公开(公告)号：WO1996031196A1

公开(公告)日：1996-10-10

申请号：PCT/US1996004208

申请日：1996-03-27

Applicant: IMARx PHARMACEUTICAL CORP.

Inventor： IMARx PHARMACEUTICAL CORP. ,  UNGER, Evan, C.

IPC: A61K09/127

CPC classification number: A61K9/127 ,  A61K9/1271 ,  A61K9/1277 ,  A61K9/1278 ,  A61K41/0028 ,  A61K41/0052 ,  A61K47/6907 ,  A61K47/6911 ,  A61K47/6925 ,  A61K49/1815 ,  A61K49/22 ,  A61K49/223 ,  A61K49/227 ,  A61M5/3145 ,  Y10T428/2984

Abstract: Compositions comprising, in an aqueous carrier, a lipid and a material which is capable of stabilizing the composition. The stabilizing material is associated non-covalently with said lipid and is present in an amount sufficient to coat the lipid but insufficient to raise the viscosity of the composition. The compositions are particularly suitable for use in diagnostic applications, including ultrasound. The compositions can take the form of vesicular compositions, such as micelles and liposomes.

Abstract translation: 在水性载体中包含能够稳定组合物的脂质和材料的组合物。 稳定材料与所述脂质非共价结合，并且以足以涂覆脂质的量存在，但不足以提高组合物的粘度。 该组合物特别适用于诊断应用，包括超声波。 组合物可以采取水泡组合物的形式，例如胶束和脂质体。

公开(公告)号：WO1996008234A1

公开(公告)日：1996-03-21

申请号：PCT/US1995009392

申请日：1995-07-26

Applicant: IMARx PHARMACEUTICAL CORP.

Inventor： IMARx PHARMACEUTICAL CORP. ,  UNGER, Evan, C. ,  MATSUNAGA, Terry, O. ,  YELLOWHAIR, David

IPC: A61K09/127

CPC classification number: A61K49/227 ,  A61K8/046 ,  A61K8/14 ,  A61K8/70 ,  A61K9/127 ,  A61K9/1277 ,  A61K9/1278 ,  A61K41/0028 ,  A61K41/0052 ,  A61K47/51 ,  A61K47/6925 ,  A61K49/1815 ,  A61K49/22 ,  A61K49/223 ,  A61K2800/87 ,  A61M5/3145 ,  A61Q19/00 ,  G01R33/5601 ,  Y10T428/2984

Abstract: A container comprising an aqueous lipid suspension and a gaseous phase substantially separate from the aqueous stabilizing phase, useful in diagnostic imaging such as ultrasound and magnetic resonance imaging and in therapeutic applications, is disclosed.

Abstract translation: 公开了一种容器，其包含水性脂质悬浮液和基本上与水稳定相分离的气相，其用于诸如超声和磁共振成像以及治疗应用的诊断成像。

公开(公告)号：CA2256592C

公开(公告)日：2010-06-01

申请号：CA2256592

申请日：1997-06-16

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C ,  MATSUNAGA TERRY O ,  FRITZ THOMAS A ,  RAMASWAMI VARADA RAJAN

IPC: A61K49/00 ,  A61M5/00 ,  A61B8/00 ,  A61B8/13 ,  A61K9/127 ,  A61K49/22 ,  A61K51/02 ,  A61M5/14

Abstract: Methods for providing an image of an internal region of a patient. Embodiments of the methods involve administering to the patient a contrast agent which comprises a vesicle composition comprising, in an aqueous carrier, a gas or gaseous precursor and vesicles comprising lipids, proteins or polymers. The patient is scanned using diagnostic imaging, such as ultrasound, to obtain a visible image of the region. The contrast agent is administered to the patient at a rate to substantially eliminate diagnostic artifacts in the image. The methods are particularly useful for diagnosing the presence of any diseased tissue in the patient.

公开(公告)号：DK0580726T4

公开(公告)日：2008-12-01

申请号：DK92910021

申请日：1992-03-18

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C

IPC: A61B6/03 ,  C08F20/06 ,  A61K9/10 ,  A61K9/14 ,  A61K49/00 ,  A61K49/04 ,  A61K51/00 ,  A61K51/06 ,  A61K101/02 ,  A61P9/00 ,  C08F122/38 ,  C08F126/10 ,  C08J9/30 ,  C08K5/02 ,  C08L101/00 ,  G01N33/60 ,  G01R33/28

公开(公告)号：CA2263924C

公开(公告)日：2008-11-18

申请号：CA2263924

申请日：1997-08-26

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C

IPC: A61K49/00 ,  A61B8/14 ,  A61K9/127 ,  A61K9/133 ,  A61K47/24 ,  A61K47/34 ,  A61K49/22

Abstract: Improved method for providing an image of an internal region of a patient, especially the cardiovascular region. Embodiments of the invention involve the administration to the patient of a contrast agent whic h comprises a vesicle composition comprising lipid or polymer vesicles and a gas or gaseous precursor, in combinationwith a coronary vasodilator. The patient is scanned using diagnostic imaging, such as ultrasound, to obtain a visible image of the region. The methods are particularly useful for diagnosing the presence of diseased tissue in the cardiovascular region of a patient, as well as for measuring blood flow in the cardiovascular region of a patient.

公开(公告)号：HK1062802B

公开(公告)日：2008-03-14

申请号：HK03106479

申请日：2003-09-10

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C

IPC: A61K20060101 ,  A61K31/401 ,  A61K9/10 ,  A61K45/08 ,  A61K49/00 ,  A61K49/22

公开(公告)号：DE69831755T2

公开(公告)日：2006-07-13

申请号：DE69831755

申请日：1998-12-17

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER C ,  WU YUNQIU

IPC: A61B8/13 ,  A61K41/00 ,  A61K49/00

Abstract: The present invention generally relates to optoacoustic contrast agents and methods of diagnostic and therapeutic imaging using optoacoustic contrast agents.

公开(公告)号：DE69632401T2

公开(公告)日：2005-05-19

申请号：DE69632401

申请日：1996-06-06

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER C ,  SHEN DEKANG ,  WU GUANLI

IPC: A61K47/48 ,  A61K45/00 ,  A61K49/00 ,  A61K49/22 ,  C08F220/44 ,  C08G65/32 ,  A61K49/18 ,  A61B5/055 ,  A61K49/04 ,  A61P7/02

公开(公告)号：DE69718519T2

公开(公告)日：2003-11-06

申请号：DE69718519

申请日：1997-08-26

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER C

IPC: A61K9/10 ,  A61K31/401 ,  A61K45/08 ,  A61K49/00 ,  A61K49/22 ,  A61B8/14

Abstract: A method for providing an image of an internal region of a patient has been developed. The method reduces imaging artifacts by providing enhanced contrast between tissue and blood during imaging. The method comprises administering to a patient a contrast agent in combination with a renal vasodilator and performing ultrasound imaging of the region. Renal disease, including renal arterial stenosis, may be diagnosed using the method.

公开(公告)号：AT246956T

公开(公告)日：2003-08-15

申请号：AT96938613

申请日：1996-06-06

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C ,  MCCREERY THOMAS ,  YELLOWHAIR DAVID ,  BARRETTE TERRENCE R

IPC: A61K49/00 ,  A61B5/055 ,  A61B8/00 ,  A61J3/00 ,  A61K8/14 ,  A61K8/70 ,  A61K9/127 ,  A61K41/00 ,  A61K47/48 ,  A61K49/18 ,  A61K49/22 ,  A61M5/31 ,  A61Q19/00 ,  B01F3/04 ,  B01F11/00 ,  B01F15/00

Abstract: A method and apparatus for making vesicles suitable for use as contrast agents in which a container containing an aqueous suspension phase and a separate gas phase is shaken using reciprocating motion. The reciprocating motion is produced by a shaker arm that moves the container in two, substantially perpendicular directions, with the motion in the first direction being along an arcuate path. The overall path of the motion occurs in a figure-8 eight pattern. The frequency of shaking is at least approximately 2800 RPM, the length of the shaker arm is at least approximately 6 cm, and the angle through which the shaker arm rotates in the first direction is at least approximately 3 DEG . The total length of travel around the figure-8 pattern is at least 0.7 cm.