公开(公告)号：US20160003773A1

公开(公告)日：2016-01-07

申请号：US14772467

申请日：2014-03-05

Applicant: MICROMASS UK LIMITED

Inventor： Kevin Giles ,  Steven Derek Pringle ,  Jason Lee Wildgoose

IPC: G01N27/62 ,  H01J49/02

CPC classification number: G01N27/622 ,  H01J49/004 ,  H01J49/02 ,  H01J49/062 ,  H01J49/40

Abstract: An analytical device for analysing ions is provided comprising a separator for separating ions according to a physico-chemical property and an interface comprising one or more ion guides. A quadrupole rod set mass filter is arranged downstream of the interface. A control system is arranged and adapted: (i) to transmit a first group of ions which emerges from the separator through the interface with a first transit time t1; and (ii) to transmit a second group of ions which subsequently emerges from the separator through the interface with a second different transit time t2.

Abstract translation: 提供了用于分析离子的分析装置，其包括用于根据物理化学性质分离离子的分离器和包含一个或多个离子导向器的界面。 四极杆组质量过滤器布置在界面的下游。 控制系统被布置和适配：（i）通过接口在第一传送时间t1传送从分离器出来的第一组离子; 以及（ii）传输第二组离子，其随后通过界面从分离器出现，具有第二不同的传播时间t2。

公开(公告)号：US20150364316A1

公开(公告)日：2015-12-17

申请号：US14832978

申请日：2015-08-21

Applicant: Thermo Fisher Scientific (Bremen) GmbH

Inventor： Alexander A. MAKAROV ,  Eduard V. DENISOV ,  Gerhard JUNG ,  Wilko BALSCHUN ,  Stevan R. HORNING

IPC: H01J49/42 ,  H01J49/40 ,  H01J49/00

CPC classification number: H01J49/4245 ,  H01J49/0027 ,  H01J49/02 ,  H01J49/282 ,  H01J49/406 ,  H01J49/425

Abstract: An electrostatic trap such as an orbitrap is disclosed, with an electrode structure. An electrostatic trapping field of the form U′(r, φ, z) is generated to trap ions within the trap so that they undergo isochronous oscillations. The trapping field U′(r, φ, z) is the result of a perturbation W to an ideal field U(r, φ, z) which, for example, is hyperlogarithmic in the case of an orbitrap. The perturbation W may be introduced in various ways, such as by distorting the geometry of the trap so that it no longer follows an equipotential of the ideal field U(r, φ, z), or by adding a distortion field (either electric or magnetic). The magnitude of the perturbation is such that at least some of the trapped ions have an absolute phase spread of more than zero but less than 2 π radians over an ion detection period Tm.

Abstract translation: 公开了诸如轨道捕获器的静电捕获器，具有电极结构。 产生形式为U'（r，＆phgr; z）的静电捕获场，以捕获陷阱内的离子，使得它们经历同步振荡。 捕获场U'（r，＆phgr; z）是对于理想场U（r，＆phgr; z）的扰动W的结果，其在例如轨道捕获的情况下例如是超对数的。 扰动W可以以各种方式引入，例如通过使陷波器的几何形状变形，使得其不再遵循理想场U（r，＆phgr; z）的等电位，或者通过添加失真场（电 或磁性）。 扰动的幅度使得至少一些捕获的离子具有大于零但小于2的绝对相位扩展; 弧度超过离子检测周期Tm。

公开(公告)号：US09209005B2

公开(公告)日：2015-12-08

申请号：US14347625

申请日：2012-09-25

Applicant: Thermo Fisher Scientific (Bremen) GmbH

Inventor： Alexander Alekseevich Makarov

IPC: H01J49/00 ,  H01J49/02 ,  H01J49/06 ,  H01J49/40

CPC classification number: H01J49/40 ,  H01J49/0027 ,  H01J49/02 ,  H01J49/067 ,  H01J49/406

Abstract: A method for analyzing ions according to their mass-to-charge ratio and mass spectrometer for performing the method, comprising directing a collimated ion beam along an ion path from an ion source to an ion detector, causing a portion of the ion beam to contact one or more surfaces prior to reaching the ion detector, wherein the method comprises providing a coating on and/or heating the one or more surfaces to reduce variation in their surface patch potentials. The method is applicable to multi-reflection time-of-flight (MR TOF) mass spectrometry.

Abstract translation: 一种用于根据其质荷比和质谱分析离子的方法，用于执行该方法，包括将准直离子束沿离子通道从离子源引导到离子检测器，使一部分离子束接触 在达到离子检测器之前的一个或多个表面，其中所述方法包括在所述一个或多个表面上和/或加热所述表面以减少其表面贴片电位的变化。 该方法适用于多反射飞行时间（MR TOF）质谱。

公开(公告)号：US09189595B2

公开(公告)日：2015-11-17

申请号：US13431126

申请日：2012-03-27

Applicant: Hongping Dai ,  Corey Donald DeHaven

Inventor： Hongping Dai ,  Corey Donald DeHaven

IPC: G06F19/00 ,  G06F19/24 ,  G06K9/00 ,  H01J49/00 ,  H01J49/26 ,  H01J49/02

CPC classification number: G06F19/24 ,  G06F19/703 ,  G06F19/707 ,  G06K9/00496 ,  G06K9/00523 ,  H01J49/0036 ,  H01J49/02 ,  H01J49/26

Abstract: A method, apparatus, and computer-readable storage medium are provided for analyzing data from a component separation/mass spectrometer (CS-MS), wherein an intensity peak is determined, with an area thereof determined using an integration procedure, in each two-dimensional data set. The intensity peak indicates a sample component, and the area thereof indicates a relative quantity of the sample component. An integration procedure determines the area of selected peaks of a first portion of the two-dimensional data sets associated with a first sample component, and is applied to the intensity peaks of a second portion having the areas thereof not determined by that integration procedure, to adjust the relative quantity of the first sample component in the second portion samples relative to the relative quantity of the first sample component in the first portion samples. The re-integration may also involve determining whether a second sample component is indicated by the intensity peak.

Abstract translation: 提供了一种方法，装置和计算机可读存储介质，用于分析来自组分分离/质谱仪（CS-MS）的数据，其中确定强度峰值，其区域由积分程序确定， 维数据集。 强度峰表示样品成分，其面积表示样品成分的相对量。 积分过程确定与第一样本分量相关联的二维数据集的第一部分的所选择的峰的面积，并将其应用于具有未被该积分程序确定的区域的第二部分的强度峰值， 调整第二部分样品中第一样品组分相对于第一部分样品中第一样品组分的相对量的相对量。 重新整合还可以涉及确定第二样本分量是否由强度峰值指示。

公开(公告)号：US20150311053A1

公开(公告)日：2015-10-29

申请号：US14703528

申请日：2015-05-04

Applicant: MSDETECTION CORP.

Inventor： WILLIAM R. STOTT ,  GHOLAMREZA JAVAHERY

IPC: H01J49/04

CPC classification number: H01J49/0459 ,  G01N1/22 ,  G01N1/24 ,  G01N2001/022 ,  G01N2001/024 ,  H01J49/00 ,  H01J49/02 ,  H01J49/04

Abstract: Methods and devices for detecting a target substance on a subject without contacting the subject are disclosed. At least one air jet blows analyte from a surface of the subject into an airflow, the airflow entraining the analyte. A desorption channel desorbs molecules from analyte in a portion of the airflow travelling through the desorption channel. An ionizer forms ions from vapour molecules in the portion of the airflow. At least one mass spectrometer analyzes the ions to detect the target substance. The airflow travels without interruption from the subject to the at least one mass spectrometer. The desorption channel causes a sufficient quantity of molecules to desorb from the analyte to enable the at least one mass spectrometer to detect the target substance.

Abstract translation: 公开了用于在不接触受试者的情况下检测被检物体上的目标物质的方法和装置。 至少一个空气喷射器将被分析物从受试者的表面吹入气流，夹带分析物的气流。 解吸通道在通过解吸通道行进的气流的一部分中从分析物解吸分子。 电离器在气流的一部分形成来自蒸气分子的离子。 至少一个质谱仪分析离子以检测目标物质。 气流不间断地从受试者传播到至少一个质谱仪。 解吸通道导致足够数量的分子从分析物解吸，使得至少一个质谱仪能够检测目标物质。

公开(公告)号：US09147564B2

公开(公告)日：2015-09-29

申请号：US14365610

申请日：2012-12-13

Applicant: NUCTECH COMPANY LIMITED

Inventor： Wen He ,  Guanxing Li ,  Yuntai Bao

IPC: G21K5/04 ,  H01J49/02 ,  G01N27/62 ,  H01J49/26

CPC classification number: H01J49/02 ,  G01N27/622 ,  H01J49/26

Abstract: An electrode structure for an ion drift tube and an ion drift tube with the electrode structure are disclosed. The electrode structure comprises an annular electrode. The annular electrode has an inner edge bent towards one side such that a section of a central portion of the annular electrode has a swallowtail shape. With the ion drift detection instrument, ions in a drift state can travel along focusing electric lines of force, and since the high-voltage intervals between the electrodes are increased at a uniform acceleration, the generated electric field enables the ions to be in a uniformly accelerated drift state so that both the sensitivity and resolution of the mobility spectrum of the detection instrument can reach optimum.

Abstract translation: 公开了一种用于离子漂移管的电极结构和具有电极结构的离子漂移管。 电极结构包括环形电极。 环形电极具有朝向一侧弯曲的内边缘，使得环形电极的中心部分的截面具有燕尾形状。 使用离子漂移检测仪器，漂移状态的离子可以沿着聚焦电力线行进，并且由于电极之间的高压间隔以均匀的加速度增加，因此所产生的电场使得离子能够均匀地 加速漂移状态，使得检测仪器的灵敏度和分辨率都能达到最佳。

公开(公告)号：US20150187553A1

公开(公告)日：2015-07-02

申请号：US14140722

申请日：2013-12-26

Applicant: SHIMADZU CORPORATION

Inventor： Yohei YAMADA

IPC: H01J49/02

CPC classification number: H01J49/02 ,  G06F3/14 ,  H01J49/025

Abstract: A mass spectrometry data display device in which the mass axis (m/z axis) is made into a ring shape and the intensity axis is the radial direction thereof, and peak information (in the drawing, the compound name and structural formula candidates) are arranged in a ring shape in correspondence with the peaks along the outer circumference of the mass spectrum and displayed together therewith on a screen.

Abstract translation: 质谱数据显示装置，质心轴（m / z轴）为环状，强度轴为径向，峰值信息（附图中，化合物名称和结构式候选）为 与沿着质谱的外周的峰对应地设置成环形，并与屏幕一起显示。

公开(公告)号：US20150014524A1

公开(公告)日：2015-01-15

申请号：US14291417

申请日：2014-05-30

Applicant: Anthony Chiappetta ,  Urs Steiner ,  Keith Ferrara

Inventor： Anthony Chiappetta ,  Urs Steiner ,  Keith Ferrara

IPC: H01J49/02 ,  H01J49/24 ,  H01J49/40

CPC classification number: H01J49/405 ,  H01J49/02 ,  H01J49/24 ,  H01J49/40

Abstract: Certain embodiments described herein are directed to time of flight tubes comprising a cylindrical tube comprising an inner surface and an outer surface, the cylindrical tube comprising an effective thickness and sized and arranged to couple to and support a reflectron assembly inside the cylindrical tube. In some configurations, the cylindrical tube further comprises a conductive material disposed on the inner surface of the cylindrical tube, the conductive material present in an effective amount to provide a field free region for ions when the conductive material is charged.

Abstract translation: 本文描述的某些实施例涉及包括包括内表面和外表面的圆柱形管的飞行管的时间，圆柱形管包括有效厚度，并且其尺寸和布置成联接到圆柱形管内部并支撑反射器组件。 在一些构造中，圆柱形管还包括设置在圆柱形管的内表面上的导电材料，导电材料以有效的量存在，以便在导电材料充电时为离子提供无场区域。

公开(公告)号：US20140353494A1

公开(公告)日：2014-12-04

申请号：US14365610

申请日：2012-12-13

Applicant: NUCTECH COMPANY LIMITED

Inventor： Wen He ,  Guanxing Li ,  Yuntai Bao

IPC: H01J49/02 ,  G01N27/62 ,  H01J49/26

CPC classification number: H01J49/02 ,  G01N27/622 ,  H01J49/26

Abstract: An electrode structure for an ion drift tube and an ion drift tube with the electrode structure are disclosed. The electrode structure comprises an annular electrode. The annular electrode has an inner edge bent towards one side such that a section of a central portion of the annular electrode has a swallowtail shape. With the ion drift detection instrument, ions in a drift state can travel along focusing electric lines of force, and since the high-voltage intervals between the electrodes are increased at a uniform acceleration, the generated electric field enables the ions to be in a uniformly accelerated drift state so that both the sensitivity and resolution of the mobility spectrum of the detection instrument can reach optimum.

Abstract translation: 公开了一种用于离子漂移管的电极结构和具有电极结构的离子漂移管。 电极结构包括环形电极。 环形电极具有朝向一侧弯曲的内边缘，使得环形电极的中心部分的截面具有燕尾形状。 使用离子漂移检测仪器，漂移状态的离子可以沿着聚焦电力线行进，并且由于电极之间的高压间隔以均匀的加速度增加，因此产生的电场使得离子能够均匀地 加速漂移状态，使得检测仪器的灵敏度和分辨率都能达到最佳。

公开(公告)号：US20140284493A1

公开(公告)日：2014-09-25

申请号：US14221734

申请日：2014-03-21

Applicant: Thermo Fisher Scientific (Bremen) GmbH

Inventor： Richard HEMING

IPC: G01T1/17

CPC classification number: G01T1/17 ,  H01J49/02 ,  H01J49/022 ,  H01J49/025 ,  H03F3/45475 ,  H03F2200/261 ,  H03F2200/534 ,  H03F2203/45512 ,  H03F2203/45518 ,  H03F2203/45528 ,  H03F2203/45594 ,  H03F2203/45621 ,  H04N5/32

Abstract: A preamplifier is provided for correction of overshoot or undershoot effects present in a signal received from a charged particle detection electrode. The preamplifier is ground-isolated from the charged particle detection electrode and comprises: a main amplification stage, configured to receive and amplify the isolated signal; a feed-forward stage, configured to generate a compensation signal from the amplified ground-isolated signal, the compensation signal being generated to mirror the overshoot or undershoot effects; and an output, arranged to provide an output signal that is a combination of the amplified ground-isolated signal and the compensation signal. A charged particle detection arrangement comprising the preamplifier is also provided.

Abstract translation: 提供前置放大器用于校正从带电粒子检测电极接收的信号中存在的过冲或下冲作用。 前置放大器与带电粒子检测电极进行研磨隔离，包括：主放大级，用于接收和放大隔离信号; 前馈级，被配置为从放大的接地隔离信号产生补偿信号，生成补偿信号以反映过冲或下冲作用; 以及输出，被布置成提供作为放大的接地隔离信号和补偿信号的组合的输出信号。 还提供了包括前置放大器的带电粒子检测装置。