公开(公告)号：NO20022156A

公开(公告)日：2002-07-04

申请号：NO20022156

申请日：2002-05-06

Applicant: ABBOTT LAB

Inventor： ELMORE STEVEN W ,  COOPER CURT S ,  SCHULTZ COLLEEN C ,  HUTCHINSON DOUGLAS K ,  DONNER PAMELA L ,  GREEN BRIAN E ,  ANDERSON DAVID D ,  XIE QINGHUA ,  DINGES JURGEN ,  LYNCH LINDA M

IPC: A61K31/4375 ,  A61K31/4436 ,  A61K31/444 ,  A61K31/4725 ,  A61K31/496 ,  A61K31/542 ,  A61P31/04 ,  A61P43/00 ,  C07B61/00 ,  C07D405/04 ,  C07D409/04 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D495/04 ,  C07D513/04 ,  C07D519/00 ,  A61K31/4709

CPC classification number: C07D405/04 ,  C07D409/04 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D495/04 ,  C07D513/04

公开(公告)号：CA2504385C

公开(公告)日：2012-12-18

申请号：CA2504385

申请日：2003-10-31

Applicant: ABBOTT LAB

Inventor： PRATT JOHN K ,  BETEBENNER DAVID A ,  DONNER PAMELA L ,  GREEN BRIAN E ,  KEMPF DALE J ,  MCDANIEL KEITH F ,  MARING CLARENCE J ,  STOLL VINCENT S ,  ZHANG RONG

IPC: C07D495/04 ,  A61K31/554 ,  A61P31/00 ,  C07D213/69 ,  C07D215/22 ,  C07D401/04 ,  C07D417/04 ,  C07D417/14 ,  C07D471/04 ,  C07D513/04 ,  C07D513/14 ,  C07D519/00

Abstract: The present invention provides an HCV polymerase inhibiting compound having the formula (I) and a composition comprising a therapeutically effective amount of said compound. The present invention also provides a method for inhibiting hepatitis C virus (HCV) polymerase, a method for inhibiting HCV viral replication, and a method for treating or preventing HCV infection. Processes for making said compounds, and synthetic intermediates employed in said processes, are also provided.

公开(公告)号：DK1560827T3

公开(公告)日：2011-04-18

申请号：DK03768559

申请日：2003-10-31

Applicant: ABBOTT LAB

Inventor： PRATT JOHN K ,  DONNER PAMELA L ,  GREEN BRIAN E ,  KEMPF DALE J ,  MCDANIEL KEITH F ,  MARING CLARENCE J ,  STOLL VINCENT S ,  BETEBENNER DAVID A ,  ZHANG RONG

IPC: C07D471/04 ,  A61K31/554 ,  A61P31/00 ,  C07D213/69 ,  C07D215/22 ,  C07D401/04 ,  C07D417/04 ,  C07D417/14 ,  C07D495/04 ,  C07D513/04 ,  C07D513/14 ,  C07D519/00

公开(公告)号：DE60335564D1

公开(公告)日：2011-02-10

申请号：DE60335564

申请日：2003-10-31

Applicant: ABBOTT LAB

Inventor： PRATT JOHN K ,  BETEBENNER DAVID A ,  DONNER PAMELA L ,  GREEN BRIAN E ,  KEMPF DALE J ,  MCDANIEL KEITH F ,  MARING CLARENCE J ,  STOLL VINCENT S ,  ZHANG RONG

IPC: C07D471/04 ,  A61K31/554 ,  A61P31/00 ,  C07D213/69 ,  C07D215/22 ,  C07D401/04 ,  C07D417/04 ,  C07D417/14 ,  C07D495/04 ,  C07D513/04 ,  C07D513/14 ,  C07D519/00

公开(公告)号：HK1122291A1

公开(公告)日：2009-05-15

申请号：HK09101287

申请日：2009-02-11

Applicant: ABBOTT LAB

Inventor： BETEBENNER DAVID A ,  DEGOEY DAVID A ,  MARING CLARENCE J ,  KRUEGER ALLAN C ,  IWASAKI NOBUHIKO ,  ROCKWAY TODD W ,  COOPER CURT S ,  ANDERSON DAVID D ,  DONNER PAMELA L ,  GREEN BRIAN E ,  KEMPF DALE J ,  LIU DACHUN ,  MCDANIEL KEITH F ,  MADIGAN DAROLD L ,  MOTTER CHRISTOPER E ,  PRATT JOHN K ,  SHANLEY JASON P ,  TUFANO MICHAEL D ,  WAGNER ROLF ,  ZHANG RONG ,  MOLLA AKHTERUZZAMAN ,  MO HONGMEI ,  PILOT-MATIAS TAMI J ,  MASSE SHERIE VL ,  CARRICK ROBERT J ,  HE WEPING ,  LU LIANGJUN ,  GRAMPOVNIK DAVID J

IPC: C07D20060101

Abstract: Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) or other viruses are disclosed. This invention is also directed to compositions comprising such compounds, co-formulation or co-administration of such compounds with other anti-viral or therapeutic agents, processes and intermediates for the syntheses of such compounds, and methods of using such compounds for the treatment of HCV or other viral infections.

公开(公告)号：BR0315897A

公开(公告)日：2008-05-13

申请号：BR0315897

申请日：2003-10-31

Applicant: ABBOTT LAB

Inventor： PRATT JOHN K ,  BETEBENNER DAVID A ,  DONNER PAMELA L ,  GREEN BRIAN E ,  KEMPF DALE J ,  MCDANIEL KEITH F ,  MARING CLARENCE J ,  STOLL VINCENT S ,  ZHANG RONG

IPC: C07D471/04 ,  A61K31/554 ,  A61P31/00 ,  C07D213/69 ,  C07D215/22 ,  C07D401/04 ,  C07D417/04 ,  C07D417/14 ,  C07D495/04 ,  C07D513/04 ,  C07D513/14 ,  C07D519/00

Abstract: The present invention provides an HCV polymerase inhibiting compound having the formula (I) and a composition comprising a therapeutically effective amount of said compound. The present invention also provides a method for inhibiting hepatitis C virus (HCV) polymerase, a method for inhibiting HCV viral replication, and a method for treating or preventing HCV infection. Processes for making said compounds, and synthetic intermediates employed in said processes, are also provided. formula (I)

公开(公告)号：PL376823A1

公开(公告)日：2006-01-09

申请号：PL37682303

申请日：2003-10-31

Applicant: ABBOTT LAB

Inventor： PRATT JOHN K ,  BETEBENNER DAVID A ,  DONNER PAMELA L ,  GREEN BRIAN E ,  KEMPF DALE J ,  MCDANIEL KEITH F ,  MARING CLARENCE J ,  STOLL VINCENT S ,  ZHANG RONG

IPC: C07D471/04 ,  A61K31/554 ,  A61P31/00 ,  C07D213/69 ,  C07D215/22 ,  C07D401/04 ,  C07D417/04 ,  C07D417/14 ,  C07D495/04 ,  C07D513/04 ,  C07D519/00

公开(公告)号：AU2003291670A1

公开(公告)日：2004-06-07

申请号：AU2003291670

申请日：2003-10-31

Applicant: ABBOTT LAB

Inventor： PRATT JOHN K ,  BETEBENNER DAVID A ,  DONNER PAMELA L ,  GREEN BRIAN E ,  KEMPF DALE J ,  MCDANIEL KEITH F ,  MARING CLARENCE J ,  STOLL VINCENT S ,  ZHANG RONG

IPC: A61P31/00 ,  C07D213/69 ,  C07D215/22 ,  C07D401/04 ,  C07D417/04 ,  C07D417/14 ,  C07D471/04 ,  C07D495/04 ,  C07D513/04 ,  C07D519/00 ,  C07D513/14 ,  A61K31/554

Abstract: The present invention provides an HCV polymerase inhibiting compound having the formula (I) and a composition comprising a therapeutically effective amount of said compound. The present invention also provides a method for inhibiting hepatitis C virus (HCV) polymerase, a method for inhibiting HCV viral replication, and a method for treating or preventing HCV infection. Processes for making said compounds, and synthetic intermediates employed in said processes, are also provided. formula (I)

公开(公告)号：BG106679A

公开(公告)日：2003-01-31

申请号：BG10667902

申请日：2002-05-09

Applicant: ABBOTT LAB

Inventor： ELMORE STEVEN W ,  COOPER CURT S ,  SCHULTZ COLLEEN C ,  HUTCHINSON DOUGLAS K ,  DONNER PAMELA L ,  GREEN BRIAN E ,  ANDERSON DAVID D ,  XIE QINGHUA ,  DINGES JURGEN ,  LYNCH LINDA M

IPC: A61K31/4375 ,  A61K31/4436 ,  A61K31/444 ,  A61K31/4725 ,  A61K31/496 ,  A61K31/542 ,  A61P31/04 ,  A61P43/00 ,  C07B61/00 ,  C07D405/04 ,  C07D409/04 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D495/04 ,  C07D513/04 ,  C07D519/00 ,  A61K31/4709 ,  C07D417/04

Abstract: Compounds having the formula are pharmaceutically acceptable salts or prodrugs thereof, are useful as antibacterial agents. 21 claims

公开(公告)号：AU1468901A

公开(公告)日：2001-05-14

申请号：AU1468901

申请日：2000-11-06

Applicant: ABBOTT LAB

Inventor： ELMORE STEVEN W ,  COOPER CURT S ,  SCHULTZ COLLEEN C ,  HUTCHINSON DOUGLAS K ,  DONNER PAMELA L ,  GREEN BRIAN E ,  ANDERSON DAVID D ,  XIE QINGHUA ,  DINGES JURGEN ,  LYNCH LINDA M

IPC: A61K31/4375 ,  A61K31/4436 ,  A61K31/444 ,  A61K31/4725 ,  A61K31/496 ,  A61K31/542 ,  A61P31/04 ,  A61P43/00 ,  C07B61/00 ,  C07D405/04 ,  C07D409/04 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D495/04 ,  C07D513/04 ,  C07D519/00 ,  C07D409/00