公开(公告)号：US09841383B2

公开(公告)日：2017-12-12

申请号：US15032735

申请日：2014-10-16

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： Evan J. Ribnick ,  John A. Ramthun ,  David D. Miller

IPC: G06K9/00 ,  G01N21/898 ,  G01N21/84 ,  G01N21/89 ,  G01N21/88 ,  G06T3/40 ,  G06T5/20 ,  G06T7/00 ,  G06T7/11 ,  G06T7/44

CPC classification number: G01N21/8983 ,  G01N21/8422 ,  G01N21/8851 ,  G01N21/8915 ,  G01N21/892 ,  G01N2021/8427 ,  G01N2021/8887 ,  G01N2021/8917 ,  G01N2201/12 ,  G06T3/40 ,  G06T5/20 ,  G06T7/0004 ,  G06T7/11 ,  G06T7/44 ,  G06T2207/20016 ,  G06T2207/20021 ,  G06T2207/30124

Abstract: A method for characterizing the uniformity of a material includes selecting a set of size scales at which to measure uniformity within an area of interest in an image of the material; suppressing features in the image smaller than a selected size scale of interest within the set of size scales; dividing the image into patches equal to the size scale of interest; and calculating a uniformity value within each patch.

公开(公告)号：US20170343475A1

公开(公告)日：2017-11-30

申请号：US15608380

申请日：2017-05-30

Applicant: Sysmex Corporation

Inventor： Kazuhiro YAMADA

IPC: G01N21/64 ,  G01N15/14 ,  G01N33/483 ,  G01N15/10 ,  G01N15/00

CPC classification number: G01N21/6456 ,  G01N15/1434 ,  G01N15/1436 ,  G01N15/1459 ,  G01N15/147 ,  G01N15/1475 ,  G01N21/6428 ,  G01N21/6458 ,  G01N33/4833 ,  G01N2015/0065 ,  G01N2015/1006 ,  G01N2015/144 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6439 ,  G01N2021/6441 ,  G01N2021/6478 ,  G01N2201/06113 ,  G01N2201/12 ,  G06T7/0012 ,  G06T2207/10056 ,  G06T2207/10064 ,  G06T2207/30024

Abstract: A fluorescence image analyzer, analyzing method, and pretreatment evaluation method capable of determining with high accuracy whether a sample is positive or negative are provided. A pretreatment part 20 performs pretreatment including a step of labeling a target site with a fluorescent dye to prepare a sample 20a. A fluorescence image analyzer 10 measures and analyzes the sample 20a. The fluorescent image analyzer 10 includes light sources 121 to 124 to irradiate light on the sample 20a, imaging part 154 to capture the fluorescent light given off from the sample 20a irradiated by light, and processing part 11 for processing the fluorescence image captured by the imaging part 154. The processing part 11 extracts the bright spot of fluorescence generated from the fluorescent dye that labels the target site from the fluorescence image for each of a plurality of cells included in the sample 20a, and generates information used for determining whether the sample 20a is positive or negative based on the bright spots extracted for each of the plurality of cells.

公开(公告)号：US20170336394A1

公开(公告)日：2017-11-23

申请号：US15522116

申请日：2015-10-27

Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Adela Ben-Yaker ,  Evan Hegarty ,  Sudip Mondal ,  Navid Ghorashian ,  Sertan Kutal Gökçe ,  Christopher Martin

IPC: G01N33/50 ,  G01N35/00 ,  G01N21/05 ,  G01N21/64 ,  G06K9/00 ,  B01L3/00

CPC classification number: G01N33/5085 ,  B01L3/502715 ,  B01L3/502723 ,  B01L3/502746 ,  B01L3/502761 ,  B01L2200/0668 ,  B01L2300/023 ,  B01L2300/0654 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/087 ,  B01L2300/14 ,  B01L2400/0487 ,  B01L2400/086 ,  G01N21/05 ,  G01N21/6458 ,  G01N33/502 ,  G01N35/00029 ,  G01N35/00871 ,  G01N2021/6482 ,  G01N2035/00148 ,  G01N2201/12 ,  G06K9/00134 ,  G06K9/0014

Abstract: A microfluidic device capable of trapping contents in a manner suitable for high-throughput imaging is described herein. The microfluidic device may include one or more trapping devices, with each trapping device having a plurality of trapping channels. The trapping channels may be configured to receive contents via an inlet channel that connects a sample reservoir to the trapping channels via fluid communication. The trapping channels are shaped such that contents within the trapping channels are positioned for optimal imaging purposes. The trapping channels are also connect to at least one exit channel via fluid communication. The fluid, and contents within the fluid, may be controlled via hydraulic pressure.

公开(公告)号：US20170328825A1

公开(公告)日：2017-11-16

申请号：US15146097

申请日：2016-05-04

Applicant: Teilch LLC

Inventor： Pedro GODOY ,  Juan BARDINA

IPC: G01N15/14 ,  G01N21/01 ,  G02B6/12 ,  G01N15/10

CPC classification number: G01N15/1434 ,  G01N15/0211 ,  G01N15/06 ,  G01N15/1431 ,  G01N15/1456 ,  G01N21/01 ,  G01N21/53 ,  G01N2015/0046 ,  G01N2015/0693 ,  G01N2015/1087 ,  G01N2015/1486 ,  G01N2021/0162 ,  G01N2201/06113 ,  G01N2201/12 ,  G01N2223/05 ,  G02B6/12 ,  G02B2006/12121 ,  G06F3/04847 ,  G06F3/0488

Abstract: An airborne particle-measuring device quantifies and qualifies contaminants of an air environment in clean-rooms, open spaces, and enclosed spaces such as homes, offices, industrial environments, airplanes in flight, cars and others. The device may include a sensor system, an electronics system, communications and information storage. The sensor system may include a high-power low-wavelength single-frequency continuous laser, an open-cavity high-efficiency mirror having an optical surface tuned to the laser frequency and a flow system that includes a vacuum pump to sample the air. The electronics system may be mounted on a single multilayer PC board with a microprocessor, firmware, electronics and a touch-screen LCD display. Innovations in light source, flow control, analog and digital signal processing, components integration and software allow provision of equipment in a wide range of high-complexity settings that require precise particle measurements.

公开(公告)号：US20170322406A1

公开(公告)日：2017-11-09

申请号：US15649067

申请日：2017-07-13

Applicant: Bioaxial SAS

Inventor： Gabriel Y. Sirat

IPC: G02B21/16 ,  G02B21/36 ,  G02B21/00 ,  G01N21/64

CPC classification number: G02B21/16 ,  G01N21/6458 ,  G01N21/6486 ,  G01N2201/06113 ,  G01N2201/12 ,  G02B21/0056 ,  G02B21/0072 ,  G02B21/0076 ,  G02B21/361

Abstract: An optical measurement method and an optical measurement device for determining the spatial or spatiotemporal distribution of a sample, the sample comprising at least one retransmission source retransmitting light depending on light projected onto the sample according to a predetermined law. The method has steps of projection onto the sample of at least two compact light distributions belonging to different topological families, which propagate along the same optical path; detection of the light retransmitted by said at least one retransmission source of the sample; generation of at least one optical image from the detected light; and algorithmic analysis of the optical images for obtaining location data on said at least one retransmission source.

公开(公告)号：US20170315055A1

公开(公告)日：2017-11-02

申请号：US15494056

申请日：2017-04-21

Applicant: ASML Netherlands B.V.

Inventor： Patricius Aloysius Jacobus TINNEMANS ,  Simon Gijsbert Josephus MATHIJSSEN ,  Sander Bas ROOBOL ,  Nan LIN

IPC: G01N21/47 ,  G01N21/88 ,  G03F7/20

CPC classification number: G03F7/70616 ,  G01N21/47 ,  G01N21/8806 ,  G01N21/9501 ,  G01N21/956 ,  G01N21/95607 ,  G01N2021/4704 ,  G01N2021/4735 ,  G01N2021/8822 ,  G01N2021/95615 ,  G01N2201/12 ,  G03F7/70625 ,  G03F7/70633 ,  G03F7/7065 ,  G03F7/70683 ,  G03F9/7003 ,  H01L22/12

Abstract: A structure of interest (T) is irradiated with radiation for example in the x-ray or EUV waveband, and scattered radiation is detected by a detector (19, 274, 908, 1012). A processor (PU) calculates a property such as linewidth (CD) or overlay (OV), for example by simulating (S16) interaction of radiation with a structure and comparing (S17) the simulated interaction with the detected radiation. The method is modified (S14a, S15a, S19a) to take account of changes in the structure which are caused by the inspection radiation. These changes may be for example shrinkage of the material, or changes in its optical characteristics. The changes may be caused by inspection radiation in the current observation or in a previous observation.

公开(公告)号：US20170315051A1

公开(公告)日：2017-11-02

申请号：US15524815

申请日：2015-11-20

Applicant: FUJIKIN INCORPORATED ,  TOHOKU UNIVERSITY

Inventor： Masaaki Nagase ,  Kouji Nishino ,  Nobukazu Ikeda ,  Michio Yamaji ,  Shigetoshi Sugawa ,  Rihito Kuroda

IPC: G01N21/27 ,  G01N21/33 ,  C23C16/18 ,  G01N33/00 ,  C23C16/52

CPC classification number: G01N21/27 ,  C23C16/18 ,  C23C16/52 ,  G01N21/314 ,  G01N21/3151 ,  G01N21/33 ,  G01N33/0027 ,  G01N2021/3155 ,  G01N2021/3159 ,  G01N2021/3181 ,  G01N2201/0627 ,  G01N2201/0696 ,  G01N2201/12 ,  H01L21/205

Abstract: To provide a concentration measurement method with which the concentrations of predetermined chemical components can be measured non-destructively, accurately, and rapidly by a simple means, up to the concentrations in trace amount ranges, as well as a concentration measurement method with which the concentrations of chemical components in a measurement target can be accurately and rapidly measured in real time up to the concentrations in nano-order trace amount ranges, and which is endowed with a versatility that can be realized in a variety of embodiments and modes. In the present invention, a measurement target is irradiated, in a time sharing manner, with light of a first wavelength and light of a second wavelength that have different optical absorption rates with respect to the measurement target. The light of each wavelength, arriving optically via the measurement target as a result of irradiation with the light of each wavelength, is received at a shared light-receiving sensor. A differential signal is formed, the differential signal being of a signal pertaining to the light of the first wavelength and a signal pertaining to the light of the second wavelength, the signals outputted from the light-receiving sensor upon receipt of the light. The concentration of a chemical component in the measurement target is derived on the basis of the differential signal.

公开(公告)号：US09805462B2

公开(公告)日：2017-10-31

申请号：US15484017

申请日：2017-04-10

Applicant: KLA-Tencor Corporation

Inventor： Abdurrahman Sezginer ,  Gang Pan ,  Bing Li

IPC: G06T7/00 ,  G06K9/62 ,  G03F1/84 ,  G03F7/20 ,  G01N21/956 ,  G01N21/95 ,  G06N99/00

CPC classification number: G06T7/001 ,  G01N21/9501 ,  G01N21/95607 ,  G01N2021/95676 ,  G01N2201/12 ,  G03F1/84 ,  G03F7/7065 ,  G06K9/6232 ,  G06K9/6252 ,  G06K9/6282 ,  G06N99/005 ,  G06T7/0008 ,  G06T2207/20081 ,  G06T2207/30148

Abstract: Apparatus and methods for inspecting a specimen are disclosed. An inspection tool is used at one or more operating modes to obtain images of a plurality of training regions of a specimen, and the training regions are identified as defect-free. Three or more basis training images are derived from the images of the training regions. A classifier is formed based on the three or more basis training images. The inspection system is used at the one or more operating modes to obtain images of a plurality of test regions of a specimen. Three or more basis test images are derived from to the test regions. The classifier is applied to the three or more basis test images to find defects in the test regions.

公开(公告)号：US09797876B2

公开(公告)日：2017-10-24

申请号：US15357225

申请日：2016-11-21

Applicant: OMNI MEDSCI, INC.

Inventor： Mohammed N. Islam

IPC: G01J3/00 ,  G01N33/15 ,  A61B5/1455 ,  A61B5/00 ,  G01J3/10 ,  G01J3/28 ,  G01J3/453 ,  G01N21/359 ,  A61B5/145 ,  G01N33/49 ,  G01N21/3563 ,  G01N21/39 ,  G01N33/02 ,  G01N33/44 ,  G01N21/88 ,  H01S3/30 ,  G01J3/14 ,  G01J3/18 ,  G01M3/38

CPC classification number: A61B5/0088 ,  A61B5/0013 ,  A61B5/0022 ,  A61B5/0075 ,  A61B5/0086 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/4547 ,  A61B5/6801 ,  A61B5/7257 ,  A61B5/7405 ,  A61B5/742 ,  A61B2562/0233 ,  A61B2562/0238 ,  A61B2562/146 ,  A61B2576/02 ,  G01J3/0218 ,  G01J3/108 ,  G01J3/14 ,  G01J3/1838 ,  G01J3/28 ,  G01J3/2823 ,  G01J3/42 ,  G01J3/453 ,  G01J2003/104 ,  G01J2003/1208 ,  G01J2003/2826 ,  G01M3/38 ,  G01N21/35 ,  G01N21/3563 ,  G01N21/359 ,  G01N21/39 ,  G01N21/85 ,  G01N21/88 ,  G01N21/9508 ,  G01N33/02 ,  G01N33/025 ,  G01N33/15 ,  G01N33/442 ,  G01N33/49 ,  G01N2021/3595 ,  G01N2021/399 ,  G01N2201/061 ,  G01N2201/06113 ,  G01N2201/062 ,  G01N2201/08 ,  G01N2201/12 ,  G01N2201/129 ,  G06F19/00 ,  G16H40/67 ,  H01S3/0092 ,  H01S3/06758 ,  H01S3/302

Abstract: A measurement system includes semiconductor light sources generating an input beam, optical amplifiers receiving the input beam and delivering an intermediate beam, and fused silica fibers with core diameters less than 400 microns receiving and delivering the intermediate beam to the fibers forming a first optical beam. A nonlinear element receives the first optical beam and broadens the spectrum to at least 10 nm through a nonlinear effect to form the output optical beam which includes a near-infrared wavelength of 700-2500 nm. A measurement apparatus is configured to receive the output optical beam and deliver it to a sample to generate a spectroscopy output beam. A receiver receives the spectroscopy output beam having a bandwidth of at least 10 nm and processes the beam to generate an output signal, wherein the light source and the receiver are remote from the sample, and wherein the sample comprises plastics or food industry goods.

公开(公告)号：US09784736B2

公开(公告)日：2017-10-10

申请号：US14900483

申请日：2014-03-24

Applicant: Danmarks Tekniske Universitet ,  CIC NanoGune

Inventor： Marco Donolato ,  Mikkel Fougt Hansen ,  Paolo Vavassori

IPC: G01N33/543 ,  G01N21/17

CPC classification number: G01N33/54333 ,  G01N21/1717 ,  G01N33/54313 ,  G01N33/54326 ,  G01N33/54366 ,  G01N2021/1727 ,  G01N2201/061 ,  G01N2201/062 ,  G01N2201/12

Abstract: Disclosed herein is a biosensor for optical detection of Brownian relaxation dynamics of magnetic particles measured by light transmission. The magnetic particles can be functionalized with biological ligands for the detection of target analytes in a sample.