公开(公告)号：US20130109950A1

公开(公告)日：2013-05-02

申请号：US13287759

申请日：2011-11-02

Applicant: Donald G. Herzog ,  Thomas G. Miller

Inventor： Donald G. Herzog ,  Thomas G. Miller

IPC: A61B6/00

CPC classification number: A61B5/0095 ,  A61B5/0035 ,  A61B5/0091 ,  A61B5/14551 ,  A61B5/6844 ,  A61B5/7425 ,  A61B5/7445 ,  A61B5/7475 ,  A61B8/0825 ,  A61B8/4281 ,  A61B8/4444 ,  A61B8/4483 ,  F04C2270/041 ,  G01N21/1702 ,  G01N2201/067 ,  G01N2201/068 ,  G01N2201/0826 ,  G02B6/3624

Abstract: A handheld optoacoustic probe includes an ultrasound transducer array and optical fibers with a first end formed into a fiber bundle providing an input and a second, distal end providing an output. A light bar guide retains the distal end of the optical fibers on the same plane. One or more optical windows may be associated with, and spaced from the light bar guide so as to prevent contact between a coupling agent and the distal ends of the optical fibers, thus mitigating a potential acoustic effect of the coupling agent in response to light emitting from the fibers. A silicon rubber acoustic lens doped with TiO2 may be provided, with a reflective metal surrounding the outer surface of the acoustic lens. A handheld probe shell houses the light bar guide, the ultrasound transducer array, and the acoustic lens.

Abstract translation: 手持式光声探头包括超声换能器阵列和光纤，其第一端形成为提供输入的纤维束，第二远端提供输出。 光条引导件将光纤的远端保持在同一平面上。 一个或多个光学窗口可以与光条引导件相关联并且与光条引导件间隔开，以便防止耦合剂与光纤的远端之间的接触，从而减轻响应于发光的耦合剂的潜在声学效应 从纤维。 可以提供掺杂有TiO 2的硅橡胶声透镜，其中包含声透镜的外表面的反射金属。 手持探针壳容纳光条引导件，超声换能器阵列和声透镜。

公开(公告)号：US20120014837A1

公开(公告)日：2012-01-19

申请号：US13031103

申请日：2011-02-18

Applicant: Adrian FEHR ,  Nathaniel Joseph McCaffrey ,  Stephen Turner

Inventor： Adrian FEHR ,  Nathaniel Joseph McCaffrey ,  Stephen Turner

IPC: G01N21/64 ,  G02B6/10 ,  G01N21/00 ,  G02B6/00

CPC classification number: C12Q1/6874 ,  B01L3/502707 ,  B01L3/502715 ,  B01L2300/0654 ,  B01L2300/0663 ,  B01L2300/0816 ,  B01L2300/168 ,  B82Y20/00 ,  C12Q1/6825 ,  C12Q1/6869 ,  G01N21/03 ,  G01N21/0303 ,  G01N21/05 ,  G01N21/64 ,  G01N21/6428 ,  G01N21/645 ,  G01N21/6452 ,  G01N21/6454 ,  G01N21/6456 ,  G01N21/648 ,  G01N21/75 ,  G01N21/77 ,  G01N33/54373 ,  G01N2021/0346 ,  G01N2021/6434 ,  G01N2021/6439 ,  G01N2021/6441 ,  G01N2021/6463 ,  G01N2021/757 ,  G01N2021/7786 ,  G01N2201/067 ,  G01N2201/068 ,  G01N2201/08 ,  G02B6/1226 ,  Y10T436/143333

Abstract: An analytical device including an optically opaque cladding, a sequencing layer including a substrate disposed below the cladding, and a waveguide assembly for receiving optical illumination and introducing illumination into the device. The illumination may be received from a top, a side edge, and a bottom of the device. The waveguide assembly may include a nanoscale aperture disposed in the substrate and extending through the cladding. The aperture defines a reaction cell for receiving a set of reactants. In various aspects, the device includes a sensor element and the illumination pathway is through the sensor element. Waveguides and illumination devices, such as plasmonic illumination devices, are also disclosed. Methods for forming and operating the devices are also disclosed.

Abstract translation: 包括光学不透明包层的分析装置，包括设置在包层下方的基板的测序层，以及用于接收光学照明并将照明引入该装置的波导组件。 照明可以从设备的顶部，侧边缘和底部接收。 波导组件可以包括设置在基板中并延伸穿过包层的纳米级孔。 孔径限定了用于接收一组反应物的反应池。 在各个方面，该装置包括传感器元件，并且该照明路径通过传感器元件。 还公开了波导和照明装置，例如等离子体激元照明装置。 还公开了用于形成和操作装置的方法。

公开(公告)号：US08077309B2

公开(公告)日：2011-12-13

申请号：US11668083

申请日：2007-01-29

Applicant: Gordon C. Brown ,  Michael Burka ,  Brian Cranton ,  David Erickson ,  James Grassi ,  Matthew Patrick Hammond ,  Maximillan Ben Shaffer ,  Pierre Villeneuve

Inventor： Gordon C. Brown ,  Michael Burka ,  Brian Cranton ,  David Erickson ,  James Grassi ,  Matthew Patrick Hammond ,  Maximillan Ben Shaffer ,  Pierre Villeneuve

IPC: G01J3/44

CPC classification number: G01N21/65 ,  G01J3/02 ,  G01J3/0208 ,  G01J3/0262 ,  G01J3/0286 ,  G01J3/0291 ,  G01J3/10 ,  G01J3/26 ,  G01J3/36 ,  G01J3/44 ,  G01J2003/1269 ,  G01N2021/1793 ,  G01N2021/8416 ,  G01N2201/0245 ,  G01N2201/067

Abstract: An optical apparatus for measurement of industrial chemical processes. The analyzer uses Raman scattering and performs measurement of chemical concentrations in continuous or batch processes. The analyzer operates at a standoff distance from the analyte (or analytes) and can measure concentrations through an optical port, facilitating continuous, non-destructive, and non-invasive analysis without extracting the analyte or analytes from the process. The analyzer can measure one or several solid, liquid, or gaseous analytes, or a mixture thereof.

Abstract translation: 一种用于测量工业化学工艺的光学装置。 分析仪使用拉曼散射，并在连续或间歇过程中进行化学浓度的测量。 分析仪与分析物（或分析物）隔开距离，并且可以通过光学端口测量浓度，有助于连续，非破坏性和非侵入性分析，而无需从该过程中提取分析物或分析物。 分析仪可以测量一种或多种固体，液体或气体分析物或其混合物。

公开(公告)号：US20100246907A1

公开(公告)日：2010-09-30

申请号：US12675677

申请日：2008-09-02

Applicant: Elliot S. Wachman ,  Jill Wachman ,  Stanley J. Geyer

Inventor： Elliot S. Wachman ,  Jill Wachman ,  Stanley J. Geyer

IPC: G06K9/00 ,  H04N7/18

CPC classification number: G01J3/2823 ,  G01J3/1256 ,  G01N21/6428 ,  G01N21/6458 ,  G01N33/5438 ,  G01N2021/6421 ,  G01N2021/6441 ,  G01N2021/6471 ,  G01N2201/067 ,  G02F1/116 ,  G02F2201/122 ,  G02F2203/055

Abstract: An imaging system includes a platform for placement of a sample or an animal to be imaged, and at least one excitation light source for irradiating the sample or animal to stimulate an emission at a plurality of different center wavelengths. An acousto-optic tunable filter (AOTF) is provided that includes a piezoelectric transducer crystal for emitting an acoustic wave having a ground electrode disposed on one side of the piezoelectric crystal. A patterned electrode layer is disposed on a side of the piezoelectric crystal opposite the ground electrode. The patterned electrode layer includes a continuous region proximate to its center and a discontinuous region, a pattern in the discontinuous region comprising a plurality of spaced apart features electrically connected to the continuous region, and an AO interaction crystal receiving the acoustic wave attached to the ground electrode or the patterned electrode layer.

Abstract translation: 成像系统包括用于放置待成像的样品或动物的平台，以及用于照射样品或动物以刺激多个不同中心波长的发射的至少一个激发光源。 提供了一种声光可调滤波器（AOTF），其包括用于发射声波的压电换能器晶体，该声波具有设置在压电晶体一侧的接地电极。 图案化电极层设置在与接地电极相对的压电晶体的一侧。 图案化电极层包括靠近其中心的连续区域和不连续区域，不连续区域中的图案包括电连接到连续区域的多个间隔的特征，以及接收附着于地面的声波的AO相互作用晶体 电极或图案化电极层。

公开(公告)号：US20090318784A1

公开(公告)日：2009-12-24

申请号：US12513990

申请日：2007-11-09

Applicant: David Michael Newman ,  John Heptinstall

Inventor： David Michael Newman ,  John Heptinstall

IPC: A61B5/145 ,  G01N27/00 ,  B01J19/12 ,  G01N21/00 ,  C12M1/34 ,  C12Q1/04

CPC classification number: G01N21/1717 ,  A61B5/0059 ,  A61B5/0095 ,  A61B5/05 ,  A61B5/6816 ,  A61B5/6826 ,  A61B5/6838 ,  G01N21/21 ,  G01N2021/1727 ,  G01N2021/218 ,  G01N2201/067 ,  G01N2201/0697 ,  G01N2333/445

Abstract: In the application, the change in the magnetic state of the haemoglobin caused by the malarial infection is exploited by detecting suitable properties of haemozoin which are dependent on the application of a magnetic field. FIG. 1 shows apparatus, shown generally at (10), for performing magneto-optical detection using photo-acoustic techniques. The apparatus (10) comprises a light source (12), producing a beam of optical radiation (14) which passes through a polariser (16), a variable LC retarder (0 or 180° retardance) (18), and a (chopper 20), before impinging on a sample (22) held in a sample holder (24). The sample is in direct contact with an acoustic detector (26). The apparatus (10) further comprises an electromagnet (28), and a Gauss meter (30) can be utilised to measure the applied magnetic field strength. Advantages associated with this approach are the—possibility of making in vivo measurements, and the avoidance of problems of optical scattering associated with conventional optical measurements on turbid liquids such as whole blood.

Abstract translation: 在应用中，通过检测依赖于磁场的应用的血红素的合适性质来开发由疟疾感染引起的血红蛋白的磁状态的变化。 图。 图1示出了总体上用（10）示出的用于使用光声技术进行磁光检测的装置。 该设备（10）包括一个光源（12），产生通过偏振器（16），可变LC延迟器（0或180°延迟）（18）和（斩波器）的光辐射束（14） 20），然后撞击保持在样品架（24）中的样品（22）。 样品与声学检测器（26）直接接触。 装置（10）还包括电磁体（28），并且高斯计（30）可用于测量所施加的磁场强度。 与该方法相关的优点是进行体内测量的可能性，以及避免与诸如全血的混浊液体的常规光学测量相关联的光学散射问题。

公开(公告)号：US07299079B2

公开(公告)日：2007-11-20

申请号：US10361895

申请日：2003-02-11

Applicant: Mihailo V. Rebec ,  James E. Smous ,  Steven D. Brown ,  Hu-Wei Tan

Inventor： Mihailo V. Rebec ,  James E. Smous ,  Steven D. Brown ,  Hu-Wei Tan

IPC: A61B5/00

CPC classification number: A61B5/14532 ,  A61B5/1455 ,  A61B5/1495 ,  A61B5/726 ,  G01N21/274 ,  G01N21/359 ,  G01N2201/067

Abstract: A system for determining the concentration of an analyte in at least one body fluid in body tissue, the system comprising an infrared light source, a body tissue interface, a detector, and a central processing unit. The body tissue interface is adapted to contact body tissue and to deliver light from the infrared light source to the contacted body tissue. The detector is adapted to receive spectral information corresponding to infrared light transmitted through the portion of body tissue being analyzed and to convert the received spectral information into an electrical signal indicative of the received spectral information. The central processing unit is adapted to compare the electrical signal to an algorithm built upon correlation with the analyte in body fluid, the algorithm adapted to convert the received spectral information into the concentration of the analyte in at least one body fluid.

Abstract translation: 一种用于确定身体组织中的至少一种体液中的分析物的浓度的系统，所述系统包括红外光源，身体组织界面，检测器和中央处理单元。 身体组织界面适于接触身体组织并将红外光源的光传送到被接触的身体组织。 检测器适于接收对应于通过被分析的身体组织部分透射的红外光的光谱信息，并将接收到的光谱信息转换为指示所接收的光谱信息的电信号。 中央处理单元适于将电信号与建立在体液中与分析物相关的算法进行比较，该算法适于将接收到的光谱信息转换成至少一个体液中分析物的浓度。

公开(公告)号：US20040257566A1

公开(公告)日：2004-12-23

申请号：US10847202

申请日：2004-05-17

Inventor： William W. Chism II

IPC: G01J004/00

CPC classification number: B82Y20/00 ,  B82Y10/00 ,  G01N21/21 ,  G01N21/39 ,  G01N2021/1725 ,  G01N2021/399 ,  G01N2201/067 ,  G01N2201/0691

Abstract: A polarization modulation photoreflectance technique has been developed for optical characterization of semiconductor quantum confined structures. By using a tunable laser source in conjunction with polarization state modulation, a single beam modulation spectroscopy technique may be used to characterize the optical response of semiconductor materials and structures. Disclosed methods and instruments are suitable for characterization of optical signatures of quantum electronic confinement, including resolution of excitonic states at the band edge or other direct or indirect critical points in the band structure. This allows for characterization of semiconductor quantum well structures, for characterization of strain in semiconductor films, and for characterization of electric fields at semiconductor interfaces.

Abstract translation: 已经开发了用于半导体量子限制结构的光学表征的偏振调制光反射技术。 通过结合极化状态调制使用可调激光源，可以使用单光束调制光谱技术来表征半导体材料和结构的光学响应。 公开的方法和仪器适用于量子电子约束的光学特征的表征，包括在带边缘处的激发态的分辨率或带结构中的其它直接或间接关键点。 这允许表征半导体量子阱结构，用于表征半导体膜中的应变以及用于表征半导体界面处的电场。

公开(公告)号：US20040195497A1

公开(公告)日：2004-10-07

申请号：US10798013

申请日：2004-03-11

Applicant: OLYMPUS CORPORATION

Inventor： Hiroshi Sasaki

IPC: G01N023/04 ,  H01J003/14 ,  H01J005/16

CPC classification number: G01N21/6458 ,  G01N2021/1774 ,  G01N2021/3137 ,  G01N2021/3174 ,  G01N2021/6417 ,  G01N2021/6471 ,  G01N2201/06113 ,  G01N2201/067 ,  G01N2201/105 ,  G02B21/0032 ,  G02B21/16

Abstract: In case of irradiating a sample with laser beam, dispersing light emitted from the sample to a spectrum, and fetching and detecting from a wavelength band extraction portion light in at least one band area from the dispersed spectrum, when at least one of a plurality of optical elements arranged between the sample and the dispersive element is switched, a positional relationship between the wavelength band extraction portion and a spectrum image formation position which is displaced in a dispersion direction due to a change in angle of light entering the dispersive element.

Abstract translation: 在用激光束照射样品的情况下，将从样品发射的光分散到光谱，并且从波长带提取部分中取出并检测来自分散光谱的至少一个带区域中的光，当多个 布置在样品和分散元件之间的光学元件被切换，波长带提取部分与由于进入分散元件的光的角度的变化而在色散方向上移位的光谱图像形成位置之间的位置关系。

公开(公告)号：US5309912A

公开(公告)日：1994-05-10

申请号：US789517

申请日：1991-11-08

Applicant: Alexander Knuttel

Inventor： Alexander Knuttel

IPC: G01N21/41 ,  G01N21/47 ,  A61B5/05

CPC classification number: G01N21/4795 ,  G01N2021/1759 ,  G01N2021/1765 ,  G01N2021/4173 ,  G01N2201/067

Abstract: Optical imaging of an object utilizes a plurality of amplitude modulated light rays propagating through the object, either sequentially or simultaneously, for detection by a single photodetector. The light rays may propagate geometrically (i.e., directly) or diffusively. Each of the rays is encoded with a different phase to provide sufficient information for decoding the light intensity detected by the photodetector. The rays may be applied simultaneously in an array, in which case different carrier frequencies as well as different phases are applied to the different rays by any of a number of modulators. Alternatively, the rays may be individually applied to the object in a sequence of phase encoded rays. In either case, the single photodetector receives sufficient information to image each of the voxels of interest in the object being imaged. Information may be obtained for different voxels selected for imaging without mechanical scanning.

Abstract translation: 物体的光学成像利用通过对象顺序或同时传播的多个幅度调制光线，以便由单个光电检测器进行检测。 光线可以几何（即直接）或扩散地传播。 每个光线被用不同的相位编码，以提供足够的信息来解码由光电检测器检测到的光强度。 射线可以同时施加在阵列中，在这种情况下，通过多个调制器中的任何一个将不同的载波频率以及不同的相位施加到不同的射线。 或者，可以以相序编码的光线的顺序将光线单独地施加到物体。 在任一情况下，单个光电检测器接收足够的信息以对被成像对象中的感兴趣的像素进行成像。 可以为不经机械扫描选择成像的不同体素获得信息。

公开(公告)号：US5221959A

公开(公告)日：1993-06-22

申请号：US667969

申请日：1991-03-12

Applicant: Nagaaki Ohyama ,  Susumu Kikuchi ,  Takeshi Mori

Inventor： Nagaaki Ohyama ,  Susumu Kikuchi ,  Takeshi Mori

IPC: G01J3/46 ,  G01J3/51 ,  G01N21/25

CPC classification number: G01N21/251 ,  G01J3/51 ,  G01J3/513 ,  G01J2003/467 ,  G01J3/0229 ,  G01J3/501 ,  G01N2201/067

Abstract: A color discrimination data input apparatus includes a light source for generating illumination light for illuminating a target object, a spectroscope for producing a spectrum having a plurality of spectral components, a color classification filter set to have a light-transmitting characteristic to pass only a light component having a wavelength range suitable for classification from the spectral components generated by the spectroscope in order to classify the spectral components reflected by the target object into predetermined classes, a photoelectric converting circuit for converting a reflected spectral component, upon radiation of the spectral component passing through the color classification filter on the target object, into an electrical signal, classifying circuit for classifying the reflected spectral components in accordance with the electrical signal output from the photoelectric converting circuit, the color estimating circuit of estimating a color of the target object from the reflected spectral component classified into any one of the classes by the classifying circuit on the basis of a preset absolute color estimation matrix, and an output unit for outputting a classification result obtained from the classifying circuit and an object color measurement result output from the color estimating circuit.

Abstract translation: 彩色识别数据输入装置包括用于产生用于照射目标物体的照明光的光源，用于产生具有多个光谱分量的光谱的分光镜，将具有透光特性的颜色分类滤光器设置为仅透过光 分量，其具有适合于由分光镜产生的光谱分量分类的波长范围，以将由目标对象反射的光谱分量分类为预定类别;光电转换电路，用于在经过光谱分量的辐射后转换反射的光谱分量 通过目标对象上的颜色分类滤波器，转换成电信号，根据从光电转换电路输出的电信号对反射光谱分量进行分类的分类电路，估计目标对象fr的颜色的颜色估计电路 基于预设的绝对颜色估计矩阵，通过分类电路分类为任何一个类别的反射光谱分量，以及用于输出从分类电路获得的分类结果的输出单元和从分类电路输出的对象颜色测量结果 颜色估计电路。