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公开(公告)号：US20180238776A1
公开(公告)日：2018-08-23
申请号：US15554626
申请日：2016-03-07
Applicant: Micromass UK Limited
Inventor： Tamas KARANCSI , Lajos GODORHAZY , Daniel SZALAY , Zoltan TAKATS , Julia BALOG , Steven Derek PRINGLE , Daniel SIMON
IPC: G01N1/22 , A61B1/273 , A61B5/00 , A61B18/20 , A61B18/04 , A61B18/14 , G01N27/62 , H01J49/04 , H01J49/00
Abstract: An apparatus for mass spectrometry and/or ion mobility spectrometry is disclosed comprising a first device arranged and adapted to generate aerosol, smoke or vapour from a target and one or more second devices arranged and adapted to aspirate aerosol, smoke, vapour and/or liquid to or towards an analyser. A liquid trap or separator is provided to capture and/or discard liquid aspirated by the one or more second devices.
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公开(公告)号：US20180103935A1
公开(公告)日：2018-04-19
申请号：US15555998
申请日：2016-03-07
Applicant: Micromass UK Limited
Inventor： Steven Derek PRINGLE , Tamas KARANCSI , Emrys JONES , Michael Raymond MORRIS , Julia BALOG , James Ian LANGRIDGE , Zoltan TAKATS , Frances BOLT , Lajos GODORHAZY , Daniel SZALAY , Daniel SIMON , Keith RICHARDSON
CPC classification number: H01J49/049 , A61B1/00013 , A61B1/041 , A61B1/2736 , A61B1/31 , A61B5/0066 , A61B5/0075 , A61B5/015 , A61B5/0507 , A61B5/055 , A61B5/14542 , A61B6/032 , A61B6/037 , A61B8/13 , A61B10/00 , A61B10/0041 , A61B10/0233 , A61B10/0283 , A61B17/00 , A61B17/320068 , A61B18/00 , A61B18/04 , A61B18/042 , A61B18/14 , A61B18/1445 , A61B18/1815 , A61B18/20 , A61B90/13 , A61B2010/0083 , A61B2017/320069 , A61B2018/00577 , A61B2018/00589 , A61B2018/00994 , A61B2218/002 , A61B2218/008 , A61F13/38 , C12Q1/025 , C12Q1/04 , C12Q1/18 , C12Q1/24 , G01N1/2202 , G01N3/00 , G01N9/00 , G01N27/622 , G01N27/624 , G01N30/724 , G01N33/487 , G01N33/48735 , G01N33/6848 , G01N33/6851 , G01N33/92 , G01N2001/2223 , G01N2333/195 , G01N2405/00 , G01N2405/04 , G01N2405/08 , G01N2570/00 , G01N2800/26 , G06F19/324 , G06F19/3481 , G16B20/00 , G16H10/40 , G16H15/00 , G16H50/20 , H01J49/0004 , H01J49/0027 , H01J49/0031 , H01J49/0036 , H01J49/025 , H01J49/0404 , H01J49/0409 , H01J49/0422 , H01J49/044 , H01J49/0445 , H01J49/0459 , H01J49/0463 , H01J49/0468 , H01J49/061 , H01J49/068 , H01J49/10 , H01J49/14 , H01J49/16 , H01J49/164 , H01J49/24 , H01J49/26
Abstract: A method of analysis using mass and/or ion mobility spectrometry or ion mobility spectrometry is disclosed comprising: using a first device to generate aerosol, smoke or vapour from one or more regions of a first target of biological material; and mass and/or ion mobility analysing and/or ion mobility analysing said aerosol, smoke, or vapour, or ions derived therefrom so as to obtain first spectrometric data. The method may use an ambient ionisation method.
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33.发明申请公开(公告)号：US20180059119A1
公开(公告)日：2018-03-01
申请号：US15555720
申请日：2016-03-07
Applicant: Micromass UK Limited
Inventor： Zoltán TAKÁTS , Júlia BALOG , Steven Derek PRINGLE , Tamás KARANCSI , Michael Raymond MORRIS , Lajos GÖDÖRHÁZY , Dániel SZALAY , Dániel SIMON
IPC: G01N33/68 , H01J49/16 , A61B17/32 , A61B18/14 , H01J49/04 , H01J49/00 , A61B10/00 , A61B17/00 , G01N33/92 , H01J49/06 , A61B10/02 , A61B18/20
Abstract: An apparatus is disclosed comprising a first device for generating aerosol, smoke or vapour from one or more regions of a target, an inlet conduit to an ion analyser or mass spectrometer, the inlet conduit having an inlet through which the aerosol, smoke or vapour passes, and a Venturi pump arrangement arranged and adapted to direct the aerosol, smoke or vapour towards the inlet.
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Patent Agency Ranking
公开(公告)号：US20180049643A1
公开(公告)日：2018-02-22
申请号：US15555888
申请日：2016-03-07
Applicant: Micromass UK Limited
Inventor： Julia BALOG , Tamas KARANCSI , Steven Derek PRINGLE , Zoltan TAKATS , James KINROSS , Jeremy K NICHOLSON
CPC classification number: H01J49/049 , A61B1/00013 , A61B1/041 , A61B1/2736 , A61B1/31 , A61B5/0066 , A61B5/0075 , A61B5/015 , A61B5/0507 , A61B5/055 , A61B5/14542 , A61B6/032 , A61B6/037 , A61B8/13 , A61B10/00 , A61B10/0041 , A61B10/0233 , A61B10/0283 , A61B17/00 , A61B17/320068 , A61B18/00 , A61B18/04 , A61B18/042 , A61B18/14 , A61B18/1445 , A61B18/1815 , A61B18/20 , A61B90/13 , A61B2010/0083 , A61B2017/320069 , A61B2018/00577 , A61B2018/00589 , A61B2018/00994 , A61B2218/002 , A61B2218/008 , A61F13/38 , C12Q1/025 , C12Q1/04 , C12Q1/18 , C12Q1/24 , G01N1/2202 , G01N3/00 , G01N9/00 , G01N27/622 , G01N27/624 , G01N30/724 , G01N33/487 , G01N33/48735 , G01N33/6848 , G01N33/6851 , G01N33/92 , G01N2001/2223 , G01N2333/195 , G01N2405/00 , G01N2405/04 , G01N2405/08 , G01N2570/00 , G01N2800/26 , G06F19/324 , G06F19/3481 , G16B20/00 , G16H10/40 , G16H15/00 , G16H50/20 , H01J49/0004 , H01J49/0027 , H01J49/0031 , H01J49/0036 , H01J49/025 , H01J49/0404 , H01J49/0409 , H01J49/0422 , H01J49/044 , H01J49/0445 , H01J49/0459 , H01J49/0463 , H01J49/0468 , H01J49/061 , H01J49/068 , H01J49/10 , H01J49/14 , H01J49/16 , H01J49/164 , H01J49/24 , H01J49/26
Abstract: An apparatus is disclosed including a tool comprising a first device for generating aerosol from a target, the first device being deployed through an opening in a tubing of the tool, wherein the tubing is provided with aspiration ports or fenestrations such that the generated aerosol is aspirated into the tubing via the aspiration ports or fenestrations. The aspirated aerosol is then transferred to a mass spectrometer for subsequent mass analysis.
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公开(公告)号：US20180047553A1
公开(公告)日：2018-02-15
申请号：US15555860
申请日：2016-03-07
Applicant: Micromass UK Limited
Inventor： Keith RICHARDSON , Steven Derek PRINGLE , Julia BALOG , Zoltan TAKATS
CPC classification number: H01J49/049 , A61B1/00013 , A61B1/041 , A61B1/2736 , A61B1/31 , A61B5/0066 , A61B5/0075 , A61B5/015 , A61B5/0507 , A61B5/055 , A61B5/14542 , A61B6/032 , A61B6/037 , A61B8/13 , A61B10/00 , A61B10/0041 , A61B10/0233 , A61B10/0283 , A61B17/00 , A61B17/320068 , A61B18/00 , A61B18/04 , A61B18/042 , A61B18/14 , A61B18/1445 , A61B18/1815 , A61B18/20 , A61B90/13 , A61B2010/0083 , A61B2017/320069 , A61B2018/00577 , A61B2018/00589 , A61B2018/00994 , A61B2218/002 , A61B2218/008 , A61F13/38 , C12Q1/025 , C12Q1/04 , C12Q1/18 , C12Q1/24 , G01N1/2202 , G01N3/00 , G01N9/00 , G01N27/622 , G01N27/624 , G01N30/724 , G01N33/487 , G01N33/48735 , G01N33/6848 , G01N33/6851 , G01N33/92 , G01N2001/2223 , G01N2333/195 , G01N2405/00 , G01N2405/04 , G01N2405/08 , G01N2570/00 , G01N2800/26 , G06F19/324 , G06F19/3481 , G16B20/00 , G16H10/40 , G16H15/00 , G16H50/20 , H01J49/0004 , H01J49/0027 , H01J49/0031 , H01J49/0036 , H01J49/025 , H01J49/0404 , H01J49/0409 , H01J49/0422 , H01J49/044 , H01J49/0445 , H01J49/0459 , H01J49/0463 , H01J49/0468 , H01J49/061 , H01J49/068 , H01J49/10 , H01J49/14 , H01J49/16 , H01J49/164 , H01J49/24 , H01J49/26
Abstract: A method of spectrometric analysis comprises obtaining one or more sample spectra for an aerosol, smoke or vapour sample. The one or more sample spectra are subjected to pre-processing and then multivariate and/or library based analysis so as to classify the aerosol, smoke or vapour sample. The results of the analysis are used for various surgical or non-surgical applications.
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36.发明申请公开(公告)号：US20180047551A1
公开(公告)日：2018-02-15
申请号：US15555818
申请日：2016-03-07
Applicant: Micromass UK Limited
Inventor： Emrys JONES , Steven Derek PRINGLE , Zoltan TAKATS
CPC classification number: H01J49/049 , A61B1/00013 , A61B1/041 , A61B1/2736 , A61B1/31 , A61B5/0066 , A61B5/0075 , A61B5/015 , A61B5/0507 , A61B5/055 , A61B5/14542 , A61B6/032 , A61B6/037 , A61B8/13 , A61B10/00 , A61B10/0041 , A61B10/0233 , A61B10/0283 , A61B17/00 , A61B17/320068 , A61B18/00 , A61B18/04 , A61B18/042 , A61B18/14 , A61B18/1445 , A61B18/1815 , A61B18/20 , A61B90/13 , A61B2010/0083 , A61B2017/320069 , A61B2018/00577 , A61B2018/00589 , A61B2018/00994 , A61B2218/002 , A61B2218/008 , A61F13/38 , C12Q1/025 , C12Q1/04 , C12Q1/18 , C12Q1/24 , G01N1/2202 , G01N3/00 , G01N9/00 , G01N27/622 , G01N27/624 , G01N30/724 , G01N33/487 , G01N33/48735 , G01N33/6848 , G01N33/6851 , G01N33/92 , G01N2001/2223 , G01N2333/195 , G01N2405/00 , G01N2405/04 , G01N2405/08 , G01N2570/00 , G01N2800/26 , G06F19/324 , G06F19/3481 , G16B20/00 , G16H10/40 , G16H15/00 , G16H50/20 , H01J49/0004 , H01J49/0027 , H01J49/0031 , H01J49/0036 , H01J49/025 , H01J49/0404 , H01J49/0409 , H01J49/0422 , H01J49/044 , H01J49/0445 , H01J49/0459 , H01J49/0463 , H01J49/0468 , H01J49/061 , H01J49/068 , H01J49/10 , H01J49/14 , H01J49/16 , H01J49/164 , H01J49/24 , H01J49/26
Abstract: A method of ion imaging is disclosed that includes automatically sampling a plurality of different locations on a sample using a front device which is arranged and adapted to generate aerosol, smoke or vapour from the sample. Mass spectral data and/or ion mobility data corresponding to each location is obtained and the obtained mass spectral data and/or ion mobility data is used to construct, train or improved a sample classification model.
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公开(公告)号：US20180042583A1
公开(公告)日：2018-02-15
申请号：US15556064
申请日：2016-03-07
Applicant: Micromass UK Limited
Inventor： Steven Derek PRINGLE , Emrys JONES , Michael Raymond MORRIS , Julia BALOG , James Ian LANGRIDGE , Keith RICHARDSON , Daniel SIMON , Lajos GODORHAZY , Daniel SZALAY , Zoltan TAKATS
IPC: A61B10/00 , A61B18/04 , A61B18/18 , H01J49/02 , A61B90/13 , G01N27/62 , H01J49/04 , H01J49/00 , G01N33/92 , A61B18/20
CPC classification number: H01J49/049 , A61B1/00013 , A61B1/041 , A61B1/2736 , A61B1/31 , A61B5/0066 , A61B5/0075 , A61B5/015 , A61B5/0507 , A61B5/055 , A61B5/14542 , A61B6/032 , A61B6/037 , A61B8/13 , A61B10/00 , A61B10/0041 , A61B10/0233 , A61B10/0283 , A61B17/00 , A61B17/320068 , A61B18/00 , A61B18/04 , A61B18/042 , A61B18/14 , A61B18/1445 , A61B18/1815 , A61B18/20 , A61B90/13 , A61B2010/0083 , A61B2017/320069 , A61B2018/00577 , A61B2018/00589 , A61B2018/00994 , A61B2218/002 , A61B2218/008 , A61F13/38 , C12Q1/025 , C12Q1/04 , C12Q1/18 , C12Q1/24 , G01N1/2202 , G01N3/00 , G01N9/00 , G01N27/622 , G01N27/624 , G01N30/724 , G01N33/487 , G01N33/48735 , G01N33/6848 , G01N33/6851 , G01N33/92 , G01N2001/2223 , G01N2333/195 , G01N2405/00 , G01N2405/04 , G01N2405/08 , G01N2570/00 , G01N2800/26 , G06F19/324 , G06F19/3481 , G16B20/00 , G16H10/40 , G16H15/00 , G16H50/20 , H01J49/0004 , H01J49/0027 , H01J49/0031 , H01J49/0036 , H01J49/025 , H01J49/0404 , H01J49/0409 , H01J49/0422 , H01J49/044 , H01J49/0445 , H01J49/0459 , H01J49/0463 , H01J49/0468 , H01J49/061 , H01J49/068 , H01J49/10 , H01J49/14 , H01J49/16 , H01J49/164 , H01J49/24 , H01J49/26
Abstract: A method is disclosed comprising obtaining or acquiring chemical or other non-mass spectrometric data from one or more regions of a target using a chemical sensor. The chemical or other non-mass spectrometric data may be used to determine one or more regions of interest of the target. An ambient ionisation ion source may then be used to generate aerosol, smoke or vapour from one or more regions of the target.
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公开(公告)号：US20170243729A1
公开(公告)日：2017-08-24
申请号：US15519286
申请日：2015-10-16
Applicant: Micromass UK Limited
Inventor： Michael Raymond MORRIS , Steven Derek PRINGLE , Richard ELLSON , Richard STEARNS , Lars MAJLOF , Ian SINCLAIR
CPC classification number: H01J49/0454 , H01J49/0031 , H01J49/105
Abstract: A method of ionising a sample is provided, comprising providing a fluid sample, wherein the fluid sample contains an analyte, applying one or more pulses of acoustic energy to the fluid sample to cause a spray of the fluid sample to eject from the surface of the fluid sample, and applying an AC, RF or alternating voltage to the fluid sample using an electrode.
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