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    NOVEL TARGETED COMPOSITIONS FOR DIAGNOSTIC AND THERAPEUTIC USE
    11.
    发明申请
    NOVEL TARGETED COMPOSITIONS FOR DIAGNOSTIC AND THERAPEUTIC USE 审中-公开
    用于诊断和治疗用途的新目标组合物

    公开(公告)号：WO1996040285A1

    公开(公告)日：1996-12-19

    申请号：PCT/US1996009938

    申请日：1996-06-06

    Applicant: IMARx PHARMACEUTICAL CORP. ,  UNGER, Evan, C. ,  SHEN, Dekang ,  WU, Guanli

    Inventor： IMARx PHARMACEUTICAL CORP.

    IPC: A61K49/00

    CPC classification number: B82Y5/00 ,  A61K49/0002 ,  A61K49/223 ,  A61K49/227 ,  A61K49/228

    Abstract: Novel targeted compositions which may be used for diagnostic and therapeutic use. The compositions may comprise a lipid, a protein or a polymer and a gas, in combination with a targeting ligand. The targeting ligand targets tissues, cells or receptors, including myocardial cells, endothelial cells, epithelial cells, tumor cells and the glycoprotein GPIIbIIIa receptor. The contrast media can be used in conjunction with diagnostic imaging, such as ultrasound, as well as therapeutic applications, such as therapeutic ultrasound.

    Abstract translation: 可用于诊断和治疗用途的新型靶向组合物。 组合物可以包含与靶向配体组合的脂质，蛋白质或聚合物和气体。 靶向配体靶向组织，细胞或受体，包括心肌细胞，内皮细胞，上皮细胞，肿瘤细胞和糖蛋白GPIIbIIIa受体。 造影剂可以与诸如超声波的诊断成像结合使用，以及诸如治疗性超声的治疗应用。

    NOVEL METHODS OF IMAGING AND TREATMENT WITH TARGETED COMPOSITIONS
    13.
    发明申请
    NOVEL METHODS OF IMAGING AND TREATMENT WITH TARGETED COMPOSITIONS 审中-公开
    用靶向成分进行成像和处理的新方法

    公开(公告)号：WO0045856A3

    公开(公告)日：2001-02-15

    申请号：PCT/US0002620

    申请日：2000-02-02

    Applicant: IMARX PHARMACEUTICAL CORP

    Inventor： UNGR EVAN C ,  WU YUNQIU

    IPC: A61B8/00 ,  A61B8/08 ,  A61K49/00 ,  A61K49/22

    CPC classification number: A61K49/225 ,  A61K49/223 ,  A61K49/227 ,  A61K49/228 ,  B82Y5/00

    Abstract: Novel ultrasound methods comprising administering to a patient a targeted vesicle composition which comprises vesicles comprising a lipid, protein or polymer, encapsulating a gas, in combination with a targeting ligand, and scanning the patient using ultrasound. The scanning may comprise exposing the patient to a first type of ultrasound energy and then interrogating the patient using a second type of ultrasound energy. The targeting ligand preferably targets tissus, cells or receptors, including myocardial cells, endothelial cells, epithelial cells, tumor cells and the glycoprotein GPIIbIIIa receptor. The methods may be used to detect a thrombus, enhancement of an old or echogenic thrombus low concentrations of vesicles and vesicles targeted to tissues, cells or receptors.

    Abstract translation: 新型超声方法包括向患者施用靶向囊泡组合物，其包含包含脂质，蛋白质或聚合物的囊泡，包封气体，与靶向配体组合，以及使用超声波扫描患者。 扫描可以包括将患者暴露于第一类型的超声能量，然后使用第二类型的超声能量来询问患者。 靶向配体优选靶向组织，细胞或受体，包括心肌细胞，内皮细胞，上皮细胞，肿瘤细胞和糖蛋白GPIIbIIIa受体。 该方法可用于检测血栓，增强靶向组织，细胞或受体的老的或回声血栓低浓度的囊泡和囊泡。

    STABILIZED HOMOGENOUS SUSPENSIONS AS COMPUTED TOMOGRAPHY CONTRAST AGENTS
    16.
    发明申请
    STABILIZED HOMOGENOUS SUSPENSIONS AS COMPUTED TOMOGRAPHY CONTRAST AGENTS 审中-公开
    作为计算机对比剂的稳定的均质悬浮液

    公开(公告)号：WO1995032005A1

    公开(公告)日：1995-11-30

    申请号：PCT/US1995006491

    申请日：1995-05-22

    Applicant: IMARx PHARMACEUTICAL CORP.

    Inventor： IMARx PHARMACEUTICAL CORP. ,  UNGER, Evan, C.

    IPC: A61K49/04

    CPC classification number: A61K49/1806 ,  A61K49/0419

    Abstract: Novel stabilized suspensions of a gas as diagnostic contrast agents, including computed tomography (CT) and magnetic resonance (MR) contrast agents. In preferred embodiments, the suspensions comprise stabilized gas-filled microspheres. Also in some preferred embodiments, at least a portion of the gas is derived from a gaseous precursor.

    Abstract translation: 新型稳定的气体悬浮液作为诊断造影剂，包括计算机断层扫描（CT）和磁共振（MR）造影剂。 在优选的实施方案中，悬浮液包含稳定的充气微球。 同样在一些优选的实施方案中，至少一部分气体来自气态前体。

    IMPROVED METHODS FOR DIAGNOSTIC IMAGING INVOLVING THE USE OF A CONTRAST AGENT AND A CORONARY VASODILATOR
    18.
    发明申请
    IMPROVED METHODS FOR DIAGNOSTIC IMAGING INVOLVING THE USE OF A CONTRAST AGENT AND A CORONARY VASODILATOR 审中-公开
    涉及使用对比剂和冠状血管扩张剂的诊断成像的改进方法

    公开(公告)号：WO1998010799A1

    公开(公告)日：1998-03-19

    申请号：PCT/US1997014986

    申请日：1997-08-26

    Applicant: IMARx PHARMACEUTICAL CORP.

    Inventor： IMARx PHARMACEUTICAL CORP. ,  UNGER, Evan, C.

    IPC: A61K49/04

    CPC classification number: A61B5/411 ,  A61B5/201 ,  A61K49/223 ,  A61K49/227

    Abstract: Improved method for providing an image of an internal region of a patient, especially the cardiovascular region. Embodiments of the invention involve the administration to the patient of a contrast agent which comprises a vesicle composition comprising lipid or polymer vesicles and a gas or gaseous precursor, in combinationwith a coronary vasodilator. The patient is scanned using diagnostic imaging, such as ultrasound, to obtain a visible image of the region. The methods are particularly useful for diagnosing the presence of diseased tissue in the cardiovascular region of a patient, as well as for measuring blood flow in the cardiovascular region of a patient.

    Abstract translation: 用于提供患者，特别是心血管区域的内部区域的图像的改进方法。 本发明的实施方案涉及向患者施用造影剂，其包含与冠状血管扩张剂组合的包含脂质或聚合物囊泡和气体或气体前体的囊泡组合物。 使用诸如超声波之类的诊断成像扫描患者，以获得该区域的可见图像。 该方法对于诊断患者的心血管区域中的患病组织的存在以及用于测量患者的心血管区域中的血流量是特别有用的。

    IMPROVED METHODS FOR DIAGNOSTIC IMAGING BY REGULATING THE ADMINISTRATION RATE OF A CONTRAST AGENT
    19.
    发明申请
    IMPROVED METHODS FOR DIAGNOSTIC IMAGING BY REGULATING THE ADMINISTRATION RATE OF A CONTRAST AGENT 审中-公开
    通过调整对比剂的行政率进行诊断成像的改进方法

    公开(公告)号：WO1997048337A1

    公开(公告)日：1997-12-24

    申请号：PCT/US1997010510

    申请日：1997-06-16

    Applicant: IMARX PHARMACEUTICAL CORP.

    Inventor： IMARX PHARMACEUTICAL CORP. ,  UNGER, Evan, C. ,  MATSUNAGA, Terry, O. ,  FRITZ, Thomas, A. ,  RAMASWAMI, Varada, Rajan

    IPC: A61B05/055

    CPC classification number: A61K49/223 ,  Y10S977/801 ,  Y10S977/927 ,  Y10S977/928 ,  Y10S977/929 ,  Y10S977/93

    Abstract: Methods for providing an image of an internal region of a patient. Embodiments of the methods involve administering to the patient a contrast agent which comprises a vesicle composition comprising, in an aqueous carrier, a gas or gaseous precursor and vesicles comprising lipids, proteins or polymers. The patient is scanned using diagnostic imaging, such as ultrasound, to obtain a visible image of the region. The contrast agent is administered to the patient at a rate to substantially eliminate diagnostic artifacts in the image. The methods are particularly useful for diagnosing the presence of any diseased tissue in the patient.

    Abstract translation: 提供患者内部区域的图像的方法。 该方法的实施方案涉及向患者施用造影剂，其包含囊泡组合物，所述囊泡组合物在水性载体中包含气体或气体前体和包含脂质，蛋白质或聚合物的囊泡。 使用诸如超声波之类的诊断成像扫描患者，以获得该区域的可见图像。 将造影剂以基本上消除图像中的诊断伪像的速率施用于患者。 该方法对于诊断患者中任何患病组织的存在特别有用。

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