公开(公告)号：ZA200705116B

公开(公告)日：2008-06-25

申请号：ZA200705116

申请日：2007-06-18

Applicant: VERTEX PHARMA

Inventor： IOANA DRUTU ,  BANDARAGE UPUL K ,  CHARIFSON PAUL S ,  MIGUEL GARCIA-GUZMAN BLANCO ,  AKIKO NAKATANI ,  HURLEY DENNIS J ,  BERGERON DANIELE M ,  DAVIES ROBERT J ,  MAKINGS LEWIS R ,  GABRIEL RAFFAI

IPC: A61K20090101 ,  A61P20090101 ,  C07D20090101

Abstract: The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.

公开(公告)号：AU2007284548A1

公开(公告)日：2008-02-21

申请号：AU2007284548

申请日：2007-08-15

Applicant: VERTEX PHARMA

Inventor： HURLEY DENNIS J ,  MAKINGS LEWIS R ,  RAFFAI GABRIEL

IPC: A61K31/527 ,  A61K31/537 ,  A61P1/00 ,  A61P9/00 ,  A61P11/06 ,  A61P17/02 ,  A61P25/00 ,  A61P25/04 ,  A61P25/16 ,  A61P25/18 ,  A61P25/24 ,  A61P25/28 ,  A61P27/02 ,  A61P27/06 ,  A61P43/00

Abstract: The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.

公开(公告)号：NO20073369A

公开(公告)日：2007-08-29

申请号：NO20073369

申请日：2007-06-29

Applicant: VERTEX PHARMA

Inventor： CHARIFSON PAUL S ,  DAVIES ROBERT J ,  MAKINGS LEWIS R ,  BLANCO MIGUEL GARCIA-GUZMAN ,  HURLEY DENNIS JAMES ,  NAKATANI AKIKO ,  RAFFAI GABRIEL ,  DRUTU IOANA ,  BANDARAGE UPUL K ,  BERGERON DANIELE M

IPC: A61K31/4353 ,  A61P25/00 ,  C07D471/10

CPC classification number: C07D471/10 ,  A61K31/435 ,  A61K31/439 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/4747 ,  C07D471/08 ,  C07D491/08 ,  C07D491/10

公开(公告)号：MX2007006382A

公开(公告)日：2007-07-11

申请号：MX2007006382

申请日：2005-11-29

Applicant: VERTEX PHARMA

Inventor： DAVIES ROBERT J ,  BLANCO MIGUEL GARCIA-GUZMAN ,  NAKATANI AKIKO ,  MAKINGS LEWIS R ,  RAFFAI GABRIEL ,  HURLEY DENNIS J ,  BERGERON DANIELE M ,  DRUTU IOANA ,  BANDARAGE UPUL K ,  CHARIFSON PAUL S

IPC: A61K31/444 ,  A61K31/4545 ,  A61P1/00 ,  A61P3/04 ,  A61P9/00 ,  A61P17/02 ,  A61P25/00 ,  A61P27/02 ,  A61P43/00 ,  C07D471/00

Abstract: La presente invencion se refiere a moduladores de receptores muscarinicos. La presente invencion tambien proporciona composiciones que comprenden tales moduladores, y metodos con estos para tratar enfermedades mediadas por el receptor muscarinico.

公开(公告)号：CA2634456A1

公开(公告)日：2007-07-05

申请号：CA2634456

申请日：2006-12-22

Applicant: VERTEX PHARMA

Inventor： TERMIN ANDREAS P ,  SILINA ALINA ,  MAKINGS LEWIS R ,  NAKATANI AKIKO ,  GARCIA-GUZMAN BLANCO MIGUEL ,  BERGERON DANIELE M ,  HURLEY DENNIS J ,  DRUTU IOANA ,  RAFFAI GABRIEL

IPC: A61K31/435 ,  A61K31/438 ,  A61K31/4545 ,  A61K31/46 ,  A61K31/497 ,  A61K31/498 ,  A61K31/501 ,  A61K31/506 ,  A61P25/00 ,  A61P43/00 ,  C07D471/00 ,  C07D471/10

Abstract: The present invention relates to spiro compounds of formula XX as modulators of muscarinic receptors, wherein R1, R2, R3, Z1, Z2, L, G, n, m, t and p are defined herein. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.

公开(公告)号：AU2006330866A1

公开(公告)日：2007-07-05

申请号：AU2006330866

申请日：2006-12-22

Applicant: VERTEX PHARMA

Inventor： DRUTU IOANA ,  HURLEY DENNIS J ,  BLANCO MIGUEL GARCIA-GUZMAN ,  MAKINGS LEWIS R ,  NAKATANI AKIKO ,  SILINA ALINA ,  RAFFAI GABRIEL ,  TERMIN ANDREAS P ,  BERGERON DANIELE M

IPC: A61K31/435 ,  A61K31/438 ,  A61K31/4545 ,  A61K31/46 ,  A61K31/497 ,  A61K31/498 ,  A61K31/501 ,  A61K31/506 ,  A61P25/00 ,  A61P43/00 ,  C07D471/00 ,  C07D471/10

Abstract: The present invention relates to spiro compounds of formula XX as modulators of muscarinic receptors, wherein R1, R2, R3, Z1, Z2, L, G, n, m, t and p are defined herein. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.

公开(公告)号：CA2589439A1

公开(公告)日：2006-06-01

申请号：CA2589439

申请日：2005-11-29

Applicant: VERTEX PHARMA

Inventor： BANDARAGE UPUL K ,  NAKATANI AKIKO ,  BERGERON DANIELE M ,  MAKINGS LEWIS R ,  DRUTU IOANA ,  HURLEY DENNIS J ,  RAFFAI GABRIEL ,  DAVIES ROBERT J ,  CHARIFSON PAUL S ,  GARCIA-GUZMAN BLANCO MIGUEL

IPC: A61K31/4747 ,  A61K31/435 ,  A61K31/439 ,  A61K31/444 ,  A61K31/4545 ,  A61P1/00 ,  A61P3/04 ,  A61P9/00 ,  A61P17/02 ,  A61P25/00 ,  A61P27/02 ,  A61P43/00 ,  C07D471/00

Abstract: The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.

公开(公告)号：CA2577677A1

公开(公告)日：2006-03-02

申请号：CA2577677

申请日：2005-08-19

Applicant: VERTEX PHARMA

Inventor： TERMIN ANDREAS P ,  SILINA ALINA ,  NAKATANI AKIKO ,  BERGERON DANIELE M ,  DRUTU IOANA ,  RAFFAI GABRIEL ,  HURLEY DENNIS J ,  GARCIA-GUZMAN BLANCO MIGUEL ,  MAKINGS LEWIS R

IPC: A61K31/435 ,  A61K31/438 ,  A61P25/00 ,  A61P43/00 ,  C07D471/00

Abstract: The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith or treating muscarinic receptor mediated diseases.

公开(公告)号：AR047759A1

公开(公告)日：2006-02-22

申请号：ARP040103481

申请日：2004-09-24

Applicant: VERTEX PHARMA

Inventor： GARCIA-GUZMAN BLANCO MIGUEL ,  BERGERON DANIELE ,  GROOTENHUIS PETER D J ,  HURLEY DENNIS ,  NAKATANI AKIKO ,  MAKINGS LEWIS R ,  DISEPIO DANIEL ,  RAFFAI GABRIEL

IPC: A61K31/495 ,  A61K31/496 ,  C07D295/02 ,  C07D295/033 ,  C07D295/073 ,  C07D295/096 ,  C07D295/135 ,  C07D295/155 ,  C07D309/14 ,  C07D451/02 ,  C07D451/04 ,  C07D493/08 ,  C07D295/04 ,  A61P43/00 ,  A61P25/00

Abstract: Moduladores de receptores muscarínicos, composiciones que comprenden tales moduladores, y métodos para tratar enfermedades mediadas por receptores muscarínicos que los utilizan.

公开(公告)号：NZ570497A

公开(公告)日：2011-09-30

申请号：NZ57049707

申请日：2007-02-22

Applicant: VERTEX PHARMA

Inventor： MAKINGS LEWIS R ,  GARCIA-GUZMAN BLANCO MIGUEL ,  HURLEY DENNIS J ,  DRUTU IOANA ,  RAFFAI GABRIEL ,  BERGERON DANIELE M ,  NAKATANI AKIKO ,  TERMIN ANDREAS P ,  SILINA ALINA

IPC: C07D471/10 ,  A61K31/404 ,  A61K31/407 ,  A61K31/438 ,  A61K31/46 ,  A61K31/4747 ,  A61P25/00 ,  C07D519/00

Abstract: Disclosed are spiro[piperidine-4,4'-quinoline] and spiro[piperidine-4,4'-indol] derivatives as represented by the general formula (I), wherein R1 is an optionally substituted aliphatic or NR6R'6; Each of R6 and R'6 is independently hydrogen or an optionally substituted aliphatic, or R6 and R'6 together with the nitrogen atom to which they are attached form an optionally substituted 4-7 membered heterocycloaliphatic; L is -(CH2)n-, wherein n is 0-2; R2 is a cycloaliphatic or a heterocycloaliphatic, each of which is optionally substituted with 1-3 of R3; p is 0 or 1; and wherein the remaining substituents are as defined herein. Further disclosed is the use of a compound as defined above for the manufacture of a medicament for treating or reducing the severity of a disease, wherein said disease is selected from CNS derived pathologies, Attention Deficit Hyperactivity Disorder (ADHD), obesity, Alzheimer's disease, various dementias, psychosis associated with CNS disorders, mania, bipolar disorders, pain conditions, Huntington's Chorea, Friederich's ataxia, Gilles de la Tourette's Syndrome, Downs Syndrome, Pick disease, clinical depression, Parkinson's disease, peripheral disorders, bradhycardia, gastric acid secretion, asthma, GI disturbances, and wound healing.