公开(公告)号：CZ288448B6

公开(公告)日：2001-06-13

申请号：CZ326096

申请日：1995-04-26

Applicant: BASF AG

Inventor： AMBERG WILHELM DR ,  BERNARD HARALD DR ,  BUSCHMANN ERNST DR ,  HAUPT ANDREAS DR ,  JANITSCHKE LOTHAR DR ,  MUELLER STEFAN DR ,  DE POTZOLLI BERND DR ,  RITTER KURT DR ,  THYES MARCO DR ,  ZIERKE THOMAS DR ,  JANSSEN BERND DR ,  KARL ULRICH DR ,  KLING ANDREAS DR

IPC: A61K38/00 ,  A61K38/08 ,  A61P35/00 ,  C07K1/08 ,  C07K5/10 ,  C07K5/103 ,  C07K7/06 ,  C07K14/52

Abstract: In the present invention, there is described pentapeptide hydrochloride of the formula Mei2Val-Val-MeVal-Pro-Pro-NHBz1.HCl, which is present in crystalline form. It is prepared from the compound of the formula Z-Val-Val-MeVal-Pro-ORe1, in which Z represents a benzyloxycarbonyl protecting group, which might be optionally substituted on the phenyl ring and Re1 represents alkyl containing 1 to 5 carbon atoms. In the present invention, there are also described intermediates for preparing the above indicated pentapeptide hydrochloride. The above-described compound exhibits antineoplastic activity.

公开(公告)号：DE19527575A1

公开(公告)日：1997-01-30

申请号：DE19527575

申请日：1995-07-28

Applicant: BASF AG

Inventor： AMBERG WILHELM DR ,  BERNARD HARALD DR ,  BUSCHMANN ERNST DR ,  HAUPT ANDREAS DR ,  JANSSEN BERND DR ,  KARL ULRICH DR ,  KLING ANDREAS DR ,  MUELLER STEFAN DR ,  RITTER KURT DR ,  ZIERKE THOMAS DR

IPC: C07K1/02 ,  C07K1/12 ,  C07K5/06 ,  C07K5/078 ,  C07K5/08 ,  C07K5/083 ,  C07K5/10 ,  C07K5/103 ,  C07K7/06 ,  A61K38/08

Abstract: The description relates to a process for producing pentapeptides of the formula (I) in which A and R -R have the meanings given, in which the pentapeptide is constructed in steps from a prolinamide of the formula (II) in which R and R have the meanings given above, and the group -NR R may be hydrolytically separated from the peptide thus obtained.

公开(公告)号：DE19533023A1

公开(公告)日：1996-04-18

申请号：DE19533023

申请日：1995-09-07

Applicant: BASF AG

Inventor： RIECHERS HARTMUT DR ,  KLINGE DAGMAR DR ,  AMBERG WILHELM DR ,  KLING ANDREAS DR ,  MUELLER STEFAN DR ,  BAUMANN ERNST DR ,  RHEINHEIMER JOACHIM DR ,  VOGELBACHER UWE JOSEF DR ,  WERNET WOLFGANG DR ,  UNGER LILIANE DR ,  RASCHACK MANFRED DR

IPC: C07D251/30 ,  A61K31/505 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P11/08 ,  A61P13/02 ,  A61P15/00 ,  A61P25/04 ,  C07D239/00 ,  C07D239/26 ,  C07D239/28 ,  C07D239/34 ,  C07D239/38 ,  C07D239/60 ,  C07D239/70 ,  C07D239/96 ,  C07D251/12 ,  C07D251/52 ,  C07D257/02 ,  C07D309/00 ,  C07D403/06 ,  C07D403/12 ,  C07D405/12 ,  C07D417/12 ,  C07D487/04 ,  C07D491/04 ,  C07D491/044 ,  C07D491/048 ,  C07D495/04 ,  C07D409/12 ,  C07D413/12 ,  A61K31/41

Abstract: Carboxylic acid derivatives have the formula (I), in which R to R , X, Y, and Z have the meanings given in the description. Also disclosed is their preparation. These new compounds are useful for controlling diseases.

公开(公告)号：DE59103749D1

公开(公告)日：1995-01-19

申请号：DE59103749

申请日：1991-05-10

Applicant: BASF AG

Inventor： MUELLER STEFAN DR ,  THEOBALD HANS DR ,  WOLF BERND DR ,  HOFMEISTER PETER DR ,  KARDORFF UWE DR ,  KUENAST CHRISTOPH DR

IPC: A01N43/72 ,  A01N43/80 ,  A01N53/00 ,  A01N53/06 ,  C07D261/08 ,  C07D261/10 ,  C07D261/12 ,  C07D261/18 ,  C07D413/12

Abstract: 3-Isoxazolylbenzyl esters of the general formulae Ia and Ib Ia Ib where R is halogen, C1-C4-alkyl, C1-C4-haloalkyl, C1-C4-alkoxy, C1-C4-haloalkoxy, C2--C4-alkenyl, C2-C4-haloalkenyl, C2-C4-alkynyl, C2-C4-haloalkynyl, unsubstituted or substituted phenylethenyl, C3-C8-cycloalkyl, aryl, hetaryl, CO2R3 or CONR4R5, R3, R4 and R5 are each hydrogen or C1-C6-alkyl, n is 0, 1 or 2, and the radicals R may be different when n is 2, R1 is halogen or C1-C4-alkyl, R2 is hydrogen, C1-C4-alkyl, C2-C4-alkenyl, C2-C4-alkynyl or cyano and A is the carbonyl radical of an acid component usually found in pyrethroids, are contained in pesticides.

公开(公告)号：DE4137940A1

公开(公告)日：1993-05-19

申请号：DE4137940

申请日：1991-11-18

Applicant: BASF AG

Inventor： MUELLER STEFAN DR ,  THEOBALD HANS DR ,  RANG HARALD DR ,  HARRIES VOLKER DR

IPC: A01N55/00 ,  A01N55/10 ,  C07F7/08 ,  C07F7/10

Abstract: 3-isoxazolylphenyl compounds Ia and Ib, … … in which the substituents and the index have the following meaning: …… R represents halogen; alkyl; haloalkyl; alkoxy; haloalkoxy; alkenyl; haloalkenyl; optionally substituted phenylethenyl; alkynyl; cycloalkyl; aryl, hetaryl; CO2R or CONR R , … (R = hydrogen, alkyl, cycloalkyl and benzyl; R and R = hydrogen, alkyl, cycloalkyl and benzyl, or all together with the nitrogen atom to which they are bonded a heterocyclic radical), … n represents O, 1 or 2; … R represents halogen or alkyl; … R represents hydrogen; alkyl; alkenyl; alkynyl or cyano; … R and R independently of one another represent optionally substituted alkyl, alkenyl, cycloalkyl, phenyl, naphthyl, pyridyl or pyrimidyl; … or R and R together represent optionally substituted alkylene; … R represents hydrogen; … optionally substituted alkyl, or one of the groups mentioned in R ; … X represents a group CH2, O, S or NR … (R = hydrogen, alkyl, cycloalkyl, alkenyl, alkynyl or optionally substituted benzyl), … their preparation, compositions comprising them, and their use.