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公开(公告)号：MY136181A
公开(公告)日：2008-08-29
申请号：MYPI20014939
申请日：2001-10-24
Applicant: ABBOTT LAB
Inventor： CLAIBORNE AKIYO K , SULLIVAN GERARD M , TONG YUNSONG , WANG GARY T , WANG LE , WANG XILU , WANG WEIBO , GWALTNEY STEPHEN L II , HASVOLD LISA A , LI QUN , LI TONGMEI , LIN NAN-HORNG , MANTEI ROBERT A , ROCKWAY TODD W , SHAM HING L
IPC: A61K31/4164 , A61K31/4178 , A61K31/426 , A61K31/4439 , A61K31/4709 , A61P35/00 , A61P43/00 , C07D233/54 , C07D233/64 , C07D277/20 , C07D277/30 , C07D401/12 , C07D405/12 , C07D409/12
Abstract: SUBSTITUTED IMIDAZOLES AND THIAZOLES HAVING THE FORMULA I ARE USEFUL FOR INHIBITING FARNESYLTRANSFERASE.ALSO DISCLOSED ARE FARNESYLTRANSFERASE-INHIBITING COMPOSITIONS AND METHODS OF INHIBITING FARNESYLTRANSFERASE IN A PATIENT .
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公开(公告)号：DK1339695T3
公开(公告)日：2006-07-31
申请号：DK01273519
申请日：2001-11-30
Applicant: ABBOTT LAB
Inventor： CLAIBORNE AKIYO K , GWALTNEY STEPHEN L II , LI TOMGMEI , MANTEI ROBERT A , ROCKWAY TODD W , TONG YUNSONG , WANG GARY T , WANG XILU , WANG WEIBO , HASVOLD LISA A , LI QUN , LIN NAN-HORNG , SHAM HING L , SULLIVAN GERARD M , WANG LE
IPC: C07D233/64 , A61K31/4164 , A61K31/4178 , A61K31/426 , A61K31/4439 , A61K31/4709 , A61P35/00 , A61P43/00 , C07D233/54 , C07D277/20 , C07D277/30 , C07D401/12 , C07D405/12 , C07D409/12
Abstract: Substituted imidazoles and thiazoles having the formula are useful for inhibiting farnesyltransferase. Also disclosed are farnesyltransferase-inhibiting compositions and methods of inhibiting farnesyltransferase in a patient.
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公开(公告)号：BR0112028A
公开(公告)日：2004-02-17
申请号：BR0112028
申请日：2001-11-30
Applicant: ABBOTT LAB
Inventor： CLAIBORNE AKIYO K , GWALTNEY STEPHEN L II , HASVOLD LISA A , LI QUN , LI TOMGMEI , LIN NAN-HORNG , MANTEI ROBERT A , ROCKWAY TODD W , SHAM HING L , SULLIVAN GERARD M , TONG YUNSONG , WANG GARY T , WANG LE , WANG XILU , WANG WEIBO
IPC: A61K31/4164 , A61K31/4178 , A61K31/426 , A61K31/4439 , A61K31/4709 , A61P35/00 , A61P43/00 , C07D233/54 , C07D233/64 , C07D277/20 , C07D277/30 , C07D401/12 , C07D405/12 , C07D409/12
Abstract: Substituted imidazoles and thiazoles having the formula are useful for inhibiting farnesyltransferase. Also disclosed are farnesyltransferase-inhibiting compositions and methods of inhibiting farnesyltransferase in a patient.
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公开(公告)号：NO20032471A
公开(公告)日：2003-07-25
申请号：NO20032471
申请日：2003-05-30
Applicant: ABBOTT LAB
Inventor： CLAIBORNE AKIYO K , GWALTNEY II STEPHEN L , HASVOLD LISA A , LI QUN , LI TOMGMEI , LIN NAN-HORNG , MANTEI ROBERT A , ROCKWAY TODD W , SHAM HING L , SULLIVAN GERARD M , TONG YUNSONG , WANG GARY T , WANG LE , WANG XILU , WANG WEIBO
IPC: A61K31/4164 , A61K31/4178 , A61K31/426 , A61K31/4439 , A61K31/4709 , A61P35/00 , A61P43/00 , C07D233/54 , C07D233/64 , C07D277/20 , C07D277/30 , C07D401/12 , C07D405/12 , C07D409/12
CPC classification number: C07D233/64 , C07D401/12 , C07D405/12 , C07D409/12
Abstract: Substituted imidazoles and thiazoles having the formula are useful for inhibiting farnesyltransferase. Also disclosed are farnesyltransferase-inhibiting compositions and methods of inhibiting farnesyltransferase in a patient.
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公开(公告)号：DE60118955T2
公开(公告)日：2007-01-04
申请号：DE60118955
申请日：2001-11-30
Applicant: ABBOTT LAB
Inventor： CLAIBORNE K , GWALTNEY L , HASVOLD A , LI QUN , LI TOMGMEI , LIN NAN-HORNG , MANTEI A , ROCKWAY W , SHAM L , SULLIVAN M , TONG YUNSONG , WANG T , WANG LE , WANG XILU , WANG WEIBO
IPC: C07D233/64 , A61K31/4164 , A61K31/4178 , A61K31/426 , A61K31/4439 , A61K31/4709 , A61P35/00 , A61P43/00 , C07D233/54 , C07D277/20 , C07D277/30 , C07D401/12 , C07D405/12 , C07D409/12
Abstract: Substituted imidazoles and thiazoles having the formula are useful for inhibiting farnesyltransferase. Also disclosed are farnesyltransferase-inhibiting compositions and methods of inhibiting farnesyltransferase in a patient.
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Patent Agency Ranking
公开(公告)号：DE60118955D1
公开(公告)日：2006-05-24
申请号：DE60118955
申请日：2001-11-30
Applicant: ABBOTT LAB
Inventor： CLAIBORNE K , GWALTNEY L , HASVOLD A , LI QUN , LI TOMGMEI , LIN NAN-HORNG , MANTEI A , ROCKWAY W , SHAM L , SULLIVAN M , TONG YUNSONG , WANG T , WANG LE , WANG XILU , WANG WEIBO
IPC: C07D233/64 , A61K31/4164 , A61K31/4178 , A61K31/426 , A61K31/4439 , A61K31/4709 , A61P35/00 , A61P43/00 , C07D233/54 , C07D277/20 , C07D277/30 , C07D401/12 , C07D405/12 , C07D409/12
Abstract: Substituted imidazoles and thiazoles having the formula are useful for inhibiting farnesyltransferase. Also disclosed are farnesyltransferase-inhibiting compositions and methods of inhibiting farnesyltransferase in a patient.
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公开(公告)号：AT323681T
公开(公告)日：2006-05-15
申请号：AT01273519
申请日：2001-11-30
Applicant: ABBOTT LAB
Inventor： CLAIBORNE AKIYO K , GWALTNEY STEPHEN L II , HASVOLD LISA A , LI QUN , LI TOMGMEI , LIN NAN-HORNG , MANTEI ROBERT A , ROCKWAY TODD W , SHAM HING L , SULLIVAN GERARD M , TONG YUNSONG , WANG GARY T , WANG LE , WANG XILU , WANG WEIBO
IPC: A61K31/4164 , A61K31/4178 , A61K31/426 , A61K31/4439 , A61K31/4709 , A61P35/00 , A61P43/00 , C07D233/54 , C07D233/64 , C07D277/20 , C07D277/30 , C07D401/12 , C07D405/12 , C07D409/12
Abstract: Substituted imidazoles and thiazoles having the formula are useful for inhibiting farnesyltransferase. Also disclosed are farnesyltransferase-inhibiting compositions and methods of inhibiting farnesyltransferase in a patient.
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公开(公告)号：MXPA03004879A
公开(公告)日：2004-05-04
申请号：MXPA03004879
申请日：2001-11-30
Applicant: ABBOTT LAB
Inventor： WANG WEIBO
IPC: A61K31/4164 , A61K31/4178 , A61K31/426 , A61K31/4439 , A61K31/4709 , A61P35/00 , A61P43/00 , C07D233/54 , C07D233/64 , C07D277/20 , C07D277/30 , C07D401/12 , C07D405/12 , C07D409/12
Abstract: Los tiazoles e imidazoles substituidos teniendo la formula (I), son utiles para inhibir la farnesiltransferasa. Tambien se describen composiciones inhibidoras de farnesiltransferasa y metodos para inhibir farnesiltransferasa en un paciente. (ver formula).
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公开(公告)号：PE06872002A1
公开(公告)日：2002-08-03
申请号：PE0011982001
申请日：2001-11-29
Applicant: ABBOTT LAB
Inventor： CLAIBORNE AKIYO K , GWALTNEY II STEPHEN L , LI QUN , LIN NAN-HORNG , ROCKWAY TODD W , SULLIVAN GERARD M , WANG GARY T , WANG XILU , WANG WEIBO , WANG LE , TONG YUNSONG , SHAM HING L , MANTEI ROBERT A , LI TONGMEI , HASVOLD LISA A
IPC: A61K31/4164 , A61K31/4178 , A61K31/426 , A61K31/4439 , A61K31/4709 , A61P35/00 , A61P43/00 , C07D233/54 , C07D233/64 , C07D277/20 , C07D277/30 , C07D401/12 , C07D405/12 , C07D409/12 , C07D401/01
CPC classification number: C07D233/64 , C07D401/12 , C07D405/12 , C07D409/12
Abstract: SE REFIERE A IMIDAZOLES Y TIAZOLES DE FORMULA I DONDE E ES UN ANILLO CARBOCICLICO AROMATICO O NO AROMATICO DE CINCO, SEIS O SIETE MIEMBROS DONDE ENTRE 0-3 ATOMOS DE CARBONO ESTAN REEMPLAZADOS POR NITROGENO; F Y G SON C Y N CON LA SALVEDAD DE QUE CUANDO UNO DE F Y G ES N EL OTRO ES C; L1 Y L2 SON ALQUENILENO, ALQUINILENO, O, NR9, C(O), S, ENTRE OTROS; X ES S, NR7; R1 ES ARILO, ARILALQUILO, HETEROCICLO, (HETEROCICLO)ALQUILO; R2 ES H, ALCOXI, ALQUILO, AMINO, AMINOALQUILO, CIANO, CIANOALQUILO, ENTRE OTROS; R3 ES ARILO, HETEROCICLO Y CICLOALQUILO; R4-R6 SON H, NR9C(O), C(N)NR9, ALCANOILO, ALQUENILO, ENTRE OTROS; R7 ES H, ALQUILO, ARILO, CICLOALQUILO, ENTRE OTROS; R9 ES H, ALCOXIALQUILO, ALQUILO, AMIDOALQUILO, ENTRE OTROS; R12 ES H, ALCOXI, ALQUILO, ENTRE OTROS; m, n, p, q SON 0-4. SON COMPUESTOS PREFERIDOS 4-(((6-CLORO-2-(3-CLOROFENIL)-3-PIRIDINIL)METOXI)(1-METIL-1H-IMIDAZOL-5-IL)METIL)BENZONITRILO, 4-(((2-(3-CLOROFENIL)-6-METIL-3-PIRIDINIL)METOXI)(1-METIL-1H-IMIDAZOL-5-IL)METIL)BENZONITRILO, ENTRE OTROS. LOS COMPUESTOS MENCIONADOS SON INHIBIDORES DE LA FARNESIL TRANSFERASA Y SON UTILES PARA EL TRATAMIENTO DE TUMORES
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公开(公告)号：PL363637A1
公开(公告)日：2004-11-29
申请号：PL36363701
申请日：2001-11-30
Applicant: ABBOTT LAB
Inventor： CLAIBORNE AKIYO K , GWALTNEY STEPHEN L II , HASVOLD LISA A , LI QUN , LI TOMGMEI , LIN NAN-HORNG , MANTEI ROBERT A , ROCKWAY TODD W , SHAM HING L , SULLIVAN GERARD M , TONG YUNSONG , WANG GARY T , WANG LE , WANG XILU , WANG WEIBO
IPC: A61K31/4164 , A61K31/4178 , A61K31/426 , A61K31/4439 , A61K31/4709 , A61P35/00 , A61P43/00 , C07D233/54 , C07D233/64 , C07D277/20 , C07D277/30 , C07D401/12 , C07D405/12 , C07D409/12
Abstract: Substituted imidazoles and thiazoles having the formula are useful for inhibiting farnesyltransferase. Also disclosed are farnesyltransferase-inhibiting compositions and methods of inhibiting farnesyltransferase in a patient.
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