公开(公告)号：US20190189415A1

公开(公告)日：2019-06-20

申请号：US16260924

申请日：2019-01-29

Applicant: Purdue Research Foundation

Inventor： Robert Graham Cooks ,  Guangtao Li ,  Guangming Huang ,  Jason Duncan ,  Xin Li ,  Ewa Sokol ,  Xin Yan

IPC: H01J49/04 ,  G01N27/62 ,  H01J49/00

CPC classification number: H01J49/045 ,  G01N27/62 ,  H01J49/0018 ,  H01J49/0445 ,  Y10T436/24

Abstract: The invention generally relates to methods and devices for synchronization of ion generation with cycling of a discontinuous atmospheric interface. In certain embodiments, the invention provides a system for analyzing a sample that includes a mass spectrometry probe that generates sample ions, a discontinuous atmospheric interface, and a mass analyzer, in which the system is configured such that ion formation is synchronized with cycling of the discontinuous atmospheric interface.

公开(公告)号：US10020177B2

公开(公告)日：2018-07-10

申请号：US14438246

申请日：2012-10-25

Applicant: Micromass UK Limited

Inventor： Stevan Bajic ,  David Douce ,  Gordon Jones

IPC: H01J49/16 ,  H01J49/04 ,  H01J49/00 ,  H01J49/06

CPC classification number: H01J49/045 ,  H01J49/0031 ,  H01J49/0445 ,  H01J49/0454 ,  H01J49/061 ,  H01J49/16 ,  H01J49/161

Abstract: An ion source is disclosed comprising a nebulizer and a target. The nebulizer is arranged and adapted to emit, in use, a stream of analyte droplets which are caused to impact upon the target and to ionize analyte to form a plurality of analyte ions. The target is vibrated by a piezo-electric vibration device to reduce the size of resultant secondary droplets.

公开(公告)号：US20180076015A1

公开(公告)日：2018-03-15

申请号：US15812913

申请日：2017-11-14

Applicant: IONSENSE INC.

Inventor： Brian D. Musselman

IPC: H01J49/16 ,  H01J49/04

CPC classification number: H01J49/165 ,  G01N1/4022 ,  G01N2001/028 ,  G01N2030/009 ,  G01N2030/062 ,  H01J49/0031 ,  H01J49/045 ,  H01J49/16

Abstract: The present invention is directed to a method and device to generate a chemical signature for a mixture of analytes. The present invention involves using a SPME surface to one or both absorb and adsorb the mixture of analytes. In an embodiment of the invention, the surface is then exposed to different temperature ionizing species chosen with appropriate spatial resolution to desorb a chemical signature for the mixture of analytes.

公开(公告)号：US20180033599A1

公开(公告)日：2018-02-01

申请号：US15552918

申请日：2016-03-15

Applicant: KEIO UNIVERSITY

Inventor： Tomoyoshi SOGA ,  Akiyoshi HIRAYAMA ,  Hiroshi ABE

IPC: H01J49/04 ,  G01N27/447 ,  B01D61/42

CPC classification number: H01J49/045 ,  B01D61/422 ,  G01N27/4473 ,  G01N27/44791 ,  G01N30/7266 ,  H01J49/0404 ,  H01J49/165

Abstract: Processing a capillary distal end into acute-angle, an electrophoretic liquid passing hole through which electrophoretic liquid pass is opened in a flexible insulating plate. An electrodialysis-membrane is bonded covering the electrophoretic liquid passing hole; the capillary is securely bonded to the insulating plate portion with no gap therebetween, the portion excluding electrophoretic liquid passing hole on the electrodialysis top-membrane. A crack forms at the capillary portion at the electrophoretic liquid passing hole, with the capillary entirely secured to the insulating plate except portion at the electrophoretic liquid passing hole. The capillary is securely bonded to the insulating plate; reservoir stores electrophoretic liquid on the insulating plate-side to which the capillary is unsecured. An electrode insertion hole into which an electrode is inserted opened in the reservoir upper portion; the electrode is securely inserted into the electrode insertion hole. By this, high-sensitivity measurement is using a spray device for sheathless CE-MS.

公开(公告)号：US20170338092A1

公开(公告)日：2017-11-23

申请号：US15597608

申请日：2017-05-17

Applicant: Chady Stephan ,  Hamid Badiei ,  Serguei Savtchenko ,  Samad Barzagan

Inventor： Chady Stephan ,  Hamid Badiei ,  Serguei Savtchenko ,  Samad Barzagan

IPC: H01J49/10 ,  G01N30/72 ,  H01J49/04 ,  H01J49/16

CPC classification number: H01J49/107 ,  G01N30/7273 ,  H01J49/045 ,  H01J49/049 ,  H01J49/167

Abstract: Devices, systems and methods including a spray chamber are described. In certain examples, the spray chamber may be configured with an outer chamber configured to provide tangential gas flows. In other instances, an inner tube can be positioned within the outer chamber and may comprise a plurality of microchannels. In some examples, the outer chamber may comprise dual gas inlet ports. In some instances, the spray chamber may be configured to provide tangential gas flow and laminar gas flows to prevent droplet formation on surfaces of the spray chamber. Optical emission devices, optical absorption devices and mass spectrometers using the spray chamber are also described.

公开(公告)号：US09824873B2

公开(公告)日：2017-11-21

申请号：US14826388

申请日：2015-08-14

Applicant: Bruker Daltonik GmbH

Inventor： Andreas Brekenfeld ,  Martin Engel

IPC: H01J49/00 ,  H01J49/04 ,  H01J49/10

CPC classification number: H01J49/0486 ,  C03B19/12 ,  C04B35/14 ,  H01J49/0422 ,  H01J49/044 ,  H01J49/045 ,  H01J49/0477 ,  H01J49/10 ,  Y02P40/57

Abstract: The invention relates to an ionization chamber for connection to a mass spectrometer. The ionization chamber has a temperature-control block with a gas inlet and a gas channel which starts at the gas inlet and leads into a gas outlet. A temperature-control device is positioned along the gas channel and ensures that a gas flowing in the gas channel is brought to a specific temperature, i.e. it is heated or cooled, before it enters the ionization chamber. The temperature-control block has a formed part into which a structure of the gas channel is incorporated and which is fabricated by means of a sol-gel process, for example out of a glass or ceramic material.

公开(公告)号：US09618488B2

公开(公告)日：2017-04-11

申请号：US14832083

申请日：2015-08-21

Applicant: Micromass UK Limited

Inventor： Stevan Bajic

IPC: H01J49/00 ,  G01N30/72 ,  G01N27/447 ,  H01J49/16 ,  G01N27/62 ,  H01J49/04 ,  H01J49/10

CPC classification number: G01N30/7266 ,  G01N27/44704 ,  G01N27/622 ,  H01J49/0031 ,  H01J49/045 ,  H01J49/0454 ,  H01J49/10 ,  H01J49/16 ,  H01J49/165

Abstract: A mass spectrometer is disclosed comprising a separation device arranged and adapted to emit an eluent over a period of time. The separation device preferably comprises a Capillary Electrophoresis (“CE”) separation device. The mass spectrometer further comprises a nebuliser and a target. Eluent emitted by the separation device is nebulised, in use, by the nebuliser wherein a stream of analyte droplets are directed to impact upon the target so as to ionise the analyte to form a plurality of analyte ions.

公开(公告)号：US20170032949A1

公开(公告)日：2017-02-02

申请号：US15104638

申请日：2014-10-31

Applicant: DH Technologies Development PTE Ltd.

Inventor： Thomas R Covey ,  Peter Kovarik

IPC: H01J49/04 ,  G01N30/72

CPC classification number: H01J49/045 ,  G01N30/724 ,  G01N30/7246 ,  G01N30/7273 ,  H01J49/0404 ,  H01J49/044 ,  H01J49/0468 ,  H01J49/167

Abstract: Systems and methods for delivering a sample to a mass spectrometer are provided. In one aspect, the systems and methods can provide efficient cooling of an ion source probe to prevent overheating and the resulting degradation in ion sampling. In some aspects, such cooling can result in improved consistency and/or efficiency of ion formation. Moreover, ion source cooling in accordance with various aspects of the present teachings can allow for the use of higher temperatures in the ionization chamber (thereby improving desolvation) and/or can enable the use of lower flow rate sample sources than with conventional techniques.

Abstract translation: 提供了将样品递送到质谱仪的系统和方法。 在一个方面，系统和方法可以提供离子源探针的有效冷却，以防止过热和离子取样导致的降解。 在一些方面，这种冷却可导致提高离子形成的一致性和/或效率。 此外，根据本教导的各个方面的离子源冷却可以允许在电离室中使用更高的温度（从而改善去溶剂化）和/或可以使用比常规技术更低的流速样品源。

公开(公告)号：US09558926B2

公开(公告)日：2017-01-31

申请号：US15149161

申请日：2016-05-08

Applicant: IONSENSE INC.

Inventor： Brian D Musselman

IPC: H01J49/00 ,  H01J49/16

CPC classification number: H01J49/165 ,  G01N1/4022 ,  G01N2001/028 ,  G01N2030/009 ,  G01N2030/062 ,  H01J49/0031 ,  H01J49/045 ,  H01J49/16

Abstract: The present invention is directed to a method and device to generate a chemical signature for a mixture of analytes. The present invention involves using a SPME surface to one or both absorb and adsorb the mixture of analytes. In an embodiment of the invention, the surface is then exposed to different temperature ionizing species chosen with appropriate spatial resolution to desorb a chemical signature for the mixture of analytes.

Abstract translation: 本发明涉及一种生成分析物混合物的化学特征的方法和装置。 本发明涉及使用SPME表面吸收和吸附分析物混合物中的一种或两种。 在本发明的一个实施方案中，然后将表面暴露于用适当的空间分辨率选择的不同温度的离子化物质以解吸分析物混合物的化学特征。

公开(公告)号：US20160329198A1

公开(公告)日：2016-11-10

申请号：US15147005

申请日：2016-05-05

Applicant: Ohio State Innovation Foundation

Inventor： Abraham Kwame Badu-Tawiah ,  Dmytro Kulyk

IPC: H01J49/04 ,  H01J49/16

CPC classification number: H01J49/045 ,  H01J49/0404

Abstract: Provided herein are apparatuses that can comprise an electrospray emitter comprising a sample capillary extending from a sample inlet to a sample outlet and an element comprising a conduit coaxially disposed around the electrospray emitter thereby forming a chamber extending between the conduit and the sample capillary and terminating in a gas outlet. The element can further comprise, in some examples, a carrier gas inlet fluidly connected to the chamber, and a working gas inlet fluidly connected to the chamber, wherein the chamber is configured to provide a path for fluid flow from the carrier gas inlet and the working gas inlet to the gas outlet. Also disclosed herein are methods of use of the apparatuses. In some examples discussed herein are methods and apparatuses for contained-electrospray, for example for use in mass spectrometry and/or droplet reactions.

Abstract translation: 本文提供了可以包括电喷射发射器的装置，其包括从样品入口延伸到样品出口的样品毛细管，以及包括同轴设置在电喷雾发射器周围的导管的元件，从而形成在导管和样品毛细管之间延伸的腔室， 一个气体出口。 该元件在一些实例中可以进一步包括流体连接到腔室的载气入口以及流体连接到腔室的工作气体入口，其中该腔室构造成提供用于从载气入口和 工作气体入口到气体出口。 本文还公开了使用该装置的方法。 在本文讨论的一些实例中，包含电喷雾的方法和装置，例如用于质谱法和/或液滴反应。