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11.发明专利
公开(公告)号：CA2315209C
公开(公告)日：2008-04-08
申请号：CA2315209
申请日：1998-11-17
Applicant: ABBOTT LAB
Inventor： RILEY DAVID A , KU YI-YIN , TIEN JIEN-HEH J , LEE ELAINE C
IPC: C07H17/08
Abstract: The claimed invention provides a novel method of preparing 6-O-methyl erythromycin A. The process comprises the steps of reducing the 9-keto group of erythromycin A to form a 9-hydroxy erythromycin A, protecting the 9-, 2'-, and/or 4"-hydroxyl groups of erythromycin A, selectively methylating the 6-position of the 9-hydroxy erythromycin A derivative, deprotecting the hydroxyl groups and oxidizing the 9-hydroxyl to afford 6-O-methyl erythromycin A.
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公开(公告)号：DK1272500T3
公开(公告)日：2005-09-05
申请号：DK00942860
申请日：2000-06-15
Applicant: ABBOTT LAB
Inventor： KU YI-YIN , COOPER ARTHUR J , HAIGHT ANTHONY R , RASMUSSEN MICHAEL , TIEN JIEN-HEH J , STONER ERIC J , PETERSON MATTHEW J , CINK RUSSELL D , DESHPANDE MAHENDRA N , GRIEME TIM , HILL DAVID R , HSU MARGARET CHI-PING , KING STEVEN A , LEANNA MARVIN R , LEE ELAINE C , MCLAUGHLIN MAUREEN A , MORTON HOWARD E , NAPIER JAMES J , PLATA DANIEL J , RAJE PRASAD S , RILEY DAVID , WITTENBERGER STEVEN J
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公开(公告)号：DE69825785T2
公开(公告)日：2005-08-18
申请号：DE69825785
申请日：1998-11-17
Applicant: ABBOTT LAB
Inventor： KU YI-YIN , RILEY DAVID A , LEE ELAINE C , TIEN JIEN-HEH J
IPC: C07H17/08
Abstract: The claimed invention provides a novel method of preparing 6-O-methyl erythromycin A. The process comprises the steps of reducing the 9-keto group of erythromycin A to form a 9-hydroxy erythromycin A, protecting the 9-, 2'-, and/or 4''-hydroxyl groups of erythromycin A, selectively methylating the 6-position of the 9-hydroxy erythromycin A derivative, deprotecting the hydroxyl groups and oxidizing the 9-hydroxyl to afford 6-O-methyl erythromycin A.
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公开(公告)号：DK1044209T3
公开(公告)日：2004-11-22
申请号：DK98959481
申请日：1998-11-17
Applicant: ABBOTT LAB
Inventor： RILEY DAVID A , KU YI-YIN , LEE ELAINE C , TIEN JIEN-HEH J
IPC: C07H17/08
Abstract: The claimed invention provides a novel method of preparing 6-O-methyl erythromycin A. The process comprises the steps of reducing the 9-keto group of erythromycin A to form a 9-hydroxy erythromycin A, protecting the 9-, 2'-, and/or 4''-hydroxyl groups of erythromycin A, selectively methylating the 6-position of the 9-hydroxy erythromycin A derivative, deprotecting the hydroxyl groups and oxidizing the 9-hydroxyl to afford 6-O-methyl erythromycin A.
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公开(公告)号：HK1053659A1
公开(公告)日：2003-10-31
申请号：HK03104301
申请日：2003-06-16
Applicant: ABBOTT LAB
Inventor： STONER ERIC J , PETERSON MATTHEW J , KU YI-YIN , CINK RUSSELL D , COOPER ARTHUR J , DESHPANDE MAHENDRA N , GRIEME TIM , HAIGHT ANTHONY R , HILL DAVID R , HSU MARGARET CHI-PING , KING STEVEN A , LEANNA MARVIN R , LEE ELAINE C , MCLAUGHLIN MAUREEN A , MORTON HOWARD E , NAPIER JAMES J , PLATA DANIEL J , RAJE PRASAD S , RASMUSSEN MICHAEL , RILEY DAVID , TIEN JIEN-HEH J , WITTENBERGER STEVEN J
Abstract: In one aspect, the invention relates to a process for preparing 6-O-substituted erythromycin derivatives comprising reacting 2'-substituted and optionally 4''-substituted 9-oxime erythromycin derivatives with an alkylating agent in the presence of a palladium catalyst and phosphine. In another aspect, the invention relates to processes for preparing 6-O-substituted erythromycin ketolides using the palladium-catalyzed alkylation reaction.
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Patent Agency Ranking
公开(公告)号：PT1272500E
公开(公告)日：2005-09-30
申请号：PT00942860
申请日：2000-06-15
Applicant: ABBOTT LAB
Inventor： COOPER ARTHUR J , HAIGHT ANTHONY R , KU YI-YIN , MORTON HOWARD E , PLATA DANIEL J , STONER ERIC J , PETERSON MATTHEW J , CINK RUSSELL D , DESHPANDE MAHENDRA N , TIM GRIEME , HILL DAVID R , CHI-PING HSU MARGARET , KING STEVEN A , LEANNA MARVIN R , LEE ELAINE C , MCLAUGHLIN MAUREEN A , NAPIER JAMES J , RAJE PRASAD S , MICHAEL RASMUSSEN , DAVID RILEY , TIEN JIEN-HEH J , WITTENBERGER STEVEN J
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公开(公告)号：DE60019976D1
公开(公告)日：2005-06-09
申请号：DE60019976
申请日：2000-06-15
Applicant: ABBOTT LAB
Inventor： STONER ERIC J , PETERSON MATTHEW J , KU YI-YIN , CINK RUSSELL D , COOPER ARTHUR J , DESHPANDE MAHENDRA N , GRIEME TIM , HAIGHT ANTHONY R , HILL DAVID R , HSU CHI-PING , KING STEVEN A , LEANNA MARVIN R , LEE ELAINE C , MCLAUGHLIN MAUREEN A , MORTON HOWARD E , NAPIER JAMES J , PLATA DANIEL J , RAJE PRASAD S , RASMUSSEN MICHAEL , RILEY DAVID , TIEN , WITTENBERGER
Abstract: In one aspect, the invention relates to a process for preparing 6-O-substituted erythromycin derivatives comprising reacting 2'-substituted and optionally 4''-substituted 9-oxime erythromycin derivatives with an alkylating agent in the presence of a palladium catalyst and phosphine. In another aspect, the invention relates to processes for preparing 6-O-substituted erythromycin ketolides using the palladium-catalyzed alkylation reaction.
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18.发明专利
公开(公告)号：ES2229552T3
公开(公告)日：2005-04-16
申请号：ES98959481
申请日：1998-11-17
Applicant: ABBOTT LAB
Inventor： KU YI-YIN , RILEY DAVID A , LEE ELAINE C , TIEN JIEN-HEH J
IPC: C07H17/08
Abstract: Un proceso para la preparación de 6-O-metil- eritromicina A que comprende: a) Proteger el grupo 2¿-hidroxilo de la eritromicina A para formar un derivado de eritromicina A protegido en 2¿; b) Reducir el grupo 9-ceto del derivado de eritromicina A protegido en 2¿ para formar un derivado de 9-hidroxi- eritromicina A protegido en 2¿; c) Proteger la 9-hidroxi eritromicina A protegida en 2¿ para formar un derivado de eritromicina A protegido en las posiciones 9 y en 2¿; d) Metilar la posición 6 del derivado de eritromicina A protegido en las posiciones 9 y en 2¿ para formar un derivado de 6-O-metil-eritromicina A protegido en las posiciones 9 y en 2¿. e) Desproteger el derivado de 6-O-metil-eritromicina A protegido en las posiciones 9 y 2¿ para formar un derivado de 9-hidroxi de eritromicina A 6-O-metilado; y f) Oxidar el 9-hidroxi de la 9-hidroxi eritromicina A 6-O- metilada para formar 6-O-metil-eritromicina A.
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公开(公告)号：DE60019976T2
公开(公告)日：2006-02-16
申请号：DE60019976
申请日：2000-06-15
Applicant: ABBOTT LAB
Inventor： STONER ERIC J , PETERSON MATTHEW J , KU YI-YIN , CINK RUSSELL D , COOPER ARTHUR J , DESHPANDE MAHENDRA N , GRIEME TIM , HAIGHT ANTHONY R , HILL DAVID R , HSU CHI-PING , KING STEVEN A , LEANNA MARVIN R , LEE ELAINE C , MCLAUGHLIN MAUREEN A , MORTON HOWARD E , NAPIER JAMES J , PLATA DANIEL J , RAJE PRASAD S , RASMUSSEN MICHAEL , RILEY DAVID , TIEN , WITTENBERGER
Abstract: In one aspect, the invention relates to a process for preparing 6-O-substituted erythromycin derivatives comprising reacting 2'-substituted and optionally 4''-substituted 9-oxime erythromycin derivatives with an alkylating agent in the presence of a palladium catalyst and phosphine. In another aspect, the invention relates to processes for preparing 6-O-substituted erythromycin ketolides using the palladium-catalyzed alkylation reaction.
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公开(公告)号：AU779219B2
公开(公告)日：2005-01-13
申请号：AU5742900
申请日：2000-06-15
Applicant: ABBOTT LAB
Inventor： STONER ERIC J , PETERSON MATTHEW J , KU YI-YIN , CINK RUSSELL D , COOPER ARTHUR J , DESHPANDE MAHENDRA N , GRIEME TIM , HAIGHT ANTHONY R , HILL DAVID R , HSU MARGARET CHI-PING , KING STEVEN A , LEANNA MARVIN R , LEE ELAINE C , MCLAUGHLIN MAUREEN A , MORTON HOWARD E , NAPIER JAMES J , PLATA DANIEL J , RAJE PRASAD S , RASMUSSEN MICHAEL , RILEY DAVID , TIEN JIEN-HEH J , WITTENBERGER STEVEN J
Abstract: In one aspect, the invention relates to a process for preparing 6-O-substituted erythromycin derivatives comprising reacting 2'-substituted and optionally 4''-substituted 9-oxime erythromycin derivatives with an alkylating agent in the presence of a palladium catalyst and phosphine. In another aspect, the invention relates to processes for preparing 6-O-substituted erythromycin ketolides using the palladium-catalyzed alkylation reaction.
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