公开(公告)号：US09508535B2

公开(公告)日：2016-11-29

申请号：US14384039

申请日：2012-03-15

Applicant: Hermann Wollnik ,  Gary A. Eiceman

Inventor： Hermann Wollnik ,  Gary A. Eiceman

IPC: H01J49/00 ,  G01N27/62 ,  H01J49/04

CPC classification number: H01J49/0031 ,  G01N27/622 ,  H01J49/0422

Abstract: An ion mobility spectrometer having an ion source for generating ions; an ion detector for recording ions, and a number of substantially flat diaphragm electrodes arranged substantially perpendicular to a straight system axis that passes through the apertures in said diaphragms, with the diaphragms being arranged in a series of cells with each cell including an entrances and an exit diaphragm and a short region in between. The exit diaphragm of one cell is identical to the entrance diaphragm of the next cell, and the cells of said ion mobility spectrometer are grouped into three parts: an ion-beam forming region, an ion analyzing region, and a decelerating ion gate.

Abstract translation: 具有离子源的离子迁移谱仪，用于产生离子; 用于记录离子的离子检测器和基本上垂直于穿过所述隔膜中的孔的直系统轴线布置的大致平坦的膜电极，其中隔膜布置在一系列单元中，每个单元包括入口和 出口隔膜和其间的短区域。 一个电池的出口隔膜与下一个电池单元的入口隔膜相同，并且将离子迁移谱仪的电池分成三部分：离子束形成区域，离子分析区域和减速离子门。

公开(公告)号：US08952325B2

公开(公告)日：2015-02-10

申请号：US12518240

申请日：2007-12-07

Applicant: Roger Giles ,  Michael Sudakov ,  Hermann Wollnik

Inventor： Roger Giles ,  Michael Sudakov ,  Hermann Wollnik

IPC: H01J49/00 ,  H01J49/40

CPC classification number: H01J49/406

Abstract: A co-axial time-of-flight mass spectrometer having a longitudinal axis and first and second ion mirrors at opposite ends of the longitudinal axis. Ions enter the spectrometer along an input trajectory offset from the longitudinal axis and after one or more passes between the mirrors ions leave along an output trajectory offset from the longitudinal axis for detection by an ion detector. The input and output trajectories are offset from the longitudinal axis by an angle no greater than formula (I): where Dmin is the or the minimum transverse dimension of the ion mirror and L is the distance between the entrances of the ion mirrors.

Abstract translation: 具有纵向轴线的同轴飞行时间质谱仪和在纵向轴线的相对端处的第一和第二离子反射镜。 离子沿着从纵向轴线偏移的输入轨迹进入光谱仪，并且在镜子之间的一个或多个通过之后，离子离开离开纵向轴线的输出轨迹离开以便由离子检测器检测。 输入和输出轨迹从纵轴偏移一个不大于公式（I）的角度：其中Dmin是离子镜的最小横向尺寸，L是离子镜入口之间的距离。

公开(公告)号：US5644128A

公开(公告)日：1997-07-01

申请号：US296312

申请日：1994-08-25

Applicant: Hermann Wollnik ,  Christoph Klein

Inventor： Hermann Wollnik ,  Christoph Klein

IPC: H01J37/244 ,  H01J49/02 ,  H05H3/00 ,  H01J47/00

CPC classification number: H01J49/025 ,  H01J37/244 ,  H01J2237/24435

Abstract: A position sensitive fast timing detector for determining time-of-flight mass analysis and position of atomic particles includes a channel plate assembly for detecting the impact of one or more atomic particles a transforming them into one or more electron clouds. The electron cloud then passes through an electron detector which includes a meandric delay line located in front of a back plate. A second meandric delay line may also be utilized, wherein the second delay line is orthogonal with the first delay line. A grid may be placed between the first and second meandric delay lines to reduce cross-talk.

Abstract translation: 用于确定飞行时间质量分析和原子粒子的位置的位置敏感快速定时检测器包括通道板组件，用于检测一个或多个原子粒子的影响，将其转变成一个或多个电子云。 然后，电子云通过电子检测器，其包括位于背板前面的蜿蜒延迟线。 还可以利用第二个奇数延迟线，其中第二延迟线与第一延迟线正交。 网格可以放置在第一和第二奇数延迟线之间以减少串扰。

公开(公告)号：US4486664A

公开(公告)日：1984-12-04

申请号：US401614

申请日：1982-07-26

Applicant: Hermann Wollnik

Inventor： Hermann Wollnik

IPC: G21K1/087 ,  H01J37/147 ,  H01J49/04 ,  B01D59/44 ,  H01J35/00

CPC classification number: H01J49/061 ,  G21K1/087 ,  H01J37/1471

Abstract: An arrangement and a process for adjusting imaging systems for bundles of charged particles, or for adjusting spectrometers for bundles of charged particles, are indicated, in which arrangement and process electric and/or magnetic correcting elements are used, which possess, in every case, a large number of electrodes and/or current conductors, which are arranged, symmetrically or asymmetrically, around the optical axis of the particle bundle, these electrodes being at potentials such that the resulting potentials V (r, .PHI.) at an azimuth angle (.PHI.) to a cylindrical surface at a radius (r) around an optical axis (Z) can be represented as the sum of V.sub.1 and V.sub.2, or, as the case may be, these current conductors carrying currents such that the magnitudes of the resulting currents I (r, .PHI.) at the azimuth angle (.PHI.), as defined above, can be represented as the sum of I.sub.1 and I.sub.2. The expressions V.sub.1, V.sub.2 and I.sub.1, I.sub.2 can, in their turn, be represented as sums, their addends being, respectively, of the type V.sub.1 =V.sub.1k sink.PHI., V.sub.2 =V.sub.2k cosk.PHI., and I.sub.1 =I.sub.1k sink.PHI. and I.sub.2 =I.sub.2k cosk.PHI., where k=1, 2, . . . P, with P representing the order of the multipole. The potentials and/or the currents are utilized, in this manner, to obtain superpositions of electric and/or magnetic dipoles, quadrupoles, hexapoles, etc.

Abstract translation: 示出了用于调整带电粒子束成像系统或用于调节带电粒子束束的光谱仪的装置和方法，其中使用了布置和处理电和/或磁校正元件，其在每种情况下都具有， 围绕颗粒束的光轴布置，对称或不对称地布置的大量电极和/或电流导体，这些电极处于电位，使得所得到的电位V（r，PHI）在方位角（PHI ）到围绕光轴（Z）的半径（r）处的圆柱形表面可以表示为V1和V2的总和，或者视情况而定，这些电流导体承载电流，使得所得到的电流的大小 如上定义的方位角（PHI）下的I（r，PHI）可以表示为I1和I2的和。 表达式V1，V2和I1，I2又可以表示为和，它们的加数分别为V1 = V1ksink PHI，V2 = V2kcosk PHI，I1 = I1ksink PHI，I2 = I2kcosk PHI， 其中k = 1,2。 。 。 P，P代表多极的顺序。 以这种方式利用电势和/或电流来获得电和/或磁偶极子，四极体，六极体等的叠加。

公开(公告)号：US20150221489A1

公开(公告)日：2015-08-06

申请号：US14384039

申请日：2012-03-15

Applicant: Hermann Wollnik ,  Gary A. Eiceman

Inventor： Hermann Wollnik ,  Gary A. Eiceman

IPC: H01J49/00 ,  G01N27/62 ,  H01J49/04

CPC classification number: H01J49/0031 ,  G01N27/622 ,  H01J49/0422

Abstract: An ion mobility spectrometer having an ion source for generating ions; an ion detector for recording ions, and a number of substantially flat diaphragm electrodes arranged substantially perpendicular to a straight system axis that passes through the apertures in said diaphragms, with the diaphragms being arranged in a series of cells with each cell including an entrances and an exit diaphragm and a short region in between. The exit diaphragm of one cell is identical to the entrance diaphragm of the next cell, and the cells of said ion mobility spectrometer are grouped into three parts: an ion-beam forming region, an ion analyzing region, and a decelerating ion gate.

Abstract translation: 具有用于产生离子的离子源的离子迁移谱仪; 用于记录离子的离子检测器和基本上垂直于穿过所述隔膜中的孔的直系统轴线布置的大致平坦的膜电极，其中隔膜布置在一系列单元中，每个单元包括入口和 出口隔膜和其间的短区域。 一个电池的出口隔膜与下一个电池的入口隔膜相同，并且所述离子迁移谱仪的电池分为三部分：离子束形成区域，离子分析区域和减速离子门。

公开(公告)号：US08138474B2

公开(公告)日：2012-03-20

申请号：US12945936

申请日：2010-11-15

Applicant: Hermann Wollnik ,  Gary Eiceman ,  Dimitrios Papanastasiou

Inventor： Hermann Wollnik ,  Gary Eiceman ,  Dimitrios Papanastasiou

IPC: H01J49/42

CPC classification number: G01N27/624

Abstract: A method for differential mobility separation of ions using digital-drive based high voltage fast switching electronics. The digital waveform delivered to the spectrometer is characterized by at least two substantially rectangular pulses of different amplitude and polarity. The control circuitry allows for waveform frequency, duty cycle and pulse amplitudes to be varied independently. Balanced as well as unbalanced asymmetric waveforms can be designed for optimum differential mobility separation of ions. The digital drive is designed for differential mobility spectrometers including parallel plate and segmented plate multipoles of planar symmetry, as well as multipoles of cylindrical symmetry, which may optionally be arranged in series. The use of the digital drive establishes alternating electric fields during which the displacement as a result of ion oscillation is determined by mobility coefficients.

Abstract translation: 使用基于数字驱动的高压快速开关电子器件进行离子差分迁移分离的方法。 传送到光谱仪的数字波形的特征在于具有不同幅度和极性的至少两个基本矩形的脉冲。 控制电路允许波形频率，占空比和脉冲幅度独立变化。 可以设计平衡和不平衡非对称波形，以实现离子的最佳差分迁移率分离。 数字驱动器设计用于差动迁移率光谱仪，包括平面板和平面对称的分段板多极体，以及圆柱对称的多极，其可以可选地串联布置。 使用数字驱动器建立交变电场，在此期间由离子振荡引起的位移由迁移率系数决定。

公开(公告)号：US20100072362A1

公开(公告)日：2010-03-25

申请号：US12518236

申请日：2007-12-07

Applicant: Roger Giles ,  Michael Sudakov ,  Hermann Wollnik

Inventor： Roger Giles ,  Michael Sudakov ,  Hermann Wollnik

IPC: H01J49/40 ,  H01J3/40

CPC classification number: H01J49/403 ,  H01J49/4295

Abstract: A time-of-flight mass spectrometer (1) comprises an ion source a segmented linear ion device (10) for receiving sample ions supplied by the ion source and a time-of-flight mass analyser for analysing ions ejected from the segmented device. A trapping voltage is applied to the segmented device to trap ions initially into a group of two or more adjacent segments and subsequently to trap them in a region of the segmented device shorter than the group of segments. The trapping voltage may also be effective to provide a uniform trapping field along the length of the device (10).

Abstract translation: 飞行时间质谱仪（1）包括离子源，用于接收由离子源提供的样品离子的分段线性离子装置（10）和用于分析从分段装置喷射的离子的飞行时间质量分析器。 捕获电压被施加到分段器件，以将离子初始化为两个或更多个相邻段的一组，并且随后将它们捕获在分段器件的比段组短的区域中。 捕获电压也可以有效地沿着装置（10）的长度提供均匀的捕获场。

公开(公告)号：US4445516A

公开(公告)日：1984-05-01

申请号：US336397

申请日：1981-12-18

Applicant: Hermann Wollnik ,  Rudiger Haas ,  Folkert Kassen

Inventor： Hermann Wollnik ,  Rudiger Haas ,  Folkert Kassen

IPC: A61B5/00 ,  G06F19/00

CPC classification number: G06F19/321 ,  A61B5/015 ,  G06F19/3406

Abstract: A method for digitizing and displaying thermographic records of biological or technical structures which makes it possible to recognize abnormal temperature distributions even if they are very small or the corresponding regions differ only very slightly in their temperature value from the adjacent temperature values. In this method, the temperature values at each image point of a thermogram are digitized and the slope of the local change in temperature, i.e. the temperature gradient, is calculated for each image point on basis of its temperature and the measured temperature values of its neighboring points. For a selected image region the local distribution of the temperature gradients is displayed. Abnormal temperature distributions can be recognized from this display at places where large temperature gradients are present.The method is particularly advantageous for use in the field of medicine and serves there for the detection of carcinomas and particularly breast cancer.

Abstract translation: PCT No.PCT / DE81 / 00076 Sec。 371日期：1981年12月18日 102（e）1981年12月18日日期PCT提交1981年5月26日PCT公布。 公开号WO81 / 03418 日期为1981年12月10日。一种用于数字化和显示生物或技术结构的热成像记录的方法，其使得即使它们非常小或相应的区域在相邻温度值中仅相差很小也可以识别异常温度分布 温度值。 在这种方法中，温度图的每个图像点的温度值被数字化，并且基于其温度和相邻的测量的温度值来计算每个图像点的局部温度变化（即温度梯度）的斜率 积分 对于所选择的图像区域，显示温度梯度的局部分布。 在存在大温度梯度的地方，可以从该显示中识别出异常的温度分布。 该方法特别有利于在医学领域中的应用，并用于检测癌症，特别是乳腺癌。

公开(公告)号：US20130140456A1

公开(公告)日：2013-06-06

申请号：US13816136

申请日：2010-08-10

Applicant: Hermann Wollnik

Inventor： Hermann Wollnik

IPC: H01J49/04

CPC classification number: H01J49/0422 ,  G01N27/624 ,  H01J49/0445

Abstract: A curtain-gas filter for a mass- or mobility-spectrometer that bars gases or vapors of a high-flux atmospheric pressure ion source, as we ions of high mobility and charged droplets, from entering an evacuated mass spectrometer or a mobility spectrometer that is at a lower pressure than the main filter volume of the curtain-gas filter. A portion of the ion-source buffer gas in the ion-source plume is sucked through an ion-source buffer gas inlet into the main filter volume of the curtain-gas filter, from where this ion-source gas is exhausted after a properly shaped electric field has pushed a large portion of the embedded ions into an externally provided stream of a clean buffer gas, which is sucked through a passage into a mass- or mobility-spectrometer that is at a lower pressure.

Abstract translation: 用于大规模或迁移率光谱仪的帘式气体过滤器，其将高通量大气压离子源的气体或蒸气截留，因为高迁移率和带电液滴的离子进入抽真空的质谱仪或迁移谱仪 在低于帘式气体过滤器的主过滤器体积的压力下。 离子源羽流中的一部分离子源缓冲气体通过离子源缓冲气体入口被吸入到幕式气体过滤器的主过滤器体积中，从该离子源缓冲气体中排出适当的形状 电场将大部分嵌入式离子推入干净的缓冲气体的外部提供的流中，该干净的缓冲气体通过通道被吸入到处于较低压力的质谱仪或移动光谱仪中。

公开(公告)号：US08013296B2

公开(公告)日：2011-09-06

申请号：US12600741

申请日：2007-05-21

Applicant: Hermann Wollnik ,  Yoshihiro Ueno

Inventor： Hermann Wollnik ,  Yoshihiro Ueno

IPC: H01J49/04 ,  H01J49/06

CPC classification number: H01J49/067

Abstract: Ions and charged droplets move from the nozzle (6) towards the orifice (22) of a charged-particle transport device or the desolvation pipe (7). This particle motion is governed by the distribution of the pseudo-potential along particle trajectories. There are RF-voltages applied to neighboring electrodes (241-246) of the electrode array (24) cause the charged particles to substantially hover above the electrode array (24). Right before the ions come to the electrode array (24) they thus experience a repelling force “F” perpendicular to the surface of the electrode array (24). This force “F” causes an effective barrier (B) right before the electrode array (24) and consequently a pseudo-potential well (A) where the charged particles stop their motion parallel to the plume axis (D). Thus they accumulate around the center line (C) of this well (A). Applying additionally to the RF-potentials also DC-potentials to neighboring electrodes within the electrode array (24) small DC-fields can be formed within the well area (23). These additional DC-fields drive the charged particles towards the axis of symmetry (C) and thus towards the orifice (22) of a charged-particle transport device or the desolvation pipe (7). Thus, many of the charged particles which would normally impinge on the wall (21) around the orifice (22) can now be analyzed.

Abstract translation: 离子和带电液滴从喷嘴（6）移动到带电粒子输送装置或去溶剂化管（7）的孔口（22）。 该粒子运动由沿着粒子轨迹的伪电位的分布决定。 施加到电极阵列（24）的相邻电极（241-246）的RF电压使得带电粒子基本上悬浮在电极阵列（24）上方。 在离子进入电极阵列（24）之前，它们因此经历与电极阵列（24）的表面垂直的排斥力“F”。 该力“F”在电极阵列（24）之前产生有效屏障（B），并因此导致带电粒子停止其平行于羽流轴线（D）的运动的伪势阱（A）。 因此，它们在该井（A）的中心线（C）周围积聚。 另外施加RF电位也可以在电极阵列（24）内的相邻电极的DC电位，可以在阱区（23）内形成小的DC场。 这些附加的直流磁场将驱动带电粒子朝向对称轴线（C），从而驱动带电粒子输送装置或去溶剂化管道（7）的孔口（22）。 因此，现在可以分析许多通常会撞击孔（22）周围的壁（21）上的带电粒子。