公开(公告)号：US20040133086A1

公开(公告)日：2004-07-08

申请号：US10657657

申请日：2003-09-08

Inventor： Emil W. Ciurczak ,  Gary Ritchie

IPC: A61B005/00

CPC classification number: G01J3/12 ,  A61B5/0022 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/14551 ,  G01J3/021 ,  G01J3/0229 ,  G01J3/0232 ,  G01J3/0254 ,  G01J3/0256 ,  G01J3/0264 ,  G01J3/08 ,  G01J3/1256 ,  G01J3/18 ,  G01J3/26 ,  G01J2003/1226 ,  G01J2003/1243 ,  G01N21/359 ,  G01N21/474 ,  G01N2021/1744 ,  G01N2021/4757 ,  G01N2201/0221 ,  G01N2201/065 ,  G01N2201/1293 ,  G01N2201/1296 ,  G16H40/67 ,  Y02A90/26

Abstract: A system for predicting blood constituent values in a patient includes a remote wireless non-invasive spectral device, the remote wireless non-invasive spectral device generating a spectral scan of a body part of the patient. Also included are a remote invasive device and a central processing device. The remote invasive device generates a constituent value for the patient, while the central processing device predicts a blood constituent value for the patient based upon the spectral scan and the constituent value.

Abstract translation: 用于预测患者中血液成分值的系统包括远程无线非侵入性光谱装置，所述远程无线非侵入光谱装置产生患者身体部位的光谱扫描。 还包括远程侵入性装置和中央处理装置。 远程侵入性装置生成患者的构成值，而中央处理装置基于光谱扫描和构成值预测患者的血液成分值。

公开(公告)号：US20040106204A1

公开(公告)日：2004-06-03

申请号：US10663566

申请日：2003-09-16

Inventor： Robert J. L. Chimenti ,  Gerald M. Halpern ,  Patricia H. Kalamaras ,  Michael P. Anderson ,  Maureen Lannucci

IPC: G01N035/08

CPC classification number: G01N33/2876 ,  G01N21/0332 ,  G01N21/314 ,  G01N2201/1293 ,  Y10T436/12

Abstract: The invention is a method to improve the prediction of the corrosivity of organic acids in petroleum crudes, feedstocks and distillation fractions by providing a more accurate, repeatable, and rapid means of determining the TAN from the IR spectrum of the material. The method can be easily practiced in refinery, terminal, and assay laboratories. It can be used in conjunction with models and hardware to optimize the usage and improve the valuation of corrosive feed stocks. The invention can be implemented on-line for blending optimization. It comprises the steps of irradiating a heated petroleum sample with IR radiation to produce its IR absorption spectrum, and predicting the TAN from the spectrum using a linear, multivariate regression model. The IR TAN value is then used as input to blending, valuation, and corrosion models.

Abstract translation: 本发明是通过提供从材料的IR光谱确定TAN的更准确，可重复和快速的方法来改进对石油原料，原料和蒸馏馏分中有机酸的腐蚀性的预测的方法。 该方法可以在炼油厂，终端和分析实验室中轻松实施。 它可以与型号和硬件结合使用，以优化使用，并提高腐蚀性原料的估价。 本发明可以在线实现混合优化。 它包括以下步骤：用IR辐射照射加热的石油样品以产生其IR吸收光谱，并使用线性多变量回归模型从光谱预测TAN。 然后将IR TAN值用作混合，估值和腐蚀模型的输入。

公开(公告)号：US06587702B1

公开(公告)日：2003-07-01

申请号：US09489617

申请日：2000-01-21

Applicant: Timothy L. Ruchti ,  Kevin H. Hazen ,  Marcy R. Makarewicz ,  George M. Acosta

Inventor： Timothy L. Ruchti ,  Kevin H. Hazen ,  Marcy R. Makarewicz ,  George M. Acosta

IPC: A61B500

CPC classification number: A61B5/4872 ,  A61B5/0059 ,  A61B5/1075 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/7264 ,  G01N21/359 ,  G01N2201/1293

Abstract: A non-invasive system for characterizing and classifying the state and structure of a tissue sample operates on a near infrared absorbance spectrum of in vivo tissue. A method that uses near-infrared spectral measurements to characterize and classify the state and structure of tissue sampled based on absorbance features related to fat in adipose tissue is provided. Also provided is a method of estimating skin fold thickness. The approach provides information about sources of tissue variability and is therefore useful for establishing the general category of the tissue structure. Categorization of subjects on the basis of the determination is suitable for further spectral analysis and the measurement of biological and chemical compounds, such as blood analytes. The invention further provides a method of estimating percent body fat based on a skin fold thickness estimate. The invention also provides an apparatus for measuring the absorbance spectra coupled with a digital processor for performing the required analyses.

Abstract translation: 用于表征和分类组织样品的状态和结构的非侵入性系统在体内组织的近红外吸收光谱上操作。 提供了一种使用近红外光谱测量来表征和分类基于与脂肪组织中的脂肪相关的吸光度特征所采集的组织的状态和结构的方法。 还提供了估计皮肤褶皱厚度的方法。 该方法提供了关于组织变异性来源的信息，因此可用于建立组织结构的一般类别。 在确定的基础上对受试者进行分类适用于进一步的光谱分析和生物化学化合物如血液分析物的测量。 本发明还提供了一种基于皮肤折叠厚度估计估计身体脂肪百分比的方法。 本发明还提供了一种用于测量与数字处理器耦合的吸光度谱进行所需分析的装置。

公开(公告)号：US06529276B1

公开(公告)日：2003-03-04

申请号：US09286881

申请日：1999-04-06

Applicant: Michael L. Myrick

Inventor： Michael L. Myrick

IPC: G01N2125

CPC classification number: G06N3/067 ,  G01J3/02 ,  G01J3/0297 ,  G01J3/18 ,  G01J3/28 ,  G01J3/42 ,  G01J3/51 ,  G01J2003/1213 ,  G01J2003/1226 ,  G01J2003/467 ,  G01N21/31 ,  G01N2201/1293 ,  G01N2201/1296 ,  G02B6/29361 ,  G02B6/29395 ,  G02B6/4215

Abstract: In optical filter systems and optical transmission systems, an optical filter compresses data into and/or derives data from a light signal. The filter way weight an incident light signal by wavelength over a predetermined wavelength range according to a predetermined function so that the filter performs the dot product of the light signal and the function.

公开(公告)号：US5596196A

公开(公告)日：1997-01-21

申请号：US449326

申请日：1995-05-24

Applicant: John B. Cooper ,  Kent L. Wise ,  William T. Welch ,  Michael B. Sumner

Inventor： John B. Cooper ,  Kent L. Wise ,  William T. Welch ,  Michael B. Sumner

IPC: G01N21/35 ,  G01N21/65 ,  G01J3/44

CPC classification number: G01N21/65 ,  G01N21/3577 ,  G01N21/359 ,  G01N2021/651 ,  G01N2021/656 ,  G01N21/658 ,  G01N2201/1293

Abstract: Oxygenated hydrocarbons can be predicted within .+-.0.2% wt or better, using Raman NIR spectroscopy and multivariate analysis, with optional fiberoptics multistreaming. The resulting signal can be used to control concentration of such compounds in product to desired levels.

Abstract translation: 使用拉曼近红外光谱和多变量分析，可以预测氧化烃在±0.2％wt或更好之内，并具有可选的光纤多流。 所得到的信号可以用于控制产品中这些化合物的浓度达到所需的水平。

公开(公告)号：US20230384228A1

公开(公告)日：2023-11-30

申请号：US18324728

申请日：2023-05-26

Applicant: CELL THERAPY CATAPULT LIMITED

Inventor： John Churchwell ,  Marc Olivier Baradez ,  Damian Marshall

IPC: G01N21/65

CPC classification number: G01N21/65 ,  G01N2201/1293

Abstract: The present invention relates to the use of Raman spectroscopy for the monitoring and assessment of viral titre.

公开(公告)号：US20190219508A1

公开(公告)日：2019-07-18

申请号：US16329364

申请日：2017-08-16

Applicant: RHEINISCH-WESTFÄLISCH TECHNISCHE HOCHSCHULE (RWTH) AACHEN

Inventor： Jochen BÜCHS ,  Tobias LADNER ,  Georg WANDREY ,  Oliver PAQUET-DURAND ,  Bernd HITZMANN

IPC: G01N21/64 ,  G01N1/28 ,  C12M1/34 ,  C12M3/06

CPC classification number: G01N21/6452 ,  B01F11/0014 ,  C12M27/16 ,  C12M41/46 ,  G01N1/286 ,  G01N21/253 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2201/08 ,  G01N2201/1293

Abstract: A method for measuring process parameters in liquid cultures in a plurality of microreactors of at least one microtiter plate includes continuously agitating the liquid cultures using an orbital agitator at least until the reaction is completed in all the microreactors. In order to allow process parameters also of such substances which themselves do not have any fluorescence activity to be measured with relatively low complexity and within a short time, 2D fluorescence spectra are recorded in a plurality of in particular different liquid cultures in the microreactors of agitated microplates. A device for carrying out the method is also disclosed.

公开(公告)号：US20180252650A1

公开(公告)日：2018-09-06

申请号：US15448069

申请日：2017-03-02

Applicant: Tokyo Electron Limited

Inventor： Daniel Morvay ,  Taejoon Han ,  Mirko Vukovic

IPC: G01N21/73 ,  H01J37/32 ,  G06T11/00 ,  G01J3/443 ,  H01L21/3065 ,  H01L21/67

CPC classification number: G01N21/73 ,  G01J3/443 ,  G01N21/68 ,  G01N2021/1787 ,  G01N2201/1293 ,  G06T11/003 ,  H01J37/32422 ,  H01J37/32972 ,  H01J2237/334 ,  H01L21/3065 ,  H01L21/67069

Abstract: Described herein are technologies to facilitate computed tomographic techniques to help identifying chemical species during plasma processing of a substrate (e.g., semiconductor wafer) using optical emission spectroscopy (OES). More particularly, the technology described herein uses topographic techniques to spatially resolves emissions and absorptions in at least two-dimension space above the substrate during the plasma processing (e.g., etching) of the substrate. With some implementations utilize optical detectors positioned along multiple axes (e.g., two or more) to receive incident incoming optical spectra from the plasma chamber during the plasma processing (e.g., etching) of the substrate. Because of the multi-axes arrangement, the incident incoming optical spectra form an intersecting grid.

公开(公告)号：US10067051B2

公开(公告)日：2018-09-04

申请号：US14606812

申请日：2015-01-27

Applicant: CIRECA THERANOSTICS, LLC ,  NORTHEASTERN UNIVERSITY

Inventor： Max Diem ,  Benjamin Bird ,  Milos Miljkovic ,  Stanley H. Remiszewski ,  Clay M. Thompson

IPC: G01N33/48 ,  G01N33/50 ,  G01N21/31 ,  A61B5/00 ,  G01N21/552 ,  G01N21/64 ,  G01N21/65 ,  G06K9/00 ,  G06F19/00 ,  G06T7/30 ,  G01N21/3581 ,  G01N21/35 ,  G06K9/46

CPC classification number: G01N21/31 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/415 ,  A61B5/418 ,  A61B5/7257 ,  G01N21/35 ,  G01N21/3581 ,  G01N21/552 ,  G01N21/6456 ,  G01N21/65 ,  G01N2021/3595 ,  G01N2021/6417 ,  G01N2021/653 ,  G01N2201/1293 ,  G01N2201/1296 ,  G06K9/00134 ,  G06K9/00147 ,  G06K2009/4657 ,  G06T7/30 ,  G06T2207/20101 ,  G06T2207/30024 ,  G16H50/20

Abstract: A method for analyzing biological specimens by spectral imaging to provide a medical diagnosis includes obtaining spectral and visual images of biological specimens and registering the images to detect cell abnormalities, pre-cancerous cells, and cancerous cells. This method eliminates the bias and unreliability of diagnoses that is inherent in standard histopathological and other spectral methods. In addition, a method for correcting confounding spectral contributions that are frequently observed in microscopically acquired infrared spectra of cells and tissue includes performing a phase correction on the spectral data. This phase correction method may be used to correct various types of absorption spectra that are contaminated by reflective components.

公开(公告)号：US20180232500A1

公开(公告)日：2018-08-16

申请号：US15429372

申请日：2017-02-10

Applicant: Savannah River Nuclear Solutions, LLC

Inventor： Robert J. Lascola ,  Patrick E. O'Rourke ,  David Immel ,  Jean R. Plummer ,  Edward A. Kyser, III

IPC: G06F19/00 ,  G01N33/20 ,  G01N21/31

CPC classification number: G16C20/70 ,  G01N21/274 ,  G01N21/31 ,  G01N33/20 ,  G01N2021/8411 ,  G01N2201/1293 ,  G16C20/20

Abstract: Analysis techniques by generation and interpretation of multivariate data that can provide for highly accurate analyte detection are described. Protocols can include a tiered principal component analysis (PCA) utilizing a partial least squares (PLS) approach for classification of a sample. Methods include selection of a particular local model for each classification category. The classification categories are determined based on assessment of sample characteristics such as solution absorbance, acidity, analyte oxidation state distribution, temperature, presence of one or more interferents, etc.