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21.发明公开5-[4’-(피페리디노메틸)페닐]-2,3-디히드로이미다조[2,1-에이]이소퀴놀린을 함유하는 염증성 질병 또는 면역질환의예방 또는 치료용 조성물 有权包含（5- [4' - （哌啶子基）苯基] -2,3-二氢吡啶并[2,1-A]异喹啉）的组合物，用于预防或治疗炎症或免疫疾病
公开(公告)号：KR1020090007655A
公开(公告)日：2009-01-20
申请号：KR1020070070926
申请日：2007-07-15
Applicant: 강원대학교산학협력단
IPC: A61K31/47 , A61K31/4184 , A61P37/02
CPC classification number: Y02A50/409 , Y02A50/423 , A61K31/4745 , Y10S424/13 , Y10S514/814 , Y10S514/824 , Y10S514/825 , Y10S514/866 , Y10S514/886 , Y10S514/893 , Y10S514/925
Abstract: A composition comprising 5-[4'-(piperidinomethyl)phenyl]-2,3-dihydroimidazo [2,1-a] isoquinoline is provided to inhibit inflammation and regulate immune responses in macrophages, thereby preventing and treating the inflammatory or immune diseases. The composition for prevention and treatment of inflammatory or immune diseases comprises 5-[4'-(piperidinomethyl)phenyl]-2,3-dihydroimidazo [2,1-a] isoquinoline or its pharmaceutically acceptable salt, and inhibits the expression of any one proinflammatory cytokine selected from the group consisting of IL-1(interleukin) beta, IL-6 and TNF-alpha(tumor necrosis factor-alpha).
Abstract translation: 提供包含5- [4' - （哌啶子基甲基）苯基] -2,3-二氢咪唑并[2,1-a]异喹啉的组合物，以抑制炎症和调节巨噬细胞中的免疫应答，从而预防和治疗炎症或免疫疾病。 用于预防和治疗炎症或免疫疾病的组合物包括5- [4' - （哌啶基甲基）苯基] -2,3-二氢咪唑并[2,1-a]异喹啉或其药学上可接受的盐，并且抑制任何一种 选自IL-1（白介素）β，IL-6和TNF-α（肿瘤坏死因子-α）的促炎细胞因子。
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公开(公告)号：KR100840558B1
公开(公告)日：2008-06-23
申请号：KR1020070022768
申请日：2007-03-08
Applicant: 강원대학교산학협력단
IPC: A61K36/185 , A61P29/00 , A61P37/02
Abstract: An extract of Hibiscus cannabinus L., Malvaceae is provided to control the function of macrophage by inhibiting generation of TNF-alpha, mRNA expression of interleukin(IL)-3 and IL-12, and generation of nitric oxide(NO), prostaglandin(PGE2) and reactive oxygen species(PROS), thereby being useful for preventing and treating diseases by immuno-reaction. A pharmaceutical composition for preventing and treating inflammation comprises an extract of Hibiscus cannabinus L. Malvaceae as an effective ingredient, wherein the extract is prepared by extracting the Hibiscus cannabinus L. with at least one solvent selected from the group consisting of water, C1-4 alcohol, glycerol, propylene glycol, 1,3-butyleneglycol, ethylacetate, benzene, hexane, diethyl ether and dichloromethane, filtering the extract and concentrating the filtrate.
Abstract translation: 提供芙蓉大麻提取物，通过抑制TNF-α的产生，白细胞介素（IL）-3和IL-12的mRNA表达以及一氧化氮（NO），前列腺素（NO）的产生来控制巨噬细胞的功能， PGE2）和活性氧（PROS），因此可用于通过免疫反应预防和治疗疾病。 用于预防和治疗炎症的药物组合物包含芙蓉大戟科的提取物作为有效成分，其中所述提取物是通过用至少一种选自水，C 1-4的溶剂萃取木槿大麻制备的 醇，甘油，丙二醇，1,3-丁二醇，乙酸乙酯，苯，己烷，乙醚和二氯甲烷，过滤提取物并浓缩滤液。
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公开(公告)号：KR100815476B1
公开(公告)日：2008-03-20
申请号：KR1020060067626
申请日：2006-07-19
Applicant: 강원대학교산학협력단
IPC: A61K36/185 , A23L1/29
Abstract: 본 발명은 케나프 추출물과 이로부터 분리된 신규 캠프페롤 화합물 및 이의 용도에 관한 것으로서, 더욱 상세하게는 케나프(
Hibiscus cannabbinus L., Malvaceae) 추출물과 이로부터 분리된 신규 캠프페롤 화합물이 항균제, 항산화제 등으로 사용할 수 있는 새로운 용도 및 이를 케나프에서 얻는 제조방법에 관한 것으로서, 본 발명의 캠프페롤 화합물이 포함된 약학적 조성물 및 케나프 추출물은 상기 효능이 탁월하여 앞으로 그 이용이 크게 기대된다.
케나프(Hibiscus cannabbinus L., Malvaceae), 캠프페롤 화합물-
24.发明授权2,6-Dibenzyl-4-chlorophenol 화합물을 유효성분으로 하는 암예방 및 치료용 약학적 조성물 有权26-二苄基-4-氯苯酚用于预防或治疗癌症的药物组合物包含26-二苄基-4-氯苯酚化合物
公开(公告)号：KR101699201B1
公开(公告)日：2017-01-24
申请号：KR1020160006228
申请日：2016-01-19
Applicant: 강원대학교산학협력단
Abstract: 본발명은 2,6-Dibenzyl-4-chlorophenol 화합물을유효성분으로함유하는암 예방및 치료용조성물에관한것으로, 2,6-Dibenzyl-4-chlorophenol 화합물이 A549세포, DU145세포, Hela세포및 HepG2세포에서농도의존적으로암세포의증식을억제하였으므로본 발명의 2,6-Dibenzyl-4-chlorophenol 화합물은암 예방및 치료용약학적조성물로유용하게사용될수 있다.
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公开(公告)号：KR1020140087724A
公开(公告)日：2014-07-09
申请号：KR1020120158317
申请日：2012-12-31
Applicant: 강원대학교산학협력단
CPC classification number: A61K38/08 , C07K7/06 , Y10S514/886
Abstract: The present invention relates to a peptide composition having an anti-inflammatory effect, wherein the peptide composition is represented by chemical formula 1. In the chemical formula 1, R1, R4, and R5 are hydrogen; R2 and R3 are hydroxyl; K is Lys; G is Gly; T is Thr; E is Glu; and C is Cys. Accordingly, the peptide composition has high in vivo transferring efficiency, does not inhibit immune macrophages, and has an anti-inflammatory effect for inhibiting the activities of PGE2 and AP-1.
Abstract translation: 本发明涉及具有抗炎作用的肽组合物，其中肽组合物由化学式1表示。在化学式1中，R 1，R 4和R 5是氢; R2和R3是羟基; K为Lys; G是Gly; T是Thr; E是Glu; C是Cys。 因此，肽组合物具有高的体内转移效率，不抑制免疫巨噬细胞，并且具有抑制PGE2和AP-1的活性的抗炎作用。
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Patent Agency Ranking
公开(公告)号：KR1020140087723A
公开(公告)日：2014-07-09
申请号：KR1020120158315
申请日：2012-12-31
Applicant: 강원대학교산학협력단
CPC classification number: A61K38/177 , A61K9/06 , C07K14/4713 , Y10S424/81 , Y10S514/886
Abstract: The present invention relates to a pharmaceutical composition for preventing and treating inflammatory and autoimmune diseases, wherein the pharmaceutical composition includes peptide represented by SEQ ID NO: 1 as an active ingredient. Accordingly, the pharmaceutical composition has high in vivo transferring efficiency, does not inhibit immune macrophages, and inhibits the activities of PGE2, AP-1, and TNF-α.
Abstract translation: 本发明涉及用于预防和治疗炎性和自身免疫性疾病的药物组合物，其中该药物组合物包含SEQ ID NO：1所示的肽作为活性成分。 因此，药物组合物具有高的体内转移效率，不抑制免疫巨噬细胞，并且抑制PGE2，AP-1和TNF-α的活性。
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公开(公告)号：KR101099895B1
公开(公告)日：2011-12-28
申请号：KR1020110035908
申请日：2011-04-18
Applicant: 강원대학교산학협력단
IPC: C07C43/23 , C07C43/205 , A61K31/085 , A61P35/00
Abstract: PURPOSE: An isooctylphenol derivative inducing the apoptosis of cancer cells by improving the activity of AMPK, and a use thereof as an anti-cancer drug are provided to generate the cell cycle arrest and MAPK of the cancer cells. CONSTITUTION: An isooctylphenol-4 compound marked with chemical formula (I) is an active component of an anti-cancer drug composition. The anti-cancer effect of the isooctylphenol-4 compound can be tested by the following steps: synthesizing a biosynthesis compound of isooctylphenol-4; and examining a transmitting process of the cancer cell death signal of the isooctylphenol-4.
Abstract translation: 目的：通过改善AMPK活性诱导癌细胞凋亡的异辛基酚衍生物，提供其作为抗癌药物的用途，以产生癌细胞的细胞周期停滞和MAPK。 构成：用化学式（I）标记的异辛基酚-4化合物是抗癌药物组合物的活性成分。 异辛基酚-4化合物的抗癌作用可以通过以下步骤来测试：合成异辛基酚-4的生物合成化合物; 并检查异辛基酚-4的癌细胞死亡信号的传递过程。
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公开(公告)号：KR101025160B1
公开(公告)日：2011-03-31
申请号：KR1020100037797
申请日：2010-04-23
Applicant: 강원대학교산학협력단
IPC: A61K31/56 , A61K31/015 , A61P29/00 , A61P37/00
CPC classification number: A61K31/56 , A61K31/122 , A61K31/575 , A61K2300/00 , Y10S514/885 , Y10S514/886
Abstract: PURPOSE: A composition for anti-inflammation and immunity regulation is provided to suppress expression of TNF-alpha and prostaglandin(PGE2) and to teat inflammatory diseases. CONSTITUTION: A composition for anti-inflammation and enhancing immunity contains trisnorhopanone, campesterol, and diplopterol as an active ingredient. The active ingredient suppresses NO generation and TNF-alpha generation. The active ingredient further contains dryocrassin, dryocrassol, dryocrassyl acetate, fernene, or flavaspidic acid.
Abstract translation: 目的：提供抗炎和免疫调节的组合物，以抑制TNF-α和前列腺素（PGE2）的表达和乳头炎。 构成：用于抗炎和增强免疫的组合物含有三羟甲喋呤，菜油甾醇和diplopterol作为活性成分。 活性成分抑制NO产生和TNF-α产生。 活性成分进一步含有干甘油三酯，干甘油三酯，醋酸干甘油酯，蕨类或黄烷酸。
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公开(公告)号：KR1020100116882A
公开(公告)日：2010-11-02
申请号：KR1020090035529
申请日：2009-04-23
Applicant: 강원대학교산학협력단
IPC: A61K36/344 , A61P17/14 , A23L1/30 , A61K8/97
Abstract: PURPOSE: A composition containing Codonopis lanceolata extract or Codonopis lanceolata saponin is provided to prevent hair loss or to promote hair growth. CONSTITUTION: A composition for promoting hair growth contains Codonopis lanceolata extract as an active ingredient. The Codonopis lanceolata extract is saponin fraction of Codonopis lanceolata. The composition contains Codonopis lanceolata saponin as an active ingredient. An external use skin formulation for hair growth containing the composition is used in the form of scalp treatment, soap, hair tonic, shampoo, rinse, hair pack, lotion conditioner, hair oil, cream, soild formulation, dispersing agent, liposome or ointment.
Abstract translation: 目的：提供含有爪蟾提取物或番茄皂甙皂甙的组合物，以防止脱发或促进毛发生长。 构成：用于促进头发生长的组合物含有爪蟾提取物作为活性成分。 Codonopis lanceolata提取物是Codonopis lanceolata的皂苷分数。 该组合物含有角叉菜皂苷皂甙作为活性成分。 使用含有该组合物的毛发生长用的外用皮肤制剂，其形式为头皮治疗，肥皂，发质，洗发剂，漂洗剂，发胶包，洗剂调理剂，发油，霜剂，乳液制剂，分散剂，脂质体或软膏。
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公开(公告)号：KR100905387B1
公开(公告)日：2009-06-30
申请号：KR1020080097396
申请日：2008-10-02
Applicant: 강원대학교산학협력단
Abstract: A composition of solvent extract from Berberis koreana Palibin is provided to suppress the generation of nitric oxide, TNF-alpha and prostaglandin E2(PGE2) and regulates the function of macrophage. A method for manufacturing a butanol fraction of Berberis koreana Palibin comprises: a step of extracting the Berberis koreana Palibin in the water of 20-100°C to obtain concentrate; a step of suspending the concentrate with water and a step of fraction-extracting the suspension with hexane, ethylacetate and butanol. A pharmaceutical composition for treating inflammatory disease or immune-modulating comprises the butanol fraction of water extract of Berberis koreana Palibin. The inflammatory disease is arthritis, the sepsis, and inflammation or the autoimmune disease.
Abstract translation: 提供小檗碱溶剂提取物的组合物，以抑制一氧化氮，TNF-α和前列腺素E2（PGE2）的产生并调节巨噬细胞的功能。 一种制备小檗的丁醇馏分的方法包括：在20-100℃的水中提取小檗Berberin获得浓缩物的步骤; 用水悬浮浓缩物的步骤和用己烷，乙酸乙酯和丁醇分馏提取悬浮液的步骤。 用于治疗炎性疾病或免疫调节的药物组合物包含小檗Berberis水提取物的丁醇级分。 炎性疾病是关节炎，败血症，炎症或自身免疫性疾病。
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