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    Method and system using acoustic ejection for selective fluid deposition on a nonuniform sample surface
    21.
    发明申请
    Method and system using acoustic ejection for selective fluid deposition on a nonuniform sample surface 有权
    在不均匀样品表面上选择性流体沉积的声喷射的方法和系统

    公开(公告)号：US20020195558A1

    公开(公告)日：2002-12-26

    申请号：US10157755

    申请日：2002-05-28

    Inventor： Richard N. Ellson ,  Mitchell W. Mutz ,  Richard Michael Caprioli

    IPC: H01J049/04

    CPC classification number: H01J49/0454 ,  G01N33/54393 ,  G01N35/1011 ,  H01J49/0004 ,  Y10T436/2575

    Abstract: A method for selectively depositing analysis-enhancing fluid on a sample surface is disclosed. The method involves providing a sample having a surface that exhibits variations in a surface characteristic that corresponds to desirability for receiving an analysis-enhancing fluid. Once a site on the sample surface is selected according to the surface characteristic at the site, focused radiation, typically acoustic radiation, is applied in a manner effective to eject a droplet of the analysis-enhancing fluid from a reservoir. As a result, the droplet is deposited on the sample surface at the selected site. Optionally, the sample at the selected site is analyzed. Systems for selectively depositing analysis-enhancing fluids are also disclosed.

    Abstract translation: 公开了一种用于在样品表面上选择性地沉积分析增强流体的方法。 该方法包括提供具有表现出表现出与分析增强流体接受的期望性相对应的表面特性变化的样品的样品。 一旦根据现场的表面特征选择样品表面上的部位，则以有效地从储存器喷射分析增强流体液滴的方式施加聚焦辐射（通常是声辐射）。 结果，液滴在所选择的位置沉积在样品表面上。 任选地，分析所选位点处的样品。 还公开了用于选择性沉积分析增强流体的系统。

    Droplet ion source for mass spectrometry
    22.
    发明申请
    Droplet ion source for mass spectrometry 有权
    用于质谱的液滴离子源

    公开(公告)号：US20020166961A1

    公开(公告)日：2002-11-14

    申请号：US10113897

    申请日：2002-03-29

    Inventor： William Travis Berggren ,  Michael Scott Westphall ,  Lloyd Michael Smith

    IPC: H01J040/04

    CPC classification number: H01J49/0454 ,  H01J49/167

    Abstract: The invention provides devices, device configurations and methods for improved sensitivity, detection level and efficiency in mass spectrometry particularly as applied to biological molecules, including biological polymers, such as proteins and nucleic acids. In one aspect, the invention relates to charged droplet sources and their use as ion sources and as components in ion sources. In another aspect, the invention relates to charged droplet traps and their use as ion sources and as elements of ion sources. Further, the invention relates to the use of aerodynamic lenses for high efficiency ion transport to a charge particle analyzer, particularly a mass analyzer. Devices of this invention allow mass spectral analysis of a single charged droplet. The ion sources of this invention can be combined with any charge particle detector or mass analyzer, but are a particularly benefit when used in combination with a time of flight mass spectrometer.

    Abstract translation: 本发明提供用于提高质谱的灵敏度，检测水平和效率的装置，装置配置和方法，特别是应用于包括生物聚合物如蛋白质和核酸的生物分子。 一方面，本发明涉及带电液滴源及其作为离子源和作为离子源中的组分的用途。 另一方面，本发明涉及带电液滴阱及其作为离子源和离子源元素的用途。 此外，本发明涉及使用空气动力学透镜进行高效率离子迁移到电荷粒子分析仪，特别是质量分析器。 本发明的装置允许单个带电液滴的质谱分析。 本发明的离子源可以与任何电荷粒子检测器或质量分析仪组合，但是当与飞行时间质谱仪组合使用时是特别有益的。

    Acoustic sample introduction for mass spectrometric analysis
    23.
    发明申请
    Acoustic sample introduction for mass spectrometric analysis 有权
    用于质谱分析的声学样品引入

    公开(公告)号：US20020109084A1

    公开(公告)日：2002-08-15

    申请号：US09784705

    申请日：2001-02-14

    Inventor： Richard N. Ellson ,  Mitchell W. Mutz

    IPC: H01J049/04

    CPC classification number: H01J49/0454 ,  Y10T436/2575

    Abstract: The invention relates to the efficient transport of a small fluid sample such as that may be required by analytical devices such as mass spectrometers configured to analyze small samples of biomolecular fluids. Such transport involves nozzleless acoustic ejection, wherein analyte molecules are introduced from a reservoir holding a fluid into an ionization chamber of an analytical device or a small capillary by directing focused acoustic radiation at a focal point near the surface of the fluid sample. This facilitates the analysis of various types of analytes such as biomolecular analytes having a high molecular weight.

    Abstract translation: 本发明涉及一种小型流体样品的有效运输，例如分析装置所需要的，例如用于分析生物分子流体的小样本的质谱仪。 这种运输涉及无喷嘴声学喷射，其中通过将集中的声辐射引导到靠近流体样品表面的焦点处，将分析物分子从保持流体的储存器引入分析装置或小毛细管的离子化室中。 这有助于分析各种类型的分析物，例如具有高分子量的生物分子分析物。

    FOCUSED ACOUSTIC RADIATION FOR THE EJECTION OF SUBWAVELENGTH DROPLETS
    25.
    发明公开
    FOCUSED ACOUSTIC RADIATION FOR THE EJECTION OF SUBWAVELENGTH DROPLETS 审中-公开

    公开(公告)号：US20230338942A1

    公开(公告)日：2023-10-26

    申请号：US18335764

    申请日：2023-06-15

    Applicant: Labcyte Inc.

    Inventor： Richard G. Stearns

    IPC: B01L3/02 ,  H01J49/04

    CPC classification number: B01L3/0268 ,  H01J49/0454 ,  B01L2200/0642 ,  B01L2200/141 ,  B01L2400/0436

    Abstract: Focused acoustic radiation, referred to as tonebursts, are applied to a volume of liquid to generate a set of droplets. The droplets generated are substantially smaller in scale than the focal spot size of the acoustic beam (e.g., the frequency at which the acoustic transducer operates). Further, the droplets have trajectories that are substantially in the direction of the acoustic beam propagation direction. In one embodiment, a first toneburst is applied to temporarily raise a protuberance on a free surface of the fluid. After the protuberance has reached a certain state, a second toneburst is applied to the protuberance to break it into very small droplets. In one embodiment, the state of the protuberance at which the second toneburst is supplied is the time period shortly after the protuberance reaches its maximum height but before the protuberance recedes back into the volume of fluid.

    AEMS Auto Tuning
    27.
    发明公开
    AEMS Auto Tuning 审中-公开

    公开(公告)号：US20230207298A1

    公开(公告)日：2023-06-29

    申请号：US17999637

    申请日：2021-05-21

    Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.

    Inventor： Chang Liu ,  Thomas R. Covey

    IPC: H01J49/04 ,  H01J49/16

    CPC classification number: H01J49/0454 ,  H01J49/165

    Abstract: An optimal value is calculated for at least one parameter of an ADE device, an OPI, or an ion source device. For each value of a plurality of parameter values for at least one parameter of the ADE device, the OPI, or the ion source device, three steps are performed using a processor. First, the at least one parameter is set to the value. Second, the ADE device, the OPI, the ion source device, and a mass spectrometer are instructed to produce one or more intensity versus time mass peaks for a sample. Third, a feature value is calculated for at least one feature of the one or more intensity versus time mass peaks. A plurality of feature values corresponding to the plurality of parameter values is produced. An optimal value is calculated for the at least one parameter from the plurality of feature values.

    Liquid Sample Introduction System and Method, for Analytical Plasma Spectrometer
    28.
    发明申请
    Liquid Sample Introduction System and Method, for Analytical Plasma Spectrometer 审中-公开

    公开(公告)号：US20170178884A1

    公开(公告)日：2017-06-22

    申请号：US15372112

    申请日：2016-12-07

    Applicant: Thermo Fisher Scientific (Bremen) GmbH

    Inventor： Ayrat MURTAZIN

    IPC: H01J49/04 ,  G01J3/02 ,  G01J3/443

    CPC classification number: H01J49/045 ,  G01J3/0267 ,  G01J3/443 ,  H01J49/0409 ,  H01J49/0454

    Abstract: A liquid sample introduction system for a plasma spectrometer includes a sample container for holding a liquid sample, a surface acoustic wave (SAW) nebulizer, arranged to receive a liquid sample from the sample container, an electronic controller for supplying electrical power to the SAW nebulizer so as to produce a surface acoustic wave on a surface of the SAW nebulizer, for generating an aerosol from the supplied sample liquid, and an aerosol transport arrangement for receiving the aerosol from the SAW nebulizer and carrying it into a plasma or flame of a spectrometer. The electronic controller is further configured to control the electrical power to the SAW nebulizer so as to permit adjustment of the aerosol parameters, and to control the aerosol transport arrangement so as to permit adjustment of the aerosol delivery into the plasma or flame of the spectrometer.

    Continuously moving target for an atmospheric pressure ion source
    29.
    发明授权
    Continuously moving target for an atmospheric pressure ion source 有权
    连续移动目标为大气压离子源

    公开(公告)号：US09437398B2

    公开(公告)日：2016-09-06

    申请号：US14438679

    申请日：2012-10-25

    Applicant: Waters Technologies Corporation

    Inventor： Michael John Tomany

    IPC: H01J49/00 ,  H01J37/317 ,  H01J49/04 ,  H01J49/16

    CPC classification number: H01J37/3171 ,  H01J49/0445 ,  H01J49/0454 ,  H01J49/16

    Abstract: An ion source includes a nebulizer and a target, with the nebulizer being arranged and adapted to emit, in use, a stream of analyte droplets which are caused to impact upon the target and to ionize analyte to form a plurality of analyte ions. The target comprises a pin or rod which is mounted off-set from a rotating shaft. The target is rotated or translated in use and follows an eccentric path such that the relative position between the nebulizer and target varies as the target is rotated or translated.

    Abstract translation: 离子源包括雾化器和靶，其中喷雾器被布置并适于在使用中发射被分析物液滴流，其被撞击到靶上并使分析物电离以形成多个分析物离子。 目标包括从旋转轴安装的销或杆。 目标在使用中旋转或平移，并且遵循偏心路径，使得雾化器和目标之间的相对位置随着目标旋转或平移而变化。

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