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公开(公告)号：UY28538A1
公开(公告)日：2005-04-29
申请号：UY28538
申请日：2004-09-24
Applicant: VERTEX PHARMA
Inventor： BLANCO MIGUEL GARCIA-GUZMAN , BERGERON DANIELE , GROOTENHUIS PETER D J , HURLEY DENNIS , NAKATANI AKIKO , MAKINGS LEWIS R , DISEPIO DANIEL , RAFFAI GABRIEL
IPC: A61K31/495 , A61K31/496 , C07D295/02 , C07D295/033 , C07D295/073 , C07D295/096 , C07D295/135 , C07D295/155 , C07D309/14 , C07D451/02 , C07D451/04 , C07D493/08 , C07D241/00
Abstract: La presente invención se refiere a moduladores de receptores muscarínicos. La presente invención también proporciona composiciones que comprenden tales moduladores, y métodos con ellos para tratar enfermedades mediadas por receptores muscarínicos.
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172.发明专利
公开(公告)号：CA2540978A1
公开(公告)日：2005-04-21
申请号：CA2540978
申请日：2004-10-08
Applicant: VERTEX PHARMA
Inventor： MILLER MARK T , SINGH ASHVANI K , HAMILTON MATTHEW , HADIDA RUAH SARA S , GROOTENHUIS PETER D J
IPC: C07D307/87 , A61K31/00 , A61K31/335 , A61K31/38 , A61K31/40 , A61K31/41 , A61K31/435 , A61K31/495 , A61K45/06 , C07C233/11 , C07C233/22 , C07C233/60 , C07C233/65 , C07C233/73 , C07C235/34 , C07C235/46 , C07C235/48 , C07C307/00 , C07C311/16 , C07C311/17 , C07C323/60 , C07D209/42 , C07D213/82 , C07D215/54 , C07D215/56 , C07D217/26 , C07D231/14 , C07D231/56 , C07D237/28 , C07D261/20 , C07D307/68 , C07D307/85 , C07D333/32 , C07D333/70 , C07D407/12
Abstract: The present invention provides compounds of Formula I useful as modulators of ABC transporter activity, or a pharmaceutically acceptable salt thereof, wherein RB, n, B, RC, RD, RE, A, and Z are described generally and in classes and subclasses below. The present invention also provides pharmaceutical compositions, methods and kits associated with Formula I, useful for as modulators, and for the treatments of disease and disease conditions associated with ABC transporter proteins.
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173.发明专利
公开(公告)号：AU2004279855A1
公开(公告)日：2005-04-21
申请号：AU2004279855
申请日：2004-10-08
Applicant: VERTEX PHARMA
Inventor： HAMILTON MATTHEW , SINGH ASHVANI K , RUAH SARA S HADIDA , MILLER MARK T , GROOTENHUIS PETER D J
IPC: A61K31/00 , A61K31/335 , A61K31/38 , A61K31/40 , A61K31/41 , A61K31/435 , A61K31/495 , A61K45/06 , C07C233/11 , C07C233/22 , C07C233/60 , C07C233/65 , C07C233/73 , C07C235/34 , C07C235/46 , C07C235/48 , C07C307/00 , C07C311/16 , C07C311/17 , C07C323/60 , C07D209/42 , C07D213/82 , C07D215/54 , C07D215/56 , C07D217/26 , C07D231/14 , C07D231/56 , C07D237/28 , C07D261/20 , C07D307/68 , C07D307/85 , C07D307/87 , C07D333/32 , C07D333/70 , C07D407/12
Abstract: The present invention provides compounds of Formula I useful as modulators of ABC transporter activity, or a pharmaceutically acceptable salt thereof, wherein RB, n, B, RC, RD, RE, A, and Z are described generally and in classes and subclasses below. The present invention also provides pharmaceutical compositions, methods and kits associated with Formula I, useful for as modulators, and for the treatments of disease and disease conditions associated with ABC transporter proteins.
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公开(公告)号：CA2540186A1
公开(公告)日：2005-04-07
申请号：CA2540186
申请日：2004-09-27
Applicant: VERTEX PHARMA
Inventor： GROOTENHUIS PETER D J , BERGERON DANIELE , HURLEY DENNIS JAMES , DISEPIO DANIEL , NAKATANI AKIKO , MAKINGS LEWIS R , GARCIA-GUZMAN BLANCO MIGUEL , RAFFAI GABRIEL
IPC: A61K31/495 , A61K31/496 , A61P43/00 , C07D295/02 , C07D295/033 , C07D295/04 , C07D295/073 , C07D295/096 , C07D295/135 , C07D295/155 , C07D309/14 , C07D451/02 , C07D451/04 , C07D493/08
Abstract: The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.
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公开(公告)号：AU2004275836A1
公开(公告)日：2005-04-07
申请号：AU2004275836
申请日：2004-09-27
Applicant: VERTEX PHARMA
Inventor： RAFFAI GABRIEL , BERGERON DANIELE , HURLEY DENNIS JAMES , MAKINGS LEWIS R , BLANCO MIGUEL GARCIA-GUZMAN , DISEPIO DANIEL , NAKATANI AKIKO , GROOTENHUIS PETER D J
IPC: A61K31/495 , A61K31/496 , A61P43/00 , C07D295/02 , C07D295/033 , C07D295/04 , C07D295/073 , C07D295/096 , C07D295/135 , C07D295/155 , C07D309/14 , C07D451/02 , C07D451/04 , C07D493/08
Abstract: The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.
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Patent Agency Ranking
公开(公告)号：CA2537841A1
公开(公告)日：2005-03-24
申请号：CA2537841
申请日：2004-09-07
Applicant: VERTEX PHARMA
Inventor： GROOTENHUIS PETER D J , MAKINGS LEWIS R , CLEVELAND THOMAS , HAMILTON MATTHEW , SINGH ASHAVINI K , HADIDA RUAH SARA S , MILLER MARK T
IPC: C07D277/82 , A61K31/426 , A61K31/427 , A61P43/00 , C07D263/48 , C07D277/46 , C07D417/02 , C07D417/04 , C07D417/06 , C07D417/12
Abstract: The present invention relates to modulators of ATP-Binding Cassette ("ABC") transporters or fragments thereof, including CF Transmembrane Regulator ("CFTR"), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
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公开(公告)号：DK2464337T4
公开(公告)日：2024-07-22
申请号：DK10708442
申请日：2010-02-18
Applicant: VERTEX PHARMA
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公开(公告)号：ES2857152T3
公开(公告)日：2021-09-28
申请号：ES17204189
申请日：2009-08-13
Applicant: VERTEX PHARMA
Inventor： ROWE WILLIAM , HURTER PATRICIA , YOUNG CHRISTOPHER , DINEHART KIRK , VERWIJS MARINUS JACOBUS , OVERHOFF KIRK , GROOTENHUIS PETER D J , BOTFIELD MARTYN , GROSSI ALFREDO
Abstract: Una composición farmacéutica que comprende una dispersión sólida, en donde la dispersión sólida comprende: a) 80% en peso de N-[2,4-Bis(1,1-dimetiletil)-5-hidroxifenil]-1,4-dihidro-4-oxoquinolin-3-carboxamida (Compuesto 1) amorfa o sustancialmente amorfa por peso de la dispersión, en donde el Compuesto 1 sustancialmente amorfo comprende menos del 15% de Compuesto 1 cristalino, b) 19,5% en peso de succinato de acetato de hidroxipropilmetilcelulosa (HPMCAS) o copolímero de vinilpirrolidona/acetato de vinilo (PVP/VA) por peso de la dispersión, y c) 0,5% en peso de lauril sulfato de sodio (SLS) por peso de la dispersión.
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公开(公告)号：SI3330255T1
公开(公告)日：2021-03-31
申请号：SI201032047
申请日：2010-03-19
Applicant: VERTEX PHARMA
Inventor： DEMATTEI JOHN , LOOKER ADAM R , NEUBERT-LANGILLE BOBBIANNA , TRUDEAU MARTIN , ROPER STEFANIE , RYAN MICHAEL , YAP DAHRIKA MILFRED LAO , KRUEGER BRIAN R , GROOTENHUIS PETER D J , VAN GROOR FREDERICK F , BOTFIELD MARTYN C , ZLOKARNIK GREGOR
IPC: C07D215/00 , C07C229/00
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公开(公告)号：HRP20210208T1
公开(公告)日：2021-03-19
申请号：HRP20210208
申请日：2021-02-05
Applicant: VERTEX PHARMA
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