公开(公告)号：CA2217718A1

公开(公告)日：1996-10-24

申请号：CA2217718

申请日：1995-04-17

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： WU GUANLI ,  UNGER EVAN C

IPC: A61K49/00

Abstract: Novel MRI contrast agents that comprise one or more metal-ion chelates in juxtaposition with one or more free-radical nitroxide compounds in a polymeric or oligomeric molecule. Both the chelate units and the free radical units may, independently, be inside the main chain of the polymer or in a side chain of the linkage portion of the polymer. The number of combined units of chelates and free radicals in the polymer or oligomer is at least two.

公开(公告)号：AU4913896A

公开(公告)日：1996-09-11

申请号：AU4913896

申请日：1996-01-29

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C ,  SHEN DEKANG ,  WU GUANLI

IPC: C12N15/09 ,  A61K9/107 ,  A61K9/127 ,  A61K38/00 ,  A61K47/14 ,  A61K47/16 ,  A61K48/00 ,  A61P37/04 ,  C07C237/10 ,  C07F9/10 ,  C07K14/135 ,  C07K14/50 ,  C12N15/88 ,  C07C69/00 ,  C07C233/00 ,  C12N15/64 ,  A61K9/50

Abstract: Cationic lipid compounds which comprise at least two cationic groups. The cationic lipid compounds are particularly suitable for use as carriers in the intracellular delivery of bioactive agents, including pharmaceuticals and genetic material. Compositions of the present cationic lipid compounds include suspensions, emulsions, micelles and liposomes.

公开(公告)号：AU3146595A

公开(公告)日：1996-03-29

申请号：AU3146595

申请日：1995-07-26

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C ,  MATSUNAGA TERRY ,  YELLOWHAIR DAVID

IPC: G01R33/28 ,  A61B5/055 ,  A61J1/00 ,  A61K8/04 ,  A61K8/14 ,  A61K8/70 ,  A61K9/127 ,  A61K9/133 ,  A61K41/00 ,  A61K47/48 ,  A61K49/00 ,  A61K49/18 ,  A61K49/22 ,  A61M5/31 ,  A61Q19/00 ,  B65D81/20

Abstract: A container comprising an aqueous lipid suspension and a gaseous phase substantially separate from the aqueous stabilizing phase, useful in diagnostic imaging such as ultrasound and magnetic resonance imaging and in therapeutic applications, is disclosed.

公开(公告)号：AU7041694A

公开(公告)日：1995-01-03

申请号：AU7041694

申请日：1994-05-19

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C ,  FRITZ THOMAS A ,  MATSUNAGA TERRY ,  RAMASWAMI VARADARAJAN ,  YELLOWHAIR DAVID ,  WU GUANLI

IPC: A61B8/00 ,  A61K8/14 ,  A61K9/127 ,  A61K41/00 ,  A61K47/48 ,  A61K48/00 ,  A61K49/00 ,  A61K49/18 ,  A61K49/22 ,  A61M5/31 ,  A61Q19/00 ,  B01J13/02

Abstract: Methods of and apparatus for preparing gas-filled liposomes are described. Gas-filled liposomes prepared by these methods are particularly useful, for example, in ultrasonic imaging applications and in therapeutic drug delivery systems.

公开(公告)号：EP0930844B1

公开(公告)日：2008-09-03

申请号：EP97928998.0

申请日：1997-06-16

Applicant: IMARX PHARMACEUTICAL CORP.

Inventor： UNGER, Evan, C. ,  MATSUNAGA, Terry, O. ,  FRITZ, Thomas, A. ,  RAMASWAMI, Varada, Rajan

IPC: A61B5/055

CPC classification number: A61K49/223 ,  Y10S977/801 ,  Y10S977/927 ,  Y10S977/928 ,  Y10S977/929 ,  Y10S977/93

Abstract: Methods for providing an image of an internal region of a patient. Embodiments of the methods involve administering to the patient a contrast agent which comprises a vesicle composition comprising, in an aqueous carrier, a gas or gaseous precursor and vesicles comprising lipids, proteins or polymers. The patient is scanned using diagnostic imaging, such as ultrasound, to obtain a visible image of the region. The contrast agent is administered to the patient at a rate to substantially eliminate diagnostic artifacts in the image. The methods are particularly useful for diagnosing the presence of any diseased tissue in the patient.

公开(公告)号：EP1535575A1

公开(公告)日：2005-06-01

申请号：EP04078475.3

申请日：1999-05-07

Applicant: IMARX PHARMACEUTICAL CORP.

Inventor： Unger, Evan C. ,  Wu, Yungui

IPC: A61B8/00 ,  G01S15/02 ,  G01N29/00 ,  H04N5/30 ,  G01N29/04

CPC classification number: A61B5/0091 ,  A61B5/0095 ,  A61B5/4312 ,  A61B8/0825 ,  A61B8/0833 ,  A61B8/5238 ,  G01S7/52074 ,  G01S15/8918 ,  G01S15/8922 ,  G01S17/89

Abstract: An optoacoustic system comprises an optoacoustic transducer including a first array of acoustic transducers and a second array of optical fibers; an acoustic subsystem for controllably exciting at least a first subset of the acoustic transducers to generate acoustic pulses with a prescribed pulse width, and for forming a first image based on return acoustic pulses reflected from a patient; an optical subsystem for controllably generating optical pulses to be transmitted through at least a first subset of the optical fibers toward the patient, and for forming a second image based on light reflected from the patient; and image correlation means for correlating the first and second images. The first and second arrays may take various forms, including the form of an annular array in which the acoustic transducers are arranged coaxially and the optical fibers are disposed around an outer periphery of the first array. The first and second arrays may also take the form of linear arrays.

Abstract translation: 光声系统包括光声换能器，其包括第一阵列的声换能器和第二阵列的光纤; 声学子系统，用于可控地激励声换能器的至少第一子集以产生具有规定脉冲宽度的声脉冲，以及用于基于从患者反射的返回声脉冲形成第一图像; 光学子系统，用于可控地产生要经由光纤的至少第一子集向患者透射的光脉冲，以及基于从患者反射的光形成第二图像; 以及用于使第一和第二图像相关联的图像相关装置。 第一和第二阵列可以采取各种形式，包括环形阵列的形式，其中声换能器同轴布置，并且光​​纤围绕第一阵列的外周设置。 第一和第二阵列也可以采取线性阵列的形式。

公开(公告)号：EP0959908A4

公开(公告)日：2002-11-20

申请号：EP98946919

申请日：1998-09-09

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C ,  FRITZ THOMAS A ,  GERTZ EDWARD W

IPC: A61K49/22 ,  A61K49/04 ,  A61K9/127 ,  A61K9/50 ,  A61K47/48

CPC classification number: A61K49/223 ,  A61K49/227 ,  A61K49/228 ,  B82Y5/00

公开(公告)号：EP0935415A4

公开(公告)日：2002-08-14

申请号：EP97921460

申请日：1997-04-30

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C ,  MCCREERY THOMAS

IPC: C12N15/09 ,  A61K9/127 ,  A61K41/00 ,  A61K45/08 ,  A61K47/02 ,  A61K47/18 ,  A61K47/30 ,  A61K47/42 ,  A61K48/00 ,  A61P3/10 ,  A61P7/00 ,  A61P9/10 ,  A61P11/00 ,  A61P21/00 ,  A61P31/18 ,  A61P35/00 ,  C12N5/10 ,  C12N15/87 ,  C12N15/88 ,  C12P21/02 ,  A01N43/04 ,  A61K31/70 ,  C07H21/04 ,  C12N15/12 ,  C12N15/85

CPC classification number: A61K48/00 ,  A61K9/1272 ,  A61K41/0028 ,  C12N15/87 ,  C12N15/88

公开(公告)号：EP1064953A3

公开(公告)日：2002-07-03

申请号：EP00203214.2

申请日：1992-03-18

Applicant: ImaRx Pharmaceutical Corp.

Inventor： Unger, Evan C.

IPC: A61K9/50 ,  A61K49/22 ,  A61K47/48 ,  A61P9/00

CPC classification number: A61K49/0419 ,  Y10T428/2982 ,  Y10T428/31862

Abstract: The invention provides contrast media for diagnostic imaging comprising a substantially homogeneous aqueous suspension of gas-filled microspheres, wherein the microspheres are filled with a perfluorocarbon gas. The microspheres are preferably formed from biocompatible synthetic polymers or copolymers.

公开(公告)号：EP1039834A1

公开(公告)日：2000-10-04

申请号：EP98964127.9

申请日：1998-12-17

Applicant: IMARX PHARMACEUTICAL CORP.

Inventor： UNGER, Evan, C. ,  WU, Yunqiu

IPC: A61B8/13 ,  A61K49/00

CPC classification number: A61K49/0002

Abstract: The present invention generally relates to optoacoustic contrast agents and methods of diagnostic and therapeutic imaging using optoacoustic contrast agents.