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11.发明授权신규한 페디오코커스 펜토사시우스 케이-643 균주, 상기 균주를 이용한 포도당항상성 개선용 인삼 발효 추출물 및 이의 제조방법 有权新型戊糖片球菌K-643和人参发酵产品的提取物使用戊糖片球菌K-643改善葡萄糖体内平衡及其制备方法
公开(公告)号：KR101149045B1
公开(公告)日：2012-06-19
申请号：KR1020090109950
申请日：2009-11-13
Applicant: 한국식품연구원
Abstract: PURPOSE: A novel Pediococcus pentosaceus K-643(KFCC11464P) is provided to improve glucose homeostasis. CONSTITUTION: A novel Pediococcus pentosaceus K-643(KFCC11464P) is used in fermenting ginseng. A method for preparing the ginseng fermentation extract comprises: a step of fermenting ginseng with Pediococcus pentosaceus K-643(KFCC11464P) to obtain a fermentation; and a step of extracting the fermentation with a solvent and filtering. A pharmaceutical formulation and health food for maintaining or improving glucose homeostasis contains ginseng fermentation extract.
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公开(公告)号：KR1020120061019A
公开(公告)日：2012-06-12
申请号：KR1020100109063
申请日：2010-11-04
Applicant: 한국식품연구원
IPC: A61K31/198 , A61P3/04 , A61P3/06 , A61P3/10
Abstract: PURPOSE: A pharmaceutical composition and health functional food containing selenomethionine are provided to prevent and treat obesity and lipid-related metabolic diseases. CONSTITUTION: A pharmaceutical composition for preventing and treating obesity and lipid-related metabolic diseases contains selenomethionine as an active ingredient. The pharmaceutical composition is manufactured in the form of powder, granules, tablets, capsules, suspension, emulsion, syrup, suppository, or sterilized injection solution. Selenomethionine suppresses differentiation of adipocyte. A health functional food contains selenomethionine as an active ingredient. The health functional food is used in the form of capsules, tablets, granules, powder, or beverage.
Abstract translation: 目的：提供含有硒代甲硫氨酸的药物组合物和保健功能食品，用于预防和治疗肥胖症和与脂质有关的代谢疾病。 构成：用于预防和治疗肥胖症和与脂质有关的代谢疾病的药物组合物含有硒代甲硫氨酸作为活性成分。 药物组合物以粉末，颗粒，片剂，胶囊，悬浮液，乳剂，糖浆，栓剂或灭菌注射液的形式制备。 硒代甲硫氨酸抑制脂肪细胞的分化。 健康功能食品含有硒代甲硫氨酸作为活性成分。 保健功能食品以胶囊，片剂，颗粒，粉末或饮料的形式使用。
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13.发明公开바이오케닌에이 또는 약리학적으로 허용되는 이의 염을 활성성분으로 함유하는 신생혈관생성과 관련된 질환의 치료용 조성물 无效用于治疗与包含生物素或其药学上接受的药物的血管生成相关的疾病的组合物
公开(公告)号：KR1020120029557A
公开(公告)日：2012-03-27
申请号：KR1020100091411
申请日：2010-09-17
Applicant: 한국식품연구원
IPC: A61K31/352 , A61K36/48 , A61P35/00 , A61P27/02
Abstract: PURPOSE: A composition containing biochanin A or pharmaceutically acceptable salt thereof for treating angiogenesis-associated diseases is provided to treat various diseases. CONSTITUTION: A composition for treating angiogenesis-associated diseases contains biochanin A or pharmaceutically acceptable salt thereof as an active ingredient. The angiogenesis-associated diseases are cancer, diabetetic retinopathy, rheumatic arthritis, psoriasis, inflammation, endometriosis, aging or hemandioma. A pharmaceutical composition for suppressing angiogenesis contains biochanin A or pharmaceutically acceptable salt thereof as an active ingredient.
Abstract translation: 目的：提供含有角鲨他汀A或其药学上可接受的盐用于治疗血管生成相关疾病的组合物以治疗各种疾病。 构成：用于治疗血管生成相关疾病的组合物含有作为活性成分的角鲨他汀A或其药学上可接受的盐。 血管生成相关疾病是癌症，糖尿病性视网膜病变，风湿性关节炎，牛皮癣，炎症，子宫内膜异位症，衰老或血管瘤。 用于抑制血管发生的药物组合物含有作为活性成分的角鲨他汀A或其药学上可接受的盐。
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公开(公告)号：KR1020120019045A
公开(公告)日：2012-03-06
申请号：KR1020100082144
申请日：2010-08-24
Applicant: 한국식품연구원
Abstract: PURPOSE: A functional composition containing Akiami paste shrimp extract is provided to suppress adipocyte differentiation in a human body and PPAR-gamma transcription. CONSTITUTION: A method for preparing a functional composition containing Akiami paste shrimp extract for anti-obesity comprises: a step of adding 0.1%(v/v) of protease to Akiami paste shrimp and hydrolyzing at 55°C for 2 hours; a step of heating the mixture at 100°C for 10 minutes and inactivating the protease; and a step of cooling the mixture and centrifuging to isolate supernatant. A functional composition for anti-obesity contains the extract.
Abstract translation: 目的：提供含有秋叶酱虾提取物的功能组合物，以抑制人体脂肪细胞分化和PPAR-γ转录。 构成：含有用于抗肥胖的秋叶糊虾提取物的功能组合物的方法包括：向秋叶酱虾中加入0.1％（v / v）的蛋白酶并在55℃下水解2小时的步骤; 在100℃下加热混合物10分钟并使蛋白酶失活的步骤; 和冷却混合物并离心以分离上清液的步骤。 用于抗肥胖的功能组合物含有提取物。
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15.发明公开
公开(公告)号：KR1020120015221A
公开(公告)日：2012-02-21
申请号：KR1020100077551
申请日：2010-08-11
Applicant: 한국식품연구원
Abstract: PURPOSE: A composition containign sesamol or pharmaceutically acceptable salt is provided to suppress angiogenesis and to treat cancer, diabetic retinopathy, rheumatic arthritis, and psoriasis. CONSTITUTION: A composition for treating angiogenesis-associated diseases contains sesemol or pharmaceutically acceptable salt thereof as an active ingredient. The angiogenesis-associated diseases are cancer, diabetic retinopaghy, rheumatic arthritis, psoriasis, inflammation, endometriosis, and hemandioma. The sesamol or pharmaceutically acceptable salt thereof is contained in 0.1-10 wt%.
Abstract translation: 目的：提供含有塞萨莫酚或药学上可接受的盐的组合物以抑制血管生成并治疗癌症，糖尿病性视网膜病变，风湿性关节炎和牛皮癣。 构成：用于治疗血管生成相关疾病的组合物含有作为有效成分的西昔莫或其药学上可接受的盐。 血管生成相关疾病是癌症，糖尿病视网膜病，风湿性关节炎，牛皮癣，炎症，子宫内膜异位症和血管瘤。 芝麻酚或其药学上可接受的盐含量为0.1-10重量％。
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Patent Agency Ranking
公开(公告)号：KR1020120015206A
公开(公告)日：2012-02-21
申请号：KR1020100077529
申请日：2010-08-11
Applicant: 한국식품연구원
IPC: A61K31/785 , A61K31/765 , A61K31/74 , A61P3/04
CPC classification number: A61K31/785 , A23L33/175 , A61K31/195 , A61K31/765 , Y10S514/909
Abstract: PURPOSE: A composition containing poly gamma glutamic acid for preventing and treating obesity is provided to suppress differentiation of adipocytes and to activate AMPK(5'AMP-activated protein kinase). CONSTITUTION: A composition for preventing and treating obesity contains poly gamma glutamic acid(PGA) as an active ingredient. The molecular weight of PGA is 100kDa to 15,000kDa. The composition is a pharmaceutical composition or food additive. The composition further contains pharmacologically acceptable carrier. The composition is manufactured in the form of powder, granules, tablets, capsules, suspension, emulsion, syrup, external use, suppository, or sterilized injection solution.
Abstract translation: 目的：提供含有用于预防和治疗肥胖症的多聚谷氨酸的组合物，以抑制脂肪细胞的分化并激活AMPK（5'AMP激活的蛋白激酶）。 构成：用于预防和治疗肥胖症的组合物含有聚γ谷氨酸（PGA）作为活性成分。 PGA的分子量为100kDa至15,000kDa。 组合物是药物组合物或食品添加剂。 组合物还含有药理学上可接受的载体。 该组合物以粉末，颗粒，片剂，胶囊，悬浮液，乳剂，糖浆，外用，栓剂或灭菌注射液的形式制备。
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17.发明公开
公开(公告)号：KR1020110125940A
公开(公告)日：2011-11-22
申请号：KR1020100045593
申请日：2010-05-14
IPC: A61K36/232 , A61K31/37 , A61P3/04 , A61P3/00
CPC classification number: A61K36/232 , A61K31/216 , A61K31/235 , A61K31/366 , Y10S514/909
Abstract: PURPOSE: A composition containing derivatives synthesized from decursin for preventing or treating obesity is provided to suppress fatty acid synthesis. CONSTITUTION: A composition for preventing or treating obesity contains decursinol benzoate which is synthedized from decursin. The decursinol benzoate suppresses fatty acid synthesis by AMPK(5' adenosine monophosphate-activated protein kinase) activity. A method for synthesizing decursinol benzoate comprises: a step of performing enfleurage of dried Angelicae gigantis Radix in methanol at room temperature for seven days and filtering; a step of suspending the methanol extract in distilled water and isolating dichloromethane; and a step of freeze-drying and performing silicagel column chromatography to prepare six fraction.
Abstract translation: 目的：提供含有由前代素合成的用于预防或治疗肥胖症的衍生物的组合物以抑制脂肪酸合成。 构成：用于预防或治疗肥胖症的组合物含有由前胡素合成的去甲基苯甲酸酯。 苯酚去甲酚抑制AMPK（5'腺苷单磷酸激活蛋白激酶）活性的脂肪酸合成。 合成前酚醇苯甲酸酯的方法包括：在室温下在甲醇中进行七天的过滤干燥的当归香草， 将甲醇提取物悬浮在蒸馏水中并分离二氯甲烷的步骤; 和冷冻干燥并进行硅胶柱色谱以制备6份。
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公开(公告)号：KR1020090070305A
公开(公告)日：2009-07-01
申请号：KR1020070138273
申请日：2007-12-27
Applicant: 한국식품연구원
IPC: A61K36/258 , A61K36/074 , A61P3/10
Abstract: A polysaccharide fraction for reducing blood sugar, which produced by fermenting the Ganoderma lucidum(KCTC 6532) is provided to improve the function related to insulin resistance and suppress the apoptosis of pancreatic beta cell. A method for manufacturing a polysaccharide fraction for reducing blood sugar comprises: a step of fermenting a ginseng with a Gnoderma lucidum; a step of filtering the fermented material with distilled water; and a step of mixing the filtered solution and ethanol and obtaining precipitate of polysaccharide fraction. The Ganoderma lucidum is Ganoderma lucidum(KCTC 6532) The polysaccharide fraction increases the activity of glucokinase in a hepatocyte, and increases the phosphorylation of AkT protein, activates AMPK(AMP-activated protein kinase), and suppress the apoptosis of pancreatic beta cell.
Abstract translation: 提供了通过发酵灵芝（KCTC 6532）产生的用于降低血糖的多糖部分，以改善与胰岛素抵抗相关的功能并抑制胰腺β细胞的凋亡。 制备用于降低血糖的多糖部分的方法包括：用灵芝发酵人参的步骤; 用蒸馏水过滤发酵物料的步骤; 和将过滤的溶液和乙醇混合并获得多糖级分的沉淀物的步骤。 灵芝灵芝（KCTC 6532）多糖级分增加肝细胞中葡萄糖激酶的活性，增加AkT蛋白磷酸化，激活AMPK（AMP激活蛋白激酶），抑制胰腺β细胞凋亡。
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公开(公告)号：KR101760433B1
公开(公告)日：2017-07-24
申请号：KR1020150107475
申请日：2015-07-29
Applicant: 한국식품연구원
IPC: A61K36/752 , A61K9/16 , A61K9/20 , A23L1/30
Abstract: 본발명은유자의알코올추출물을유효성분으로함유하는골다공증의예방또는치료용약학조성물및 건강기능식품에관한것이다. 또한, 본발명은유자의골다공증예방및 치료효능의유효성분을최대한파괴하지않으면서골다공증예방및 치료효능이우수한, 최적화된유자의알코올추출방법에관한것이다.
Abstract translation: 本发明涉及用于预防或治疗含有枸橼醇提取物作为活性成分的骨质疏松症的药物组合物和保健功能食品。 本发明还涉及尽可能不破坏骨质疏松症预防和治疗效果的有效成分而优化用于预防和治疗骨质疏松症的柑橘类水果的醇提取方法。
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