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公开(公告)号：JP2010065035A
公开(公告)日：2010-03-25
申请号：JP2009208935
申请日：2009-09-10
Applicant: Abbott Lab , Enanta Pharmaceuticals Inc , アボット・ラボラトリーズAbbott Laboratories , エナンタ ファーマシューティカルズ インコーポレイテッド
Inventor： KU YIYIN , MCDANIEL KEITH F , CHEN HUI-JU , SHANLEY JASON P , KEMPF DALE J , GRAMPOVNIK DAVID J , SUN YING , LIU DONG , GAI YONGHUA , OR YAT SUN , WAGAW SABLE H , ENGSTROM KEN , GRIEME TIM
IPC: C07D487/04 , A61K31/473 , A61K31/498 , A61K31/506 , A61P31/12 , A61P43/00
CPC classification number: C07K1/113 , C07D487/04
Abstract: PROBLEM TO BE SOLVED: To provide a large cyclic compound, and to provide a method for using the large cyclic compound. SOLUTION: A pharmaceutical composition is provided. The composition comprises a compound, e.g., tert-butyl(2R,6S,13aS,14aR,16aS,Z)-2-(3-(benzo[d]thiazol-2-yl)quinoxalin-2-yloxy)-14a-(cyclopropylsulfonylcarbamoyl)-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diaza cyclopentadecin-6-yl carbamate or its pharmaceutically permissible salt, ester or prodrug, in combination with a pharmaceutically permissible carrier or excipient. COPYRIGHT: (C)2010,JPO&INPIT
Abstract translation: 待解决的问题：提供大的环状化合物，并提供使用该大环状化合物的方法。 解决方案：提供药物组合物。 组合物包含化合物，例如（2R，6S，13aS，14aR，16aS，Z）-2-（3-（苯并[d]噻唑-2-基）喹喔啉-2-基氧基） （环丙基）-5,16-二氧代1,2,3,5,6,7,8,9,10,11,13a，14,14A，15,16,16a十六[e]吡咯并[1,2 2-a] [1,4]二氮杂环戊烯-6-基氨基甲酸酯或其药学上允许的盐，酯或前药与药学上允许的载体或赋形剂组合。 版权所有（C）2010，JPO＆INPIT
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公开(公告)号：JP2013163680A
公开(公告)日：2013-08-22
申请号：JP2013092318
申请日：2013-04-25
Applicant: Abbott Lab , アボット・ラボラトリーズAbbott Laboratories , Enanta Pharmaceuticals Inc , エナンタ ファーマシューティカルズ インコーポレイテッド
Inventor： KU YIYIN , MCDANIEL KEITH F , CHEN HUI-JU , SHANLEY JASON P , KEMPF DALE J , GRAMPOVNIK DAVID J , SUN YING , LIU DONG , GAI YONGHUA , OR YAT SUN , WAGAW SABLE H , ENGSTROM KEN , GRIEME TIM
IPC: C07D487/04 , A61K31/473 , A61K31/4738 , A61K31/497 , A61K31/498 , A61K31/506 , A61P31/14 , A61P43/00 , C07D519/00
CPC classification number: C07K1/113 , C07D487/04
Abstract: PROBLEM TO BE SOLVED: To provide novel macrocyclic compounds and to provide methods for using the macrocyclic compounds.SOLUTION: The present invention further relates to pharmaceutical compositions comprising compounds, or pharmaceutically acceptable salts, esters or prodrugs thereof, in combination with a pharmaceutically acceptable carrier or excipient.
Abstract translation: 要解决的问题：提供新的大环化合物并提供使用大环化合物的方法。解决方案：本发明还涉及包含化合物或其药学上可接受的盐，酯或前药与药学上可接受的载体的药物组合物 或赋形剂。
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公开(公告)号：JP2013227314A
公开(公告)日：2013-11-07
申请号：JP2013092319
申请日：2013-04-25
Applicant: Abbott Lab , アボット・ラボラトリーズAbbott Laboratories , Enanta Pharmaceuticals Inc , エナンタ ファーマシューティカルズ インコーポレイテッド
Inventor： KU YIYIN , MCDANIEL KEITH F , CHEN HUI-JU , SHANLEY JASON P , KEMPF DALE J , GRAMPOVNIK DAVID J , SUN YING , LIU DONG , GAI YONGHUA , OR YAT SUN , WAGAW SABLE H , ENGSTROM KEN , GRIEME TIM
IPC: C07D487/04 , A61K31/473 , A61K31/497 , A61K31/498 , A61K31/501 , A61K31/506 , A61P1/16 , A61P31/14 , A61P43/00 , C07D519/00
CPC classification number: C07K1/113 , C07D487/04
Abstract: PROBLEM TO BE SOLVED: To provide a method for producing a macrocyclic compound useful in treating hepatitis C infection.SOLUTION: The present invention provides a method for producing a macrocyclic compound represented by a skeleton of the following formula: 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-14a-carboxamide.
Abstract translation: 待解决的问题：提供一种生产用于治疗丙型肝炎感染的大环化合物的方法。解决方案：本发明提供一种由下式的骨架代表的大环化合物的制备方法：1,2,3,5 ，6,7,8,9,10,11,13a，14,14a，15,16,16a-十六氢环丙基[e]吡咯并[1,2-a] [1,4]二氮杂环十八碳-α-14a-甲酰胺。
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公开(公告)号：JP2012136546A
公开(公告)日：2012-07-19
申请号：JP2012046166
申请日：2012-03-02
Applicant: Abbott Lab , Enanta Pharmaceuticals Inc , アボット・ラボラトリーズAbbott Laboratories , エナンタ ファーマシューティカルズ インコーポレイテッド
Inventor： KU YIYIN , MCDANIEL KEITH F , CHEN HUI-JU , SHANLEY JASON P , KEMPF DALE J , GRAMPOVNIK DAVID J , SUN YING , LIU DONG , GAI YONGHUA , OR YAT SUN , WAGAW SABLE H , ENGSTROM KEN , GRIEME TIM
IPC: C07D487/04 , A61K31/437 , A61K31/473 , A61K31/498 , A61P31/14 , C07D519/00
CPC classification number: C07K1/113 , C07D487/04
Abstract: PROBLEM TO BE SOLVED: To provide novel macrocyclic compounds, and to provide a method of using the macrocyclic compounds.SOLUTION: The present invention relates to pharmaceutical compositions comprising the compounds represented by the following formula (I) or (I'), or pharmaceutically acceptable salts, esters, or prodrugs thereof, in combination with a pharmaceutically acceptable carrier or excipient.
Abstract translation: 要解决的问题：提供新的大环化合物，并提供使用大环化合物的方法。 解决方案：本发明涉及药物组合物，其包含由下式（I）或（I'）表示的化合物或其药学上可接受的盐，酯或前药与药学上可接受的载体或赋形剂的组合。 版权所有（C）2012，JPO＆INPIT
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公开(公告)号：WO2010030359A8
公开(公告)日：2011-05-12
申请号：PCT/US2009005082
申请日：2009-09-10
Applicant: ENANTA PHARM INC , ABBOTT LAB , KU YIYIN , MCDANIEL KEITH F , CHEN HUI-JU , SHANLEY JASON P , KEMPF DALE J , GRAMPOVNIK DAVID J , SUN YING , LIU DONG , GAI YONGHUA , OR YAT SUN , WAGAW SABLE H , ENGSTROM KEN , GRIEME TIM , SHEIKH AHMAD , MEI JIANZHANG
Inventor： KU YIYIN , MCDANIEL KEITH F , CHEN HUI-JU , SHANLEY JASON P , KEMPF DALE J , GRAMPOVNIK DAVID J , SUN YING , LIU DONG , GAI YONGHUA , OR YAT SUN , WAGAW SABLE H , ENGSTROM KEN , GRIEME TIM , SHEIKH AHMAD , MEI JIANZHANG
CPC classification number: C07K1/113 , C07D487/04
Abstract: The present invention relates to novel macrocyclic compounds and methods of use thereof. The present invention further relates to pharmaceutical compositions comprising the compounds of the present invention, or pharmaceutically acceptable salts, esters, or prodrugs thereof, in combination with a pharmaceutically acceptable carrier or excipient.
Abstract translation: 本发明涉及新的大环化合物及其使用方法。 本发明还涉及包含本发明化合物或其药学上可接受的盐，酯或前药与药学上可接受的载体或赋形剂组合的药物组合物。
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Patent Agency Ranking6.发明申请
公开(公告)号：WO0078773A3
公开(公告)日：2001-02-22
申请号：PCT/US0016579
申请日：2000-06-15
Applicant: ABBOTT LAB
Inventor： STONER ERIC J , PETERSON MATTHEW J , KU YI-YIN , CINK RUSSELL D , COOPER ARTHUR J , DESHPANDE MAHENDRA N , GRIEME TIM , HAIGHT ANTHONY R , HILL DAVID R , HSU MARGARET CHI-PING , KING STEVEN A , LEANNA MARVIN R , LEE ELAINE C , MCLAUGHLIN MAUREEN A , MORTON HOWARD E , NAPIER JAMES J , PLATA DANIEL J , RAJE PRASAD S , RASMUSSEN MICHAEL , RILEY DAVID , TIEN JIEN-HEH J , WITTENBERGER STEVEN J
CPC classification number: C07H17/08
Abstract: In one aspect, the invention relates to a process for preparing 6-O-substituted erythromycin derivatives comprising reacting 2'-substituted and optionally 4"-substituted 9-oxime erythromycin derivatives with an alkylating agent in the presence of a palladium catalyst and phosphine. In another aspect, the invention relates to processes for preparing 6-O-substituted erythromycin ketolides using the palladium-catalyzed alkylation reaction.
Abstract translation: 一方面，本发明涉及一种制备6-O-取代的红霉素衍生物的方法，包括在钯催化剂和膦存在下使2'-取代的和任选的4'-取代的9-肟红霉素衍生物与烷基化剂反应。 另一方面，本发明涉及使用钯催化的烷基化反应制备6-O-取代的红霉素酮内酯的方法。
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公开(公告)号：WO2010030359A3
公开(公告)日：2010-05-27
申请号：PCT/US2009005082
申请日：2009-09-10
Applicant: ENANTA PHARJMACEUTICALS INC , ABBOTT LAB , KU YIYIN , MCDANIEL KEITH F , CHEN HUI-JU , SHANLEY JASON P , KEMPF DALE J , GRAMPOVNIK DAVID J , SUN YING , LIU DONG , GAI YONGHUA , OR YAT SUN , WAGAW SABLE H , ENGSTROM KEN , GRIEME TIM , SHEIKH AHMAD , MEI JIANZHANG
Inventor： KU YIYIN , MCDANIEL KEITH F , CHEN HUI-JU , SHANLEY JASON P , KEMPF DALE J , GRAMPOVNIK DAVID J , SUN YING , LIU DONG , GAI YONGHUA , OR YAT SUN , WAGAW SABLE H , ENGSTROM KEN , GRIEME TIM , SHEIKH AHMAD , MEI JIANZHANG
CPC classification number: C07K1/113 , C07D487/04
Abstract: The present invention relates to novel macrocyclic compounds and methods of use thereof. The present invention further relates to pharmaceutical compositions comprising the compounds of the present invention, or pharmaceutically acceptable salts, esters, or prodrugs thereof, in combination with a pharmaceutically acceptable carrier or excipient.
Abstract translation: 本发明涉及新的大环化合物及其使用方法。 本发明还涉及包含本发明化合物或其药学上可接受的盐，酯或前药与药学上可接受的载体或赋形剂组合的药物组合物。
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公开(公告)号：EP2340029A4
公开(公告)日：2012-06-13
申请号：EP09813360
申请日：2009-09-10
Applicant: ENANTA PHARM INC , ABBOTT LAB
Inventor： KU YIYIN , MCDANIEL KEITH F , CHEN HUI-JU , SHANLEY JASON P , KEMPF DALE J , GRAMPOVNIK DAVID J , SUN YING , LIU DONG , GAI YONGHUA , OR YAT SUN , WAGAW SABLE H , ENGSTROM KEN , GRIEME TIM , SHEIKH AHMAD , MEI JIANZHANG
IPC: A61K38/00 , A61K38/12 , C07D487/04
CPC classification number: C07K1/113 , C07D487/04
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公开(公告)号：AU2013205039A1
公开(公告)日：2013-05-16
申请号：AU2013205039
申请日：2013-04-13
Applicant: ABBOTT LAB , ENANTA PHARM INC
Inventor： KU YIYIN , MCDANIEL KEITH F , CHEN HUI-JU , SHANLEY JASON P , KEMPF DALE J , GRAMPOVNIK DAVID J , SUN YING , LIU DONG , YONGHUA GAI , OR YAT SUN , WAGAW SABLE H , ENGSTROM KEN , GRIEME TIM , SHEIKH AHMAD , MEI JIANZHANG
Abstract: MACROCYCLIC HEPATITIS C SERINE PROTEASE Abstract The present invention relates to novel macrocyclic compounds and methods of use thereof. The present invention further relates to pharmaceutical compositions comprising the compounds of the present invention, or pharmaceutical acceptable salts, esters, or prodrugs thereof, in combination with a pharmaceutical carrier or excipient.
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公开(公告)号：AT294809T
公开(公告)日：2005-05-15
申请号：AT00942860
申请日：2000-06-15
Applicant: ABBOTT LAB
Inventor： STONER ERIC J , PETERSON MATTHEW J , KU YI-YIN , CINK RUSSELL D , COOPER ARTHUR J , DESHPANDE MAHENDRA N , GRIEME TIM , HAIGHT ANTHONY R , HILL DAVID R , HSU MARGARET CHI-PING , KING STEVEN A , LEANNA MARVIN R , LEE ELAINE C , MCLAUGHLIN MAUREEN A , MORTON HOWARD E , NAPIER JAMES J , PLATA DANIEL J , RAJE PRASAD S , RASMUSSEN MICHAEL , RILEY DAVID , TIEN JIEN-HEH J , WITTENBERGER STEVEN J
Abstract: In one aspect, the invention relates to a process for preparing 6-O-substituted erythromycin derivatives comprising reacting 2'-substituted and optionally 4''-substituted 9-oxime erythromycin derivatives with an alkylating agent in the presence of a palladium catalyst and phosphine. In another aspect, the invention relates to processes for preparing 6-O-substituted erythromycin ketolides using the palladium-catalyzed alkylation reaction.
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