公开(公告)号：GB2128402B

公开(公告)日：1986-03-05

申请号：GB8326055

申请日：1983-09-29

Applicant: SONY CORP

Inventor： ODA TATSUJI ,  MAMINE TAKAYOSHI ,  YONEYAMA OSAMU

IPC: H01S5/00 ,  H01S5/16 ,  H01S5/20 ,  H01S5/223 ,  H01S3/06

Abstract: A semiconductor laser device having a stripe light emission region formed in an active layer, a bent portion formed in the active layer on a light end portion of the light emission region in a range of approximately the width of the light emission region, and a flat portion formed in the active layer the width of which is made larger than that of the light emission region inside of the end portion of the light emission region.

公开(公告)号：GB2163288A

公开(公告)日：1986-02-19

申请号：GB8518182

申请日：1985-07-18

Applicant: SONY CORP

Inventor： MAMINE TAKAYOSHI ,  OKADA TSUNEKAZU ,  CHIBA MICHIRO

IPC: H01S5/00 ,  H01S5/223 ,  H01S3/19

Abstract: A semiconductor laser comprises a substrate (31) in which there are formed, in turn, a first cladding layer (32), an active layer (33), a second cladding layer (34) and a light absorbing layer (35) for limiting a current path and for absorbing light emitted from the active layer (33). The light absorbing layer (35) is provided with a stripe-shaped removed portion (35a) for forming the current path. The width (W) of the removed portion (35a) is selected to be in a range of from 1 to 4 microns, the thickness (d1) of the active layer (33) is selected to be not less than approximately 500 Angstroms, and the distance (d2) between the active layer (33) and the light absorbing layer (35) is selected to be in a range of from 0.2 to 0.7 microns.

公开(公告)号：GB2128402A

公开(公告)日：1984-04-26

申请号：GB8326055

申请日：1983-09-29

Applicant: SONY CORP

Inventor： ODA TATSUJI ,  MAMINE TAKAYOSHI ,  YONEYAMA OSAMU

IPC: H01S5/00 ,  H01S5/16 ,  H01S5/20 ,  H01S5/223 ,  H01S3/06

Abstract: A semiconductor laser device having a stripe light emission region formed in an active layer, a bent portion formed in the active layer on a light end portion of the light emission region in a range of approximately the width of the light emission region, and a flat portion formed in the active layer the width of which is made larger than that of the light emission region inside of the end portion of the light emission region.

公开(公告)号：EP1548103A4

公开(公告)日：2008-06-25

申请号：EP03792746

申请日：2003-08-20

Applicant: SONY CORP

Inventor： SEGAWA YUJI ,  MAMINE TAKAYOSHI ,  SAKAMOTO YASUHIRO ,  YOSHIO AKIRA ,  YAMAMOTO TAKURO

IPC: C12N15/00 ,  B01J19/00 ,  B01L3/00 ,  C12M1/00 ,  C12Q1/68 ,  G01N27/02 ,  G01N33/487 ,  G01N33/543

CPC classification number: B01J19/0046 ,  B01J2219/00436 ,  B01J2219/00529 ,  B01J2219/00576 ,  B01J2219/00596 ,  B01J2219/00608 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/0063 ,  B01J2219/00653 ,  B01J2219/00713 ,  B01J2219/00722 ,  B01L3/502761 ,  B01L2200/0663 ,  B01L2300/0819 ,  B01L2400/0424 ,  B03C5/005 ,  B03C5/026 ,  G01N33/54373

Abstract: A hybridization sensing part (1a) for improvement of hybridization efficiency by a contrivance of aligning and immobilizing a sensing nucleotide chain in an elongated state. The reaction region (R) to serve as a field of hybridization of a sensing nucleotide chain (X) and a target nucleotide chain (Y) having a base sequence complementary to the sensing nucleotide chain (X) can be immobilized at the end (E) of a scanning electrode (C) by dielectrophoresis while elongating the sensing nucleotide chain (X) by an electric field. A sensor chip having such a sensing part (1a) and a hybridization method using them are also disclosed.

公开(公告)号：EP1775589A4

公开(公告)日：2007-11-14

申请号：EP05768495

申请日：2005-08-04

Applicant: SONY CORP

Inventor： MAMINE TAKAYOSHI ,  SAKAMOTO YASUHIRO

IPC: G01N33/53 ,  C12M1/00 ,  C12M1/34 ,  C12M1/40 ,  C12Q1/68 ,  G01N21/64 ,  G01N21/78 ,  G01N33/543 ,  G01N33/566 ,  G01N35/04 ,  G01N37/00

CPC classification number: G01N33/5308 ,  G01N33/5438 ,  G01N35/00069

Abstract: There is provided a DNA chip- related technique capable of effectively performing hybridization in a short time and obtaining a highly accurate detection result. By using a disc-shaped substrate (1) or a DNA chip (10) including a detection unit (3) having at least a reaction area R as a place for hybridization and opposing electrodes (E

公开(公告)号：EP1548438A4

公开(公告)日：2005-11-09

申请号：EP03799124

申请日：2003-09-24

Applicant: SONY CORP

Inventor： MAMINE TAKAYOSHI ,  KINOSHITA TAKASHI

IPC: C12M1/00 ,  C12N15/09 ,  C12Q1/68 ,  G01N27/00 ,  G01N33/53 ,  G01N37/00 ,  G01Q10/00 ,  G01Q60/24 ,  G01Q80/00 ,  C12N15/00 ,  G01N13/16 ,  G01N33/566

CPC classification number: G01N29/036 ,  B82Y5/00 ,  C12Q1/6816 ,  G01N2291/0257 ,  C12Q2565/60

Abstract: In a cell detection unit (2), the end face (13a) of a cantilever (13) is surface-treated in advance to enable a detecting nucleotide chain (D) to be immobilized. In a reaction area (10), an electric field is produced by an anode (11) and a cathode (12) to move a target nucleotide chain (T) dripped from a nozzle (3) toward an end face (13a) while kept stretched. Since hybridizing between the detecting nucleotide chain (D) and the target nucleotide chain (T) increases the mass of a cantilever (13), a natural frequency decreases. When an ac voltage is applied to a cantilever (13) to measure a change in natural frequency, the presence or absence of hybridization is detected and the number or the like of the hybridized target nucleotide chains (T) is quantitatively detected.

公开(公告)号：EP1637872A4

公开(公告)日：2012-01-18

申请号：EP04736587

申请日：2004-06-10

Applicant: SONY CORP

Inventor： MAMINE TAKAYOSHI ,  SAKAMOTO YASUHIRO ,  FURUKI MOTOHIRO ,  NAKAO ISAMU

IPC: G01N21/64 ,  C12M1/00 ,  C12N15/09 ,  C12Q1/68 ,  G01N21/25 ,  G01N33/53 ,  G01N33/536 ,  G01N33/58 ,  G01N35/00 ,  G01N37/00

CPC classification number: G01N21/6452 ,  G01N21/6428 ,  G01N33/582 ,  G01N35/00069 ,  G01N2021/6482

公开(公告)号：EP1643250A4

公开(公告)日：2008-11-05

申请号：EP04747013

申请日：2004-07-05

Applicant: SONY CORP

Inventor： NAKAO ISAMU ,  MAMINE TAKAYOSHI ,  YAMAMOTO MASANOBU ,  TAKEDA MINORU ,  FURUKI MOTOHIRO

IPC: G01N33/53 ,  C12M1/00 ,  C12Q1/68 ,  G01N33/543 ,  G01N33/553 ,  G01N33/566 ,  G01N37/00

CPC classification number: G01N33/5438 ,  G01N33/553

Abstract: A bioassay substrate (1) has a circular, planar major surface similar to that of an optical disc, e.g. a CD. The substrate (1) is rotary-driven about a central hole (2). The substrate (1) is provided, on the surface (1a) thereof, with a plurality of wells (8) where hybridization reaction takes place between a probe DNA (nucleotide chain for detection) and a sample DNA (target nucleotide chain). A transparent electrode layer (4) is formed beneath the well (8) in the substrate (1). At the time of hybridization, an external electrode (18) is brought closer from the upper surface (1a) side of the substrate (1) and an AC power is fed between the transparent electrode layer (4) and the external electrode (18), thus applying an AC field to the substrate (1) in the vertical direction.

公开(公告)号：EP1679369A4

公开(公告)日：2007-12-12

申请号：EP04792334

申请日：2004-10-06

Applicant: SONY CORP

Inventor： MATSUMOTO SAYOKO ,  MAMINE TAKAYOSHI ,  WASHIZU MASAO ,  KUROSAWA OSAMU

IPC: C12N15/00 ,  G01N33/53 ,  C12M1/00 ,  C12N15/09 ,  C12Q20060101 ,  C12Q1/68 ,  G01N37/00

CPC classification number: C12Q1/6837 ,  C12Q1/6806 ,  C12Q1/6832 ,  C12Q2523/301 ,  C12Q2523/307

Abstract: The action of high-frequency AC electric field on a single-stranded nucleic acid being present in an aqueous solution is verified, and the action is utilized for enhancement of the efficiency of hybridization for conversion of the single-stranded nucleic acid to a companion complementary strand. There are provided, for example, a method of nucleic acid extension and nucleic acid extending apparatus, wherein high-frequency AC electric field is applied to a single-stranded nucleic acid being present in liberated form in pure water or an aqueous solution of 5 to 11 pH (R), or to a single-stranded nucleic acid fixed onto the surface (f) of one or both (E) of counter electrodes (E,E) provided so as to face the aqueous solution (R), thereby extending the single-stranded nucleic acid.

公开(公告)号：AU2003235387A1

公开(公告)日：2003-12-02

申请号：AU2003235387

申请日：2003-05-21

Applicant: SONY CORP

Inventor： MAMINE TAKAYOSHI ,  YAMAMOTO TAKURO

IPC: C12Q1/68 ,  C40B40/06 ,  C40B40/10 ,  C40B60/14 ,  G01N33/543 ,  G01N33/53 ,  G01N37/00

Abstract: Disclosed is a bioassay method in which, by controlling the electric field formation in the reaction region where an interaction between substances, such as a hybridization, is performed, the efficiency of the interaction can be improved. Also disclosed is a bioassay apparatus in which the method can be favorably carried out. In the method, an interaction between substances is detected by a detecting element 1 (10), the detecting element including at least a detection surface S (S') which is surface-treated for immobilizing a detecting substance D, a reaction region R (R') which provides a field for interaction between the detecting substance D immobilized on the detection surface S (S') and a target substance T, and an electric field-forming means E which forms an electric field in the reaction region R (R') by applying a potential difference in the reaction region R (R'), and the method includes at least a step of turning on/off the electric field formation by the electric field-forming means E at a predetermined timing.