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公开(公告)号：US08772710B2
公开(公告)日：2014-07-08
申请号：US14010130
申请日：2013-08-26
Applicant: Purdue Research Foundation
Inventor： Zheng Ouyang , Jason Harper , Nicholas Charipar , Robert Graham Cooks
CPC classification number: H01J37/32009 , H01J27/022 , H01J37/00 , H01J37/32348 , H01J49/02 , H01J49/105 , H01J49/142 , H01J2237/0044 , H05H1/24 , H05H1/2406 , H05H1/30 , H05H2001/2412 , H05H2001/2443 , H05H2240/10 , H05H2240/20 , Y10T436/145555 , Y10T436/147777 , Y10T436/173076 , Y10T436/203332 , Y10T436/24
Abstract: The present invention generally relates to a low temperature plasma probe for desorbing and ionizing at least one analyte in a sample material and methods of use thereof. In one embodiment, the invention generally relates to a low temperature plasma probe including: a housing having a discharge gas inlet port, a probe tip, two electrodes, and a dielectric barrier, in which the two electrodes are separated by the dielectric barrier, in which application of voltage from a power supply generates a low temperature plasma, and in which the low temperature plasma is propelled out of the discharge region by the electric field and/or the discharge gas flow.
Abstract translation: 本发明一般涉及用于解吸和电离样品中至少一种分析物的低温等离子体探针及其使用方法。 在一个实施方案中，本发明一般涉及一种低温等离子体探针，其包括：壳体，其具有放电气体入口端口，探针尖端，两个电极和介电屏障，其中两个电极由电介质屏障隔开， 来自电源的电压的施加产生低温等离子体，其中通过电场和/或放电气体流将低温等离子体推出排出区域。
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公开(公告)号：US08686351B2
公开(公告)日：2014-04-01
申请号：US13937913
申请日：2013-07-09
Applicant: Purdue Research Foundation
Inventor： Zheng Ouyang , Robert Graham Cooks , Sandilya Venkata Garimella , Jason David Harper , Nicholas Alan Charipar
IPC: H01J37/301 , H01J49/04 , H01J3/18
CPC classification number: H01J49/0404 , G01N27/622 , H01J49/0027 , H01J49/0031 , H01J49/04 , H01J49/0409 , H01J49/0422 , H01J49/0459 , H01J49/10 , H01J49/26 , H01J49/40 , H01J49/4215
Abstract: The invention generally relates to systems and methods for transferring ions for analysis. In certain embodiments, the invention provides a system for analyzing a sample including an ionizing source for converting molecules of a sample into gas phase ions in a region at about atmospheric pressure, an ion analysis device, and an ion transfer member operably coupled to a gas flow generating device, in which the gas flow generating device produces a laminar gas flow that transfers the gas phase ions through the ion transfer member to an inlet of the ion analysis device.
Abstract translation: 本发明一般涉及用于转移离子进行分析的系统和方法。 在某些实施方案中，本发明提供了一种用于分析样品的系统，该样品包括用于将样品分子转化成大气压的区域中的气相离子的电离源，离子分析装置和可操作地耦合到气体的离子传递构件 气体发生装置，其中气体流动产生装置产生将气相离子通过离子传递构件转移到离子分析装置的入口的层流气流。
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公开(公告)号：US20130330714A1
公开(公告)日：2013-12-12
申请号：US13926645
申请日：2013-06-25
Applicant: Purdue Research Foundation
Inventor： Robert Graham Cooks , Ahmed Mohamed Hamid , Alan Keith Jarmusch , Zheng Ouyang
IPC: C12Q1/04
CPC classification number: H01J49/0036 , C12Q1/04 , G01N2560/00 , H01J49/04 , H01J49/0409 , H01J49/0422 , H01J49/10 , H01J49/16 , H01J49/26
Abstract: The invention generally relates to systems and methods for mass spectrometry analysis of microorganisms in samples.
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公开(公告)号：US20130273560A1
公开(公告)日：2013-10-17
申请号：US13909619
申请日：2013-06-04
Applicant: Purdue Research Foundation
Inventor： Robert Graham Cooks , Kevin Scott Kerian , Alan Keith Jarmusch , Ahmed Mohamed Hamid , Livia Schiavinato Eberlin
IPC: G01N27/62
CPC classification number: G01N33/6848 , G01N27/62 , G01N33/50 , G01N33/57407 , G01N2560/00 , G01N2800/7028 , H01J49/0004 , H01J49/0031 , H01J49/142 , H01J49/165
Abstract: The invention generally relates to methods for analyzing a metabolite level in a sample. In certain embodiments, methods of the invention may involve obtaining a sample, analyzing the sample using a mass spectrometry technique to determine a level of at least one metabolite in the sample, and correlating the metabolite level with an originating source of the sample, thereby analyzing the sample.
Abstract translation: 本发明一般涉及用于分析样品中代谢物水平的方法。 在某些实施方案中，本发明的方法可包括获得样品，使用质谱技术分析样品以确定样品中至少一种代谢物的水平，并将代谢物水平与样品的起始来源相关联，从而分析 例子。
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55.发明申请公开(公告)号：US20250041870A1
公开(公告)日：2025-02-06
申请号：US18921948
申请日：2024-10-21
Applicant: Purdue Research Foundation
Inventor： Robert Graham Cooks , Zhenwei Wei
Abstract: The invention generally relates to systems and methods for synthesizing a reaction product and increasing yield of the same. In certain aspects, the invention provides a multi-mode reaction system in which in a first mode one or more valves of the system are configured to cause reagents to flow from one or more reagent reservoirs of the system through one or more components of the system to generate a reaction product; and in a second mode the one or more valves are configured to change flow within the system such that the one or more reagent reservoirs are isolated from a remainder of the system and the generated reaction product and any remaining reactants are recycled back through the multi-mode reaction system to increase a yield of the reaction product.
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Patent Agency Ranking
56.发明授权公开(公告)号：US12157126B2
公开(公告)日：2024-12-03
申请号：US17183691
申请日：2021-02-24
Applicant: Purdue Research Foundation
Inventor： Robert Graham Cooks , Zhenwei Wei
Abstract: The invention generally relates to systems and methods for synthesizing a reaction product and increasing yield of the same. In certain aspects, the invention provides a multi-mode reaction system in which in a first mode one or more valves of the system are configured to cause reagents to flow from one or more reagent reservoirs of the system through one or more components of the system to generate a reaction product; and in a second mode the one or more valves are configured to change flow within the system such that the one or more reagent reservoirs are isolated from a remainder of the system and the generated reaction product and any remaining reactants are recycled back through the multi-mode reaction system to increase a yield of the reaction product.
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公开(公告)号：US12055550B2
公开(公告)日：2024-08-06
申请号：US17342804
申请日：2021-06-09
Applicant: Purdue Research Foundation
Inventor： Robert Graham Cooks , Zane Baird , Michael Pugia , Adam Hollerbach , Stephen Ayrton
IPC: G01N33/68 , G01N33/531 , G01N33/574
CPC classification number: G01N33/6848 , G01N33/531 , G01N33/5748 , G01N33/574 , G01N2560/00
Abstract: The invention generally relates to charged mass label compositions and methods of use thereof for detecting a target analyte in a sample. In certain aspects, the invention provides a charged mass label composition including an affinity reagent, and a mass label precursor bound to the affinity reagent. The mass label precursor includes a label binding unit and a mass label. The label binding unit reversibly binds the mass label to the affinity reagent. The mass label includes a charge unit and a mass label unit having a pre-defined mass-to-charge-value in a mass spectrum.
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公开(公告)号：US11860172B2
公开(公告)日：2024-01-02
申请号：US17331264
申请日：2021-05-26
Applicant: Purdue Research Foundation
Inventor： Robert Graham Cooks , Livia Schiavinato Eberlin , Christina Ramires Ferreira , Allison Lisa Dill , Demian R. Ifa
CPC classification number: G01N33/92 , H01J49/0036 , H01J49/165 , H01J49/0004 , H01J49/142
Abstract: The invention generally relates to mass spectral analysis. In certain embodiments, methods of the invention involve analyzing a lipid containing sample using a mass spectrometry technique, in which the technique utilizes a liquid phase that does not destroy native tissue morphology during analysis. Due to the use of a liquid phase that does not destroy native tissue morphology during analysis, a subsequent staining technique can be performed on the tissue sample and an overlaid image can be produced of a mass spectral image and a staining image.
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59.发明公开公开(公告)号：US20230420236A1
公开(公告)日：2023-12-28
申请号：US18209074
申请日：2023-06-13
Applicant: Purdue Research Foundation
Inventor： Robert Graham Cooks , Guangtao Li , Guangming Huang , Jason Duncan , Xin Li , Ewa Sokol , Xin Yan
CPC classification number: H01J49/04 , H01J49/0445 , H01J49/0018 , H01J49/045 , G01N27/62 , H01J49/0031 , H01J49/4205 , Y10T436/24
Abstract: The invention generally relates to methods and devices for synchronization of ion generation with cycling of a discontinuous atmospheric interface. In certain embodiments, the invention provides a system for analyzing a sample that includes a mass spectrometry probe that generates sample ions, a discontinuous atmospheric interface, and a mass analyzer, in which the system is configured such that ion formation is synchronized with cycling of the discontinuous atmospheric interface.
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公开(公告)号：US11837455B2
公开(公告)日：2023-12-05
申请号：US17831951
申请日：2022-06-03
Applicant: Purdue Research Foundation
Inventor： Robert Graham Cooks , Zane Baird , Pu Wei
IPC: H01J49/00 , H01J49/24 , H01J49/06 , G01N27/623 , G01N27/622 , H01J49/14
CPC classification number: H01J49/24 , G01N27/622 , G01N27/623 , H01J49/0013 , H01J49/061 , H01J49/142
Abstract: The invention generally relates to sample analysis systems and methods of use thereof. In certain aspects, the invention provides a system for analyzing a sample that includes an ion generator configured to generate ions from a sample. The system additionally includes an ion separator configured to separate at or above atmospheric pressure the ions received from the ion generator without use of laminar flowing gas, and a detector that receives and detects the separated ions.
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