公开(公告)号：US20180102239A1

公开(公告)日：2018-04-12

申请号：US15836101

申请日：2017-12-08

Applicant: Thermo Finnigan LLC

Inventor： Alan E. SCHOEN ,  Harald OSER

IPC: H01J49/00 ,  H01J49/42

CPC classification number: H01J49/005 ,  H01J49/0031 ,  H01J49/421

Abstract: A mass spectrometer system comprises: (a) an ion source; (b) a mass filter; (c) a mass analyzer; (d) a partitioned ion fragmentation cell configured to receive ions from the mass filter and to outlet fragment ions to the mass analyzer comprising: (d1) a set of multipole rod electrodes; a housing enclosing the set of multipole rod electrodes and comprising an ion inlet and an ion outlet; (d2) a set of partitions within the housing separating the housing interior into a plurality of compartments; and (d3) a plurality of gas inlets, each gas inlet fluidically coupled to a source of a collision gas and to a respective compartment and having a respective inlet shutoff valve; and (e) a controller electrically coupled to each inlet shutoff valve and configured to independently control the pressure of collision gas within each compartment.

公开(公告)号：US20170243730A1

公开(公告)日：2017-08-24

申请号：US15337016

申请日：2016-10-28

Applicant: NISSIN ION EQUIPMENT CO., LTD.

Inventor： Naoya TAKAHASHI ,  Hideki FUJITA ,  Yosuke YOSHIMURA ,  Shigeki SAKAI

IPC: H01J49/42 ,  H01J49/06

CPC classification number: H01J49/421 ,  H01J37/3171 ,  H01J49/065 ,  H01J49/30 ,  H01J49/463

Abstract: An ion beam irradiation apparatus is provided. The apparatus includes an ion source, a mass separator, and an energy filter. The mass separator sorts dopant ions having a specific mass number and valence from an ion beam extracted from the ion source, and outputs the dopant ions. The energy filter is formed to define a beam passing region for allowing the ion beam to pass therethrough, and configured to have a given filter potential in response to application of a voltage thereto to separate passable ions capable of passing through the beam passing region and non-passable ions incapable of passing through the beam passing region, from each other by a difference in ion energy. The given filter potential is set such that the dopant ions are included in the passable ions, and a portion of unwanted ions which cannot be separated from the dopant ions by the mass separator are included in the non-passable ions.

公开(公告)号：US20170076928A1

公开(公告)日：2017-03-16

申请号：US14852294

申请日：2015-09-11

Applicant: Thermo Finnigan LLC

Inventor： Mikhail V. UGAROV

IPC: H01J49/04 ,  H01J49/42 ,  H01J49/00

CPC classification number: H01J49/04 ,  G01N27/624 ,  H01J49/0009 ,  H01J49/0031 ,  H01J49/421

Abstract: A system for analyzing a sample includes a source configured to generate ions from constituent components of the sample; a mobility separation device, a plurality of ion channels, and a mass analyzer configured to determine the mass-to-charge ratio of the ions. The mobility device is configured to separate ions received from the source based on the mobility in a gas. The mobility separation device provides a gas flow in a first direction and an electric field gradient along a second direction such that ions move in the first direction and drift according to their mobility in the second direction and are sorted based on their respective mobility. The ion channels are arranged adjacent to the mobility separation device such that ions from the mobility separation device are directed to different channels according to their respective mobility.

Abstract translation: 用于分析样品的系统包括被配置为从样品的构成组分产生离子的源; 移动性分离装置，多个离子通道和配置成确定离子的质荷比的质量分析器。 移动装置被配置为基于气体中的移动性来分离从源接收的离子。 移动性分离装置沿着第二方向提供沿第一方向的气流和电场梯度，使得离子在第一方向上移动并根据其在第二方向上的迁移率而漂移，并且基于它们各自的移动性进行排序。 离子通道被布置成与移动性分离装置相邻，使得来自移动性分离装置的离子根据它们各自的移动性被引导到不同的通道。

公开(公告)号：US20160293391A1

公开(公告)日：2016-10-06

申请号：US15035965

申请日：2014-11-11

Applicant: Micromass UK Limited

Inventor： John Brian Hoyes ,  Steven Derek Pringle ,  Farnoush Salarzaei ,  Jason Lee Wildgoose

IPC: H01J49/00 ,  H01J49/42

CPC classification number: H01J49/0031 ,  G01N27/622 ,  H01J49/0045 ,  H01J49/421

Abstract: A method of mass spectrometry is disclosed comprising separating precursor ions using an ion mobility separator such that different precursor ions have different drift times through the on mobility separator; mass filtering said separated precursor ions with a mass filter, wherein the mass to charge ratios of the precursor ions transmitted by the mass filter vary as a function of the drift times of the precursor ions through the ion mobility separator; performing a first mode of operation comprising fragmenting the separated and mass filtered precursor ions in a fragmentation device to form fragment ions; urging the fragment ions through the fragmentation device such that fragment ions derived from different precursor ions that have been separated by the ion mobility separator are maintained spatially separated from each other as they are urged through the fragmentation device; and detecting the fragment ions. The method enables precursor ions to be associated with their related fragment ions more accurately.

Abstract translation: 公开了一种质谱法，其包括使用离子迁移率分离器分离前体离子，使得不同的前体离子通过上迁移分离器具有不同的漂移时间; 用质量过滤器对所分离的前体离子进行质量过滤，其中由质量过滤器传输的前体离子的质荷比随着前体离子通过离子迁移分离器的漂移时间的变化而变化; 执行第一操作模式，包括在分离装置中分离和质量过滤的前体离子碎裂以形成碎片离子; 促使碎片离子通过碎裂装置，使得衍生自已被离子迁移率分离器分离的不同前体离子的碎片离子保持空间上彼此分离，因为它们通过破碎装置被推动; 并检测碎片离子。 该方法使前体离子更准确地与其相关的片段离子相关联。

公开(公告)号：US09355831B2

公开(公告)日：2016-05-31

申请号：US14293073

申请日：2014-06-02

Applicant: Urs Steiner

Inventor： Urs Steiner

IPC: H01J49/06 ,  H01J49/42

CPC classification number: H01J49/063 ,  H01J49/24 ,  H01J49/421 ,  H01J49/4255

Abstract: Certain embodiments described herein are directed to rod assemblies such as, for example, quadrupole, hexapole and octupole rod assemblies. In some instances, the rod assemblies include at least one pole comprising an integral fluid path configured to fluidically couple an ion volume formed by the assembly to an outer volume of the assembly to remove fluid within the ion volume to the outer volume while containing ions of a selected mass-to-charge range.

Abstract translation: 本文描述的某些实施例涉及杆组件，例如四极杆，六极棒和八极棒组件。 在一些情况下，杆组件包括至少一个极，所述至少一个极包括一体式流体路径，其被构造成将由组件形成的离子体流动地耦合到组件的外部体积，以将离子体内的流体除去到外部体积， 一个选定的质量到电荷范围。

公开(公告)号：US20150021492A1

公开(公告)日：2015-01-22

申请号：US14293073

申请日：2014-06-02

Applicant: Urs Steiner

Inventor： Urs Steiner

IPC: H01J49/06

CPC classification number: H01J49/063 ,  H01J49/24 ,  H01J49/421 ,  H01J49/4255

Abstract: Certain embodiments described herein are directed to rod assemblies such as, for example, quadrupole, hexapole and octupole rod assemblies. In some instances, the rod assemblies include at least one pole comprising an integral fluid path configured to fluidically couple an ion volume formed by the assembly to an outer volume of the assembly to remove fluid within the ion volume to the outer volume while containing ions of a selected mass-to-charge range.

Abstract translation: 本文描述的某些实施例涉及杆组件，例如四极杆，六极棒和八极棒组件。 在一些情况下，杆组件包括至少一个极，所述至少一个极包括一体式流体路径，其被构造成将由组件形成的离子体流动耦合到组件的外部体积，以将离子体内的流体除去到外部体积， 一个选定的质量到电荷范围。

公开(公告)号：US08704163B2

公开(公告)日：2014-04-22

申请号：US13784497

申请日：2013-03-04

Applicant: Alan E. Schoen ,  Robert A. Grothe, Jr.

Inventor： Alan E. Schoen ,  Robert A. Grothe, Jr.

IPC: H01J49/42

CPC classification number: H01J49/4215 ,  H01J49/0031 ,  H01J49/0036 ,  H01J49/025 ,  H01J49/26 ,  H01J49/42 ,  H01J49/421

Abstract: A novel method and mass spectrometer apparatus is introduced to spatially and temporally resolve images of one or more ion exit patterns of a multipole instrument. In particular, the methods and structures of the present invention measures the ion current as a function of time and spatial displacement in the beam cross-section of a quadrupole mass filter via an arrayed detector. The linearity of the detected quadrupole ion current in combination with it reproducible spatial-temporal structure enables the deconvolution of the contributions of signals from individual ion species in complex mixtures where both sensitivity and mass resolving power are essential.

Abstract translation: 引入了一种新颖的方法和质谱仪装置来空间和时间地分辨多极仪器的一个或多个离子出口图案的图像。 特别地，本发明的方法和结构通过阵列检测器测量作为四极质量过滤器的束横截面中时间和空间位移的函数的离子电流。 检测到的四极离子电流的线性与可重复的空间 - 时间结构相结合使得能够在复杂混合物中来自各种离子物质的信号的贡献的反卷积，其中灵敏度和质量分辨能力都是必需的。

公开(公告)号：US20120305759A1

公开(公告)日：2012-12-06

申请号：US13177780

申请日：2011-07-07

Applicant: Melvin Andrew PARK

Inventor： Melvin Andrew PARK

IPC: H01J49/36 ,  H01J49/26 ,  H01J49/28 ,  H01J49/06

CPC classification number: H01J49/063 ,  H01J49/421 ,  H01J49/4235 ,  H01J49/424

Abstract: An abridged multipole structure for the transport and selection of ions along a central axis in a vacuum system is constructed from a plurality of rectilinear electrode structures, each having a substantially planar face with a first dimension and a second dimension perpendicular to the first dimension. When a voltage is applied across the second dimension, an electrical potential is produced at the planar face whose amplitude is a linear function of position along the second dimension. Two electrode structures can be arranged parallel to each other with the first dimension extending along the central axis or more electrodes structures can be arranged to form multipole structures with various polygonal cross sections. Additional embodiments can act as linear ion traps or Paul ion traps.

Abstract translation: 用于在真空系统中沿着中心轴输送和选择离子的简单多极结构由多个直线电极结构构成，每个直线电极结构具有基本平坦的面，其具有垂直于第一维度的第一尺寸和第二尺寸。 当跨越第二维度施加电压时，在平面处产生电位，其幅度是沿着第二维度的位置的线性函数。 两个电极结构可以彼此平行地布置，其中第一尺寸沿着中心轴延伸，或者更多的电极结构可被布置成形成具有各种多边形横截面的多极结构。 另外的实施例可以用作线性离子阱或保护离子阱。

公开(公告)号：US20100301227A1

公开(公告)日：2010-12-02

申请号：US12474161

申请日：2009-05-28

Applicant: Felician Muntean

Inventor： Felician Muntean

IPC: H01J3/14 ,  H01J49/00

CPC classification number: H01J49/421 ,  H01J49/063

Abstract: An ion guide includes a plurality of curved electrodes and an ion deflecting device. The electrodes are arranged about and radially spaced from a central curved axis, and circumscribe a curved ion guide region from an ion entrance to an ion exit. The ion deflecting device may include a device for applying a DC electric field to one or more electrodes in a radial direction. The magnitude of the DC electric field, and thus the ion deflecting force, varies along the curved axis. The ion guide may for example operate as a collision cell or like instrument.

Abstract translation: 离子导向器包括多个弯曲电极和离子偏转装置。 电极围绕中心弯曲的轴线并且沿径向隔开设置，并且从离子入口到离子出口限定弯曲的离子引导区域。 离子偏转装置可以包括用于沿径向向一个或多个电极施加DC电场的装置。 DC电场的大小，从而离子偏转力沿曲线轴线变化。 离子导向器例如可以作为碰撞室或类似仪器工作。

公开(公告)号：US07638766B1

公开(公告)日：2009-12-29

申请号：US11601342

申请日：2006-11-17

Applicant: Alan E. Schoen

Inventor： Alan E. Schoen

IPC: B01D59/44 ,  H01J49/00

CPC classification number: H01J49/421 ,  H01J49/022

Abstract: The current invention facilitates the construction of a compact high performance quadrupole mass analyzer which has the operational characteristics of a modern research grade system and the ergonomic and cost structure of a moderate benchtop system. A multipole field device is physically located within the windings of the RF resonant circuit. By combining the space consumed by the RF windings and its housing and the space consumed by the multipole field device and its vacuum housing, the overall size of the resultant mass spectrometer is reduced.

Abstract translation: 本发明有利于构建紧凑型高性能四极杆质量分析仪，其具有现代研究级系统的操作特性和中等台式系统的人机工程学和成本结构。 多极场设备物理地位于RF谐振电路的绕组内。 通过将RF绕组及其壳体消耗的空间与由多极场设备及其真空壳体消耗的空间组合，所得到的质谱仪的总体尺寸减小。