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公开(公告)号：WO2009067578A3
公开(公告)日：2009-11-26
申请号：PCT/US2008084142
申请日：2008-11-20
Applicant: ABBOTT LAB , VON GELDERN THOMAS W , BURKALOW JUFANG H , BARNES DAVID M , HAIGHT ANGHONY R , HENGEVELD JOHN E , LI XIAOFENG , MCLAUGHLIN MAUREEN A , NOONAN WILLIAM T , PEI ZHONGHUA , WU-WONG JINSHYUN RUTH
Inventor： VON GELDERN THOMAS W , BURKALOW JUFANG H , BARNES DAVID M , HAIGHT ANGHONY R , HENGEVELD JOHN E , LI XIAOFENG , MCLAUGHLIN MAUREEN A , NOONAN WILLIAM T , PEI ZHONGHUA , WU-WONG JINSHYUN RUTH
IPC: C07C401/00
CPC classification number: C07C401/00 , C07C2601/14 , C07C2602/24
Abstract: The invention relates to compounds that are vitamin D receptor activators, compositions comprising such compounds, methods of using such compounds and compositions, processes for preparing such compounds, and intermediates obtained during such processes.
Abstract translation: 本发明涉及作为维生素D受体激活剂的化合物，包含此类化合物的组合物，使用此类化合物和组合物的方法，制备此类化合物的方法以及在此类过程中获得的中间体。
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2.发明申请
公开(公告)号：WO0078773A3
公开(公告)日：2001-02-22
申请号：PCT/US0016579
申请日：2000-06-15
Applicant: ABBOTT LAB
Inventor： STONER ERIC J , PETERSON MATTHEW J , KU YI-YIN , CINK RUSSELL D , COOPER ARTHUR J , DESHPANDE MAHENDRA N , GRIEME TIM , HAIGHT ANTHONY R , HILL DAVID R , HSU MARGARET CHI-PING , KING STEVEN A , LEANNA MARVIN R , LEE ELAINE C , MCLAUGHLIN MAUREEN A , MORTON HOWARD E , NAPIER JAMES J , PLATA DANIEL J , RAJE PRASAD S , RASMUSSEN MICHAEL , RILEY DAVID , TIEN JIEN-HEH J , WITTENBERGER STEVEN J
CPC classification number: C07H17/08
Abstract: In one aspect, the invention relates to a process for preparing 6-O-substituted erythromycin derivatives comprising reacting 2'-substituted and optionally 4"-substituted 9-oxime erythromycin derivatives with an alkylating agent in the presence of a palladium catalyst and phosphine. In another aspect, the invention relates to processes for preparing 6-O-substituted erythromycin ketolides using the palladium-catalyzed alkylation reaction.
Abstract translation: 一方面，本发明涉及一种制备6-O-取代的红霉素衍生物的方法，包括在钯催化剂和膦存在下使2'-取代的和任选的4'-取代的9-肟红霉素衍生物与烷基化剂反应。 另一方面，本发明涉及使用钯催化的烷基化反应制备6-O-取代的红霉素酮内酯的方法。
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公开(公告)号：DK1272500T3
公开(公告)日：2005-09-05
申请号：DK00942860
申请日：2000-06-15
Applicant: ABBOTT LAB
Inventor： KU YI-YIN , COOPER ARTHUR J , HAIGHT ANTHONY R , RASMUSSEN MICHAEL , TIEN JIEN-HEH J , STONER ERIC J , PETERSON MATTHEW J , CINK RUSSELL D , DESHPANDE MAHENDRA N , GRIEME TIM , HILL DAVID R , HSU MARGARET CHI-PING , KING STEVEN A , LEANNA MARVIN R , LEE ELAINE C , MCLAUGHLIN MAUREEN A , MORTON HOWARD E , NAPIER JAMES J , PLATA DANIEL J , RAJE PRASAD S , RILEY DAVID , WITTENBERGER STEVEN J
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公开(公告)号：HK1053659A1
公开(公告)日：2003-10-31
申请号：HK03104301
申请日：2003-06-16
Applicant: ABBOTT LAB
Inventor： STONER ERIC J , PETERSON MATTHEW J , KU YI-YIN , CINK RUSSELL D , COOPER ARTHUR J , DESHPANDE MAHENDRA N , GRIEME TIM , HAIGHT ANTHONY R , HILL DAVID R , HSU MARGARET CHI-PING , KING STEVEN A , LEANNA MARVIN R , LEE ELAINE C , MCLAUGHLIN MAUREEN A , MORTON HOWARD E , NAPIER JAMES J , PLATA DANIEL J , RAJE PRASAD S , RASMUSSEN MICHAEL , RILEY DAVID , TIEN JIEN-HEH J , WITTENBERGER STEVEN J
Abstract: In one aspect, the invention relates to a process for preparing 6-O-substituted erythromycin derivatives comprising reacting 2'-substituted and optionally 4''-substituted 9-oxime erythromycin derivatives with an alkylating agent in the presence of a palladium catalyst and phosphine. In another aspect, the invention relates to processes for preparing 6-O-substituted erythromycin ketolides using the palladium-catalyzed alkylation reaction.
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公开(公告)号：DK0777655T3
公开(公告)日：2001-05-07
申请号：DK95927566
申请日：1995-08-03
Applicant: ABBOTT LAB
Inventor： EHRLICH PAUL P , MICHAELIDES MICHAEL R , MCLAUGHLIN MAUREEN A , HSAIO CHI-NUNG
IPC: C07D221/18 , C07D491/04 , C07D491/048 , C07D495/04 , A61K31/47
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Patent Agency Ranking
公开(公告)号：DE69519864D1
公开(公告)日：2001-02-15
申请号：DE69519864
申请日：1995-08-03
Applicant: ABBOTT LAB
Inventor： EHRLICH PAUL P , MICHAELIDES MICHAEL R , MCLAUGHLIN MAUREEN A , HSAIO CHI-NUNG
IPC: C07D221/18 , C07D491/04 , C07D491/048 , C07D495/04 , A61K31/47
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公开(公告)号：BRPI0820043A2
公开(公告)日：2015-05-12
申请号：BRPI0820043
申请日：2008-11-20
Applicant: ABBOTT LAB
Inventor： GELDERN THOMAS W VON , BARKALOW JUFANG H , BARNES DAVID M , HAIGHT ANTHONY R , HENGEVELD JOHN E , LI XIAOFENG , MCLAUGHLIN MAUREEN A , NOONAN WILLIAM T , PEI ZHONGHUA , WU-WONG JINSHYUN RUTH
IPC: C07C401/00
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公开(公告)号：CA2375364C
公开(公告)日：2008-11-25
申请号：CA2375364
申请日：2000-06-15
Applicant: ABBOTT LAB
Inventor： MCLAUGHLIN MAUREEN A , HAIGHT ANTHONY R , MORTON HOWARD E , PETERSON MATTHEW J , GRIEME TIM , RILEY DAVID , DESHPANDE MAHENDRA N , WITTENBERGER STEVEN J , NAPIER JAMES J , TIEN JIEN-HEH J , RAJE PRASAD S , PLATA DANIEL J , KU YI-YIN , CINK RUSSELL D , COOPER ARTHUR J , KING STEVEN A , RASMUSSEN MICHAEL , STONER ERIC J , HSU MARGARET CHI-PING , LEE ELAINE C , LEANNA MARVIN R , HILL DAVID R
IPC: C07H17/08 , A61K31/7048 , A61P31/04 , C07B61/00 , C07H1/00
Abstract: In one aspect, the invention relates to a process for preparing 6-O- substituted erythromycin derivatives comprising reacting 2'-substituted and optionally 4"-substituted 9-oxime erythromycin derivatives with an alkylating agent in the presence of a palladium catalyst and phosphine. In another aspect, the invention relates t o processes for preparing 6-O-substituted erythromycin ketolides using the palladium-catalyzed alkylation reaction.
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公开(公告)号：MX9701221A
公开(公告)日：1998-02-28
申请号：MX9701221
申请日：1995-08-03
Applicant: ABBOTT LAB
Inventor： EHRLICH PAUL P , MICHAELIDES MICHAEL R , MCLAUGHLIN MAUREEN A , HSAIO CHI-NUNG
IPC: A61K31/47 , C07D491/048 , C07D495/04
Abstract: Un procedimiento para la preparacion de un compuesto tetracíclico quiral de la formula (1), en donde R es hidrogeno o un grupo alquilo C1-C6 y Z es oxigeno, azufre o -CH=CH-, los compuestos teniendo usos como agonistas de dopamina. El procedimiento involucra hacer reaccionar un material de partida quiral y los intermediarios quirales subsecuentes en una serie de reacciones sintéticas de conservacion de quiralidad.
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公开(公告)号：MX2010005530A
公开(公告)日：2010-06-02
申请号：MX2010005530
申请日：2008-11-20
Applicant: ABBOTT LAB
Inventor： BARNES DAVID M , WU-WONG JINSHYUN RUTH , LI XIAOFENG , HENGEVELD JOHN E , GELDERN THOMAS W VON , BURKALOW JUFANG H , HAIGHT ANGHONY R , MCLAUGHLIN MAUREEN A , NOONAN WILLIAM T , PEI ZHONGHUA
IPC: C07C401/00
Abstract: La presente invención se refiere a compuestos que son activadores del receptor de vitamina D, composiciones que comprenden dichos compuestos, métodos para usar dichos compuestos y composiciones, procesos para preparar dichos compuestos e intermediarios obtenidos durante dichos procesos.
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