambers, which includes two ion funnels connected in series in the first two vacuum chambers, followed by a mass spectrometer analyzer and ion detector in the third vacuum chamber. The ion funnels are arranged with their central axes aligned in a linear fashion. The sample inlet to the portable mass spectrometer is from an external ion source, typically operating at atmospheric, or near atmospheric, pressure. An improvement in desolvation, and a reduction in the injection of neutrals, excited state molecules, and particulates into the analyzer is achieved by incorporating a lateral offset for the inlet capillary used to transfer ions into the first injection funnel. Additional efficiency for ion focusing is achieved by replacing the ion guide, typically used with atmospheric pressure ionization sources, with an additional ion funnel.

    Abstract translation: 用于便携式或手持式质谱仪的入口和真空系统。 质谱仪包括三个真空室，其包括在前两个真空室中串联连接的两个离子漏斗，随后是第三真空室中的质谱仪分析仪和离子检测器。 离子漏斗被布置成其中心轴以线性方式对准。 便携式质谱仪的样品入口来自外部离子源，通常在大气压或接近大气压下运行。 通过对用于将离子转移到第一注入漏斗中的入口毛细管的侧向偏移来实现去溶剂化的改进以及将中性粒子，激发态分子和微粒注入到分析器中的减少。 通过用额外的离子漏斗代替通常与大气压电离源一起使用的离子导向器实现离子聚焦的附加效率。

    APPARATUS FOR PROVIDING GASEOUS SAMPLE IONS/MOLECULES AND A CORRESPONDING METHOD
    24.
    发明申请
    APPARATUS FOR PROVIDING GASEOUS SAMPLE IONS/MOLECULES AND A CORRESPONDING METHOD 审中-公开
    用于提供气体样品离子/分子的装置和相应的方法

    公开(公告)号：US20140084154A1

    公开(公告)日：2014-03-27

    申请号：US14026083

    申请日：2013-09-13

    Applicant: Alexander Bazhenov ,  Sergey Valer'evich Bulovich ,  Roger Giles

    Inventor： Alexander Bazhenov ,  Sergey Valer'evich Bulovich ,  Roger Giles

    IPC: H01J49/04 ,  B01D1/00

    CPC classification number: H01J49/0422 ,  B01D1/00 ,  H01J49/044

    Abstract: An apparatus for providing gaseous sample ions/molecules from liquid droplets containing sample ions/molecules. The apparatus has a chamber having one or more walls which define an interior of the chamber, the chamber being configured to receive liquid droplets containing sample ions/molecules. The apparatus also has a gas flow producing means configured to produce a flow of gas within the chamber for promoting evaporation of liquid droplets in the chamber to provide gaseous sample ions/molecules. The apparatus is configured such that the flow of gas produced within the chamber inhibits liquid droplets in the chamber from coming into contact with the one or more walls of the chamber.

    Abstract translation: 用于从含有样品离子/分子的液滴提供气态样品离子/分子的装置。 该装置具有一个腔室，该腔室具有一个或多个限定腔室内部的壁，该腔室被构造成容纳含有样品离子/分子的液滴。 该装置还具有气流产生装置，其构造成在室内产生气体流，以促进腔室中液滴的蒸发，以提供气态样品离子/分子。 该装置被配置为使得在室内产生的气体流阻止室中的液滴与室的一个或多个壁接触。

    Converging-diverging supersonic shock disruptor for fluid nebulization and drop fragmentation
    25.
    发明授权
    Converging-diverging supersonic shock disruptor for fluid nebulization and drop fragmentation 有权
    用于流体雾化和分散破碎的会聚 - 发散的超音速冲击破坏器

    公开(公告)号：US08680460B2

    公开(公告)日：2014-03-25

    申请号：US12346089

    申请日：2008-12-30

    Applicant: Peter T. Williams ,  Harvey Dean Loucks, Jr.

    Inventor： Peter T. Williams ,  Harvey Dean Loucks, Jr.

    IPC: H01J49/00

    CPC classification number: G01N30/7246 ,  H01J49/0404 ,  H01J49/044 ,  H01J49/045

    Abstract: A disruptor apparatus comprises a nozzle comprising: a converging section; a diverging section; and a throat between the converging section and the diverging section. The disruptor apparatus also comprises a holder configured to receive a fluid conduit, which comprises an outlet located in the converging section; and a channel disposed about the holder and configured to guide a gas past the outlet of the fluid conduit, through the converging section, through the throat and into the diverging section where the gas travels at supersonic speed and establishes a standing shock wave in the diverging section. A mass spectrometer and a method are also described.

    Abstract translation: 一种破坏装置，包括：喷嘴，包括：会聚部; 分歧部分 以及在会聚部分和发散部分之间的喉部。 所述破坏装置还包括构造成接收流体导管的保持器，所述流体导管包括位于所述会聚部分中的出口; 以及设置在所述保持器周围并且被配置为引导气体通过所述会聚部分的气体经过所述喉部并且进入所述扩散部分，在所述扩散部分中所述气体以超音速行进，并且在所述发散中产生驻立冲击波 部分。 还描述了质谱仪和方法。

    ATMOSPHERIC PRESSURE IONIZATION APPARATUS AND METHOD
    26.
    发明申请
    ATMOSPHERIC PRESSURE IONIZATION APPARATUS AND METHOD 有权
    大气压力放电装置及方法

    公开(公告)号：US20120318973A1

    公开(公告)日：2012-12-20

    申请号：US13164386

    申请日：2011-06-20

    Applicant: Harvey D. Loucks, JR. ,  Paul C. Goodley

    Inventor： Harvey D. Loucks, JR. ,  Paul C. Goodley

    IPC: H01J27/02 ,  H01J49/10

    CPC classification number: H01J49/044 ,  H01J49/10

    Abstract: An atmospheric pressure ionization apparatus includes a chamber, an ion inlet structure, an electrode, a sample emitter, and a gas passage. The ion inlet structure includes a sampling orifice. The electrode includes an electrode bore. An ionization region is defined between the ion inlet structure and the electrode. The flared structure is coaxially disposed about the ion inlet structure, and extends along an outward direction that includes a radial component relative to the sampling axis. The sample emitter is oriented at an angle to the sampling axis for directing a sample stream toward the ionization region. The gas passage directs a stream of gas from a gas source to the chamber. The flared structure and the wall cooperatively form an outward-directed portion of the gas passage that extends annularly about the sampling axis and along the outward direction. The gas flows through the outward-directed portion, around the flared structure, and toward the ionization region and the electrode bore.

    Abstract translation: 大气压离子化装置包括室，离子入口结构，电极，样品发射体和气体通道。 离子入口结构包括采样孔。 电极包括电极孔。 在离子入口结构和电极之间限定电离区域。 扩口结构围绕离子入口结构同轴设置，并且沿着包括相对于采样轴线的径向分量的向外方向延伸。 样品发射器与采样轴成一角度定向，以将样品流引向电离区。 气体通道将气流从燃气源引导到腔室。 扩口结构和壁协同地形成气体通道的向外的部分，其环绕取样轴线并沿着向外方向延伸。 气体在扩张结构周围流过外向部分，并朝向电离区域和电极孔流动。

    CONVERGING-DIVERGING SUPERSONIC SHOCK DISRUPTOR FOR FLUID NEBULIZATION AND DROP FRAGMENTATION
    27.
    发明申请
    CONVERGING-DIVERGING SUPERSONIC SHOCK DISRUPTOR FOR FLUID NEBULIZATION AND DROP FRAGMENTATION 有权
    用于流体渗透和液滴分散的混合超声冲击震荡器

    公开(公告)号：US20100163719A1

    公开(公告)日：2010-07-01

    申请号：US12346089

    申请日：2008-12-30

    Applicant: Harvey Dean Loucks, JR. ,  Peter T. Williams

    Inventor： Harvey Dean Loucks, JR. ,  Peter T. Williams

    IPC: H01J49/00 ,  G01N30/00

    CPC classification number: G01N30/7246 ,  H01J49/0404 ,  H01J49/044 ,  H01J49/045

    Abstract: A disrupter apparatus comprises a nozzle comprising: a converging section; a diverging section; and a throat between the converging section and the diverging section. The disrupter apparatus also comprises a holder configured to receive a fluid conduit, which comprises an outlet located in the converging section; and a channel disposed about the holder and configured to guide a gas past the outlet of the fluid conduit, through the converging section, through the throat and into the diverging section where the gas travels at supersonic speed and establishes a standing shock wave in the diverging section. A mass spectrometer and a method are also described.

    Abstract translation: 一种破坏器装置，包括：喷嘴，包括：会聚部分; 分歧部分 以及在会聚部分和发散部分之间的喉部。 破碎器装置还包括保持器，其构造成接收流体导管，该流体导管包括位于会聚部分中的出口; 以及设置在所述保持器周围并且被配置为引导气体通过所述会聚部分的气体经过所述喉部并且进入所述扩散部分，在所述扩散部分中所述气体以超音速行进，并且在所述发散中产生驻立冲击波 部分。 还描述了质谱仪和方法。

    Atmospheric pressure charged particle discriminator for mass spectrometry
    28.
    发明授权
    Atmospheric pressure charged particle discriminator for mass spectrometry 有权
    用于质谱的大气压电荷粒子鉴别器

    公开(公告)号：US07462826B2

    公开(公告)日：2008-12-09

    申请号：US11447785

    申请日：2006-06-06

    Applicant: Bradley Schneider ,  Thomas R. Covey

    Inventor： Bradley Schneider ,  Thomas R. Covey

    IPC: H01J49/04

    CPC classification number: H01J49/06 ,  H01J49/044

    Abstract: An apparatus and method for performing mass spectroscopy uses an ion interface to provide the function of removing undesirable particulates from an ion stream from an atmospheric pressure ion source, such as an electrospray source or a MALDI source, before the ion stream enters a vacuum chamber containing the mass spectrometer. The ion interface includes an entrance cell with a bore that may be heated for desolvating charged droplets when the ion source is an electrospray source, and a particle discrimination cell with a bore disposed downstream of the bore of the entrance cell and before an aperture leading to the vacuum chamber. The particle discrimination cell creates gas dynamic and electric field conditions that enables separation of undesirable charged particulates from the ion stream.

    Abstract translation: 用于执行质谱的装置和方法使用离子界面来提供在离子流进入真空室之前从大气压离子源（例如电喷雾源或MALDI源）从离子流中除去不期望的微粒的功能， 质谱仪。 离子界面包括具有孔的入口单元，其可以在离子源是电喷雾源时被加热用于对带电液滴进行脱溶剂;以及颗粒鉴别单元，孔设置在入口单元的孔的下游，并且在通向孔 真空室。 颗粒鉴别池产生气体动态和电场条件，其使得能够从离子流中分离不期望的带电粒子。

    Electrospray ion source
    29.
    发明申请
    Electrospray ion source 失效

    公开(公告)号：US20080073555A1

    公开(公告)日：2008-03-27

    申请号：US11491439

    申请日：2006-07-21

    Applicant: Jean-Jacques Dunyach ,  Nigel P. Gore ,  Paul R. Atherton

    Inventor： Jean-Jacques Dunyach ,  Nigel P. Gore ,  Paul R. Atherton

    IPC: H01J27/00

    CPC classification number: H01J49/167 ,  H01J49/044

    Abstract: An on-axis ion source has an ionization chamber and an adjacent low-pressure region. The on-axis ion source also includes a capillary tube having an axial bore for supporting fluid communication between the ionization chamber and the adjacent low-pressure region, the axial bore of the capillary tube being substantially concentrically aligned with the orifice of a skimmer located downstream in the ion path from the capillary tube. A blocking element is provided in an aligned facing arrangement with the axial bore of the capillary tube and on an opposite side of the orifice relative to the capillary tube. The blocking element receives droplets or particles flowing through the axial bore of the capillary tube and passing through the orifice of the skimmer. The combination of an on-axis arrangement and the use of a blocking element results in improved signal-to-noise level due to enhanced ion transmission and reduction of noise arising from passage of undesolvated droplets and particles to the mass analyzer.

    Mass spectrometer
    30.
    发明授权
    Mass spectrometer 有权
    质谱仪

    公开(公告)号：US07265362B2

    公开(公告)日：2007-09-04

    申请号：US11051608

    申请日：2005-02-04

    Applicant: Stevan Bajic ,  Robert Harold Bateman

    Inventor： Stevan Bajic ,  Robert Harold Bateman

    IPC: H01J27/00

    CPC classification number: H01J49/168 ,  H01J49/044 ,  H01J49/045 ,  H01J49/0468 ,  H01J49/165

    Abstract: An Electrospray Ionisation ion source and an Atmospheric Pressure Chemical Ionisation ion source are disclosed which comprise a probe 1 comprising two co-axial capillary tubes 2,3. A blue-flame gas torch 6 is provided downstream of the probe 1 as a combustion source. An analyte solution is sprayed from an inner capillary tube 2 of the probe 1 and a combustible gas is supplied to an outer capillary tube 3 of the probe 1. The combustible gas supplies heat to aid desolvation of the droplets emerging from the probe 1 via combustion with the surrounding oxygen-containing atmosphere when combusted by the blue flame torch 6.

    Abstract translation: 公开了一种电喷雾离子源和大气压化学电离离子源，其包括包含两个同轴毛细管2,3的探针1。 蓝色火焰焰炬6设置在探头1的下游，作为燃烧源。 从探针1的内部毛细管2喷射分析物溶液，将可燃气体供给到探针1的外部毛细管3。 当由蓝色火焰焰炬6燃烧时，可燃气体通过与周围的含氧气氛的燃烧而提供热量以帮助从探针1出来的液滴的去溶剂化。

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