公开(公告)号：US12209907B2

公开(公告)日：2025-01-28

申请号：US17784870

申请日：2020-10-15

Applicant: Foss Analytical A/S

Inventor： Jeppe Sandvik Clausen

IPC: G01J3/427 ,  G01N21/03 ,  G01N21/27

Abstract: A method for determining an optical pathlength through a cuvette of a spectrophotometric apparatus includes obtaining a first single beam spectrum of a liquid zero-material at least in a first energy region in which the liquid zero-material absorbs at least a portion of incident optical radiation; obtaining a second single beam spectrum of a second liquid at least in the first energy region, the second liquid having a composition excluding the liquid zero-material and having no absorption of incident optical radiation in the first energy region; determining a dual beam spectrum of the liquid zero-material relative to the second liquid at least in the first energy region from the first and second single beam spectra; and calculating an optical pathlength through the cuvette based on processing spectral information obtained from the first energy region of the determined dual beam spectrum.

公开(公告)号：US20240175815A1

公开(公告)日：2024-05-30

申请号：US18511664

申请日：2023-11-16

Applicant: University of Science and Technology of China ,  Hefei National Laboratory

Inventor： Shuiming Hu ,  Cunfeng Cheng

IPC: G01N21/63 ,  G01J3/427 ,  G01N21/03 ,  G01N21/31 ,  G01N21/39

CPC classification number: G01N21/636 ,  G01J3/427 ,  G01N21/0332 ,  G01N21/3151 ,  G01N21/39 ,  G01N2021/391 ,  G01N2021/637

Abstract: An apparatus for quantitatively detecting isotopologue of carbon dioxide using dual-photon absorption, comprising a laser source, a laser frequency stabilizer, a sample chamber, a signal detector, and a signal analyzer. The sample chamber comprises an optical resonator and a piezoelectric ceramic. The laser source is configured to output a laser beam. The laser frequency stabilizer is configured to lock the laser beam to a mode frequency of the optical resonator. The piezoelectric ceramic is configured to adjust a length of the optical resonator to alter the mode frequency of the optical resonator to match energy levels of a target molecular isotopologue. The signal detector is configured to detect a transmission intensity of the light beam passing the optical resonator to obtain a dual-photon absorption signal. The signal analyzer is configured to analyze and process the dual-photon absorption signal to obtain a concentration of the target molecular isotopologue.

公开(公告)号：US11903699B2

公开(公告)日：2024-02-20

申请号：US17203087

申请日：2021-03-16

Applicant: Rijul Gupta

Inventor： Rijul Gupta

IPC: A61B5/1455 ,  A61B5/145 ,  G01J3/00 ,  A61B5/00 ,  G01N21/31 ,  G01N21/47 ,  G01J3/28 ,  G01N21/49 ,  G01J3/02 ,  G01J3/10 ,  G01J3/427 ,  G01J3/457

CPC classification number: A61B5/1455 ,  A61B5/0059 ,  A61B5/0075 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/6826 ,  A61B5/7267 ,  A61B5/7475 ,  G01J3/00 ,  G01J3/0262 ,  G01J3/10 ,  G01J3/28 ,  G01J3/427 ,  G01J3/457 ,  G01N21/31 ,  G01N21/474 ,  G01N21/49 ,  G01J2003/102 ,  G01N2021/3155 ,  G01N2021/3181

Abstract: A multi-channel measurement device for measuring properties of human tissue, may comprise a microcontroller and first and second source/sensor complexes. The first source/sensor complex may include a first housing having a first measurement portion, a first light sensor coupled to the microcontroller and exposed to the first measurement portion, and a first plurality of light sources coupled to the microcontroller and exposed to the first measurement portion. The second source/sensor complex may include a second housing having a second measurement portion, a second light sensor coupled to the microcontroller and exposed to the second measurement portion, and a second plurality of light sources coupled to the microcontroller and exposed to the second measurement portion. The first and second source/sensor complexes are coupled to each other such that the first measurement portion is opposite the second measurement portion and human tissue may be placed between the first and second measurement portions. The microprocessor is configured with instructions stored in non-volatile memory to individually activate each of the light sources of the first and second pluralities of light sources and to record light intensity detected by the first and second light sources while an individual light source is activated. Each combination of an individually activated light source and one of the first and second light sensors provides a distinct measurement channel for measuring the absorption spectra of human blood and tissue.

公开(公告)号：US11448590B2

公开(公告)日：2022-09-20

申请号：US16967209

申请日：2019-02-01

Applicant: ELICHENS

Inventor： Thanh Trung Le

IPC: G01N21/35 ,  G01N21/3504 ,  G01N21/31 ,  G01J3/427

Abstract: A method—for measuring an amount of a gaseous species present in a gas—comprises placing the gas between a light source and a measurement photodetector. The light source is able to emit an incident light wave that propagates through the gas to the measurement photodetector. The gas is illuminated with the light source. A measurement intensity, of the light wave transmitted by the gas, is measured with the measurement photodetector. An intensity of a reference light wave, emitted by the light source in a reference spectral band, is measured with a reference photodetector. The illumination and measuring are performed at multiple measurement times, at each of which the gas's absorption of the incident light wave is estimated and an amount of the gaseous species is estimated on the basis of the estimated absorption. Estimating the absorption comprises applying a correction function, that varies over time, to the reference intensity.

公开(公告)号：US11154216B2

公开(公告)日：2021-10-26

申请号：US15796012

申请日：2017-10-27

Applicant: Drägerwerk AG & Co. KGaA

Inventor： Peter Dreyer ,  Günter Steinert ,  Bernd-Michael Dicks ,  Ralph-Peter Jacobi

IPC: A61B5/083 ,  A61B5/08 ,  G01N21/31 ,  G01J3/42 ,  G01J3/02 ,  G01J3/427 ,  G01N21/3504 ,  G01N21/05 ,  G01J3/28 ,  G01J3/12

Abstract: A device (1) for determining the concentration of a gas component is configured with a radiation source (30) for radiating (31) light as a light emission in an infrared wavelength range. Two detector arrays (52, 62) with two detector elements (50, 60) are configured suitably for detecting the light emission generated by the radiation source (30) in two detector arrays (52, 62). Two filter elements (51, 61) are associated with the detector elements (50, 60). The two detector elements (50, 60) are oriented in relation to the radiation source, so that a range of overlap (65) is obtained due to the two detector arrays (52, 62). The range of overlap (65) causes attenuations in the propagation of light, which may be due to gas molecules or moisture (400). The attenuations in the propagation of light affect both detector elements (50, 60) and are compensated concerning the determination of the concentration.

公开(公告)号：US20210063243A1

公开(公告)日：2021-03-04

申请号：US16555130

申请日：2019-08-29

Applicant: Dublin City University

Inventor： Prince Anandarajah ,  Eamonn Patrick Martin

IPC: G01J3/453 ,  G01J9/04 ,  G01J3/427

Abstract: A gain switched dual comb spectroscopy device for spectroscopically detecting a sample substance, comprising a first slave laser light source configured to generate a first frequency comb having a first comb free spectral range, and a second slave laser light source configured to generate a second frequency comb having a second comb free spectral range which is different from the first comb free spectral range. A master laser light source is configured to inject seed light in to both slave laser light sources therewith to injection lock the generation of both the first and the second frequency combs. A photodetector part is arranged to combine the first and the second frequency combs and to detect a beat signal the spectrum of which comprises a third frequency comb including beat tones produced by interference between the combined first and second frequency combs. The device comprises a sample detection area configured for receiving the sample for detection and for directing at least one of the first and the second frequency comb to the photodetector part via the sample detection area.

公开(公告)号：US10444076B2

公开(公告)日：2019-10-15

申请号：US15778753

申请日：2015-11-26

Applicant: Sensirion AG

Inventor： Martin Winger ,  Marc Von Waldkirch ,  Matthias Streiff ,  Alexander Lochbaum ,  Jürg Leuthold

IPC: G01J5/08 ,  G01J3/427 ,  G01J5/06 ,  G01J5/10 ,  G01N21/3504 ,  G01J3/42

Abstract: An infrared device comprises a substrate (1), and arranged on or in the substrate (1) a configuration (3) for one of selectively emitting and selectively absorbing infrared radiation of a band, the configuration (3) comprising a pattern made from an electrically conducting material on a first level (L1), an electrically conducting film (33) on a second level (L2), and a dielectric layer (24) between the pattern and the film (33). One or more of a heater (4) for heating the configuration (3), and a thermal sensor (5) arranged for sensing the selective infrared radiation of the band absorbed by the configuration (3) on or in the substrate.

公开(公告)号：US10429242B2

公开(公告)日：2019-10-01

申请号：US15802504

申请日：2017-11-03

Applicant: SOCIETE FRANCAISE DE DETECTEURS INFRAROUGES—SOFRADIR

Inventor： Laurent Baud ,  Alexandre Maltere

IPC: G01J3/36 ,  G01J1/44 ,  G01J1/46 ,  G01J3/427 ,  G01J3/28 ,  G01J3/50 ,  H04N5/235

Abstract: The multispectral detection device comprises first and second photodetectors sensitive to two different wavelengths. The two photodetectors are connected to two integration capacitors of two different readout circuits. Two reset circuits are configured so as to initialise the two integration capacitors separately. A first synchronisation circuit is connected to the first readout circuit and to the synchronisation signal and clock signal generators. The first synchronisation circuit is configured in such a way as to define the frame by detection of a leading edge of the synchronisation signal, count the number of occurrences of a trailing edge of the clock signal, initiate or terminate a data acquisition phase when the number of occurrences of trailing edges is equal to a threshold value recorded in a register of the first synchronisation circuit.

公开(公告)号：US10337920B2

公开(公告)日：2019-07-02

申请号：US15768548

申请日：2017-03-02

Applicant: CI SYSTEMS (ISRAEL) LTD.

Inventor： Dario Cabib

IPC: G01J3/02 ,  G01J3/26 ,  G01J3/42 ,  G01J3/45 ,  G01J3/427 ,  G01J3/433 ,  G01J3/453 ,  G02B27/50

Abstract: An interference fringe pattern generator forms an interference fringe pattern from the light rays diffused from a region of an object positioned against a background. A planar array of detector pixels is arranged to capture an image of the interference fringe pattern. A storage medium records information indicative of intensity values of the image of the interference fringe pattern captured by a selected group of pixels of the planar array of detector pixels. The information is recorded as a function of the optical path difference values traversed by the diffused light rays through the interference fringe pattern generator for each of the pixels in the selected group of pixels. A processor determines the spectral characteristics of the object based on the information indicative of the intensity values recorded by the storage medium and the optical path difference values traversed by the diffused light rays.

公开(公告)号：US20190079005A1

公开(公告)日：2019-03-14

申请号：US16121909

申请日：2018-09-05

Applicant: Regeneron Pharmaceuticals, Inc.

Inventor： Andria Skinner ,  Natallia Kulyba

IPC: G01N21/31 ,  G01J3/427 ,  G01N21/27 ,  G06F19/00 ,  A61K47/68 ,  G06F19/12

Abstract: The present disclosure provides methods of assessing DAR of ADC products that provide advantages over known methods. Specifically, methods of the disclosure can be used in high-throughput applications and/or without having to dilute ADC samples during the assessment.