公开(公告)号：EP1976515A2

公开(公告)日：2008-10-08

申请号：EP07716699.9

申请日：2007-01-17

Applicant: ABBOTT LABORATORIES

Inventor： WERNET, Wolfgang ,  PENNING, Thomas D. ,  GIRANDA, Vincent L.

IPC: A61K31/41 ,  A61K31/4164 ,  C07D401/02 ,  C07D471/00 ,  A61K49/00

CPC classification number: C07D403/04 ,  A61K31/41 ,  A61K31/4164 ,  A61K41/0038 ,  A61K45/06 ,  A61N2005/1098 ,  A61K2300/00

Abstract: The present invention describes benzimidazole derivatives of Formula (I) which constitute potent PARP inhibitors in combination with radiotherapy or in combination with other chemotherapeutic agents.

公开(公告)号：EP1966157B1

公开(公告)日：2010-03-24

申请号：EP06837694.6

申请日：2006-11-15

Applicant: ABBOTT LABORATORIES

Inventor： PENNING, Thomas D. ,  THOMAS, Sheela A. ,  ZHU, Gui-Dong ,  GONG, Jianchun ,  GIRANDA, Vincent L. ,  GANDHI, Viraj B.

IPC: C07D235/18

CPC classification number: C07D235/18 ,  C07D409/04 ,  C07D413/04 ,  C07D417/04

Abstract: Compounds of Formula (I) inhibit the PARP enzyme and are useful for treating a disease or a disorder associated with PARP. Also disclosed are pharmaceutical compositions comprising compounds of Formula (I), methods of treatment comprising compounds of Formula (I), and methods of inhibiting the PARP enzyme comprising compounds of Formula (I).

公开(公告)号：EP2012780B1

公开(公告)日：2012-04-11

申请号：EP07761722.3

申请日：2007-05-02

Applicant: ABBOTT LABORATORIES

Inventor： GIRANDA, Vincent L. ,  PENNING, Thomas D. ,  GANDHI, Virajkumar B. ,  THOMAS, Sheela A. ,  ZHU, Gui-dong ,  GONG, Jianchun

IPC: C07D403/10 ,  C07D235/18 ,  C07D409/04 ,  A61P29/00 ,  A61P37/00 ,  A61K31/4184

CPC classification number: C07D403/10 ,  C07D235/18 ,  C07D409/04

Abstract: The present invention relates to 1H-benzimidazole-4-carboxamides of formula (I), their preparation, and their use as inhibitors of the enzyme poly(ADP-ribose)polymerase for the preparation of drugs.

公开(公告)号：EP2120579A1

公开(公告)日：2009-11-25

申请号：EP07869628.3

申请日：2007-12-20

Applicant: ABBOTT LABORATORIES

Inventor： GANDHI, Viraj B. ,  GIRANDA, Vincent L. ,  GONG, Jianchun ,  PENNING, Thomas D. ,  ZHU, Gui-dong

IPC: A01N43/58 ,  A61K31/50 ,  A61K31/495

CPC classification number: C07D403/10 ,  C07D237/32 ,  C07D403/12 ,  C07D403/14 ,  Y02P20/582

Abstract: Inhibitors of poly(ADP-ribose)polymerase, ways to make them and methods of treating patients using them are disclosed.

公开(公告)号：EP2069351A2

公开(公告)日：2009-06-17

申请号：EP07784490.0

申请日：2007-06-20

Applicant: ABBOTT LABORATORIES

Inventor： PENNING, Thomas D. ,  THOMAS, Sheela A. ,  HAJDUK, Philip J. ,  SAUER, Daryl R. ,  SARRIS, Kathy ,  GIRANDA, Vincent L.

IPC: C07D487/04 ,  A61K31/519

CPC classification number: C07D487/04

Abstract: The present invention relates to 1H-benzimidazole-4-carboxamides of formula (I), their preparation, and their use as inhibitors of the enzyme poly(ADP-ribose)polymerase for the preparation of drugs.

Abstract translation: 本发明涉及式（I）的1H-苯并咪唑-4-甲酰胺，它们的制备以及它们作为用于制备药物的聚（ADP-核糖）聚合酶聚合酶的抑制剂的用途。

公开(公告)号：EP2012780A2

公开(公告)日：2009-01-14

申请号：EP07761722.3

申请日：2007-05-02

Applicant: ABBOTT LABORATORIES

Inventor： GIRANDA, Vincent L. ,  PENNING, Thomas D. ,  GANDHI, Virajkumar B. ,  THOMAS, Sheela A. ,  ZHU, Gui-dong ,  GONG, Jianchun

IPC: A61K31/4184 ,  C07D403/02

CPC classification number: C07D403/10 ,  C07D235/18 ,  C07D409/04

Abstract: The present invention relates to 1H-benzimidazole-4-carboxamides of formula (I), their preparation, and their use as inhibitors of the enzyme poly(ADP-ribose)polymerase for the preparation of drugs.

公开(公告)号：EP2114948A2

公开(公告)日：2009-11-11

申请号：EP07855102.5

申请日：2007-12-12

Applicant: ABBOTT LABORATORIES

Inventor： GIRANDA, Vincent L. ,  MIYASHIRO, Julie M. ,  PENNING, Thomas D. ,  WOODS, Keith W.

IPC: C07D487/04 ,  C07D243/14 ,  C07D241/06 ,  C07D241/36 ,  A61K31/4188 ,  A61K31/4965 ,  A61K31/502 ,  A61K31/5513 ,  A61K31/5517

CPC classification number: C07D241/08 ,  C07D241/44 ,  C07D243/08 ,  C07D243/14 ,  C07D471/04 ,  C07D487/04

Abstract: Inhibitors of poly(ADP-ribose)polymerase, ways to make them and methods of treating patients using them are disclosed.

公开(公告)号：EP2021316A1

公开(公告)日：2009-02-11

申请号：EP07797725.4

申请日：2007-05-24

Applicant: ABBOTT LABORATORIES

Inventor： DIEBOLD, Robert B. ,  DJURIC, Stevan W. ,  GIRANDA, Vincent L ,  HEXAMER, Laura ,  LIN, Nan-horng ,  MIYASHIRO, Julie M. ,  PENNING, Thomas D. ,  PRZYTULINSKA, Magdalena ,  SOWIN, Thomas ,  SULLIVAN, Gerard ,  TAO, Zhi-fu ,  TONG, Yunsong ,  VASUDEVAN, Anil ,  WANG, Le ,  WOODS, Keith W. ,  XIA, Zhiren ,  ZHANG, Henry Q.

IPC: C07C225/20 ,  C07D249/14 ,  C07D277/64 ,  C07D285/06 ,  C07D333/20 ,  A61P35/00 ,  A61K31/132 ,  A61K31/505

CPC classification number: C07D249/14 ,  C07C225/20 ,  C07C2601/02 ,  C07C2601/04 ,  C07D277/64 ,  C07D285/06 ,  C07D333/20

Abstract: Compounds that inhibit Plk1, compositions containing the compounds and methods of treating diseases using the compounds are disclosed.

Abstract translation: 其中X1，C1和D1在本文中定义的式（I）化合物是polo样激酶的抑制剂。 式（I）化合物可用于治疗细胞增殖疾病，例如癌症。