公开(公告)号：KR100838702B1

公开(公告)日：2008-06-16

申请号：KR1020070013408

申请日：2007-02-08

Applicant: 한국화학연구원

Inventor： 전동주 ,  송종환 ,  이계형 ,  김익연 ,  소원영

IPC: C07D401/06

Abstract: A method for preparing a 1-[1-(3,4-dialkoxyaryl)-pyridylmethyl]-1H-pyrazole compound is provided to produce a desired product with high purity economically and industrially compared with a method for separating the desired product using a chiral column. A method for preparing a 1-[1-(3,4-dialkoxyaryl)-pyridylmethyl]-1H-pyrazole compound represented by a formula(1) comprises the steps of: (a) subjecting an aryl aldehyde compound represented by a formula(2) and 2-methyl-2-propanesulfinamide to condensation in the presence of titanium ethoxide(Ti(OEt)4) to prepare a compound represented by a formula(4); (b) reacting the compound of the formula(4) with a compound represented by a formula(5) to prepare a compound represented by a formula(6); (c) removing a sulfinyl group of the compound of the formula(6) under acidic condition to prepare an amine compound represented by a formula(7); (d) reacting the compound of the formula(7) with a compound represented by a formula(8) to prepare a cis-type compound represented by a formula(9); and (e) after N-aminating the cis-type compound of the formula(9) by dropping amino 4-nitrobenzoate represented by a formula(10) therein in the existence of a strong base, cyclizing the N-aminated compound to prepare the compound of the formula(1). In the formulae, A is CH; R1 is linear or branched saturated or unsaturated C1-7 alkyl which may be substituted or unsubstituted by halogen; R2 is C3-7 cycloalkyl or (C3-10)cycloalkyl(C1-7)alkyl; and R3 is phenyl which may be substituted by at least one substituent selected from the group consisting of C1-7 alkyl, C3-7 cycloalkyl, (C3-10)cycloalkyl(C1-7)alkyl, C1-7 alkoxy, (C1-7)alkoxy(C1-7)alkyl, (C1-7)alkylsiloxy(C1-7)alkyl, C1-5 alkoxycarbonyl, benzyloxy, halogen, nitro, cyano, C1-7 alkylsiloxy, carboxyl and formyl.

Abstract translation: 提供了一种制备1- [1-（3,4-二烷氧基芳基） - 吡啶基甲基] -1H-吡唑化合物的方法，与使用手性的分离所需产物的方法相比，在经济和工业上产生具有高纯度的所需产物 柱。 制备由式（1）表示的1- [1-（3,4-二烷氧基芳基） - 吡啶基甲基] -1H-吡唑化合物的方法包括以下步骤：（a）使由式 2）和2-甲基-2-丙磺酰胺在乙醇钛（Ti（OEt）4）存在下缩合以制备由式（4）表示的化合物; （b）使式（4）的化合物与式（5）表示的化合物反应，制备由式（6）表示的化合物; （c）在酸性条件下除去式（6）化合物的亚磺酰基以制备由式（7）表示的胺化合物; （d）使式（7）的化合物与式（8）表示的化合物反应，制备由式（9）表示的顺式化合物; 和（e）通过在存在强碱的情况下滴加由式（10）表示的式（10）表示的氨基-4-硝基苯甲酸将式（9）的顺式式化合物N-胺化后，使N-胺化化合物环化以制备 式（1）的化合物。 在式中，A为CH; R1是可被卤素取代或未取代的直链或支链饱和或不饱和C 1-7烷基; R2是C3-7环烷基或（C3-10）环烷基（C1-7）烷基; 并且R 3是可以被至少一个选自C 1-7烷基，C 3-7环烷基，（C 3-10）环烷基（C 1-7）烷基，C 1-7烷氧基， 7）烷氧基（C 1-7）烷基，（C 1-7）烷基甲硅烷氧基（C 1-7）烷基，C 1-5烷氧基羰基，苄氧基，卤素，硝基，氰基，C 1-7烷基甲硅烷氧基，羧基和甲酰基。

公开(公告)号：KR100837785B1

公开(公告)日：2008-06-13

申请号：KR1020070005148

申请日：2007-01-17

Applicant: 한국화학연구원

Inventor： 이계형 ,  원종화 ,  김익연 ,  노재성 ,  김지영 ,  원혜경 ,  정은주 ,  허민규 ,  김성주 ,  김영림 ,  전동주 ,  송종환 ,  강남숙 ,  유성은

IPC: A61K31/4152 ,  A61P29/00

CPC classification number: A61K31/433 ,  A61K31/4439 ,  A61K31/496 ,  A61K31/5377 ,  Y10S514/825 ,  Y10S514/886

Abstract: A novel 1,2,4-thiadiazolidine-3,5-dione compound is provided to show excellent activity and enzyme selectivity on Lck SH2, thereby being usefully used for treating and preventing inflammation related diseases such as rheumatoid arthritis with high selectivity without side effects. A pharmaceutical composition for treating and preventing a disease induced by inflammation comprises a 1,2,4-thiadiazolidine-3,5-dione compound represented by a formula(1) or a pharmaceutically acceptable salt thereof as an effective ingredient. In the formula(1), A is linear or branched saturated or unsaturated C1-7 alkyl, indenyl, (C1-7)alkoxycarbonyl(C1-7)alkyl, phenyl, benzyl or C2H5(C=O)HR2R3(wherein A may be substituted by halogen, carboxyl, C1-7 alkoxycarbonyl, C1-7 alkoxy, nitro or hydroxy when A is alkyl, phenyl or benzyl); R1 is H, linear or branched saturated or unsaturated C1-7 alkyl, (C1-7)alkoxycarbonyl(C1-7)alkyl, phenyl, phenyl(C1-5)alkyl or phenylcarbonylmethyl; and each R2 and R2 is independently H, linear or branched saturated or unsaturated C1-7 alkyl or phenyl, or R2 and R3 may form a ring together with C1-5 alkylene. A pharmaceutical composition for treating and preventing rheumatoid arthritis comprises the 1,2,4-thiadiazolidine-3,5-dione compound of the formula(1) or a pharmaceutically acceptable salt thereof as an effective ingredient.

Abstract translation: 提供了一种新的1,2,4-噻二唑烷-3,5-二酮化合物，以显示对Lck SH2的极好的活性和酶选择性，从而有效地用于治疗和预防炎症相关疾病如类风湿性关节炎，具有高选择性，无副作用 。 用于治疗和预防炎性疾病的药物组合物包含由式（1）表示的1,2,4-噻二唑烷-3,5-二酮化合物或其药学上可接受的盐作为有效成分。 在式（1）中，A是直链或支链饱和或不饱和的C1-7烷基，茚基，（C1-7）烷氧基羰基（C1-7）烷基，苯基，苄基或C2H5（C = O）HR2R3（其中A可以 苯基或苄基）被卤素，羧基，C 1-7烷氧基羰基，C 1-7烷氧基，硝基或羟基取代。 R1是H，直链或支链饱和或不饱和的C1-7烷基，（C1-7）烷氧基羰基（C1-7）烷基，苯基，苯基（C1-5）烷基或苯基羰基甲基; 并且每个R 2和R 2独立地为H，直链或支链饱和或不饱和的C 1-7烷基或苯基，或者R 2和R 3可与C 1-5亚烷基一起形成环。 用于治疗和预防类风湿性关节炎的药物组合物包含式（1）的1,2,4-噻二唑烷-3,5-二酮化合物或其药学上可接受的盐作为有效成分。

公开(公告)号：KR100454099B1

公开(公告)日：2004-10-26

申请号：KR1020020049819

申请日：2002-08-22

Applicant: 한국화학연구원

Inventor： 유응걸 ,  전동주 ,  김형래 ,  송종환 ,  박관용 ,  하진열 ,  김진석

IPC: C07D495/04

Abstract: PURPOSE: Provided are derivatives of 9-(5-isoxazolinemethoxyphenyl)imino-8-thia-1.6-diazabicylco£4.3.0|nonane-7-one, represented by the formula(1) and herbicides containing them as active ingredients and having excellent herbicidal activity and selectivity when applied to a rice paddy. CONSTITUTION: Derivatives are represented by the formula(1), wherein R is C1-C6 alkyl, phenyl or substituted phenyl, wherein substituents are 1-3 of halogen atom, C1-C3 alkyl, C1-C3 alkoxy, C1-C3 haloalkyl, cyano, nitro, carboxyl and esters of carboxy acid.

Abstract translation: 用途：提供由式（1）表示的9-（5-异恶唑啉甲氧基苯基）亚氨基-8-硫杂-1,6-二氮杂双环[4.3.0]壬烷-7-酮的衍生物和含有它们作为活性成分的除草剂， 除草活性和选择性，当应用到稻田。 构成：衍生物由式（1）表示，其中R为C 1 -C 6烷基，苯基或取代的苯基，其中取代基为卤素原子，C 1 -C 3烷基，C 1 -C 3烷氧基，C 1 -C 3卤代烷基， 氰基，硝基，羧基和羧酸的酯。

公开(公告)号：KR100424862B1

公开(公告)日：2004-03-31

申请号：KR1020010011544

申请日：2001-03-06

Applicant: 한국화학연구원

Inventor： 김은경 ,  조성윤 ,  전동주 ,  김영미

IPC: C07D413/14

CPC classification number: C07D413/14 ,  C07D333/56 ,  C07D333/58 ,  C08K5/0041 ,  C08K5/353

Abstract: Novel photochromic diarylethenes substituted with an isoxazole group and the method of preparation are disclosed. Also disclosed are compositions made with the photochromic diarylethenes. The preparation of thin films with the photochromic diarylethenes or compositions thereof are disclosed. The photochromic diarylethenes or compositions thereof may be used, for example in recording materials, photochromic windows, indicating elements, plastic mirrors, photochromic filters, photo switches, photosensitive drums, recording elements, solar cells, lens, fibers and optical elements.

Abstract translation: 公开了用异恶唑基团取代的新型光致变色二芳基乙烯化合物和制备方法。 还公开了用光致变色二芳基乙烯制成的组合物。 公开了用光致变色二芳基乙烯或其组合物制备薄膜。 光致变色二芳基乙烯或其组合物可用于例如记录材料，光致变色窗，指示元件，塑料镜，光致变色滤光片，光敏开关，感光鼓，记录元件，太阳能电池，透镜，纤维和光学元件。

公开(公告)号：KR1020020019751A

公开(公告)日：2002-03-13

申请号：KR1020000052918

申请日：2000-09-07

Applicant: 한국화학연구원

Inventor： 유응걸 ,  김형래 ,  전동주 ,  송종환 ,  김경만 ,  이정노 ,  김형철 ,  홍경식

IPC: A01N43/80

CPC classification number: A01N43/80 ,  C07D413/04

Abstract: PURPOSE: Provided are 5-benzyloxymethyl-1,2-isoxazoline derivatives having an excellent herbicidal activity, its manufacturing method and herbicides containing the derivative as an active ingredient. CONSTITUTION: 5-benzyloxymethyl-1,2-isoxazoline derivative is represented by the formula(I), in which each X1, X2 and X3 represents hydrogen, methyl group, ethyl group, halogen group, methoxy group or nitro group (provided that it is an exception that X1, X2 and X3 are decimals all together); and Y1, Y2 and Y3 are respectively hydrogen or fluorine.

Abstract translation: 目的：提供具有优异除草活性的5-苄氧基甲基-1,2-异恶唑啉衍生物，其制造方法和含有该衍生物作为活性成分的除草剂。 构成：5-苄氧基甲基-1,2-异恶唑啉衍生物由式（I）表示，其中X1，X2和X3各自表示氢，甲基，乙基，卤素基，甲氧基或硝基（条件是它 是一个例外，X1，X2和X3都是小数） Y1，Y2和Y3分别为氢或氟。

公开(公告)号：KR100322236B1

公开(公告)日：2002-02-07

申请号：KR1019990040742

申请日：1999-09-21

Applicant: 한국화학연구원

Inventor： 유응걸 ,  김형래 ,  송종환 ,  전동주 ,  김경만 ,  이정노 ,  홍경식

IPC: A01N43/00

Abstract: 본발명은다음화학식 1로표시되는신규의-(5-이속사졸린메틸옥시페닐)-3,4,5,6-테트라히드로프탈리미드유도체와이를유효성분으로포함하는제초제및 식물생장조절제에관한것이다. 상기화학식 1에서: R은발명의상세한설명란에서정의한바와같다. 또한, 본발명에따른상기화학식 1로표시되는화합물은입체이성질체또는이의라세믹혼합물을포함한다.

公开(公告)号：KR1020000056677A

公开(公告)日：2000-09-15

申请号：KR1019990006209

申请日：1999-02-25

Applicant: 한국화학연구원

Inventor： 유응걸 ,  전동주 ,  송종환 ,  김형래 ,  이정노 ,  김경만 ,  조광연

IPC: C07D235/00

CPC classification number: C07D413/12 ,  A01N43/80

Abstract: PURPOSE: 2-(5-Isoxazolinyl methyloxyphenyl)-4,5,6,7-tetrahydro-2H-indazole derivatives having herbicidal activity is provided which is useful as herbicides for control of paddy weeds. CONSTITUTION: A herbicidal compound of formula 1, their preparation method and their use as herbicides are described. In formula, X is Cl or hydroxy, R is C1-5 alkyl, substituted or unsubstituted phenyl, cyano, carboxylic acid group, carboxylic acid ester or substituted or unsubstituted hetero. As the compounds have excellent herbicidal activity against paddy weeds comprising ECHOR, SCPJU, MOOVA, CYPSE and SAGPY, and better selectivity, the compounds are typically useful as herbicides for control of paddy weeds in conditions with seeded rice and transferred rice.

Abstract translation: 目的：提供具有除草活性的2-（5-异唑啉基甲氧基苯基）-4,5,6,7-四氢-2H-吲唑衍生物，其可用作防治稻田杂草的除草剂。 构成：描述了式1的除草化合物，其制备方法及其作为除草剂的用途。 在式中，X为Cl或羟基，R为C 1-5烷基，取代或未取代的苯基，氰基，羧酸基，羧酸酯或取代或未取代的杂原子。 由于化合物对包括ECHOR，SCPJU，MOOVA，CYPSE和SAGPY的稻田杂草具有优异的除草活性，并且具有更好的选择性，所以化合物通常可用作用于在播种稻和转移稻的条件下控制稻田杂草的除草剂。

公开(公告)号：KR100070673B1

公开(公告)日：1994-02-03

申请号：KR1019910004063

申请日：1991-03-14

Applicant: 한국화학연구원

Inventor： 김대황 ,  전동주 ,  박상순 ,  우재춘 ,  김태준

IPC: C07D405/12

公开(公告)号：KR101769338B1

公开(公告)日：2017-08-30

申请号：KR1020150136231

申请日：2015-09-25

Applicant: 한국화학연구원

Inventor： 박보근 ,  정택모 ,  김창균 ,  전동주 ,  한정환 ,  한성호 ,  이선주

IPC: C07F15/06 ,  C07F13/00 ,  H01M4/525 ,  H01M4/505

Abstract: 본발명은전이금속함유전구체, 이의제조방법및 이를이용하여박막을제조하는방법에관한것으로, 본발명에따른전이금속함유전구체는열적안정성과휘발성이개선되어낮은온도에서도쉽게양질의코발트산화물또는망간산화물을포함하는박막의제조가가능하다.

公开(公告)号：KR1020170055274A

公开(公告)日：2017-05-19

申请号：KR1020150158237

申请日：2015-11-11

Applicant: 한국화학연구원

Inventor： 박보근 ,  정택모 ,  전동주 ,  한정환 ,  남지현 ,  김창균

IPC: C07F7/22 ,  C23C16/06 ,  C23C16/455 ,  H01L21/205 ,  H01L21/02

Abstract: 본발명은열적안정성과휘발성이개선된신규한주석전구체에관한것으로, 상기주석전구체를이용하여낮은온도에서우수한성장속도로, 쉽게양질의주석산화물박막을제조하는방법및 이를통해제조된박막을제공할수 있다.

Abstract translation: 本发明提供了热稳定性，并通过使用锡前体，可容易地制造优良品质的氧化锡薄膜的方法以及通过制备该薄膜涉及一种新的前体的锡的挥发性的提高，与在较低温度下优于增长率 你可以。