公开(公告)号：US20160356708A1

公开(公告)日：2016-12-08

申请号：US14861606

申请日：2015-09-22

Applicant: KABUSHIKI KAISHA TOSHIBA

Inventor： Anthony John BENNETT ,  David Julian Peter ELLIS ,  Andrew James SHIELDS ,  Thomas David MEANY

IPC: G01N21/45 ,  G02B6/293 ,  G02F1/01

CPC classification number: G01N21/45 ,  G01N2021/458 ,  G01N2201/08 ,  G02B6/125 ,  G02B6/29352 ,  G02B2006/12121 ,  G02B2006/12123 ,  G02B2006/12159 ,  G02F1/0147

Abstract: An optical measuring device for measuring a measurement region, the optical device comprising a photonic chip with an interferometer defined on said chip, said interferometer comprising first and second waveguides on said photonic chip and an interference region, wherein the first and second waveguides carry signals from the interference region to the sample region and back to the interference region, the device further comprising a phase adjusting unit configured to vary a phase difference between the signals in the first and second waveguides reflected by the measurement region.

Abstract translation: 一种用于测量测量区域的光学测量装置，所述光学装置包括具有限定在所述芯片上的干涉仪的光子芯片，所述干涉仪包括所述光子芯片上的第一和第二波导和干涉区域，其中所述第一和第二波导传送来自 所述干扰区域到所述采样区域并且返回到所述干扰区域，所述装置还包括相位调整单元，被配置为改变由所述测量区域反射的所述第一和第二波导中的信号之间的相位差。

公开(公告)号：US09513220B1

公开(公告)日：2016-12-06

申请号：US14982740

申请日：2015-12-29

Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATION

Inventor： Yann Astier ,  Stephen W. Bedell ,  Ning Li ,  Devendra K. Sadana ,  William T. Spratt ,  Chao Wang

IPC: G01N21/64 ,  H01L31/0216 ,  H01L31/0232

CPC classification number: G01N21/6428 ,  B01L3/502707 ,  B01L3/502715 ,  B01L2200/12 ,  B01L2300/168 ,  G01N15/1436 ,  G01N15/1459 ,  G01N21/05 ,  G01N21/645 ,  G01N2015/0065 ,  G01N2015/1006 ,  G01N2021/6439 ,  G01N2021/6471 ,  G01N2201/06113 ,  G01N2201/062 ,  G01N2201/08 ,  H01L25/167 ,  H01L31/02162 ,  H01L31/02164 ,  H01L31/02322 ,  H01L31/03044 ,  H01L31/036 ,  H01L31/1856

Abstract: A semiconductor device used for fluorescent-based molecule detection and a method for manufacturing the same are provided. The semiconductor device has a fluid channel layer defining a fluid channel through which a sample stream flows. A target cell coupled with a fluorescent source is contained by the sample stream. The semiconductor device also has an excitation light source for generating excitation light that reaches the target cell coupled with the fluorescent source to generate fluorescent light. The semiconductor device also has a light filter layer for permitting the fluorescent light to pass through and to block the excitation light and a light detection layer for detecting the fluorescent light. The functional components of the device are highly integrated. Leakage of the excitation light and background noise into the light detection component can be minimized to improve the quality of detection.

Abstract translation: 提供了一种用于荧光基分子检测的半导体器件及其制造方法。 半导体器件具有限定流体通道的流体通道层，样品流通过该流体通道流动。 与荧光源耦合的靶细胞被样品流包含。 半导体器件还具有用于产生到与荧光源耦合的目标单元产生荧光的激发光的激发光源。 半导体器件还具有用于允许荧光通过并阻挡激发光的滤光层和用于检测荧光的光检测层。 设备的功能组件高度集成。 将激发光和背景噪声泄漏到光检测部件中可以最小化以提高检测质量。

公开(公告)号：US09494567B2

公开(公告)日：2016-11-15

申请号：US14650897

申请日：2013-12-17

Applicant: OMNI MEDSCI, INC.

Inventor： Mohammed N. Islam

IPC: G01J3/00 ,  G01N33/15 ,  A61B5/1455 ,  A61B5/00 ,  G01J3/10 ,  G01J3/28 ,  G01J3/453 ,  G01N21/359 ,  A61B5/145 ,  G01N33/49 ,  H01S3/30 ,  G01J3/14 ,  G01J3/18

CPC classification number: A61B5/0088 ,  A61B5/0013 ,  A61B5/0022 ,  A61B5/0075 ,  A61B5/0086 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/4547 ,  A61B5/6801 ,  A61B5/7257 ,  A61B5/7405 ,  A61B5/742 ,  A61B2562/0233 ,  A61B2562/0238 ,  A61B2562/146 ,  A61B2576/02 ,  G01J3/0218 ,  G01J3/108 ,  G01J3/14 ,  G01J3/1838 ,  G01J3/28 ,  G01J3/2823 ,  G01J3/42 ,  G01J3/453 ,  G01J2003/104 ,  G01J2003/1208 ,  G01J2003/2826 ,  G01M3/38 ,  G01N21/35 ,  G01N21/3563 ,  G01N21/359 ,  G01N21/39 ,  G01N21/85 ,  G01N21/88 ,  G01N21/9508 ,  G01N33/02 ,  G01N33/025 ,  G01N33/15 ,  G01N33/442 ,  G01N33/49 ,  G01N2021/3595 ,  G01N2021/399 ,  G01N2201/061 ,  G01N2201/06113 ,  G01N2201/062 ,  G01N2201/08 ,  G01N2201/12 ,  G01N2201/129 ,  G06F19/00 ,  G16H40/67 ,  H01S3/0092 ,  H01S3/06758 ,  H01S3/302

Abstract: Non-invasive monitoring of blood constituents such as glucose, ketones, or hemoglobin A1c may be accomplished using near-infrared or short-wave infrared (SWIR) light sources through absorbance, diffuse reflection, or transmission spectroscopy. As an example, hydro-carbon related substances such as glucose or ketones have distinct spectral features in the SWIR between approximately 1500 and 2500 nm. An SWIR super-continuum laser based on laser diodes and fiber optics may be used as the light source for the non-invasive monitoring. Light may be transmitted or reflected through a tooth, since an intact tooth and its enamel and dentine may be nearly transparent in the SWIR. Blood constituents or analytes within the capillaries in the dental pulp may be detected. The non-invasive monitoring device may communicate with a device such as a smart phone or tablet, which may transmit a signal related to the measurement to the cloud with cloud-based value-added services.

Abstract translation: 通过吸收，漫反射或透射光谱可以使用近红外或短波红外（SWIR）光源实现对血液成分如葡萄糖，酮或血红蛋白A1c的非侵入性监测。 作为示例，水 - 碳相关物质如葡萄糖或酮在SWIR中在约1500和2500nm之间具有不同的光谱特征。 可以使用基于激光二极管和光纤的SWIR超连续激光器作为非侵入性监测的光源。 光可以通过牙齿传播或反射，因为完整的牙齿及其牙釉质和牙质在SWIR中可能几乎是透明的。 可以检测牙髓中毛细血管内的血液成分或分析物。 非侵入式监测设备可以与诸如智能电话或平板电脑的设备进行通信，智能电话或平板电脑可以使用基于云的增值业务将与测量相关的信号传输到云。

公开(公告)号：US20160320293A1

公开(公告)日：2016-11-03

申请号：US15089214

申请日：2016-04-01

Applicant: Lam Research Corporation

Inventor： Seonkyung LEE ,  Dmitry OPAITS

IPC: G01N21/27 ,  G01N21/55

CPC classification number: G01N21/55 ,  G01N21/272 ,  G01N2021/8411 ,  G01N2201/0633 ,  G01N2201/08 ,  G01N2201/1222 ,  H01J37/00 ,  H01J37/32972

Abstract: A spectral reflectometer system for measuring a substrate is provided. A light source is provided. At least one optical detector is provided. An optical cable comprises a plurality of optical fibers, wherein the plurality of optical fibers comprises a first plurality of optical fibers, which are transmission optical fibers which extend from the light source to an optical path, and a second plurality of optical fibers, which are reflection optical fibers which extend from the optical path to the at least one optical detector. A microlens array is in the optical path.

Abstract translation: 提供了用于测量衬底的光谱反射计系统。 提供光源。 提供至少一个光学检测器。 一种光缆包括多根光纤，其中多根光纤包括第一多根光纤，其是从光源延伸到光路的传输光纤，以及第二多根光纤，其是 从光路延伸到至少一个光学检测器的反射光纤。 微透镜阵列位于光路中。

公开(公告)号：US20160305880A1

公开(公告)日：2016-10-20

申请号：US15029289

申请日：2014-10-14

Applicant: IFE INNOVATIVE FORSCHUNGS-UND ENTWICKLUNGS-GMBH & CO. KG

Inventor： Thomas Willuweit ,  Ralf Griesbach

IPC: G01N21/64 ,  G01J3/28 ,  G01J3/02

CPC classification number: G01N21/64 ,  G01J3/0218 ,  G01J3/0256 ,  G01J3/0264 ,  G01J3/0272 ,  G01J3/0291 ,  G01J3/10 ,  G01J3/28 ,  G01J3/32 ,  G01J3/4406 ,  G01N21/251 ,  G01N21/645 ,  G01N2201/024 ,  G01N2201/08

Abstract: The invention provides a measuring device for analyzing a luminescent sample and, in particular, for measuring the concentration of at least one analyte in a luminescent sample, comprising: a housing with a sample receptacle space for accommodating a sample container; a sample container for accommodating the luminescent sample; a radiation receiver apparatus for receiving radiation emitted by the luminescent sample; and an evaluation apparatus for evaluating the radiation from the luminescent sample received by the radiation receiver apparatus. The invention moreover provides a measuring device comprising a base part and a measuring head arranged at the base part in an interchangeable manner, wherein the measuring head is embodied to analyze the luminescent sample or it is embodied as a spectrometer measuring head.

Abstract translation: 本发明提供了一种用于分析发光样品，特别是用于测量发光样品中至少一种分析物的浓度的测量装置，包括：具有用于容纳样品容器的样品容纳空间的壳体; 用于容纳发光样品的样品容器; 用于接收由发光样品发射的辐射的辐射接收装置; 以及评估装置，用于评估由辐射接收装置接收的发光样品的辐射。 本发明还提供了一种测量装置，其包括以可互换的方式布置在基部的基部和测量头，其中测量头被实施为分析发光样品或者被实施为光谱仪测量头。

公开(公告)号：US20160299077A1

公开(公告)日：2016-10-13

申请号：US15100346

申请日：2014-11-25

Applicant: KONINKLIJKE PHILIPS N.V.

Inventor： JOHANNES JOSEPH HUBERTINA BARBARA SCHLEIPEN ,  REINHOLD WIMBERGER-FRIEDL ,  PIETER JAN VAN DER ZAAG ,  HENDRIK PAUL URBACH ,  MITRADEEP SARKAR

IPC: G01N21/64 ,  C12Q1/68 ,  G01N21/77

CPC classification number: G01N21/648 ,  C12Q1/6869 ,  G01N21/6452 ,  G01N21/7743 ,  G01N2021/7773 ,  G01N2021/7786 ,  G01N2201/06113 ,  G01N2201/068 ,  G01N2201/08

Abstract: The invention relates to an optical device (110) and a corresponding detection apparatus (100) that may for example be used for monitoring the replication of nucleotide sequences at a surface. In a preferred embodiment, the optical device (110) comprises a waveguide substrate (130) with a wiregrid (140) on a bottom surface (132), wherein apertures (141) of the wiregrid are in at least one direction (x) smaller than a characteristic wavelength (λ) of input light (IL). Moreover, a diffractive structure (120) is disposed on the opposite surface (131) of the substrate (130) for coupling input light (IL) into the substrate (130) such that constructive interference occurs at the apertures (141). Thus evanescent waves can be generated with high efficiency in these apertures, allowing for example for a surface-specific excitation of fluorescence (FL) that can be sensed by a detector (160).

Abstract translation: 本发明涉及可以例如用于监测表面上的核苷酸序列的复制的光学装置（110）和相应的检测装置（100）。 在优选实施例中，光学装置（110）包括在底表面（132）上具有丝网（140）的波导基底（130），其中，丝网的孔（141）在至少一个方向（x）上较小 比输入光（IL）的特征波长（λ）大。 此外，衍射结构（120）设置在衬底（130）的相对表面（131）上，用于将输入光（IL）耦合到衬底（130）中，使得在孔（141）处发生相长的干涉。 因此，可以在这些孔中以高效率产生ev逝波，例如允许由检测器（160）感测的荧光（FL）的表面特异性激发。

公开(公告)号：US20160290890A1

公开(公告)日：2016-10-06

申请号：US15036610

申请日：2014-02-14

Applicant: HALLIBURTON ENERGY SERVICES, INC.

Inventor： Rory D. Daussin ,  Neal G. Skinner

IPC: G01M3/38 ,  G01J5/00 ,  G01N21/17 ,  G01M3/00 ,  G01F1/684

CPC classification number: G01M3/38 ,  E21B33/13 ,  E21B41/0085 ,  E21B43/26 ,  G01F1/6845 ,  G01J5/0014 ,  G01M3/002 ,  G01N21/1702 ,  G01N2021/1704 ,  G01N2201/08

Abstract: A gaseous fuel monitoring system can include a gaseous fuel supply enclosure, an optical line extending along the gaseous fuel supply enclosure, and a relatively highly thermally conductive material contacting both the gaseous fuel supply enclosure and the optical line. The relatively highly thermally conductive material can comprise a pyrolytic carbon material. A method of detecting leakage from a gaseous fuel supply enclosure can include securing an optical line to the gaseous fuel supply enclosure, the securing comprising contacting a pyrolytic carbon material with the optical line and the gaseous fuel supply enclosure. A gaseous fuel monitoring system can include an optical interrogator connected to the optical line, which interrogator detects changes in light transmitted by the optical line due to changes in vibrations of the enclosure.

Abstract translation: 气体燃料监测系统可以包括气体燃料供应外壳，沿着气体燃料供应外壳延伸的光学线路，以及接触气体燃料供应外壳和光学线路的相对高度导热的材料。 相对高度导热的材料可以包括热解碳材料。 检测来自气体燃料供应外壳的泄漏的方法可以包括将光学线路固定到气体燃料供应外壳，固定包括使热解碳材料与光学线路和气体燃料供应外壳接触。 气体燃料监测系统可以包括连接到光学线路的光学询问器，该询问器检测由于外壳振动的变化而被光学线路传输的光的变化。

公开(公告)号：US20160266029A1

公开(公告)日：2016-09-15

申请号：US15163556

申请日：2016-05-24

Applicant: Octrolix BV

Inventor： Frederik Schreuder ,  Marcel Hoekman ,  Ronald Dekker ,  Seyed Naser Hosseini

IPC: G01N15/14 ,  G01N33/483

CPC classification number: G01N15/1484 ,  B01L2300/0654 ,  G01N15/1425 ,  G01N15/1436 ,  G01N15/1459 ,  G01N21/05 ,  G01N33/483 ,  G01N2015/0065 ,  G01N2015/145 ,  G01N2015/1454 ,  G01N2021/0346 ,  G01N2021/4742 ,  G01N2021/6484 ,  G01N2201/08 ,  G01S17/88

Abstract: A flow cytometry system having a flow channel defined through the thickness of a substrate is disclosed. Fluid flowing through the flow channel is illuminated by a first plurality of surface waveguides that are arranged around the flow channel in a first plane, while a second plurality of surface waveguides arranged around the flow channel in a second plane receive light after it has interacted with the fluid. The illumination pattern provided to the fluid is controlled by controlling the phase of the light in the first plurality of surface waveguides. As a result, the fluid is illuminated with light that is uniform and has a low coefficient of variation, improving the ability to distinguish and quantify characteristics of the fluid, such as cell count, DNA content, and the like.

Abstract translation: 公开了一种具有通过衬底的厚度限定的流动通道的流式细胞仪系统。 流过流动通道的流体由在第一平面中围绕流动通道布置的第一多个表面波导照射，而在第二平面中围绕流动通道布置的第二多个表面波导在其与 流体。 通过控制第一多个表面波导中的光的相位来控制提供给流体的照明图案。 结果，流体被均匀的光照射并且具有低的变异系数，提高了区分和量化流体特性的能力，例如细胞数量，DNA含量等。

公开(公告)号：US20160202186A1

公开(公告)日：2016-07-14

申请号：US14912131

申请日：2014-08-15

Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM ,  MESA PHOTONICS, LLC

Inventor： Katherine Romanak ,  David Bomse ,  Marwood N. Ediger

IPC: G01N21/65 ,  G01N30/16 ,  G01N33/00

CPC classification number: G02B6/02328 ,  G01J3/0205 ,  G01J3/0218 ,  G01J3/44 ,  G01N21/65 ,  G01N30/16 ,  G01N33/0036 ,  G01N2021/651 ,  G01N2201/06113 ,  G01N2201/08 ,  G02B6/02347 ,  G02B2006/12138

Abstract: The present invention includes an apparatus (10) and method for detecting nitrogen gas comprising: a conduit (12) for a gas sample (16); one or more hollow core photonic crystal fibers HC-PCF (20) having a proximal portion and a distal portion, wherein the proximal portion is in communication with the gas sample (16) in the conduit (12); a laser (14) positioned to strike the gas sample (16) in the conduit (12) and opposite the one or more hollow core photonic crystal fibers (20); and a Raman spectra detector (30) connected to the distal portion of the hollow core photonic crystal fibers (20), wherein a Raman spectra is generated when the laser (14) strikes the gas sample (16) that is detected by the Raman spectra detector (30).

Abstract translation: 本发明包括一种用于检测氮气的设备（10）和方法，包括：用于气体样品（16）的导管（12）; 一个或多个具有近端部分和远端部分的中空光子晶体光纤HC-PCF（20），其中近端部分与导管（12）中的气体样品（16）连通; 定位成撞击导管（12）中的气体样品（16）并与一个或多个空心光子晶体光纤（20）相对的激光器（14）; 以及连接到中空光子晶体光纤（20）的远端部分的拉曼光谱检测器（30），其中当激光器（14）撞击通过拉曼光谱检测的气体样品（16）时产生拉曼光谱 检测器（30）。

公开(公告)号：US09389174B2

公开(公告)日：2016-07-12

申请号：US14308296

申请日：2014-06-18

Applicant: WEATHERFORD/LAMB, INC.

Inventor： Domino Taverner ,  John J. Grunbeck ,  Jason Scott Kiddy

IPC: G01N21/47 ,  G01M11/00 ,  G01M11/02 ,  E21B47/00 ,  G01D5/353

CPC classification number: G01N21/4788 ,  E21B47/0002 ,  G01D5/35383 ,  G01D5/3539 ,  G01M11/02 ,  G01M11/33 ,  G01N2201/061 ,  G01N2201/0696 ,  G01N2201/08

Abstract: Methods and apparatus for interrogating sets of optical elements having characteristic wavelengths spanning a sweep range while avoiding overlapping reflections from the different sets when performing a wavelength sweep are provided. One example method generally includes introducing a pulse of light, by an optical source, into an optical waveguide to interrogate at least first and second sets of optical elements, wherein the optical elements within each set have different characteristic wavelengths and wherein the first and second sets are separated in time such that a first time window over which light is reflected from the optical elements in the first set and reaches a receiver does not overlap with a second time window over which light is reflected from the optical elements in the second set and reaches the receiver; and processing the reflected light to determine one or more parameters corresponding to the optical elements.

Abstract translation: 提供了用于询问具有跨越扫描范围的特征波长的光学元件组的方法和装置，同时避免当执行波长扫描时来自不同组的重叠反射。 一个示例性方法通常包括通过光源将光脉冲引入到光波导中以询问至少第一组和第二组光学元件，其中每组中的光学元件具有不同的特征波长，并且其中第一和第二组 在时间上分离，使得光从第一组中的光学元件反射并到达接收器的第一时间窗口不与第二时间窗口重叠，在第二时间窗口中光从第二组中的光学元件反射，并且到达第二时间窗口 收件人; 以及处理所述反射光以确定与所述光学元件对应的一个或多个参数。