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    HIGH SPEED MICROSCOPE WITH TWO-STAGE SCANNING FOR DETECTION OF RARITIES IN SAMPLES
    32.
    发明申请
    HIGH SPEED MICROSCOPE WITH TWO-STAGE SCANNING FOR DETECTION OF RARITIES IN SAMPLES 审中-公开
    具有两级扫描的高速显微镜，用于检测样品中的浓度

    公开(公告)号：US20120257037A1

    公开(公告)日：2012-10-11

    申请号：US13439954

    申请日：2012-04-05

    Applicant: Valerica Raicu ,  Thomas John Mozer ,  Uwe Richard Muller

    Inventor： Valerica Raicu ,  Thomas John Mozer ,  Uwe Richard Muller

    IPC: H04N7/18 ,  G06K9/00

    CPC classification number: G01J3/2803 ,  G01J3/027 ,  G01J3/0294 ,  G01J3/06 ,  G01J3/4406 ,  G01N15/1434 ,  G01N15/1463 ,  G01N15/1475 ,  G01N2015/1006 ,  G02B21/002 ,  G02B21/0076 ,  G02B21/16 ,  G02B27/0927 ,  G02B27/0983

    Abstract: A system and method of implementing a two-stage scanning technique with a high-speed microscope. The microscope is operable to provide spectrally resolved, multi-dimensional images from a single scan of a sample. The microscope may include one of a multi-beam point scanning microscope, a single beam line scanning microscope, and a multi-beam line scanning microscope. The sample is first tagged such that, if the sample has a particular makeup, it emits energy at particular wavelengths upon receiving excitation beams. The microscope is used to perform a first, wide area scan. If the sample is determined to have emitted energy having particular characteristics, the microscope performs a second, focused scan of the area that emitted the energy having the particular characteristics. The two-stage scanning technique is automated and may be used to quickly identify rare cells, microbes, viruses, and other components within one or more samples.

    Abstract translation: 用高速显微镜实现两级扫描技术的系统和方法。 显微镜可操作以从样品的单次扫描提供光谱分辨的多维图像。 显微镜可以包括多光束点扫描显微镜，单束线扫描显微镜和多光束线扫描显微镜中的一个。 样品首先被标记，使得如果样品具有特定的组成，则在接收到激发光束时，其以特定波长发射能量。 显微镜用于执行第一次广域扫描。 如果确定样品具有具有特定特征的发射能量，则显微镜对发射具有特定特征的能量的区域进行第二次聚焦扫描。 两级扫描技术是自动化的，可用于快速识别一个或多个样品中的稀有细胞，微生物，病毒和其他成分。

    HYPERSPECTRAL IMAGING SYSTEMS
    34.
    发明申请
    HYPERSPECTRAL IMAGING SYSTEMS 审中-公开
    超高速成像系统

    公开(公告)号：US20120218548A1

    公开(公告)日：2012-08-30

    申请号：US13465911

    申请日：2012-05-07

    Applicant: Andrew Bodkin

    Inventor： Andrew Bodkin

    IPC: G01J3/28

    CPC classification number: G01J3/02 ,  G01J3/0205 ,  G01J3/0208 ,  G01J3/021 ,  G01J3/0229 ,  G01J3/0235 ,  G01J3/0294 ,  G01J3/14 ,  G01J3/2803 ,  G01J3/2823 ,  G01J3/36

    Abstract: Hyperspectral imaging system and methods that may be used for imaging objects in three-dimensions are disclosed. A cylindrical lens array and/or a slit array may be used to re-image and divide a field of view into multiple channels. The multiple channels are dispersed into multiple spectral signatures and observed on a two-dimensional focal plane array in real time. The entire hyperspectral data cube is collected simultaneously.

    Abstract translation: 公开了可以用于三维成像对象的高光谱成像系统和方法。 可以使用柱面透镜阵列和/或狭缝阵列来将视场重新图像分割成多个通道。 将多个通道分散到多个光谱特征中，并在二维焦平面阵列上实时观察。 整个高光谱数据立方体被同时收集。

    Raman characterization of transplant tissue
    35.
    发明授权
    Raman characterization of transplant tissue 有权
    移植组织的拉曼表征

    公开(公告)号：US08253936B2

    公开(公告)日：2012-08-28

    申请号：US12537513

    申请日：2009-08-07

    Applicant: Jeffrey Cohen ,  John S Maier ,  Shona Stewart

    Inventor： Jeffrey Cohen ,  John S Maier ,  Shona Stewart

    IPC: G01J3/44

    CPC classification number: G01N21/65 ,  G01J3/02 ,  G01J3/0237 ,  G01J3/0291 ,  G01J3/0294 ,  G01J3/44 ,  G01N2021/656

    Abstract: A system and method for determining a disease state and clinical outcome of a sample. A sample is illuminated to produce Raman scattered photons, the Raman scattered photons are assessed to generate a Raman spectroscopic data set representative of the sample, wherein said Raman spectroscopic data set comprises at least one of: a Raman spectra of the sample and a spatially accurate wavelength resolved Raman image of the sample; the Raman spectroscopic data set is evaluated using a chemometric technique to classify the disease state of the sample as: acute, chronic, incipient, or none. In one embodiment, the chemontric technique is principle component analysis. In another embodiment, the sample is obtained prior to transplantation and analysis can determine the likelihood of rejection by a host.

    Abstract translation: 用于确定样品的疾病状态和临床结果的系统和方法。 照射样品以产生拉曼散射光子，评估拉曼散射光子以产生代表样品的拉曼光谱数据集，其中所述拉曼光谱数据集包括以下至少一个：样品的拉曼光谱和空间准确的 样品的波长分辨拉曼图像; 使用化学计量技术评估拉曼光谱数据集，以将样品的疾病状态分类为急性，慢性，初期或无。 在一个实施方案中，化学方法是主要成分分析。 在另一个实施方案中，在移植之前获得样品，并且分析可以确定宿主排斥的可能性。

    Slab waveguide spatial heterodyne spectrometer assembly
    37.
    发明授权
    Slab waveguide spatial heterodyne spectrometer assembly 有权
    平板波导空间外差光谱仪组装

    公开(公告)号：US08018597B2

    公开(公告)日：2011-09-13

    申请号：US12142860

    申请日：2008-06-20

    Applicant: Alan Douglas Scott

    Inventor： Alan Douglas Scott

    IPC: G01B9/02 ,  G01J3/45

    CPC classification number: G01J3/4532 ,  G01J3/02 ,  G01J3/024 ,  G01J3/0259 ,  G01J3/0289 ,  G01J3/0294 ,  G01J3/1895 ,  G01J3/4531 ,  G02B6/29352 ,  G02B6/29358 ,  G02B6/29389 ,  G02B6/30 ,  G02B2006/12119 ,  G02B2006/12159

    Abstract: An optical broadband micro-spectrometer containing an input optical assembly, a group of slab waveguide spatial heterodyne spectrometer (SHS) integrated circuits (ICs), a detection module and a processor for multi-line detection. The input optical assembly applies an input light signal uniformly with respect to brightness and frequency to the apertures of the waveguides and may project a pupil image onto the SHS input face and may be a scanner. Each slab waveguide spatial heterodyne spectrometer (SHS) integrated circuit (IC) contains at least one slab waveguide SHS IC. The detection module bonds directly to the slab waveguide output apertures. Each slab waveguide SHS IC may contain one or more slab waveguide SHS.

    Abstract translation: 一种含有输入光学组件，一组平板波导空间外差光谱仪（SHS）集成电路（IC），检测模块和用于多线检测的处理器的光学宽带微光谱仪。 输入光学组件将输入光信号相对于亮度和频率均匀地施加到波导的孔，并且可以将瞳孔图像投影到SHS输入面上，并且可以是扫描仪。 每个平板波导空间外差谱仪（SHS）集成电路（IC）包含至少一个平板波导SHS IC。 检测模块直接连接到平板波导输出孔。 每个平板波导SHS IC可以包含一个或多个平板波导SHS。

    Optical Assemblies For Low Cost Spectral Imaging With High Spectral Resolution
    39.
    发明申请
    Optical Assemblies For Low Cost Spectral Imaging With High Spectral Resolution 有权
    用于具有高光谱分辨率的低成本光谱成像的光学组件

    公开(公告)号：US20110026021A1

    公开(公告)日：2011-02-03

    申请号：US12511603

    申请日：2009-07-29

    Applicant: Steven Henry Peterson ,  Harold VanAken

    Inventor： Steven Henry Peterson ,  Harold VanAken

    IPC: G01J3/46 ,  G01J3/42

    CPC classification number: G01J3/50 ,  G01J3/02 ,  G01J3/0229 ,  G01J3/0294 ,  G01J3/501 ,  G01J3/51

    Abstract: The optical assemblies disclosed herein advantageously utilize a beamsplitting apparatus in association with either (i) the illumination path or (ii) the collection path of a color measurement instrument. For implementations involving the illumination path, the beamsplitting apparatus may be configured to spectrally divide one or more initial beams of light so as to emit a plurality of resultant beams of light, wherein the optical assembly is configured to illuminate a target using at least a first and a second of the plurality of resultant beams of light. Similarly, for implementations involving the collection path, the beamsplitting apparatus may be configured to spectrally divide light received from a target so as to emit a plurality of resultant beams of light, wherein the optical assembly is configured to detect at least a first and a second of the plurality of resultant beams of light. Advantageously, each of the first and second resultant beams of light is a product of a distinct set of one or more spectral constraints exacted by the beamsplitting apparatus.

    Abstract translation: 本文公开的光学组件有利地利用与（i）照明路径或（ii）颜色测量仪器的收集路径相关联的分束设备。 对于涉及照明路径的实施方案，分束装置可以被配置为光谱地划分一个或多个初始光束，以便发射多个合成的光束，其中光学组件被配置为使用至少第一 以及多个合成光束中的第二光束。 类似地，对于涉及收集路径的实施方案，分束装置可以被配置为对从目标接收的光进行光谱分割，以便发射多个合成的光束，其中光学组件被配置为检测至少第一和第二 的多个合成光束。 有利地，第一和第二合成光束中的每一个是由分束装置强制的一个或多个光谱约束的不同集合的乘积。

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