公开(公告)号：US20180053644A1

公开(公告)日：2018-02-22

申请号：US15555758

申请日：2016-03-07

Applicant: Micromass UK Limited

Inventor： Emrys JONES ,  Tamas KARANCSI ,  Steven Derek PRINGLE ,  Julia BALOG ,  Daniel SIMON ,  Lajos GODORHAZY ,  Daniel SZALAY ,  Zoltan TAKATS

IPC: H01J49/26 ,  G01N27/62 ,  G01N30/72 ,  H01J49/04 ,  H01J49/06 ,  H01J49/10 ,  H01J49/14 ,  H01J49/16 ,  H01J49/24

CPC classification number: H01J49/049 ,  A61B1/00013 ,  A61B1/041 ,  A61B1/2736 ,  A61B1/31 ,  A61B5/0066 ,  A61B5/0075 ,  A61B5/015 ,  A61B5/0507 ,  A61B5/055 ,  A61B5/14542 ,  A61B6/032 ,  A61B6/037 ,  A61B8/13 ,  A61B10/00 ,  A61B10/0041 ,  A61B10/0233 ,  A61B10/0283 ,  A61B17/00 ,  A61B17/320068 ,  A61B18/00 ,  A61B18/04 ,  A61B18/042 ,  A61B18/14 ,  A61B18/1445 ,  A61B18/1815 ,  A61B18/20 ,  A61B90/13 ,  A61B2010/0083 ,  A61B2017/320069 ,  A61B2018/00577 ,  A61B2018/00589 ,  A61B2018/00994 ,  A61B2218/002 ,  A61B2218/008 ,  A61F13/38 ,  C12Q1/025 ,  C12Q1/04 ,  C12Q1/18 ,  C12Q1/24 ,  G01N1/2202 ,  G01N3/00 ,  G01N9/00 ,  G01N27/622 ,  G01N27/624 ,  G01N30/724 ,  G01N33/487 ,  G01N33/48735 ,  G01N33/6848 ,  G01N33/6851 ,  G01N33/92 ,  G01N2001/2223 ,  G01N2333/195 ,  G01N2405/00 ,  G01N2405/04 ,  G01N2405/08 ,  G01N2570/00 ,  G01N2800/26 ,  G06F19/324 ,  G06F19/3481 ,  G16B20/00 ,  G16H10/40 ,  G16H15/00 ,  G16H50/20 ,  H01J49/0004 ,  H01J49/0027 ,  H01J49/0031 ,  H01J49/0036 ,  H01J49/025 ,  H01J49/0404 ,  H01J49/0409 ,  H01J49/0422 ,  H01J49/044 ,  H01J49/0445 ,  H01J49/0459 ,  H01J49/0463 ,  H01J49/0468 ,  H01J49/061 ,  H01J49/068 ,  H01J49/10 ,  H01J49/14 ,  H01J49/16 ,  H01J49/164 ,  H01J49/24 ,  H01J49/26

Abstract: A method of mass spectrometry or ion mobility spectrometry is disclosed comprising: providing an analyte; supplying a matrix compound to said analyte such that said analyte dissolves in said matrix; forming first droplets of the dissolved analyte; and colliding said first droplets with a collision surface. The use of matrix improves the analyte ion signal.

公开(公告)号：US09870904B2

公开(公告)日：2018-01-16

申请号：US15104638

申请日：2014-10-31

Applicant: DH Technologies Development PTE Ltd.

Inventor： Thomas R Covey ,  Peter Kovarik

IPC: H01J49/00 ,  H01J49/04 ,  H01J49/16 ,  G01N30/72

CPC classification number: H01J49/045 ,  G01N30/724 ,  G01N30/7246 ,  G01N30/7273 ,  H01J49/0404 ,  H01J49/044 ,  H01J49/0468 ,  H01J49/167

Abstract: Systems and methods for delivering a sample to a mass spectrometer are provided. In one aspect, the systems and methods can provide efficient cooling of an ion source probe to prevent overheating and the resulting degradation in ion sampling. In some aspects, such cooling can result in improved consistency and/or efficiency of ion formation. Moreover, ion source cooling in accordance with various aspects of the present teachings can allow for the use of higher temperatures in the ionization chamber (thereby improving desolvation) and/or can enable the use of lower flow rate sample sources than with conventional techniques.

公开(公告)号：US20180012745A1

公开(公告)日：2018-01-11

申请号：US15654373

申请日：2017-07-19

Applicant: Wayne State University

Inventor： Sarah Trimpin

IPC: H01J49/04 ,  H01J27/24 ,  H01J49/16

CPC classification number: H01J49/044 ,  H01J27/24 ,  H01J49/0468 ,  H01J49/164

Abstract: Disclosed herein are systems and methods for mass spectrometry using laserspray ionization (LSI). LSI can create multiply-charged ions at atmospheric pressure for analysis and allows for analysis of high molecular weight molecules including molecules over 4000 Daltons. The analysis can be solvent-based or solvent-free. Solvent-free analysis following LSI allows for improved spatial resolution beneficial in surface and/or tissue imaging.

公开(公告)号：US09721774B2

公开(公告)日：2017-08-01

申请号：US15023099

申请日：2014-09-17

Applicant: Micromass UK Limited

Inventor： Anthony Hess ,  Steve O'Brien ,  Ian Trivett

IPC: H01J49/02 ,  H01J49/00 ,  H01J49/04 ,  H01J49/10 ,  G01N27/62

CPC classification number: H01J49/02 ,  G01N27/622 ,  H01J49/0013 ,  H01J49/0031 ,  H01J49/044 ,  H01J49/049 ,  H01J49/10

Abstract: A mass spectrometer or ion mobility spectrometer is disclosed comprising: an ion block for receiving ions; a heater for heating the ion block; a vacuum housing; and an interface block arranged between the ion block and the vacuum housing; wherein the interface block is formed from a polymer. The polymer interface block inhibits the heat transfer from the ion block to the vacuum housing and also electrically isolates the ion block and vacuum housing. The interface block further comprises at least one conduit through the body of the interface block. This enables gas to be transmitted through the interface block to the ion block, and also enables the interface block to be cooled.

公开(公告)号：US20170200596A1

公开(公告)日：2017-07-13

申请号：US15402108

申请日：2017-01-09

Applicant: Thermo Fisher Scientific (Bremen) GmbH

Inventor： Alexander A. MAKAROV ,  Stevan R. HORNING

IPC: H01J49/04

CPC classification number: H01J49/0422 ,  G01N15/0266 ,  H01J49/044

Abstract: A sample introduction system for a spectrometer comprises a desolvation region that receives or generates sample ions from a solvent matrix and removes at least some of the solvent matrix from the sample ions. A separation chamber downstream of the desolvation region has a separation chamber inlet communicating with the desolvation region, for receiving the desolvated sample ions along with non-ionised solvent and solvent ion vapours. The separation chamber has electrodes for generating an electric field within the separation chamber, defining a first flow path for sample ions between the separation chamber inlet and a separation chamber outlet. Unwanted solvent ions and non-ionised solvent vapours are directed away from the separation chamber outlet. The sample introduction system has a reaction chamber with an inlet communicating with the separation chamber outlet, for receiving the sample ions from the separation chamber and for decomposing the received ions into smaller products.

公开(公告)号：US09202680B2

公开(公告)日：2015-12-01

申请号：US13376132

申请日：2010-06-03

Applicant: Sarah Trimpin

Inventor： Sarah Trimpin

IPC: H01J49/00 ,  H01J49/16 ,  H01J49/04

CPC classification number: H01J49/044 ,  H01J27/24 ,  H01J49/0468 ,  H01J49/164

Abstract: Disclosed herein are systems and methods for mass spectrometry using laserspray ionization (LSI). LSI can create multiply-charged ions at atmospheric pressure for analysis and allows for analysis of high molecular weight molecules including molecules over 4000 Daltons. The analysis can be solvent-based or solvent-free. Solvent-free analysis following LSI allows for improved spatial resolution beneficial in surface and/or tissue imaging.

Abstract translation: 本文公开了使用激光喷射电离（LSI）的质谱的系统和方法。 LSI可以在大气压下产生多电荷离子进行分析，并允许分析高分子量分子，包括超过4000道尔顿的分子。 分析可以是溶剂型或无溶剂型。 在LSI之后的无溶剂分析允许有利于表面和/或组织成像的改善的空间分辨率。

公开(公告)号：US20150214021A1

公开(公告)日：2015-07-30

申请号：US14573858

申请日：2014-12-17

Applicant: Ionics Mass Spectrometry Group Inc.

Inventor： Charles Jolliffe ,  Gholamreza Javahery ,  Lisa Cousins

IPC: H01J49/04 ,  H01J49/26

CPC classification number: H01J49/0422 ,  H01J49/04 ,  H01J49/044 ,  H01J49/0468 ,  H01J49/06 ,  H01J49/26 ,  Y10T436/24

Abstract: A mass spectrometer interface, having improved sensitivity and reduced chemical background, is disclosed. The mass spectrometer interface provides improved desolvation, chemical selectivity and ion transport. A flow of partially solvated ions is transported along a tortuous path into a region of disturbance of flow, where ions and neutral molecules collide and mix. Thermal energy is applied to the region of disturbance to promote liberation of at least some of the ionized particles from any attached impurities, thereby increasing the concentration of the ionized particles having the characteristic m/z ratios in the flow. Molecular reactions and low pressure ionization methods can also be performed for selective removal or enhancement of particular ions.

Abstract translation: 公开了具有改进的灵敏度和降低的化学背景的质谱仪界面。 质谱仪界面提供改进的去溶剂化学选择性和离子迁移。 部分溶剂化离子的流动沿曲折路径输送到流动扰动区域，其中离子和中性分子碰撞和混合。 热能被施加到扰动区域以促进至少一些离子化颗粒从任何附着的杂质的释放，从而增加流动中具有特征m / z比的离子化颗粒的浓度。 还可以进行分子反应和低压离子化方法以选择性去除或增强特定的离子。

公开(公告)号：US08946622B2

公开(公告)日：2015-02-03

申请号：US14013747

申请日：2013-08-29

Applicant: Ionics Mass Spectrometry Group Inc.

Inventor： Charles Jolliffe ,  Gholamreza Javahery ,  Lisa Cousins

IPC: H01J49/00 ,  H01J49/04 ,  H01J49/06

CPC classification number: H01J49/0422 ,  H01J49/04 ,  H01J49/044 ,  H01J49/0468 ,  H01J49/06 ,  H01J49/26 ,  Y10T436/24

Abstract: A mass spectrometer interface, having improved sensitivity and reduced chemical background, is disclosed. The mass spectrometer interface provides improved desolvation, chemical selectivity and ion transport. A flow of partially solvated ions is transported along a tortuous path into a region of disturbance of flow, where ions and neutral molecules collide and mix. Thermal energy is applied to the region of disturbance to promote liberation of at least some of the ionized particles from any attached impurities, thereby increasing the concentration of the ionized particles having the characteristic m/z ratios in the flow. Molecular reactions and low pressure ionization methods can also be performed for selective removal or enhancement of particular ions.

Abstract translation: 公开了具有改进的灵敏度和降低的化学背景的质谱仪界面。 质谱仪界面提供改进的去溶剂化学选择性和离子迁移。 部分溶剂化离子的流动沿曲折路径输送到流动扰动区域，其中离子和中性分子碰撞和混合。 热能被施加到扰动区域以促进至少一些离子化颗粒从任何附着的杂质的释放，从而增加流动中具有特征m / z比的离子化颗粒的浓度。 还可以进行分子反应和低压离子化方法以选择性去除或增强特定的离子。

公开(公告)号：US08841607B2

公开(公告)日：2014-09-23

申请号：US13602249

申请日：2012-09-03

Applicant: Zicheng Yang ,  Roy P Moeller ,  Stephen Zanon

Inventor： Zicheng Yang ,  Roy P Moeller ,  Stephen Zanon

IPC: H01J49/26

CPC classification number: H01J49/044 ,  H01J49/165 ,  H01J49/168 ,  H01J49/24

Abstract: An atmospheric pressure ion source, employing the principle of electrospray ionization, chemical ionization, or photo-ionization, comprises a spray probe for spraying a liquid into an ionization chamber and has an exhaust port through which residual spray mist and waste gas, such as evaporated solvent, are extracted. The ion source further comprises an exhaust system comprising a conduit which is connected to the exhaust port. The conduit has a transition from a first cross-section to a second cross section at a point downstream of the exhaust port wherein the second cross section is reduced in relation to the first cross section. Gas is injected via a gas injector into the conduit in a region of the transition to create a low pressure region that removes unwanted material from the chamber.

Abstract translation: 使用电喷雾电离，化学电离或光电离原理的大气压离子源包括用于将液体喷射到电离室中的喷射探针，并具有排气口，残留的喷雾和废气如蒸发 溶剂，萃取。 离子源还包括排气系统，其包括连接到排气口的导管。 导管在排气口下游的点处具有从第一横截面到第二横截面的过渡，其中第二横截面相对于第一横截面减小。 气体通过气体注入器在过渡区域中被注入导管，以产生从腔室去除不需要的材料的低压区域。

公开(公告)号：US20140087478A1

公开(公告)日：2014-03-27

申请号：US14013747

申请日：2013-08-29

Applicant: Ionics Mass Spectrometry Group Inc.

Inventor： Charles Jolliffe ,  Gholamreza Javahery ,  Lisa Cousins

IPC: H01J49/04

CPC classification number: H01J49/0422 ,  H01J49/04 ,  H01J49/044 ,  H01J49/0468 ,  H01J49/06 ,  H01J49/26 ,  Y10T436/24

Abstract: A mass spectrometer interface, having improved sensitivity and reduced chemical background, is disclosed. The mass spectrometer interface provides improved desolvation, chemical selectivity and ion transport. A flow of partially solvated ions is transported along a tortuous path into a region of disturbance of flow, where ions and neutral molecules collide and mix. Thermal energy is applied to the region of disturbance to promote liberation of at least some of the ionized particles from any attached impurities, thereby increasing the concentration of the ionized particles having the characteristic m/z ratios in the flow. Molecular reactions and low pressure ionization methods can also be performed for selective removal or enhancement of particular ions.

Abstract translation: 公开了具有改进的灵敏度和降低的化学背景的质谱仪界面。 质谱仪界面提供改进的去溶剂化学选择性和离子迁移。 部分溶剂化离子的流动沿曲折路径输送到流动扰动区域，其中离子和中性分子碰撞和混合。 热能被施加到扰动区域以促进至少一些离子化颗粒从任何附着的杂质的释放，从而增加流动中具有特征m / z比的离子化颗粒的浓度。 还可以进行分子反应和低压离子化方法以选择性去除或增强特定的离子。