公开(公告)号：CO2024000890A2

公开(公告)日：2024-04-29

申请号：CO2024000890

申请日：2024-01-30

Applicant: PTC THERAPEUTICS INC

Inventor： KARP GARY MITCHELL ,  BABU SURESH ,  ALAM RAUFUL ,  BHATTACHARYYA ANURADHA ,  CHEN GUANGMING ,  EASTWOOD MATTHEW S ,  HOSSEYNI SEYEDMORTEZA ,  JIANG YAO ,  MOON YOUNG-CHOON ,  NARASIMHAN JANA ,  REN HONGYU ,  SYDORENKO NADIYA ,  WOLL MATTHEW G ,  ZHANG NANJING

IPC: C07D487/04 ,  A61K31/5025 ,  A61P25/14 ,  A61P25/28

Abstract: La presente descripción se refiere a compuestos, formas y composiciones farmacéuticas de los mismos y métodos de uso de dichos compuestos, formas o composiciones de los mismos para tratar o mejorar la enfermedad de Huntington. En particular, la presente descripción se refiere a compuestos de heteroarilo bicíclicos sustituidos, formas y composiciones farmacéuticas de los mismos y métodos de uso de dichos compuestos, formas o composiciones de los mismos para tratar o mejorar la enfermedad de Huntington.

公开(公告)号：AU2021254418A1

公开(公告)日：2022-11-03

申请号：AU2021254418

申请日：2021-04-08

Applicant: PTC THERAPEUTICS INC

Inventor： SYDORENKO NADIYA ,  ALAM RAUFUL ,  BABU SURESH ,  BHATTACHARYYA ANURADHA ,  CHEN GUANGMING ,  CHIERCHIA MATTEO ,  KARP GARY MITCHELL ,  LUONG TOM TUAN ,  MAZZOTTI ANTHONY R ,  MOON YOUNG-CHOON ,  MSZAR NICHOLAS WALTER ,  NARASIMHAN JANA ,  PATEL JIGAR S ,  REN HONGYU ,  WANG GANG ,  WOLL MATTHEW G ,  ZHANG NANJING ,  ZHANG XIAOYAN

IPC: C07D401/14 ,  A61K31/53 ,  A61P25/28 ,  C07D403/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D491/04 ,  C07D498/04 ,  C07D513/04

Abstract: The present description relates to compounds of Formula (I), forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.

公开(公告)号：AU2019294482B2

公开(公告)日：2022-09-01

申请号：AU2019294482

申请日：2019-06-25

Applicant: PTC THERAPEUTICS INC

Inventor： ZHANG NANJING ,  BABU SURESH ,  BARRAZA SCOTT J ,  BHATTACHARYYA ANURADHA ,  CHEN GUANGMING ,  KARP GARY MITCHELL ,  KASSICK ANDREW J ,  MAZZOTTI ANTHONY R ,  MOON YOUNG-CHOON ,  NARASIMHAN JANA ,  SYDORENKO NADIYA ,  TURPOFF ANTHONY ,  WOLL MATTHEW G ,  YAN WUMING

IPC: C07D417/14 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/46 ,  A61K31/496 ,  A61K31/5025 ,  A61K31/519 ,  A61K31/55 ,  A61P25/00 ,  A61P25/14 ,  A61P25/28 ,  C07D471/04 ,  C07D487/04 ,  C07D513/04 ,  C07D519/00

Abstract: The present description relates to compounds, forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease. In particular, the present description relates to substituted benzothiazole compounds of Formula (I) or (II), forms and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.

公开(公告)号：AU2022209304A1

公开(公告)日：2022-08-25

申请号：AU2022209304

申请日：2022-07-28

Applicant: PTC THERAPEUTICS INC

Inventor： ZHANG NANJING ,  BABU SURESH ,  BARRAZA SCOTT J ,  BHATTACHARYYA ANURADHA ,  CHEN GUANGMING ,  KARP GARY MITCHELL ,  KASSICK ANDREW J ,  MAZZOTTI ANTHONY R ,  MOON YOUNG-CHOON ,  NARASIMHAN JANA ,  SYDORENKO NADIYA ,  TURPOFF ANTHONY ,  WOLL MATTHEW G ,  YAN WUMING

IPC: C07D417/14 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/46 ,  A61K31/496 ,  A61K31/5025 ,  A61K31/519 ,  A61K31/55 ,  A61P25/00 ,  A61P25/14 ,  A61P25/28 ,  C07D471/04 ,  C07D487/04 ,  C07D513/04 ,  C07D519/00

Abstract: The present description relates to compounds, forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease. W3 R2 R 3 X (I) (II) In particular, the present description relates to substituted benzothiazole compounds of Formula (I), forms and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.

公开(公告)号：SG11202112504YA

公开(公告)日：2021-12-30

申请号：SG11202112504Y

申请日：2020-05-12

Applicant: PTC THERAPEUTICS INC

Inventor： SYDORENKO NADIYA ,  ALAM MD RAUFUL ,  AMEDZO LUKIANA ,  ARNOLD MICHAEL A ,  BABU SURESH ,  BHATTACHARYYA ANURADHA ,  KARP GARY MITCHELL ,  KENTON NATHANIEL T ,  LUONG TOM TUAN ,  MAZZOTTI ANTHONY R ,  MOON YOUNG-CHOON ,  MORRILL CHRISTIE ,  NARASIMHAN JANA ,  MSZAR NICHOLAS WALTER ,  PATEL JIGAR S ,  REN HONGYU ,  TURPOFF ANTHONY ,  WANG GANG ,  WOLL MATTHEW G ,  ZHANG NANJING ,  ZHANG XIAOYAN

IPC: C07D401/14 ,  A61K31/501 ,  A61K31/53 ,  A61P25/28 ,  C07D413/14 ,  C07D417/14 ,  C07D487/04

Abstract: The present description relates to compounds, forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease. In particular, the present description relates to substituted monocyclic heteroaryl compounds of Formula (I), Formula (II), or Formula (III), forms and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.

公开(公告)号：DK2812004T3

公开(公告)日：2018-10-15

申请号：DK13747100

申请日：2013-02-08

Applicant: PTC THERAPEUTICS INC ,  HOFFMANN LA ROCHE

Inventor： QI HONGYAN ,  DAKKA AMAL ,  KARP GARY MITCHELL ,  NARASIMHAN JANA ,  NARYSHKIN NIKOLAI ,  TURPOFF ANTHONY A ,  WELCH ELLEN ,  WOLL MATTHEW G ,  YANG TIANLE ,  ZHANG NANJING ,  ZHANG XIAOYAN ,  ZHAO XIN ,  CHOI SOONGYU ,  WEETALL MARLA L ,  GREEN LUKE ,  PINARD EMMANUEL ,  RATNI HASANE

IPC: A61K31/53 ,  A61K31/4375 ,  A61K31/519 ,  A61P25/00 ,  C07D471/04 ,  C07D487/04 ,  C07D519/00

公开(公告)号：SG10201609188WA

公开(公告)日：2016-12-29

申请号：SG10201609188W

申请日：2013-02-08

Applicant: PTC THERAPEUTICS INC ,  HOFFMANN LA ROCHE

Inventor： QI HONGYAN ,  CHOI SOONGYU ,  DAKKA AMAL ,  KARP GARY MITCHELL ,  NARASIMHAN JANA ,  NARYSHKIN NIKOLAI ,  TURPOFF ANTHONY A ,  WEETALL MARLA L ,  WELCH ELLEN ,  WOLL MATTHEW G ,  YANG TIANLE ,  ZHANG NANJING ,  ZHANG XIAOYAN ,  ZHAO XIN ,  GREEN LUKE ,  PINARD EMMANUEL ,  RATNI HASANE

Abstract: Provided herein are compounds of formula (IIa1), compositions thereof and uses therewith for treating spinal muscular atrophy.

公开(公告)号：ZA201402248B

公开(公告)日：2016-06-29

申请号：ZA201402248

申请日：2014-03-26

Applicant: PTC THERAPEUTICS INC

Inventor： ZHANG XIAOYAN ,  ZHANG NANJING ,  YANG TIANLE ,  WOLL MATTHEW G ,  SMITH SEAN WESLEY ,  QI HONGYAN ,  PEDDI SRINIVASA ,  NARASIMHAN JANA ,  GINZBURG OLYA ,  CHEN GUANGMING ,  BAIRD JOHN DAVID ,  WANG JIASHI ,  KARP GARY ,  GERASYUTO ALEKSEY I ,  ARNOLD MICHAEL ANDREW ,  JOSYULA VARA PRASAD VENKATA NAGENDRA ,  BRANSTROM ARTHUR

Abstract: The present description relates to compounds and forms and pharmaceutical compositions thereof and methods for use thereof to treat or ameliorate bacterial infections caused by wild-type and multi-drug resistant Gram-negative and Gram-positive pathogens.

公开(公告)号：NZ623063A

公开(公告)日：2016-04-29

申请号：NZ62306312

申请日：2012-08-29

Applicant: PTC THERAPEUTICS INC

Inventor： BRANSTROM ARTHUR ,  JOSYULA VARA PRASAD VENKATA NAGENDRA ,  ARNOLD MICHAEL ANDREW ,  KARP GARY ,  WANG JIASHI ,  CHEN GUANGMING ,  GINZBURG OLYA ,  NARASIMHAN JANA ,  PEDDI SRINIVASA ,  SMITH SEAN WESLEY ,  WOLL MATTHEW G ,  ZHANG NANJING ,  ZHANG XIAOYAN ,  BAIRD JOHN DAVID ,  QI HONGYAN ,  YANG TIANLE ,  GERASYUTO ALEKSEY I

IPC: A61K31/4412 ,  A61K31/437 ,  A61K31/4427 ,  A61K31/4439 ,  A61K31/4709 ,  A61K31/5377 ,  A61P31/04 ,  C07D401/04 ,  C07D401/14 ,  C07D405/14 ,  C07D413/04 ,  C07D471/04

Abstract: Provided are dihydropyridine derivative compounds of the general formula (I), wherein the variables are as defined in the specification. Examples of the compounds include 5-ethyl-6-(1-methyl-1,2,3,4-tetrahydroquinolin-6-yl)-2-oxo-1,2-dihydropyridine-3-carboxylic acid and 5-ethyl-4-hydroxy-2-oxo-6-(1H-pyrrolo[2,3-b]pyridin-6-yl)-1,2-dihydropyridine-3-carboxylic acid. The compounds are antibacterial agents.

公开(公告)号：CL2014002100A1

公开(公告)日：2015-10-23

申请号：CL2014002100

申请日：2014-08-08

Applicant: HOFFMANN LA ROCHE ,  PTC THERAPEUTICS INC

Inventor： PINARD EMMANUEL ,  NARASIMHAN JANA ,  QI HONGYAN ,  YANG TIANLE ,  ZHANG NANJING ,  ZHANG XIAOYAN ,  WOLL MATTHEW G ,  KARP GARY MITCHELL ,  NARYSHKIN NIKOLAI ,  WEETALL MARLA L ,  WELCH ELLEN ,  ZHAO XIN ,  GREEN LUKE ,  RATNI HASANE ,  CHOI SOONGYU ,  DAAKA AMAL ,  TURPOFF ANTHONY A

IPC: C07D239/70 ,  A61K31/519 ,  A61K31/55 ,  A61P21/00