公开(公告)号：NZ708598A

公开(公告)日：2017-05-26

申请号：NZ70859811

申请日：2011-04-07

Applicant: VERTEX PHARMA

Inventor： YOUNG CHRISTOPHER RYAN ,  KAUSHIK RITU ROHIT ,  ALARGOVA ROSSITZA GUEORGUIEVA ,  KADIYALA IRINA NIKOLAEVNA ,  VERWIJS MARINUS JACOBUS

IPC: A61K9/16 ,  A61K9/20 ,  A61K9/28 ,  C07D213/75 ,  C07D405/12 ,  C07D405/14

Abstract: Disclosed is a pharmaceutical composition comprising Compound 1, (3-(6-(1-(2,2- difluorobenzo[d][1,3]dioxol-5-y1)cyclopropanecarboxamido)-3-methylpyridin-2-y1)benzoic acid), and at least one excipient selected from: a filler, a diluent, a disintegrant, a surfactant, a binder, a glidant and a lubricant, the composition being suitable for oral administration to a patient in need thereof to treat a CFTR mediated disease such as Cystic Fibrosis.

公开(公告)号：HK1209318A1

公开(公告)日：2016-04-01

申请号：HK15109966

申请日：2015-10-13

Applicant: VERTEX PHARMA

Inventor： ALARGOVA ROSSITZA GUEORGUIEVA ,  DUNBAR CRAIG ANTONY ,  KADIYALA IRINA NIKOLAEVNA

IPC: A61K20060101 ,  A61P20060101

公开(公告)号：AU2015202975A1

公开(公告)日：2015-06-18

申请号：AU2015202975

申请日：2015-06-03

Applicant: VERTEX PHARMA

Inventor： ALARGOVA ROSSITZA GUEORGUIEVA ,  DUNBAR CRAIG ANTONY ,  KADIYALA IRINA NIKOLAEVNA

IPC: A61K9/20 ,  A61K31/404

Abstract: PHARMACEUTICAL COMPOSITION OF (R)-1-(2,2 DIFLUOROBENZO[D][1,3]DIOXOL-5-YL)-N-(1 -(2,3-DIHYDROXY PROPYL)-6-FLUORO-2-(1 -HYDROXY-2-METHYLPROPAN-2-YL)-1 H INDOL-5-YL) CYCLOPROPANECARBOXAMIDE AND ADMINISTRATION THEREOF A pharmaceutical composition comprising Compound , (R)-1-(2,2-difluorobenzo[d][1,3]dioxol 5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-IH-indol-5 yl)cyclopropanecarboxamide, and at least one excipient selected from: a filler, a diluent, a disintegrant, a surfactant, a glidant and a lubricant, the composition being suitable for oral administration to a patient in need thereof to treat a CFTR mediated disease such as Cystic Fibrosis. Methods for treating a patient in need thereof include administering the pharmaceutical composition of Compound I are also disclosed.

公开(公告)号：CA2927631A1

公开(公告)日：2015-04-23

申请号：CA2927631

申请日：2014-10-17

Applicant: VERTEX PHARMA

Inventor： KADIYALA IRINA NIKOLAEVNA ,  O'NEIL SIMON ADAM ,  STROHMEIER MARK ,  WALDO MICHAEL ,  NAVAMAL METTACHIT ,  STAVROPOULOS KATHY ,  MUDUNURI PRAVEEN ,  SONG BIN ,  VAN ALSTEN JOHN GREGG ,  NTI-ADDAE KWAME WIREDU ,  ZHANG YUEGANG

IPC: C07D401/14 ,  A61K31/506 ,  A61P35/00

Abstract: The present invention relates to compositions and co-crystals each comprising a compound of formula I having the structure: wherein each of R1 and R2 is H or 2H and a co-crystal former selected from adipic acid, citric acid, fumaric acid, maleic acid, succinic acid, or benzoic acid. Also within the scope of this invention are methods of making and using the same.

公开(公告)号：AR084473A1

公开(公告)日：2013-05-22

申请号：ARP110103065

申请日：2011-08-23

Applicant: VERTEX PHARMA

Inventor： ALARGOVA ROSSITZA GUEORGUIEVA ,  DUNBAR CRAIG ANTONY ,  KADIYALA IRINA NIKOLAEVNA

IPC: A61K9/20 ,  A61K31/404

Abstract: Una composición farmacéutica que comprende el compuesto 1, (R)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-il)-N-(1-(2,3-dihidroxipropil)-6-fluoro-2-(1-hidroxi-2-metilpropan-2-il)-1H-indol-5-il)ciclopropanecarboxamida, y al menos un excipiente seleccionado del grupo consistente en: un relleno, a diluyente, un desintegrante, un surfactante, un deslizante y un lubricante, siendo la composición adecuada para su administración oral a un paciente que la necesita para tratar una enfermedad mediada por CFTR tales como fibrosis quística. Se describen métodos para tratar un paciente que lo necesite, los cuales incluyen administrar la composición farmacéutica del compuesto 1.

公开(公告)号：CA2854879A1

公开(公告)日：2013-05-16

申请号：CA2854879

申请日：2012-11-06

Applicant: VERTEX PHARMA

Inventor： KADIYALA IRINA NIKOLAEVNA ,  JAMZAD SHAHLA ,  HOOCK THOMAS CARL ,  TAYLOR LORI KELL ,  SEWELL KATHRYN LEA

IPC: A61K31/506 ,  A61K45/06 ,  A61P29/00

Abstract: The present invention provides method of treating or lessening the severity of a disease selected from spondyloarthropathy, systemic lupus erythematosus, rheumatoid arthritis, or any combination thereof comprising the administration of a compound of Formula I and an optional co-therapy (e.g., chemotherapy agent, DMARD, or any combination thereof). The present invention also provides a pharmaceutical composition comprising a compound of Formula I, a method of manufacturing a pharmaceutical composition comprising a compound of Formula I, and a method of administering a pharmaceutical composition comprising a solid form of a compound of Formula I.

公开(公告)号：AU2011237601A1

公开(公告)日：2012-11-01

申请号：AU2011237601

申请日：2011-04-07

Applicant: VERTEX PHARMA

Inventor： VERWIJS MARINUS JACOBUS ,  ALARGOVA ROSSITZA GUEORGUIEVA ,  KAUSHIK RITU ROHIT ,  KADIYALA IRINA NIKOLAEVNA ,  YOUNG CHRISTOPHER RYAN

IPC: A61K9/20

Abstract: A pharmaceutical composition comprising Compound 1, (3-(6-(1-(2,2- difluorobenzo [d] [ 1,3 ] dioxol-5 -y1) cyclopropanecarboxamido)-3 -methylpyridin-2-y1)benzoic acid), and at least one excipient selected from: a filler, a diluent, a disintegrant, a surfactant, a binder, a glidant and a lubricant, the composition being suitable for oral administration to a patient in need thereof to treat a CFTR mediated disease such as Cystic Fibrosis. Methods for treating a patient in need thereof include administering an oral pharmaceutical formulation of Compound 1 to the patient.

公开(公告)号：AR081760A1

公开(公告)日：2012-10-17

申请号：ARP110101172

申请日：2011-04-07

Applicant: VERTEX PHARMA

Inventor： VERWIJS MARINUS JACOBUS ,  ALARGOVA ROSSITZA GUEORGUIEVA ,  KAUSHIK RITU ROHIT ,  KADIYALA IRINA NIKOLAEVNA ,  YOUNG CHRISTOPHER RYAN

IPC: A61K31/4427 ,  A61P11/00

Abstract: Una composición farmacéutica para administración oral que comprende ácido 3-(6-(1-(2,2-difluorobenzo[D][1,3]dioxol-5-il)ciclopropancarboxamido)-3-metilpiridin-2-il)benzoico (compuesto 1), caracterizada por comprender: a) el compuesto de fórmula (1) en cualquiera de sus formas cristalinas I o II y/o su forma A de clorhidrato, b) un agente de relleno, c) un diluyente, d) un desintegrante, e) un surfactante, f) un lubricante, y g) al menos uno entre un ligante y un deslizante. Un método para producir dicha composición farmacéutica, a una tableta y a un forma unitaria de dosificación oral que comprenden los ingredientes de dicha composición farmacéutica, al uso dicha composición farmacéutica para la fabricación de un medicamento y a un kit que comprende dicha composición farmacéutica, tableta o unidad de dosificación con instrucciones para su utilización.

公开(公告)号：CA2796642A1

公开(公告)日：2011-10-27

申请号：CA2796642

申请日：2011-04-22

Applicant: VERTEX PHARMA

Inventor： VAN GOOR FREDRICK F ,  ALARGOVA ROSSITZA GUEORGUIEVA ,  ALCACIO TIM EDWARD ,  AREKAR SNEHA G ,  JOHNSTON STEVEN C ,  KADIYALA IRINA NIKOLAEVNA ,  KESHAVARZ-SHOKRI ALI ,  KRAWIEC MARIUSZ ,  LEE ELAINE CHUNGMIN ,  MEDEK ALES ,  MUDUNURI PRAVEEN ,  SULLIVAN MARK JEFFREY ,  ZAMAN NOREEN TASNEEM ,  ZHANG BEILI ,  ZHANG YUEGANG ,  ZLOKARNIK GREGOR

IPC: A61K31/4704 ,  A61K31/404 ,  A61K31/443

Abstract: The present invention relates to pharmaceutical compositions comprising a compound of Formula I in combination with one or both of a Compound of Formula II and/or a Compound of Formula III. The invention also relates to solid forms and to pharmaceutical formulations thereof, and to methods of using such compositions in the treatment of CFTR mediated diseases, particularly cystic fibrosis.

公开(公告)号：AU2007254990A1

公开(公告)日：2007-12-13

申请号：AU2007254990

申请日：2007-05-30

Applicant: VERTEX PHARMA

Inventor： KADIYALA IRINA NIKOLAEVNA ,  LIN WU ,  HURTER PATRICIA

IPC: A61K9/16 ,  A61K9/20 ,  A61K31/401

Abstract: The invention relates to a controlled release formulation for an oral cytokine inhibitor of interleukin-1 beta converting enzyme.