公开(公告)号：US12005451B2

公开(公告)日：2024-06-11

申请号：US17256348

申请日：2019-06-28

Applicant: RAB MICROFLUIDICS RESEARCH AND DEVELOPMENT COMPANY LIMITED

Inventor： Oluwarotimi Alabi ,  Surakat Kudehunbu ,  Barry James Warden ,  Stephen McIntosh

IPC: F01M11/10 ,  B01L3/00 ,  G01J3/10 ,  G01N33/28

CPC classification number: B01L3/502753 ,  F01M11/10 ,  G01J3/10 ,  G01N33/2858 ,  G01N33/2888 ,  B01L2300/0681 ,  F01M2011/1413 ,  F01M2011/144

Abstract: The invention provides a microfluidic system for monitoring the condition of lubricating oil. The microfluidic system comprises a microfluidic device with at least one microchannel (40) configured to allow a sample of lubricating oil (52a) to pass therethrough as a laminar flow. The device has at least one separating device (41) configured to selectively separate at least one component (54b) from the lubricating oil (52a) in the fluid flow. The microfluidic system also comprises a detector device (20, 22) configured to detect the presence and/or measure at least one property of the at least one component passing through the microfluidic device after separation in the microchannel (40).

公开(公告)号：US20240180428A1

公开(公告)日：2024-06-06

申请号：US18438144

申请日：2024-02-09

Applicant: OMNI MEDSCI, INC.

Inventor： Mohammed N. ISLAM

IPC: A61B5/00 ,  A61B5/145 ,  A61B5/1455 ,  A61C1/00 ,  A61C19/04 ,  G01J3/02 ,  G01J3/10 ,  G01J3/12 ,  G01J3/14 ,  G01J3/18 ,  G01J3/28 ,  G01J3/42 ,  G01J3/453 ,  G01M3/38 ,  G01N21/35 ,  G01N21/3504 ,  G01N21/3563 ,  G01N21/359 ,  G01N21/39 ,  G01N21/85 ,  G01N21/88 ,  G01N21/95 ,  G01N33/02 ,  G01N33/15 ,  G01N33/44 ,  G01N33/49 ,  G16H40/67 ,  G16Z99/00 ,  H01S3/00 ,  H01S3/067 ,  H01S3/30

CPC classification number: A61B5/0088 ,  A61B5/0013 ,  A61B5/0022 ,  A61B5/0075 ,  A61B5/0086 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/4547 ,  A61B5/6801 ,  A61B5/7203 ,  A61B5/7257 ,  A61B5/7405 ,  A61B5/742 ,  A61C19/04 ,  G01J3/02 ,  G01J3/0218 ,  G01J3/108 ,  G01J3/14 ,  G01J3/28 ,  G01J3/2823 ,  G01J3/42 ,  G01J3/453 ,  G01N21/35 ,  G01N21/3504 ,  G01N21/3563 ,  G01N21/359 ,  G01N21/39 ,  G01N21/88 ,  G01N33/02 ,  G01N33/025 ,  G01N33/15 ,  G01N33/442 ,  G01N33/49 ,  G16H40/67 ,  G16Z99/00 ,  A61B5/0024 ,  A61B2562/0233 ,  A61B2562/0238 ,  A61B2562/146 ,  A61B2576/02 ,  A61C1/0046 ,  G01J2003/104 ,  G01J2003/1208 ,  G01J3/1838 ,  G01J2003/2826 ,  G01M3/38 ,  G01N2021/3513 ,  G01N2021/3595 ,  G01N2021/399 ,  G01N21/85 ,  G01N21/9508 ,  G01N2201/061 ,  G01N2201/06113 ,  G01N2201/062 ,  G01N2201/08 ,  G01N2201/12 ,  G01N2201/129 ,  H01S3/0092 ,  H01S3/06758 ,  H01S3/302 ,  Y02A90/10

Abstract: An optical system comprises a wearable device for measuring one or more physiological parameters. The physiological parameters may change in response to stretching of the hand or movement of fingers or thumb of the user, or the parameters may be related to blood constituents or blood flow. The wearable device comprises a light source with a plurality of semiconductor diodes and a detection system that measures reflected light from tissue comprising skin. The semiconductor diodes may be light emitting diodes or laser diodes. The signal to noise ratio for the output signal may be improved by synchronizing the detection system to the light source, increasing light intensity of at least one of the plurality of semiconductor diodes from an initial light intensity, and using change detection that compares light on versus light off for the detection system output. The wearable device is also configured to identify an object.

公开(公告)号：US11988557B2

公开(公告)日：2024-05-21

申请号：US17545106

申请日：2021-12-08

Applicant: BATTELLE SAVANNAH RIVER ALLIANCE, LLC

Inventor： Kimberly Alicia Strange Fessler ,  Steven Michael Serkiz

IPC: G01J3/44 ,  G01J3/02 ,  G01J3/10 ,  G01N21/65

CPC classification number: G01J3/44 ,  G01J3/10 ,  G01N21/65 ,  G01J3/0218

Abstract: Methods and systems are described for use in determination of the presence, type (static or AC), direction, and/or strength of an electric field. Methods include examination of a gaseous sample to determine the presence of perturbation effects brought about by dielectrophoretic forces acting on components of the gaseous sample, and thereby, to identify the presence of an electric field. Examination of a gaseous sample can include Raman spectroscopy. A gaseous sample can be analyzed to determine the presence of molecular polarization due to an induced dipole on a polarizable molecule.

公开(公告)号：US20240151582A1

公开(公告)日：2024-05-09

申请号：US18483765

申请日：2023-10-10

Applicant: MGI Tech Co., Ltd.

Inventor： Paul Lundquist ,  Razvan Chirita

IPC: G01J3/28 ,  G01J3/02 ,  G01J3/10

CPC classification number: G01J3/2803 ,  G01J3/0208 ,  G01J3/10

Abstract: Systems and methods for immersion imaging of a flowcell. In one example, an imaging system includes liquid ports in leading and trailing positions relative to a scanned imaging objective. The leading liquid port dispenses an immersion liquid into a space between the distal end of the imaging objective and the flowcell's cover, with the trailing liquid port collecting the immersion liquid. In another example, an imaging system includes a flowcell with a cover that is moveable relative a substrate. The system is configured to move the imaging objective and flowcell cover as a unit relative to the flowcell substrate.

公开(公告)号：US11967799B2

公开(公告)日：2024-04-23

申请号：US15508889

申请日：2015-08-28

Applicant: PILOT PHOTONICS LIMITED

Inventor： Jules Braddell ,  Frank Smyth

IPC: H01S5/065 ,  G01J3/10 ,  G01J3/42 ,  G01N21/31 ,  G01N21/3504 ,  G01N21/39 ,  G01N21/45 ,  H01S5/00 ,  H01S5/042 ,  H01S5/10 ,  H01S5/40

CPC classification number: H01S5/0656 ,  G01J3/10 ,  G01J3/42 ,  G01N21/3504 ,  H01S5/0064 ,  H01S5/0085 ,  H01S5/0427 ,  H01S5/1096 ,  H01S5/4006 ,  G01N2021/3133 ,  G01N2021/3148 ,  G01N2021/399 ,  G01N2021/451 ,  G01N2201/0612

Abstract: A method of performing spectroscopic measurements provides an optical frequency comb, and directs the comb through or at a sample. The optical frequency comb is generated by gain switching a laser diode constructed from Gallium Nitride and related materials. Various techniques are described for manipulating the comb source to achieve desired benefits for spectroscopy.

公开(公告)号：US11957460B2

公开(公告)日：2024-04-16

申请号：US16777855

申请日：2020-01-30

Applicant: LifePlus Inc

Inventor： Kevin Hazen ,  Alan Abul-Haj ,  Roxanne Abul-Haj ,  Christopher Slawinski ,  Alodeep Sanyal ,  Benjamin Mbouombouo

IPC: A61B5/1455 ,  A61B5/00 ,  A61B5/145 ,  G01J3/10 ,  G01N33/49

CPC classification number: A61B5/1455 ,  A61B5/0022 ,  A61B5/0051 ,  A61B5/0053 ,  A61B5/14532 ,  A61B5/6824 ,  A61B5/6832 ,  G01J3/10 ,  G01N33/49 ,  A61B5/0004 ,  A61B5/7264 ,  A61B2562/0233 ,  A61B2562/0238 ,  A61B2562/046 ,  G01J2003/102 ,  G01J2003/106

Abstract: The invention comprises a method and apparatus for sampling a common tissue volume and/or a common skin layer skin of a person as a part of noninvasively determining an analyte property with an analyzer including: a set of detectors at least partially embedded in a probe housing, the probe housing comprising a sample side surface, the detectors including a first and second range of detection zones of differing radial distances from a first illumination zone and second illumination zone, respectively coupled to separate sources, with surface paths between the sources and detectors overlapping a common skin area during use.

公开(公告)号：US20240094130A1

公开(公告)日：2024-03-21

申请号：US18214507

申请日：2023-06-26

Applicant: SHIMADZU CORPORATION

Inventor： Fumiya KATSUTANI ,  Tomoki SASAYAMA ,  Tomoyo TAO ,  Atsuhiko OTAGURO ,  Ryuta SHIBUTANI ,  Hisato FUKUDA

IPC: G01N21/65 ,  G01J3/02 ,  G01J3/10 ,  G01J3/44 ,  G02B21/06

CPC classification number: G01N21/65 ,  G01J3/0208 ,  G01J3/10 ,  G01J3/44 ,  G02B21/06 ,  G01J2003/102

Abstract: A Raman infrared compound microscope device includes: a first light source that generates laser light; a second light source that generates infrared light; a third light source that generates visible light; and a first optical system. The first optical system orients the visible light having reached the first optical system in different directions between when performing a Raman analysis using Raman light generated from a sample by irradiation of the laser light and when performing a first infrared analysis using the infrared light having passed through the sample.

公开(公告)号：US20240060895A1

公开(公告)日：2024-02-22

申请号：US18496681

申请日：2023-10-27

Applicant: Illumina, Inc.

Inventor： Rui JIANG ,  Joseph PINTO

IPC: G01N21/64 ,  C12Q1/6869 ,  G01J3/10 ,  G02B27/09

CPC classification number: G01N21/6428 ,  C12Q1/6869 ,  G01J3/10 ,  G01N21/6452 ,  G01N21/6456 ,  G02B27/0994 ,  G01N2021/6419 ,  G01N2021/6439 ,  G01N2021/6463 ,  G01N2201/0638 ,  G01N2201/08 ,  G01N2201/0806 ,  H01L27/14612

Abstract: There is set forth herein a light energy exciter that can include one or more light sources. A light energy exciter can emit excitation light directed toward a detector surface that can support biological or chemical samples.

公开(公告)号：US11892281B2

公开(公告)日：2024-02-06

申请号：US17655899

申请日：2022-03-22

Applicant: Otsuka Electronics Co., Ltd.

Inventor： Shiro Kawaguchi ,  Kazuya Nakajima ,  Hayato Takizawa ,  Goro Maeda

IPC: G01B11/06 ,  G01J3/02 ,  G01J3/10 ,  G01B5/00 ,  G01N21/27 ,  G01B9/02055 ,  G01J3/28 ,  G01N21/25 ,  G01B21/04

CPC classification number: G01B11/0625 ,  G01B5/0014 ,  G01B9/0207 ,  G01B11/06 ,  G01B11/0675 ,  G01B21/045 ,  G01J3/02 ,  G01J3/027 ,  G01J3/0232 ,  G01J3/0286 ,  G01J3/0291 ,  G01J3/0297 ,  G01J3/10 ,  G01J3/28 ,  G01N21/25 ,  G01N21/274 ,  G01N21/276 ,  G01J2003/2836

Abstract: An optical measurement system includes a light source, a spectroscopic detector, a reference sample, a switching mechanism that switches between a first optical path through which a sample to be measured is irradiated with light from the light source and light produced at the sample is guided to the spectroscopic detector and a second optical path through which the reference sample is irradiated with light from the light source and light produced at the reference sample is guided to the spectroscopic detector, and a processing unit that calculates, by performing correction processing based on change between a first detection result at first time and a second detection result at second time, a measurement value of the sample from a third detection result provided from the spectroscopic detector as a result of irradiation of the sample with light from the light source at third time temporally proximate to the second time.

公开(公告)号：US11874229B2

公开(公告)日：2024-01-16

申请号：US17715862

申请日：2022-04-07

Applicant: Onto Innovation Inc.

Inventor： George Andrew Antonelli

IPC: G01N21/65 ,  G01J3/44 ,  G01J3/02 ,  G01J3/18 ,  G02B27/14 ,  G01J3/10

CPC classification number: G01N21/65 ,  G01J3/0208 ,  G01J3/0224 ,  G01J3/10 ,  G01J3/18 ,  G01J3/4412 ,  G02B27/141

Abstract: An optical metrology device performs multi-wavelength polarized confocal Raman spectroscopy. The optical metrology device uses a first light source to produce a first light beam with a first wavelength and a second light source to produce a second light beam with a second wavelength. A dichroic beam splitter partially reflects the first light beam and transmits the second light beam to combine the light beams along a same optical axis that is incident on a sample. The dichroic beam splitter directs the Raman response emitted from the sample in response to the first light beam and the second light beam together towards at least one spectrometer and directs the first light beam away from the at least one spectrometer. A chopper may be used to isolate the Raman response to the first and second light beams that is received and spectrally measured by the at least one spectrometer.