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公开(公告)号:ZA953584B
公开(公告)日:1996-11-04
申请号:ZA953584
申请日:1995-05-04
Applicant: BASF AG
Inventor: BUSCHMANN ERNST , AMBERG WILHELM , BERNARD HARALD , HAUPT ANDREAS , JANSSEN BERND , KARL ULRICH , KLING ANDREAS , MUELLER STEFAN , JANITSCHKE LOTHAR , RITTER KURT , THYES MARCO , ZIERKE THOMAS , POTZOLLI BERND DE
IPC: A61K38/08 , A61P35/00 , A61K38/00 , C07K1/08 , C07K5/10 , C07K5/103 , C07K7/06 , C07K14/52 , C07K , A61K
Abstract: PCT No. PCT/EP95/01577 Sec. 371 Date Nov. 4, 1996 Sec. 102(e) Date Nov. 4, 1996 PCT Filed Apr. 26, 1995 PCT Pub. No. WO95/30691 PCT Pub. Date Nov. 16, 1995The compound Me2Val-Val-MeVal-Pro-Pro-NHBzlxHCl is described. It is prepared from Z-Val-Val-MeVal-Pro-OR1 where Z and R1 have the meanings stated in the description. The compound shows antineoplastic activity.
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公开(公告)号:ES2081134T3
公开(公告)日:1996-02-16
申请号:ES92920691
申请日:1992-09-26
Applicant: BASF AG
Inventor: KAST JUERGEN , ZIERKE THOMAS , BRATZ MATTHIAS , MISSLITZ ULF , MEYER NORBERT , LANDES ANDREAS , RADEMACHER WILHELM , WESTPHALEN KARL-OTTO , WALTER HELMUT
IPC: A01N37/42 , A01N37/48 , A01N37/50 , A01N39/00 , C07C67/313 , C07C69/757 , C07C249/02 , C07C249/08 , C07C251/18 , C07C251/42 , C07C251/52 , C07C251/54 , C07C255/56 , C07C255/61 , C07C255/62 , C07C317/28 , C07D295/18 , C07D521/00
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公开(公告)号:DE59204447D1
公开(公告)日:1996-01-04
申请号:DE59204447
申请日:1992-09-26
Applicant: BASF AG
Inventor: KAST JUERGEN , ZIERKE THOMAS , BRATZ MATTHIAS , MISSLITZ ULF , MEYER NORBERT , LANDES ANDREAS , RADEMACHER WILHELM , WESTPHALEN KARL-OTTO , WALTER HELMUT
IPC: A01N37/42 , A01N37/48 , A01N37/50 , A01N39/00 , C07C67/313 , C07C69/757 , C07C249/02 , C07C249/08 , C07C251/18 , C07C251/42 , C07C251/52 , C07C251/54 , C07C255/56 , C07C255/61 , C07C255/62 , C07C317/28 , C07D295/18 , C07D521/00
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公开(公告)号:HU208017B
公开(公告)日:1993-07-28
申请号:HU571290
申请日:1990-08-30
Applicant: BASF AG
Inventor: KOBER REINER , SEELE RAINER , ZIERKE THOMAS , ISAK HEINZ , KARBACH STEFAN , WEGNER GUENTER
Abstract: Preparation of ether solutions of arylmethylmagnesium halides… Ar-CH2-Mg-Hal I… (Aryl = unsubstituted or substituted aryl; Hal = Cl, Br) by the Grignard process from arylmethyl halides II… Ar-CH2-Hal II… with magnesium in an ether as a solvent, by using III… tert-butyl-O-R III… (R = C1-C3-alkyl) for this purpose.
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公开(公告)号:HU207701B
公开(公告)日:1993-05-28
申请号:HU434490
申请日:1990-07-17
Applicant: BASF AG
Inventor: KOBER REINER , SEELE RAINER , ISAK HEINZ , HICKMANN ECKHARD , GOETZ NORBERT , ZIERKE THOMAS
IPC: C07B53/00 , C07C17/00 , C07C17/35 , C07C17/357 , C07C22/04 , C07C25/24 , C07C41/18 , C07C41/48 , C07C43/225 , C07C43/29 , C07D233/56 , C07D233/58 , C07D249/08 , C07D301/16 , C07D303/08 , C07D405/06 , C07D521/00
Abstract: Preparation of Z-1,2-diarylallyl chlorides of the general formula I in which the radicals R and R independently of one another are hydrogen, halogen, alkyl, haloalkyl, alkoxy, haloalkoxy or a substituted aromatic radical, and n and m represent 1, 2 or 3, by dehydrating chlorohydrins of the formula II in which the radicals have the abovementioned meanings, at temperatures of up to 50 DEG C in the presence of a carboxylic anhydride and of an organic or inorganic acid, in an inert ether or carboxylate as the solvent, the reaction of these products to give azolylmethyloxiranes, and novel intermediates.
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公开(公告)号:ZA9101021B
公开(公告)日:1992-10-28
申请号:ZA9101021
申请日:1991-02-12
Applicant: BASF AG
Inventor: ZIERKE THOMAS , THOMAS ZIERKE , KUEKENHOEHNER THOMAS , THOMAS KUEKENHOEHNER , AMMERMAN EBERHARD , EBERHARD AMMERMAN , LORENZ GISELA , GISELA LORENZ
IPC: A01N43/40 , C07D213/30 , C07D213/42 , C07D213/57 , C07D213/89 , C07D , A01G , A01N
CPC classification number: C07D213/30 , A01N43/40
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公开(公告)号:ZA9010431B
公开(公告)日:1992-08-26
申请号:ZA9010431
申请日:1990-12-28
Applicant: BASF AG
Inventor: ZIERKE THOMAS , THOMAS ZIERKE , ZIPPERER BERNHARD , BERNHARD ZIPPERER , SAUTER HUBERT , HUBERT SAUTER , AMMERMANN EBERHARD , EBERHARD AMMERMANN , LORENZ GISELA , GISELA LORENZ
IPC: A01N43/40 , C07D213/30 , C07D213/50 , C07D405/04 , C07D , A01N
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公开(公告)号:HUT55954A
公开(公告)日:1991-07-29
申请号:HU849390
申请日:1990-12-28
Applicant: BASF AG
Inventor: ZIPPERER BERNHARD , AMMERMANN EBERHARD , LORENZ GISELA , ZIERKE THOMAS , SAUTER HUBERT
IPC: A01N43/40 , C07D213/30 , C07D213/50 , C07D405/04 , C07D405/14 , C07D409/06 , C07D409/14 , C07D413/06 , C07D413/14
Abstract: 3-Substituted pyridines I … …… … (X = OH; Y = -O-CHO, -O-CO-W R , -O-SO2-W R or X + Y = -O-CH(W R )-O-, O CH(O W R )-O-, -O-C-(W R )(O-W R )-O-; W -W = direct bond, -CH2-, -CH2-CH2, -CH(CH3)-, -CH2O-, -CH2S-; R -R = optionally cycloalkyl-substituted C1-C6-alkyl, C1-C6-haloalkyl, C3-C8-cycloalkyl which is optionally substituted by 1-3 alkyl radicals, or C1-C4-alkoxy-C1-C4-alkyl, C1-C4-alkylthio-C1-C4-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, optionally substituted phenyl or naphthyl, optionally substituted 5-/6-membered heteroaryl having 1 to 3 hetero atoms; … R is additionally H when X + Y = -O-CH(W R )-O-, -O-CH(O-W R )-O- or -O-C(W R )(O-W R )-O- and W2 = direct bond), … with the exception of cis-1-(2,4-dichlorophenyl)-2-(pyrid-3-yl)- 1,2-epoxypropane, trans-1-(2,4-dichlorophenyl)-2-(pyrid-3-yl)- 1,2-epoxypropane, 1-(2,4-dichlorophenyl)-2-(pyrid-3-yl)- 1,2-epoxybutane and 2,4-dichloro- alpha -[1-hydroxy-1-(pyrid-3-yl)ethyl]- benzyl methanesulphonate … and the N-oxides and phytophysiologically acceptable salts with mineral acids, and metal complexes of I. … The compounds I are suitable as fungicides.
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公开(公告)号:AU6854990A
公开(公告)日:1991-07-11
申请号:AU6854990
申请日:1990-12-28
Applicant: BASF AG
Inventor: ZIERKE THOMAS , ZIPPERER BERNHARD , SAUTER HUBERT , AMMERMANN EBERHARD , LORENZ GISELA
IPC: A01N43/40 , C07D213/30 , C07D213/50 , C07D405/04 , C07D409/06 , C07D413/06 , C07D413/14 , C07D409/14
Abstract: 3-Substituted pyridines I … …… … (X = OH; Y = -O-CHO, -O-CO-W R , -O-SO2-W R or X + Y = -O-CH(W R )-O-, O CH(O W R )-O-, -O-C-(W R )(O-W R )-O-; W -W = direct bond, -CH2-, -CH2-CH2, -CH(CH3)-, -CH2O-, -CH2S-; R -R = optionally cycloalkyl-substituted C1-C6-alkyl, C1-C6-haloalkyl, C3-C8-cycloalkyl which is optionally substituted by 1-3 alkyl radicals, or C1-C4-alkoxy-C1-C4-alkyl, C1-C4-alkylthio-C1-C4-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, optionally substituted phenyl or naphthyl, optionally substituted 5-/6-membered heteroaryl having 1 to 3 hetero atoms; … R is additionally H when X + Y = -O-CH(W R )-O-, -O-CH(O-W R )-O- or -O-C(W R )(O-W R )-O- and W2 = direct bond), … with the exception of cis-1-(2,4-dichlorophenyl)-2-(pyrid-3-yl)- 1,2-epoxypropane, trans-1-(2,4-dichlorophenyl)-2-(pyrid-3-yl)- 1,2-epoxypropane, 1-(2,4-dichlorophenyl)-2-(pyrid-3-yl)- 1,2-epoxybutane and 2,4-dichloro- alpha -[1-hydroxy-1-(pyrid-3-yl)ethyl]- benzyl methanesulphonate … and the N-oxides and phytophysiologically acceptable salts with mineral acids, and metal complexes of I. … The compounds I are suitable as fungicides.
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公开(公告)号:CA2004489A1
公开(公告)日:1990-07-18
申请号:CA2004489
申请日:1989-12-04
Applicant: BASF AG
Inventor: ZIERKE THOMAS , SAUTER HUBERT , SCHULZ GUENTER , WILL WOLFGANG
IPC: C07C49/83 , C07D303/14 , C07F7/18 , C07C49/76 , C07D303/12
Abstract: A process for the preparation of 1-hydroxymethyloxiranes which are Z-substituted in the 2-position, of the general formulae I and ent-I and (I) (ent-I) where A and B independently of one another are each C1C4-alkyl, phenyl, naphthyl or diphenyl or are each phenyl which is substituted by one to three radicals from the group consisting of halogen, C1-C4-alkyl, C1-C4-alkoxy, C1C4-haloalkyl, nitro and phenoxy, by reacting a ketone of the general formula II (II) where A and B have the abovementioned meanings and X is a group which can be eliminated under the reaction conditions, with trimethylsulfonium methylsulfate and a suitable base or with dimethyloxosulfonium methylide, and novel ketones of the general formula II' (II') where A' is phenyl or 4-fluorophenyl, B' is 2-fluoro-phenyl, 2-chlorophenyl, 2-bromophenyl or 2-trifluoro-methylphenyl and X' is hydroxyl or a leaving group, with the proviso that B' is not 2-chlorophenyl when A' is phenyl is described.
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