公开(公告)号：US20160025633A1

公开(公告)日：2016-01-28

申请号：US14775255

申请日：2014-03-14

Applicant: BIOGEN MA INC.

Inventor： Justin Moretto ,  Brandon Berry ,  Alex Doane

IPC: G01N21/65

CPC classification number: G01N21/65 ,  G01J3/44 ,  G01N2201/0446 ,  G01N2201/06113

Abstract: In one aspect, the disclosure provides a method of defining a Raman signature of a culture component, the method comprising: obtaining a Raman spectrum of a culture component in a non-interfering or minimally-interfering solution, identifying peaks in the Raman spectrum that are associated with the culture component, obtaining a Raman spectrum of a culture medium comprising the culture component, and, removing peaks of the culture component in the Raman spectrum of the culture medium that are distorted compared to the peaks identified in the Raman spectrum of the culture component in a non-interfering or minimally-interfering solution.

Abstract translation: 一方面，本公开提供了一种限定培养组分的拉曼特征的方法，所述方法包括：获得非干扰或最小干扰溶液中培养组分的拉曼光谱，鉴定拉曼光谱中的峰，其为 与培养组分相关，获得包含培养组分的培养基的拉曼光谱，并且除去与在培养物的拉曼光谱中鉴定的峰相比变形的培养基的拉曼光谱中的培养成分的峰 在非干扰或最小干扰的解决方案中的组件。

公开(公告)号：US20160003866A1

公开(公告)日：2016-01-07

申请号：US14761726

申请日：2014-01-13

Applicant: Ecole Polytechnique ,  Centre National de la Recherche Scientifique

Inventor： Marc Chaigneau ,  Akli Karar ,  Bernard Drevillon ,  Razvigor Ossikovski

IPC: G01Q10/00 ,  G01J3/06 ,  G01J3/44 ,  G01Q40/00

CPC classification number: G01Q10/00 ,  G01J3/06 ,  G01J3/44 ,  G01N21/658 ,  G01Q10/045 ,  G01Q20/04 ,  G01Q30/02 ,  G01Q40/00 ,  G01Q60/04 ,  G01Q60/16 ,  G01Q60/26

Abstract: The present invention relates to a multimode local probe microscope having a resonator (1), a first electrode (9), and a second electrode (8), an excitation source adapted to generate mechanical resonance in the resonator, a metal tip (4) fastened to the resonator, movement means for imparting relative movement between the local probe and a sample and adapted to bring the end of the tip to within a distance Z lying in the range 0 to 100 nm, and detector means for detecting at least one electrical signal representative of friction forces at the terminals of said electrodes (8, 9). According to the invention, said metal tip (4) is electrically connected to said output second electrode (9) and the microscopy apparatus includes amplifier and filter means for amplifying and filtering signals relating to the friction forces and to the tunnelling current in a single electronic circuit, and means for regulating the distance Z between the end of the tip and the surface of the sample.

Abstract translation: 本发明涉及具有共振器（1），第一电极（9）和第二电极（8）的多模式局部探针显微镜，适于在谐振器中产生机械共振的激发源，金属尖端（4） 固定在谐振器上的移动装置，用于在局部探针和样品之间施加相对运动并适于使尖端的端部处于位于0至100nm范围内的距离Z内;以及检测器装置，用于检测至少一个电气 代表在所述电极（8,9）的端子处的摩擦力的信号。 根据本发明，所述金属端头（4）电连接到所述输出第二电极（9），并且所述显微镜装置包括放大器和滤波器装置，用于放大和滤波与单个电子装置中的摩擦力和隧道电流有关的信号 电路和用于调节尖端端部和样品表面之间的距离Z的装置。

公开(公告)号：US09222834B2

公开(公告)日：2015-12-29

申请号：US13767769

申请日：2013-02-14

Applicant: ASML Netherlands B.V.

Inventor： Arie Jeffrey Den Boef

IPC: G01J3/44 ,  G03F7/20 ,  G03F9/00 ,  G01N21/956 ,  G01N21/47 ,  G01N21/95

CPC classification number: G01J3/4412 ,  G01J3/44 ,  G01N21/4788 ,  G01N21/9501 ,  G01N21/956 ,  G01N21/95607 ,  G02B5/205 ,  G03F7/70591 ,  G03F7/70625 ,  G03F7/70633 ,  G03F9/7026

Abstract: A spectroscopic scatterometer detects both zero order and higher order radiation diffracted from an illuminated spot on a target grating. The apparatus forms and detects a spectrum of zero order (reflected) radiation, and separately forms and detects a spectrum of the higher order diffracted radiation. Each spectrum is formed using a symmetrical phase grating, so as to form and detect a symmetrical pair of spectra. The pair of spectra can be averaged to obtain a single spectrum with reduced focus sensitivity. Comparing the two spectra can yield information for improving height measurements in a subsequent lithographic step. The target grating is oriented obliquely so that the zero order and higher order radiation emanate from the spot in different planes. Two scatterometers can operate simultaneously, illuminating the target from different oblique directions. A radial transmission filter reduces sidelobes in the spot and reduces product crosstalk.

Abstract translation: 光谱散射仪检测从目标光栅上的照明光点衍射的零级和高阶辐射。 该装置形成和检测零级（反射）辐射的光谱，并分别形成和检测高阶衍射辐射的光谱。 每个光谱使用对称相位光栅形成，以便形成和检测对称的光谱对。 这对光谱可以被平均以获得具有降低的聚焦灵敏度的单个光谱。 比较两个光谱可以产生用于在随后的光刻步骤中改善高度测量的信息。 目标光栅倾斜定向，使得零级和高阶辐射从不同平面中的光点发出。 两个散射仪可以同时操作，从不同的倾斜方向照射目标。 径向传输过滤器可减少现场的旁瓣并减少产品串扰。

公开(公告)号：US20150369742A1

公开(公告)日：2015-12-24

申请号：US14764632

申请日：2013-12-18

Applicant: SONY CORPORATION

Inventor： Sakuya TAMADA ,  Isamu NAKAO ,  Takuya KISHIMOTO ,  Kazuki IKESHITA

IPC: G01N21/65

CPC classification number: G01N21/65 ,  G01J3/02 ,  G01J3/44 ,  G01N2021/653 ,  G01N2201/06113

Abstract: Provided is a measuring apparatus including: a light source unit to emit pulsed laser light used for pump light and Stokes light that excite a molecular vibration of a sample; a Stokes light generating unit to modulate an intensity of the pulsed laser light and to generate Stokes light using the pulsed laser light having the modulated intensity; a time delaying unit to delay the pump light using the pulsed laser light or the Stokes light; a detecting unit to detect, by lock-in detection, light transmitted through the sample irradiated with the pump light and the Stokes light having a controlled time delay amount, or reflected light from the sample; and an arithmetic processing device to perform arithmetic processing on the basis of anti-Stokes light detected by the lock-in detection while controlling the intensity modulation and the time delay amount.

Abstract translation: 提供了一种测量装置，包括：发射用于泵浦光的脉冲激光的光源单元和激发样品的分子振动的斯托克斯光; 斯托克斯光产生单元，用于调制脉冲激光的强度，并使用具有调制强度的脉冲激光产生斯托克斯光; 时间延迟单元，使用脉冲激光或斯托克斯光来延迟泵浦光; 检测单元，其通过锁定检测来检测透过来自被照射的泵浦光的样品的光和具有受控时间延迟量的斯托克斯光或来自样品的反射光; 以及算术处理装置，用于在控制强度调制和时间延迟量的同时基于由锁定检测检测到的反斯托克斯光进行运算处理。

公开(公告)号：US20150346609A1

公开(公告)日：2015-12-03

申请号：US14825728

申请日：2015-08-13

Applicant: ASML Netherlands B.V.

Inventor： Arie Jeffrey DEN BOEF

IPC: G03F7/20 ,  G01N21/95 ,  G02B5/20 ,  G01J3/44

CPC classification number: G01J3/4412 ,  G01J3/44 ,  G01N21/4788 ,  G01N21/9501 ,  G01N21/956 ,  G01N21/95607 ,  G02B5/205 ,  G03F7/70591 ,  G03F7/70625 ,  G03F7/70633 ,  G03F9/7026

Abstract: A spectroscopic scatterometer detects both zero order and higher order radiation diffracted from an illuminated spot on a target grating. The apparatus forms and detects a spectrum of zero order (reflected) radiation, and separately forms and detects a spectrum of the higher order diffracted radiation. Each spectrum is formed using a symmetrical phase grating, so as to form and detect a symmetrical pair of spectra. The pair of spectra can be averaged to obtain a single spectrum with reduced focus sensitivity. Comparing the two spectra can yield information for improving height measurements in a subsequent lithographic step. The target grating is oriented obliquely so that the zero order and higher order radiation emanate from the spot in different planes. Two scatterometers can operate simultaneously, illuminating the target from different oblique directions. A radial transmission filter reduces sidelobes in the spot and reduces product crosstalk.

Abstract translation: 光谱散射仪检测从目标光栅上的照明光点衍射的零级和高阶辐射。 该装置形成和检测零级（反射）辐射的光谱，并分别形成和检测高阶衍射辐射的光谱。 每个光谱使用对称相位光栅形成，以便形成和检测对称的光谱对。 这对光谱可以被平均以获得具有降低的聚焦灵敏度的单个光谱。 比较两个光谱可以产生用于在随后的光刻步骤中改善高度测量的信息。 目标光栅倾斜定向，使得零级和高阶辐射从不同平面中的光点发出。 两个散射仪可以同时操作，从不同的倾斜方向照射目标。 径向传输过滤器可减少现场的旁瓣并减少产品串扰。

公开(公告)号：US09200962B1

公开(公告)日：2015-12-01

申请号：US13529101

申请日：2012-06-21

Applicant: Timothy J. Russin ,  Alicia M Russin

Inventor： Timothy J. Russin ,  Alicia M Russin

IPC: G02F1/39 ,  G01J3/45 ,  G01J3/02

CPC classification number: G01J3/45 ,  G01J3/02 ,  G01J3/28 ,  G01J3/44

Abstract: A method includes determining a highest peak of an optical spectrum waveform contained within a wavelength window having a fixed wavelength range, the wavelength window having a beginning wavelength value and an ending wavelength value, and iteratively modifying the beginning and ending wavelength values, within the fixed wavelength range, to shift the wavelength window so the highest peak is centered at a first position within the wavelength window. The method may further include determining a second highest peak of the optical spectrum waveform and iteratively expanding or contracting the optical spectrum waveform, while maintaining the highest peak centered at the first position, to locate the second highest peak at a predetermined position within the wavelength window. The method may be used for window calibration to enable repeatable and precise harmonic analysis of optical spectra, such as Raman spectra.

Abstract translation: 一种方法包括确定包含在具有固定波长范围的波长窗口内的光谱波形的最高峰值，波长窗口具有起始波长值和结束波长值，并且在固定的波长范围内迭代地修改开始和结束波长值 波长范围，以移动波长窗口，使得最高峰位于波长窗口内的第一位置。 该方法还可以包括确定光谱波形的第二高峰并且迭代地扩展或收缩光谱波形，同时保持以第一位置为中心的最高峰，以将第二高峰定位在波长窗口内的预定位置 。 该方法可用于窗口校准，以实现诸如拉曼光谱的光谱的可重复和精确的谐波分析。

公开(公告)号：US20150339262A1

公开(公告)日：2015-11-26

申请号：US14282780

申请日：2014-05-20

Applicant: Kaiser Optical Systems Inc.

Inventor： Patrick Wiegand ,  Ronald C. Fairchild

IPC: G06F17/10 ,  G01J3/44

CPC classification number: G06F17/10 ,  G01J3/28 ,  G01J3/44 ,  G06F17/18

Abstract: Raw data inputs are treated as independent signal sources to reduce computational lag without adversely affecting signal-to-noise ratio (SNR). Applications include spectroscopy, multiple linear regression, mass balance quantitation and the calculation of physical properties. The input-specific averaging has been applied to Raman spectroscopy, where the inputs are averaged spectra from which peak heights or areas are obtained from integration. Alternatively, peak areas or heights can be obtained from unaveraged spectra and are then averaged before use in further calculations as inputs to produce a desired output. The output(s) are linear or nonlinear combinations of the peak heights or areas, coupled with weighting factors which relate the raw inputs to a quantitative output such as concentration of a chemical species. Each specific input can use a different type of averaging. The overall goal may be optimization for best precision, and/or optimization for minimum lag time.

Abstract translation: 原始数据输入被视为独立信号源，以减少计算滞后，而不会不利地影响信噪比（SNR）。 应用包括光谱学，多元线性回归，质量平衡定量和物理性质的计算。 输入特异性平均已经应用于拉曼光谱，其中输入是从积分获得峰高或区域的平均光谱。 或者，可以从未平整光谱获得峰面积或高度，然后在进一步计算之前对其进行平均，作为输出以产生期望的输出。 输出是峰值高度或面积的线性或非线性组合，以及将原始输入与定量输出（例如化学物质的浓度）相关联的加权因子。 每个具体的输入可以使用不同类型的平均值。 总体目标可能是优化最佳精度，和/或优化最小滞后时间。

公开(公告)号：US09182352B2

公开(公告)日：2015-11-10

申请号：US14051396

申请日：2013-10-10

Applicant: OptoTrace (Suzhou) Technologies, Inc.

Inventor： Hong Wang ,  Xun Guo ,  Xue Zhong ,  Dong Zhang ,  Chunwei Liu ,  Hao Zhou ,  Tianrui Ni

IPC: G01J3/44 ,  G01N21/65 ,  B82Y20/00 ,  G01N33/543 ,  G01J3/02 ,  B82Y40/00

CPC classification number: G01N21/65 ,  B82Y20/00 ,  B82Y40/00 ,  G01J3/0264 ,  G01J3/44 ,  G01N21/658 ,  G01N33/54346

Abstract: A method for detecting crude oil or gas in a drilling sample includes introducing a drilling sample into a sample solution containing nano particles, illuminating the sample solution comprising the drilling sample and the nano particles by a laser beam, collecting light scattered by the drilling sample and the nano particles in the sample solution, obtaining a Raman spectrum from the light scattered by the drilling sample and the nano particles in the sample solution, identifying, in the Raman spectrum, a spectral signature associated with a substance around a predetermined Raman shift, and detecting targeted chemicals correlated with crude oil or gas existence underground from where the drilling sample, based on the spectral signature of the substance in the Raman spectrum.

Abstract translation: 一种用于检测钻井样品中的原油或气体的方法，包括将钻探样品引入到含有纳米颗粒的样品溶液中，通过激光束照射包括钻探样品和纳米颗粒的样品溶液，收集由钻孔样品散射的光，以及 在样品溶液中的纳米颗粒，从由钻孔样品散射的光和样品溶液中的纳米颗粒获得拉曼光谱，在拉曼光谱中鉴定与预定拉曼位移相关的物质的光谱特征，以及 根据拉曼光谱中物质的光谱特征，检测与钻井样品相关的与原油或天然气存在的目标化学物质。

公开(公告)号：US20150316413A1

公开(公告)日：2015-11-05

申请号：US14795954

申请日：2015-07-10

Applicant: SciAps, Inc.

Inventor： David Day

IPC: G01J3/02 ,  G01J3/443

CPC classification number: G01J3/443 ,  G01J3/0208 ,  G01J3/0237 ,  G01J3/0272 ,  G01J3/06 ,  G01J3/44 ,  H01L22/26

Abstract: An analysis system (e.g., LIBS) includes a laser source generating a laser beam, a movable optic configured to move said laser beam to multiple locations on a sample, and a spectrometer responsive to photons emitted by the sample at those locations and having an output. A controller is responsive to a trigger signal and is configured in a moving spot cycle to adjust the moveable optic, activate the laser source sequentially generating photons at multiple locations on the sample, and process the spectrometer output at each location.

Abstract translation: 分析系统（例如，LIBS）包括产生激光束的激光源，配置成将所述激光束移动到样品上的多个位置的可移动光学器件，以及响应于在那些位置的样品发射的光子的光谱仪，并具有输出 。 控制器响应于触发信号并且被配置成移动点周期以调整可移动光学元件，激活激光源在样本上的多个位置顺序地生成光子，并且处理每个位置处的光谱仪输出。

公开(公告)号：US09177877B2

公开(公告)日：2015-11-03

申请号：US14259906

申请日：2014-04-23

Applicant: First Solar, Inc.

Inventor： Markus E. Beck ,  Ming L. Yu

IPC: H01L21/66 ,  G01J3/02 ,  G01J3/28 ,  G01J3/44 ,  G01N21/65 ,  H01L31/032 ,  H01L31/18 ,  G01J5/08

CPC classification number: H01L22/20 ,  G01J3/02 ,  G01J3/0208 ,  G01J3/0218 ,  G01J3/0232 ,  G01J3/0286 ,  G01J3/28 ,  G01J3/44 ,  G01J3/4412 ,  G01J5/0846 ,  G01N21/65 ,  G01N2201/1211 ,  H01L31/0322 ,  H01L31/18 ,  Y10T29/41

Abstract: A temperature-adjusted spectrometer can include a light source and a temperature sensor.

Abstract translation: 温度调节光谱仪可以包括光源和温度传感器。