公开(公告)号：SI2674428T1

公开(公告)日：2016-07-29

申请号：SI200731780

申请日：2007-04-09

Applicant: VERTEX PHARMA

Inventor： RUAH SARA S HADIDA ,  GROOTENHUIS PETER D J ,  VAN GOOR FREDRICK ,  ZHOU JINGLAN ,  BEAR BRIAN ,  MILLER MARK T ,  MCCARTNEY JASON ,  NUMA MEHDI MICHEL JAMEL ,  YANG XIAOQING

IPC: C07D405/00 ,  A61K31/00 ,  A61P31/00 ,  C07D471/00

公开(公告)号：AU2010226400B2

公开(公告)日：2016-07-14

申请号：AU2010226400

申请日：2010-03-19

Applicant: VERTEX PHARMA

Inventor： DEMATTEI JOHN ,  LOOKER ADAM R ,  NEUBERT-LANGILLE BOBBIANNA ,  TRUDEAU MARTIN ,  ROEPER STEFANIE ,  RYAN MICHAEL P ,  YAP GUERETTE DAHRIKA MILFRED LAO ,  KRUEGER BRIAN R ,  GROOTENHUIS PETER D J ,  VAN GOOR FREDRICK F ,  BOTFIELD MARTYN C ,  ZLOKARNIK GREGOR

IPC: C07D215/233

Abstract: The invention provides a process for the preparation of a compound of Formula 1; comprising coupling a carboxylic acid of Formula 2; with an aniline of Formula 3; in the presence of a coupling agent.

公开(公告)号：BRPI1011506A8

公开(公告)日：2016-07-05

申请号：BRPI1011506

申请日：2010-03-19

Applicant: VERTEX PHARMA

Inventor： LOOKER ADAM R ,  NEUBERT-LANGILLE BOBBIANNA ,  KRUEGER BRIAN R ,  YAP DAHRIKA MILFRED LAO ,  GOOR FREDERICK F VAN ,  ZLOKARNIK GREGOR ,  DEMATTEI JOHN ,  TRUDEAU MARTIN ,  BOTFIELD MARTYN C ,  RYAN MICHAEL P ,  GROOTENHUIS PETER D J ,  ROEPER STEFANIE

IPC: C07D215/233

公开(公告)号：CA2705562C

公开(公告)日：2016-05-17

申请号：CA2705562

申请日：2008-11-14

Applicant: VERTEX PHARMA

Inventor： HADIDA RUAH SARA ,  MILLER MARK ,  ZHOU JINGLAN ,  BEAR BRIAN ,  GROOTENHUIS PETER D J

IPC: C07D217/22 ,  A61K31/472 ,  A61K31/4725 ,  A61P11/00 ,  C07D401/04 ,  C07D405/12 ,  C07D405/14

Abstract: Compounds of the present invention, of formula (I) and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator ("CFTR"). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.

公开(公告)号：CA2699382C

公开(公告)日：2016-05-10

申请号：CA2699382

申请日：2008-09-15

Applicant: VERTEX PHARMA

Inventor： BINCH HAYLEY ,  GROOTENHUIS PETER D J ,  HADIDA RUAH SARA S ,  ZHOU JINGLAN ,  HAZLEWOOD ANNA ,  FANNING LEV T D

IPC: C07D471/04 ,  A61K31/4375 ,  A61P3/00

Abstract: The present invention relates to modulators of ATP-B inding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.

公开(公告)号：PL2578571T3

公开(公告)日：2016-03-31

申请号：PL12181370

申请日：2008-11-14

Applicant: VERTEX PHARMA

Inventor： HADIDA RUAH SARA ,  MILLER MARK ,  ZHOU JINGLAN ,  BEAR BRIAN ,  GROOTENHUIS PETER D J

IPC: C07D217/22 ,  A61K31/472 ,  A61K31/4725 ,  A61P11/00 ,  C07D401/04 ,  C07D405/12 ,  C07D405/14

公开(公告)号：PL2408750T3

公开(公告)日：2016-02-29

申请号：PL10710749

申请日：2010-03-19

Applicant: VERTEX PHARMA

Inventor： DEMATTEI JOHN ,  LOOKER ADAM R ,  NEUBERT-LANGILLE BOBBIANNA ,  TRUDEAU MARTIN ,  ROEPER STEFANIE ,  RYAN MICHAEL P ,  YAP DAHRIKA MILFRED LAO ,  KRUEGER BRIAN R ,  GROOTENHUIS PETER D J ,  VAN GOOR FREDERICK F ,  BOTFIELD MARTYN C ,  ZLOKARNIK GREGOR

IPC: C07D215/233

公开(公告)号：BRPI0916877A2

公开(公告)日：2016-02-10

申请号：BRPI0916877

申请日：2009-08-13

Applicant: VERTEX PHARMA

Inventor： GROSSI ALFREDO ,  YOUNG CHRISTOPHER ,  OVERHOFF KIRK ,  DINEHART KRIK ,  VERWIJS MARINUS JACOBUS ,  BOTFIELD MARTYN ,  HURTER PATRICIA ,  GROOTENHUIS PETER D J ,  ROWE WILLIAM

IPC: A61K47/32

公开(公告)号：AU2009308232B2

公开(公告)日：2016-02-04

申请号：AU2009308232

申请日：2009-10-23

Applicant: VERTEX PHARMA

Inventor： BINCH HAYLEY ,  FANNING LEV T D ,  BOTFIELD MARTYN ,  GROOTENHUIS PETER D J ,  VAN GOOR FREDRICK ,  NUMA MEHDI MICHEL DJAMEL

IPC: C07D487/08 ,  A61K31/4709 ,  A61P11/00 ,  A61P43/00

Abstract: The present invention relates to modulators of cystic fibrosis transmembrane conductance regulator ("CFTR"), compositions thereof, and methods therewith. The present invention also relates to methods of treating diseases using modulators of CFTR (Formula I) or pharmaceutically acceptable salts thereof, wherein: ring A is selected from: (a), (b), (c), (d), wherein: R

公开(公告)号：PL2007756T3

公开(公告)日：2016-01-29

申请号：PL07755298

申请日：2007-04-09

Applicant: VERTEX PHARMA

Inventor： RUAH SARA S HADIDA ,  GROOTENHUIS PETER D J ,  VAN GOOR FREDRICK ,  ZHOU JINGLAN ,  BEAR BRIAN ,  MILLER MARK T ,  MCCARTNEY JASON ,  NUMA MEHDI MICHEL JAMEL ,  YANG XIAOQING

IPC: C07D405/12 ,  A61K31/404 ,  A61P31/00 ,  C07D405/14