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公开(公告)号：CA2135890A1
公开(公告)日：1994-07-07
申请号：CA2135890
申请日：1993-12-16
Applicant: ABBOTT LAB
Inventor： KEMPF DALE J , NORBECK DANIEL W , SHAM HING L , ZHAO CHEN , SOWIN THOMAS J , RENO DANIEL S , HAIGHT ANTHONY R , COOPER ARTHUR J
IPC: C07D275/02 , A61K31/395 , A61K31/415 , A61K31/4164 , A61K31/42 , A61K31/421 , A61K31/422 , A61K31/425 , A61K31/426 , A61K31/427 , A61K31/535 , A61K31/5375 , A61K31/5377 , A61K31/54 , A61K38/00 , A61K45/06 , A61P31/12 , A61P31/18 , A61P35/00 , A61P35/02 , A61P37/04 , A61P43/00 , C07C33/46 , C07C43/164 , C07C43/174 , C07C43/205 , C07C43/215 , C07C43/23 , C07C43/30 , C07C43/315 , C07C45/00 , C07C45/29 , C07C45/56 , C07C45/62 , C07C45/67 , C07C45/74 , C07C53/134 , C07C69/34 , C07C69/65 , C07C69/732 , C07C211/27 , C07C215/18 , C07C215/20 , C07C215/28 , C07C229/08 , C07C229/26 , C07C229/34 , C07C233/36 , C07C233/40 , C07C235/10 , C07C235/12 , C07C235/34 , C07C235/78 , C07C237/10 , C07C237/20 , C07C237/22 , C07C239/10 , C07C239/18 , C07C239/20 , C07C247/10 , C07C251/40 , C07C271/20 , C07C271/22 , C07C271/34 , C07C275/16 , C07C275/24 , C07C311/03 , C07C311/13 , C07C311/18 , C07C317/10 , C07C317/28 , C07C317/44 , C07C323/12 , C07C323/25 , C07C381/00 , C07D20060101 , C07D213/26 , C07D213/30 , C07D213/34 , C07D213/40 , C07D213/54 , C07D213/56 , C07D213/61 , C07D213/75 , C07D233/54 , C07D233/84 , C07D235/10 , C07D235/14 , C07D235/16 , C07D239/26 , C07D241/12 , C07D261/06 , C07D261/08 , C07D263/24 , C07D263/30 , C07D263/32 , C07D263/48 , C07D265/30 , C07D277/22 , C07D277/24 , C07D277/28 , C07D277/30 , C07D277/32 , C07D277/34 , C07D277/36 , C07D277/40 , C07D277/42 , C07D277/56 , C07D295/13 , C07D295/205 , C07D295/215 , C07D303/36 , C07D307/42 , C07D333/16 , C07D401/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D521/00 , C07F5/02 , C07F5/04 , C07K5/06 , C07K5/065
Abstract: A retroviral protease inhibiting compound of formula (A) is disclosed for use in combination with other active pharmaceutical agents for treating a human infected by HIV. Intermediates and processes useful in the manufacture of compounds of formula (A) are also disclosed.
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公开(公告)号：CA2170020A1
公开(公告)日：1994-06-30
申请号：CA2170020
申请日：1993-12-16
Applicant: ABBOTT LAB
Inventor： KEMPF DALE J , NORBECK DANIEL W , SHAM HING LEUNG , ZHAO CHEN , SOWIN THOMAS J , RENO DANIEL S , HAIGHT ANTHONY R , COOPER ARTHUR J
IPC: C07D275/02 , A61K31/395 , A61K31/415 , A61K31/4164 , A61K31/42 , A61K31/421 , A61K31/422 , A61K31/425 , A61K31/426 , A61K31/427 , A61K31/535 , A61K31/5375 , A61K31/5377 , A61K31/54 , A61K38/00 , A61K45/06 , A61P31/12 , A61P31/18 , A61P35/00 , A61P35/02 , A61P37/04 , A61P43/00 , C07C33/46 , C07C43/164 , C07C43/174 , C07C43/205 , C07C43/215 , C07C43/23 , C07C43/30 , C07C43/315 , C07C45/00 , C07C45/29 , C07C45/56 , C07C45/62 , C07C45/67 , C07C45/74 , C07C53/134 , C07C69/34 , C07C69/65 , C07C69/732 , C07C211/27 , C07C215/18 , C07C215/20 , C07C215/28 , C07C229/08 , C07C229/26 , C07C229/34 , C07C233/36 , C07C233/40 , C07C235/10 , C07C235/12 , C07C235/34 , C07C235/78 , C07C237/10 , C07C237/20 , C07C237/22 , C07C239/10 , C07C239/18 , C07C239/20 , C07C247/10 , C07C251/40 , C07C271/20 , C07C271/22 , C07C271/34 , C07C275/16 , C07C275/24 , C07C311/03 , C07C311/13 , C07C311/18 , C07C317/10 , C07C317/28 , C07C317/44 , C07C323/12 , C07C323/25 , C07C381/00 , C07D20060101 , C07D213/26 , C07D213/30 , C07D213/34 , C07D213/40 , C07D213/54 , C07D213/56 , C07D213/61 , C07D213/75 , C07D233/54 , C07D233/84 , C07D235/10 , C07D235/14 , C07D235/16 , C07D239/26 , C07D241/12 , C07D261/06 , C07D261/08 , C07D263/24 , C07D263/30 , C07D263/32 , C07D263/48 , C07D265/30 , C07D277/22 , C07D277/24 , C07D277/28 , C07D277/30 , C07D277/32 , C07D277/34 , C07D277/36 , C07D277/40 , C07D277/42 , C07D277/56 , C07D295/13 , C07D295/205 , C07D295/215 , C07D303/36 , C07D307/42 , C07D333/16 , C07D401/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D521/00 , C07F5/02 , C07F5/04 , C07K5/06 , C07K5/065
Abstract: A retroviral protease inhibiting compound of formula (A) is disclosed
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公开(公告)号：MX9204259A
公开(公告)日：1993-02-01
申请号：MX9204259
申请日：1992-07-21
Applicant: ABBOTT LAB
Inventor： KEMPF DALE J , NORBECK DANIEL W , CODACOVI LYNN M , PLATTNER JACOB J , SHAM HING LEUNG , CHENZHAO , WITTENBERGER STEVEN J
IPC: C12N15/00
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公开(公告)号：MX9203693A
公开(公告)日：1992-09-01
申请号：MX9203693
申请日：1992-06-29
Applicant: ABBOTT LAB
Inventor： KEMPF DALE J , CODACOVI LYNN M , NORBECK DANIEL W
IPC: C12N15/49
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公开(公告)号：CA2393271A1
公开(公告)日：1992-05-21
申请号：CA2393271
申请日：1991-11-15
Applicant: ABBOTT LAB
Inventor： WITTENBERGER STEVEN J , ZHAO CHEN , SHAM HING L , PLATTNER JACOB J , KEMPF DALE J , CODACOVI LYNN M , NORBECK DANIEL W
IPC: A61K31/42 , A61K31/421 , A61K31/425 , A61K31/426 , A61K31/427 , A61K31/435 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/4418 , A61K31/4427 , A61K31/443 , A61K31/444 , A61K38/00 , A61P31/12 , A61P31/18 , A61P43/00 , C07C53/134 , C07C211/00 , C07C215/18 , C07C215/20 , C07C215/28 , C07C215/30 , C07C215/80 , C07C219/18 , C07C233/40 , C07C237/10 , C07C237/22 , C07C269/04 , C07C271/02 , C07C271/16 , C07C271/20 , C07C271/22 , C07C271/34 , C07C275/24 , C07D20060101 , C07D213/00 , C07D213/26 , C07D213/30 , C07D213/34 , C07D213/36 , C07D213/40 , C07D213/54 , C07D213/56 , C07D213/61 , C07D213/75 , C07D213/79 , C07D215/20 , C07D233/54 , C07D233/84 , C07D235/14 , C07D235/16 , C07D237/10 , C07D239/26 , C07D241/12 , C07D261/08 , C07D261/12 , C07D263/20 , C07D263/32 , C07D277/20 , C07D277/24 , C07D277/28 , C07D277/30 , C07D277/32 , C07D277/34 , C07D277/36 , C07D277/40 , C07D277/42 , C07D277/56 , C07D295/02 , C07D295/13 , C07D295/205 , C07D295/215 , C07D303/36 , C07D307/34 , C07D307/42 , C07D307/66 , C07D333/16 , C07D333/36 , C07D401/12 , C07D405/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D521/00 , C07K1/113 , C07K5/06 , C07K5/065 , C07K5/08 , C07K14/81
Abstract: A retroviral protease inhibiting compound is diclosed. The compound is of the formula (see formule I) wherein R1 is hydrogen and R2 and R3 are independently selected from C6-aryl-C1-to-C6-alkyl, C9-to-C10-aryl-C1-to-C6-alkyl, C3-to-C7- cycloalkyl-C1-to-C6-alkyl and (heterocyclic)-C1-to-C6-alkyl; and A and B are independently selected from R6-C(O)-(NH)-(CH(R5))- C(O)- and R6-C(O)- wherein at each occurrence R6 is independently selected from R7-N(C1-to-C6-loweralkyl)-, R7-O- and R7-S- wherein R7 is heterocyclic or (heterocyclic)-C1-to-C6-alkyl and at each occurrence R5 is independently selected from C1-to-C6-loweralkyl; or a pharmaceutically acceptable salt, thereof. Also disclosed are a composition use and kit for inhibiting a retroviral protease and for treating an HIV infection. Also disclosed are processes and intermediates useful for the preparation of the retroviral protease inhibitors.
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Patent Agency Ranking
公开(公告)号：AU613956B2
公开(公告)日：1991-08-15
申请号：AU2222388
申请日：1988-09-14
Applicant: ABBOTT LAB
Inventor： BAKER WILLIAM R , KEMPF DALE J , SHAM HING LEUNG , DELLARIA JOSEPH F , ROSENBERG SAUL HOWARD
IPC: C07C271/10 , A61K31/395 , A61K31/415 , A61K31/42 , A61K31/421 , A61K31/535 , A61K31/536 , A61K31/5375 , A61K31/5377 , A61K31/538 , A61K31/54 , A61K38/00 , A61P9/12 , C07C67/00 , C07C69/24 , C07C213/00 , C07C215/10 , C07C215/20 , C07C215/28 , C07C217/08 , C07C217/28 , C07C229/22 , C07C229/26 , C07C229/30 , C07C229/32 , C07C229/34 , C07C229/36 , C07C231/00 , C07C231/02 , C07C233/11 , C07C233/22 , C07C233/40 , C07C233/47 , C07C233/51 , C07C235/20 , C07C237/12 , C07C237/20 , C07C239/20 , C07C255/46 , C07C265/02 , C07C265/04 , C07C271/16 , C07C271/20 , C07C271/22 , C07C275/24 , C07C317/28 , C07C317/44 , C07C317/48 , C07C323/24 , C07C323/41 , C07C323/56 , C07C323/59 , C07C323/60 , C07D207/12 , C07D211/76 , C07D213/40 , C07D233/32 , C07D233/61 , C07D263/04 , C07D263/06 , C07D263/16 , C07D263/22 , C07D263/24 , C07D263/28 , C07D265/10 , C07D273/04 , C07D277/24 , C07D285/10 , C07D295/12 , C07D295/13 , C07D295/185 , C07D295/205 , C07D295/215 , C07D295/22 , C07D309/14 , C07D319/06 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D521/00 , C07K5/02 , C07K5/06 , C07K5/065 , C07K5/08 , C07D263/08 , C07D317/38 , C07D233/34 , C07D239/10 , A61K37/64
Abstract: A renin inhibiting compound of the formula: wherein A is a substituent; W is C=O, CHOH or NR2 wherein R2 is hydrogen or loweralkyl; U is C=O, CH2 or NR2 wherein R2 is hydrogen or loweralkyl, with the proviso that when W is CHOH then U is CH2 and with the proviso that U is C=O or CH2 when W is NR2; V is CH, C(OH) or C(halogen) with the proviso that V is CH when U is NR2; R1 is loweralkyl, cycloalkylalkyl, benzyl, (alpha, alpha)-dimethylbenzyl, 4-methoxybenzyl, halobenzyl, 4-hydroxybenzyl, (1-naphthyl)methyl, (2-naphthyl)methyl, (unsubstituted heterocyclic)methyl, (substituted heterocyclic)methyl, phenethyl, 1-benzyloxyethyl, phenoxy, thiophenoxy or anilino, provided that B is CH2 or CHOH or A is hydrogen when R1 is phenoxy, thiophenoxy or anilino; R3 is loweralkyl, loweralkenyl, ((alkoxy)alkoxy)alkyl, carboxyalkyl, (thioalkoxy)alkyl, azidoalkyl, aminoalkyl, (alkyl)aminoalkyl, dialkylaminoalkyl, (alkoxy)(alkyl)aminoalkyl, (alkoxy)aminoalkyl, benzyl or heterocyclic ring substituted methyl; R4 is loweralkyl, cycloalkylmethyl or benzyl; R5 is OH or NH2; and Z is a substituent. Also disclosed are compositions for and a method of treating hypertension, methods of making the renin inhibiting compounds and intermediates useful in making the renin inhibiting compounds.
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公开(公告)号：DK59991D0
公开(公告)日：1991-04-04
申请号：DK59991
申请日：1991-04-04
Applicant: ABBOTT LAB
Inventor： FUNG ANTHONY K L , BAKER WILLIAM R , BOYD STEVEN A , KEMPF DALE J , ARMIGER YOEK-LIN , ROSENBERG SAUL H , DE BISWANATH , PLATTNER JACOB J , SHAM HING LEUNG , KLEINERT HOLLIS D , MANTEI ROBERT A
IPC: A61K31/16 , A61K31/19 , A61K31/265 , A61K31/415 , A61K31/4166 , A61K31/445 , A61K31/4465 , A61K31/66 , A61P9/00 , A61P9/12 , A61P43/00 , C07C237/08 , C07C237/22 , C07C317/28 , C07C323/57 , C07C323/58 , C07D203/18 , C07D211/44 , C07D211/46 , C07D211/62 , C07D211/96 , C07D233/36 , C07D233/54 , C07D233/56 , C07D263/22 , C07D295/185 , C07D401/12 , C07D407/12 , C07D413/12 , C07D521/00 , C07C237/20 , C07D205/04 , C07D233/64 , C07D295/182 , C07D405/12 , C07K5/06
Abstract: A renin inhibiting compound of the formula: wherein A is a substituent; R1 is hydrogen, loweralkyl, substituted loweralkyl or loweralkenyl; X is CH2, CHOH, C(O), O, S, S(O), SO2, NH, N(O) or -P(O)O-; R3 is loweralkyl, loweralkenyl or substituted loweralkyl; and T is mimic of the Leu-Val cleavage site of angiotensinogen; or a pharmaceutically acceptable salt, ester or prodrug thereof.
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公开(公告)号：AU3566089A
公开(公告)日：1989-11-29
申请号：AU3566089
申请日：1989-05-12
Applicant: ABBOTT LAB
Inventor： KEMPF DALE J , PLATTNER JACOB J , NORBECK DANIEL W , BOYD STEVEN A , BAKER WILLIAM R , ERICKSON JOHN W , CROWLEY STEVEN R , FUNG ANTHONY K L
IPC: A61K31/16 , A61K31/275 , A61K31/335 , A61K31/34 , A61K31/341 , A61K31/357 , A61K31/365 , A61K31/38 , A61K31/381 , A61K31/40 , A61K31/405 , A61K31/42 , A61K31/421 , A61K31/4245 , A61K31/425 , A61K31/426 , A61K31/428 , A61K31/44 , A61K31/535 , A61K31/5375 , A61K31/5377 , A61K31/54 , A61K38/00 , A61K38/55 , A61P31/12 , A61P43/00 , C07C233/36 , C07C233/47 , C07C235/10 , C07C235/12 , C07C237/10 , C07C237/12 , C07C237/22 , C07C271/22 , C07C317/44 , C07C323/60 , C07D207/12 , C07D207/337 , C07D213/81 , C07D231/12 , C07D233/32 , C07D233/36 , C07D233/64 , C07D239/04 , C07D239/10 , C07D257/04 , C07D263/06 , C07D263/16 , C07D263/20 , C07D263/22 , C07D263/24 , C07D263/26 , C07D265/06 , C07D265/10 , C07D271/10 , C07D273/00 , C07D277/28 , C07D277/64 , C07D277/66 , C07D295/20 , C07D295/205 , C07D295/215 , C07D307/14 , C07D307/28 , C07D307/58 , C07D307/68 , C07D309/04 , C07D309/20 , C07D317/34 , C07D317/36 , C07D333/38 , C07D407/04 , C07D413/04 , C07D413/06 , C07K5/06 , C07K5/065 , C07K5/103 , C07K5/107 , C07K7/02 , A61K37/02 , C07K7/06 , C07K7/08 , C07K7/10
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公开(公告)号：ZA201101558B
公开(公告)日：2018-11-28
申请号：ZA201101558
申请日：2011-02-28
Applicant: ABBOTT LAB , ENANTA PHARM INC
Inventor： ENGSTROM KEN , GRIEME TIM , WAGAW SABLE H , CHEN HUI-JU , KU YIYIN , MEI JIANZHANG , GAI YONGHUA , LIU DONG , OR YAT SUN , SHANLEY JASON P , GRAMPOVNIK DAVID J , SUN YING , SHEIKH AHMAD , MCDANIEL KEITH F , KEMPF DALE J
Abstract: The present invention relates to novel macrocyclic compounds and methods of use thereof. The present invention further relates to pharmaceutical compositions comprising the compounds of the present invention, or pharmaceutically acceptable salts, esters, or prodrugs thereof, in combination with a pharmaceutically acceptable carrier or excipient.
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公开(公告)号：CA2736895C
公开(公告)日：2016-02-09
申请号：CA2736895
申请日：2009-09-10
Applicant: ENANTA PHARM INC , ABBOTT LAB
Inventor： KU YIYIN , MCDANIEL KEITH F , CHEN HUI-JU , SHANLEY JASON P , KEMPF DALE J , GRAMPOVNIK DAVID J , SUN YING , LIU DONG , GAI YONGHUA , OR YAT SUN , WAGAW SABLE H , ENGSTROM KEN , GRIEME TIM , SHEIKH AHMAD , MEI JIANZHANG
IPC: C07D487/04 , A61K31/473 , A61K31/498 , A61K31/501 , A61K31/506 , A61P31/14
Abstract: The present invention relates to novel macrocyclic compounds and methods of use thereof. The present invention further relates to pharmaceutical compositions comprising the compounds of the present invention, or pharmaceutically acceptable salts, esters, or prodrugs thereof, in combination with a pharmaceutically acceptable carrier or excipient.
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