公开(公告)号：CA2764177C

公开(公告)日：2018-06-05

申请号：CA2764177

申请日：2010-06-17

Applicant: VERTEX PHARMA

Inventor： CHARIFSON PAUL ,  CLARK MICHAEL P ,  BANDARAGE UPUL K ,  BETHIEL RANDY S ,  COURT JOHN J ,  DENG HONGBO ,  DRUTU IOANA ,  DUFFY JOHN P ,  FARMER LUC J ,  GAO HUAI ,  GU WENXIN ,  JACOBS DYLAN H ,  KENNEDY JOSEPH M ,  LEDEBOER MARK W ,  LEDFORD BRIAN ,  MALTAIS FRANCOIS ,  PEROLA EMANUELE ,  WANG TIANSHENG ,  WANNAMAKER M WOODS ,  BYRN RANDAL ,  ZHOU YI ,  LIN CHAO ,  JIANG MIN ,  JONES STEVEN ,  GERMANN URSULA A ,  SALITURO FRANCESCO G ,  KWONG ANN DAK-YEE

IPC: C07D471/04 ,  A61K31/506 ,  A61P31/16

Abstract: Methods of inhibiting the replica-tion of influenza viruses in a biological sample or patient, of reducing the amount of influenza viruses in a biological sample or patient, and of treating in-fluenza in a patient, comprises administering to said biological sample or patient an effective amount of a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (IA) are as described herein. A compound is represented by Structural Formula (IA) or a pharmaceutically ac-ceptable salt thereof, wherein the values of Struc-tural Formula (IA) are as described herein. A phar-maceutical composition comprises an effective amount of such a compound or pharmaceutically acceptable salt thereof, and a pharmaceutically ac-ceptable carrier, adjuvant or vehicle.

公开(公告)号：UA115983C2

公开(公告)日：2018-01-25

申请号：UAA201412561

申请日：2013-04-23

Applicant: VERTEX PHARMA

Inventor： CHARIFSON PAUL S ,  COTTRELL KEVIN MICHAEL ,  DENG HONGBO ,  DUFFY JOHN P ,  GAO HUAI ,  GIROUX SIMON ,  GREEN JEREMY ,  JACKSON KATRINA LEE ,  MAXWELL JOHN PATRICK ,  MORRIS MARK A ,  PIERCE ALBERT CHARLES ,  WAAL NATHAN D ,  KENNEDY JOSEPH M ,  LAUFFER DAVID J ,  LEDEBOER MARK WILLEM ,  LI PAN ,  XU JINWANG

IPC: C07D401/14 ,  C07D239/42 ,  C07D401/04 ,  C07D403/04 ,  C07D403/10 ,  C07D405/14 ,  C07D409/04 ,  C07D409/14 ,  C07D413/04 ,  C07D413/10 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14 ,  C07D471/04 ,  C07D491/048

Abstract: Винахід, щопропонується, стосуєтьсясполук, яківідповідаютьнаступнійформулі EMBED ISISServer , (I) якізастосовуютьсяякінгібіториДНК-ПК. Такожу винаходіпропонуютьсяфармацевтичноприйнятнікомпозиції, щомістятьвказанісполуки, іспособиз використаннямкомпозиційу лікуваннірізнихзахворювань, станівабопорушень, такихякрак.

公开(公告)号：HRP20161577T1

公开(公告)日：2017-01-27

申请号：HRP20161577

申请日：2016-11-28

Applicant: VERTEX PHARMA

Inventor： CHARIFSON PAUL ,  CLARK MICHAEL P ,  BANDARAGE UPUL K ,  BETHIEL RANDY S ,  COURT JOHN J ,  DENG HONGBO ,  DRUTU IOANA ,  DUFFY JOHN P ,  FARMER LUC ,  GAO HUAI ,  GU WENXIN ,  JACOBS DYLAN H ,  KENNEDY JOSEPH M ,  LEDEBOER MARK W ,  LEDFORD BRIAN ,  MALTAIS FRANCOIS ,  PEROLA EMANUELE ,  WANG TIANSHENG ,  WANNAMAKER M WOODS ,  BYRN RANDAL ,  ZHOU YI ,  LIN CHAO ,  JIANG MIN ,  GERMANN URSULA A ,  JONES STEVEN ,  SALITURO FRANCESCO G ,  KWONG ANN DAK-YEE

IPC: A61K31/506 ,  A61P31/16

公开(公告)号：EA025276B1

公开(公告)日：2016-12-30

申请号：EA201270032

申请日：2010-06-17

Applicant: VERTEX PHARMA

Inventor： CHARIFSON PAUL ,  CLARK MICHAEL P ,  BANDARAGE UPUL K ,  BETHIEL RANDY S ,  COURT JOHN J ,  DENG HONGBO ,  DRUTU IOANA ,  DUFFY JOHN P ,  FARMER LUC ,  GAO HUAI ,  GU WENXIN ,  JACOBS DYLAN H ,  KENNEDY JOSEPH M ,  LEDEBOER MARK W ,  LEDFORD BRIAN ,  MALTAIS FRANCOIS ,  PEROLA EMANUELE ,  WANG TIANSHENG ,  WANNAMAKER M WOODS ,  BYRN RANDAL ,  ZHOU YI ,  LIN CHAO ,  JIANG MIN ,  JONES STEVEN ,  GERMANN URSULA A

IPC: A61K31/506 ,  A61P31/16

Abstract: Изобретениеотноситсяк новомусоединению, аименно - к (2S,3S)-3-((2-(5-фтор-1Н-пирроло[2,3-b]пиридин-3-ил)-5-фторпиримидин-4-ил)амино)бицикло[2,2,2]октан-2-карбоновойкислоте, обладающейсвойствомингибированиярепликациивирусагриппаА вбиологическомобразцеилиу пациента, уменьшенияколичествавирусовгриппав биологическомобразцеилиу пациента. Изобретениетакжеотноситсяк фармацевтическойкомпозиции, содержащейэффективноеколичествотакогосоединенияилиегофармацевтическиприемлемойсолии фармацевтическиприемлемыйноситель, наполнительилиразбавитель, ипредназначенодлясниженияколичествавирусовгриппаА. ТакжераскрываетсяспособсниженияколичествавирусовгриппаА в in vitro биологическомобразце, включающийвведениев указанныйбиологическийобразецэффективногоколичестваданногосоединения.

公开(公告)号：AU2016228190A1

公开(公告)日：2016-10-27

申请号：AU2016228190

申请日：2016-09-14

Applicant: VERTEX PHARMA

Inventor： CHARIFSON PAUL ,  CLARK MICHAEL P ,  BANDARAGE UPUL K ,  BETHIEL RANDY S ,  BOYD MICHAEL J ,  DAVIES IOANA ,  DENG HONGBO ,  DUFFY JOHN P ,  FARMER LUC J ,  GAO HUAI ,  GU WENXIN ,  KENNEDY JOSEPH M ,  LEDFORD BRIAN ,  LEDEBOER MARK W ,  MALTAIS FRANCOIS ,  PEROLA EMANUELE ,  WANG TIANSHENG

IPC: C07D471/04 ,  A61K31/444 ,  A61K31/506 ,  A61P31/16

Abstract: Abstract The present invention relates to compounds of Formula I or a pharmaceutically acceptable salt thereof and methods of inhibiting the replication of influenza viruses and/or reducing the amount of influenza viruses in a biological sample or patient comprising administering an effective amount of a compound of Formula I or a pharmaceutically acceptable salt thereof to the biological sample or patient. The present invention further provides for pharmaceutical compositions comprising a compound of Formula I or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, adjuvant or vehicle. x2 "'N \Z1Z" Formula I

公开(公告)号：AU2016204286A1

公开(公告)日：2016-08-11

申请号：AU2016204286

申请日：2016-06-23

Applicant: VERTEX PHARMA

Inventor： CHARIFSON PAUL ,  CLARK MICHAEL P ,  BANDARAGE UPUL K ,  BETHIEL RANDY S ,  COURT JOHN J ,  DENG HONGBO ,  DRUTU IOANA ,  DUFFY JOHN P ,  FARMER LUC ,  GAO HUAI ,  GU WENXIN ,  JACOBS DYLAN H ,  KENNEDY JOSEPH M ,  LEDEBOER MARK W ,  LEDFORD BRIAN ,  MALTAIS FRANCOIS ,  PEROLA EMANUELE ,  WANG TIANSHENG ,  WANNAMAKER M WOODS ,  BYRN RANDAL ,  ZHOU YI ,  LIN CHAO ,  JIANG MIN ,  JONES STEVEN ,  GERMANN URSULA A ,  SALITURO FRANCESCO G ,  KWONG ANN DAK-YEE

IPC: A61K31/506 ,  A61P31/16

Abstract: Abstract Methods of inhibiting the replication of influenza viruses in a biological sample or patient, of reducing the amount of influenza viruses in a biological sample or patient, and of treating influenza in a patient, comprises administering to said biological sample or patient an effective amount of a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (IA) are as described herein. A compound is represented by Structural Formula (IA) or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (IA) are as described herein. A pharmaceutical composition comprises an effective amount of such a compound or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, adjuvant or vehicle.

公开(公告)号：SG10201503833SA

公开(公告)日：2015-06-29

申请号：SG10201503833S

申请日：2012-08-01

Applicant: VERTEX PHARMA

Inventor： CHARIFSON PAUL S ,  CLARK MICHAEL P ,  BANDARAGE UPUL K ,  BETHIEL RANDY S ,  BOYD MICHAEL J ,  DAVIES IOANA ,  DENG HONGBO ,  DUFFY JOHN P ,  FARMER LUC J ,  GAO HUAI ,  GU WENXIN ,  KENNEDY JOSEPH M ,  LEDFORD BRIAN ,  LEDEBOER MARK W ,  MALTAIS FRANCOIS ,  PEROLA EMANUELE ,  WANG TIANSHENG

Abstract: Methods of inhibiting the replication of influenza viruses in a biological sample or patient, of reducing the amount of influenza viruses in a biological sample or patient, and of treating influenza in a patient, comprises administering to said biological sample or patient an effective amount of a compound represented by Structural Formula ( I ): or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula ( I ) are as described herein. A compound is represented by Structural Formula ( I ) or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula ( I ) are as described herein. A pharmaceutical composition comprises an effective amount of such a compound or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, adjuvant or vehicle.

公开(公告)号：SG10201405827PA

公开(公告)日：2014-11-27

申请号：SG10201405827P

申请日：2010-06-17

Applicant: VERTEX PHARMA

Inventor： CHARIFSON PAUL ,  CLARK MICHAEL P ,  BANDARAGE UPUL K ,  BETHIEL RANDY S ,  COURT JOHN J ,  DENG HONGBO ,  DRUTU IOANA ,  DUFFY JOHN P ,  FARMER LUC ,  GAO HUAI ,  GU WENXIN ,  JACOBS DYLAN H ,  KENNEDY JOSEPH M ,  LEDEBOER MARK W ,  LEDFORD BRIAN ,  MALTAIS FRANCOIS ,  PEROLA EMANUELE ,  WANG TIANSHENG ,  WANNAMAKER M WOODS ,  BYRN RANDAL ,  ZHOU YI ,  LIN CHAO ,  JIANG MIN ,  JONES STEVEN ,  GERMANN URSULA A ,  FRANCESCO G SALITURO ,  ANN DAK-YEE KWONG

Abstract: Methods of inhibiting the replication of influenza viruses in a biological sample or patient, of reducing the amount of influenza viruses in a biological sample or patient, and of treating influenza in a patient, comprises administering to said biological sample or patient an effective amount of a compound represented by Structural Formula ( I ): or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (IA) are as described herein. A compound is represented by Structural Formula ( IA ) or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula ( IA ) are as described herein. A pharmaceutical composition comprises an effective amount of such a compound or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, adjuvant or vehicle.

公开(公告)号：CL2014000245A1

公开(公告)日：2014-08-18

申请号：CL2014000245

申请日：2014-01-31

Applicant: VERTEX PHARMA

Inventor： CHARIFSON PAUL S ,  CLARK MICHEL P ,  BANDARAGE UPUL K ,  BETHIEL RANDY S ,  BOYD MICHAEL J ,  DENG HONGBO ,  DUFFY JOHN P ,  FARMER LUC J ,  GAO HUAI ,  GU WENXIN ,  KENNEDY JOSEPH M ,  LEDFORD BRIAN ,  LEDEBOER MARK W ,  MALTAIS FRANCOIS ,  PEROLA EMANUELE ,  WANG TIANSHENG ,  DAVIS IOANA

IPC: C07D471/04 ,  A61K31/506 ,  A61P31/16

公开(公告)号：AU2011343647A1

公开(公告)日：2013-05-02

申请号：AU2011343647

申请日：2011-12-16

Applicant: VERTEX PHARMA

Inventor： CHARIFSON PAUL S ,  CLARK MICHAEL P ,  BANDARAGE UPUL K ,  DENG HONGBO ,  DAVIES IOANA ,  DUFFY JOHN P ,  FARMER LUC J ,  GAO HUAI ,  GU WENXIN ,  KENNEDY JOSEPH M ,  LEDEBOER MARK W ,  LEDFORD BRIAN ,  MALTAIS FRANCOIS ,  PEROLA EMANUELE ,  WANNAMAKER MARION W ,  WANG TIANSHENG ,  SALITURO FRANCESCO G

IPC: C07D471/04 ,  A61K31/4439 ,  A61K31/497 ,  A61K31/506 ,  A61K31/53

Abstract: Methods of inhibiting the replication of influenza viruses in a biological sample or patient, of reducing the amount of influenza viruses in a biological sample or patient, and of treating influenza in a patient, comprises administering to said biological sample or patient an effective amount of a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (I) are as described herein. A compound is represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (I) are as described herein. A pharmaceutical composition comprises an effective amount of such a compound or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, adjuvant or vehicle.