公开(公告)号：PT874808E

公开(公告)日：2003-08-29

申请号：PT96940406

申请日：1996-11-13

Applicant: ABBOTT LAB

Inventor： STEINMAN DOUGLAS H ,  FESIK STEPHEN W ,  SHEPPARD GEORGE S ,  CARRERA GEORGE M JR ,  SUMMERS JAMES B JR ,  DAVIDSEN STEVEN K ,  HOLMS JAMES H ,  FLORJANCIC ALAN

IPC: A61P19/02 ,  A61K31/185 ,  A61K31/275 ,  A61P29/00 ,  A61P35/04 ,  A61P43/00 ,  C07C259/06 ,  C07C323/60 ,  A61K31/16

Abstract: Compounds of formula or a pharmaceutically acceptable salt thereof inhibit matrix metalloproteinases and TNF alpha secretion and are useful in the treatment of inflammatory disease states. Also disclosed are matrix metalloproteinases and TNF alpha secretion inhibiting compositions and a method for inhibiting matrix metalloproteinases and TNF alpha secretion.

公开(公告)号：MXPA01010183A

公开(公告)日：2003-07-21

申请号：MXPA01010183

申请日：2000-04-07

Applicant: ABBOTT LAB

Inventor： FESIK STEPHEN W

IPC: C12N15/09 ,  C07B59/00 ,  C07C51/09 ,  C07C51/353 ,  C07C59/185 ,  C07C229/08 ,  C07K1/107 ,  C07K1/13 ,  C07K14/47 ,  C12N9/64 ,  C12P13/04 ,  C12P13/06 ,  C12P13/08 ,  C12P21/00 ,  C12P21/02 ,  C07M5/00

公开(公告)号：ZA200107919B

公开(公告)日：2003-03-26

申请号：ZA200107919

申请日：2001-09-27

Applicant: ABBOTT LAB

Inventor： FESIK STEPHEN W ,  AUGERI DAVID J

IPC: C12N15/09 ,  C07B59/00 ,  C07C51/09 ,  C07C51/353 ,  C07C59/185 ,  C07C229/08 ,  C07K1/107 ,  C07K1/13 ,  C07K14/47 ,  C12N9/64 ,  C12P13/04 ,  C12P13/06 ,  C12P13/08 ,  C12P21/00 ,  C12P21/02 ,  C07B ,  C07C ,  C12P ,  C07K ,  C07M

Abstract: Site-specific isotopically-labeled valine, leucine, and isoleucine and biosynthetic precursors for these amino acids are provided. The amino acids are labeled with C or C at the methyl group carbon atom(s) most remote from the carboxyl group. Also disclosed are the biochemical precursors of these labeled amino acids, 2-keto-4-( C)butyric acid and 2-keto-3-( C-methyl)-4-( C)-butyric acid in which n, at each occurrence, is 13 or 14. Also disclosed are proteins, protein fragments, and polypeptides containing these site-specifically isotopically labeled amino acids, and methods for preparing the biochemical precursors, the amino acids, and the proteins, protein fragments, and polypeptides.

公开(公告)号：CA2423103A1

公开(公告)日：2002-03-28

申请号：CA2423103

申请日：2001-09-20

Applicant: ABBOTT LAB

Inventor： THOMAS SHEELA A ,  PETROS ANDREW M ,  DING HONG ,  BAUMEISTER STEVEN A ,  AUGERI DAVID J ,  DICKMAN DANIEL A ,  MCCLELLAN WILLIAM ,  SHEN WANG ,  FESIK STEPHEN W ,  WENDT MICHAEL D ,  WANG XILU ,  BRUNCKO MILAN ,  NETTESHEIM DAVID G ,  KUNZER AARON R ,  DINGES JURGEN ,  ROSENBERG SAUL H ,  HAJDUK PHILIP J ,  OOST THORSTEN

IPC: A61K31/18 ,  A61K31/428 ,  A61K31/63 ,  A61K31/635 ,  A61P9/10 ,  A61P25/16 ,  A61P25/28 ,  A61P29/00 ,  A61P31/12 ,  A61P31/18 ,  A61P35/00 ,  A61P37/02 ,  C07C311/46 ,  C07C311/51 ,  C07C317/28 ,  C07C323/12 ,  C07C323/17 ,  C07C323/25 ,  C07C323/30 ,  C07C323/37 ,  C07C323/43 ,  C07C323/44 ,  C07C323/48 ,  C07C323/58 ,  C07C323/60 ,  C07D203/10 ,  C07D205/04 ,  C07D205/12 ,  C07D207/09 ,  C07D207/24 ,  C07D207/40 ,  C07D207/404 ,  C07D209/08 ,  C07D209/52 ,  C07D209/54 ,  C07D209/96 ,  C07D211/14 ,  C07D211/44 ,  C07D211/70 ,  C07D211/74 ,  C07D213/56 ,  C07D213/61 ,  C07D213/64 ,  C07D213/69 ,  C07D213/70 ,  C07D213/71 ,  C07D215/14 ,  C07D215/22 ,  C07D215/227 ,  C07D215/38 ,  C07D215/48 ,  C07D217/04 ,  C07D221/20 ,  C07D231/12 ,  C07D233/60 ,  C07D235/08 ,  C07D235/26 ,  C07D241/08 ,  C07D241/16 ,  C07D249/04 ,  C07D263/32 ,  C07D263/56 ,  C07D263/58 ,  C07D277/62 ,  C07D277/64 ,  C07D295/13 ,  C07D295/155 ,  C07D295/16 ,  C07D295/185 ,  C07D295/20 ,  C07D295/205 ,  C07D295/215 ,  C07D295/26 ,  C07D307/14 ,  C07D317/54 ,  C07D333/28 ,  C07D333/68 ,  C07D333/70 ,  C07D401/06 ,  C07D401/12 ,  C07D405/04 ,  C07D405/06 ,  C07D417/12 ,  C07D451/02 ,  C07D491/107 ,  C07D295/14 ,  C07D317/58

Abstract: N-Benzoyl arylsulfonamides having the formula (I) are BCL-Xl inhibitors and are useful for promoting apoptosis. Also disclosed are BCL-Xl inhibiting compositions and methods of promoting apoptosis in a mammal.

公开(公告)号：TR200102842T2

公开(公告)日：2002-03-21

申请号：TR200102842

申请日：2000-04-07

Applicant: ABBOTT LAB

Inventor： FESIK STEPHEN W ,  AUGERI DAVID J

IPC: C12N15/09 ,  C07B59/00 ,  C07C51/09 ,  C07C51/353 ,  C07C59/185 ,  C07C229/08 ,  C07K1/107 ,  C07K1/13 ,  C07K14/47 ,  C12N9/64 ,  C12P13/04 ,  C12P13/06 ,  C12P13/08 ,  C12P21/00 ,  C12P21/02

Abstract: Site-specific isotopically-labeled valine, leucine, and isoleucine and biosynthetic precursors for these amino acids are provided. The amino acids are labeled with C or C at the methyl group carbon atom(s) most remote from the carboxyl group. Also disclosed are the biochemical precursors of these labeled amino acids, 2-keto-4-( C)butyric acid and 2-keto-3-( C-methyl)-4-( C)-butyric acid in which n, at each occurrence, is 13 or 14. Also disclosed are proteins, protein fragments, and polypeptides containing these site-specifically isotopically labeled amino acids, and methods for preparing the biochemical precursors, the amino acids, and the proteins, protein fragments, and polypeptides.

公开(公告)号：PT870197E

公开(公告)日：2001-11-30

申请号：PT96939709

申请日：1996-11-13

Applicant: ABBOTT LAB

Inventor： FESIK STEPHEN W ,  ONEJNICZAK EDWARD T ,  HAJDUK PHILIP J

IPC: G01R33/465 ,  G01N33/15 ,  G01N33/50 ,  G01N33/53 ,  G01N33/543 ,  G01N33/68 ,  G01N33/94 ,  G01R33/32 ,  G01R33/46 ,  G01N33/48 ,  G01N24/08

公开(公告)号：PT866967E

公开(公告)日：2000-04-28

申请号：PT96940448

申请日：1996-11-13

Applicant: ABBOTT LAB

Inventor： FESIK STEPHEN W ,  HAJDUK PHILIP J

IPC: G01R33/465 ,  C12Q1/00 ,  G01N20060101 ,  G01N24/08 ,  G01N33/15 ,  G01N33/50 ,  G01N33/53 ,  G01N33/542 ,  G01N33/566 ,  G01N33/58 ,  G01N33/68

Abstract: A method for designing and forming a ligand which binds to a specific target molecule comprises the steps of: (a) identifying a first ligand moiety that binds to the target molecule using two-dimensional N/ H NMR correlation spectroscopy; (b) identifying subsequent ligand moieties that bind to the target molecule using two-dimensional N/ H NMR correlation spectroscopy; (c) forming a complex of the first and subsequent ligand moieties to the target molecule; (d) determining the three-dimensional structure of the complex and, thus, the spatial orientation of the first and subsequent ligand moieties on the target molecule; and (e) linking the first and subsequent ligand moieties to form a new ligand to maintain the spatial orientation of the ligand moieties.

公开(公告)号：CA2365385C

公开(公告)日：2009-11-03

申请号：CA2365385

申请日：2000-03-21

Applicant: ABBOTT LAB

Inventor： FESIK STEPHEN W ,  HAJDUK PHILIP J

IPC: G01N24/08 ,  G01N24/12 ,  B08B9/04 ,  C07K1/13 ,  E21B37/04 ,  G01N33/483 ,  G01N33/50 ,  G01N33/53 ,  G01N33/542 ,  G01N33/566 ,  G01N33/58 ,  G01N33/68 ,  G01N33/94 ,  G01R33/46 ,  G01R33/465

Abstract: Methods of detecting binding of a putative ligand to a 13C-enriched target molecule, methods of screening for compounds which bind to a 13C-enriched target molecule, methods for calculating the dissociation constant of a ligand compound which binds to a 13C-enriched target molecule, and methods employed in the determination of the specific amino acids in a 13C-enriched target molecule affected by the binding of a ligand, as well as compounds identified by these screening methods, are provided herewith.

公开(公告)号：SK285411B6

公开(公告)日：2007-01-04

申请号：SK141699

申请日：1998-04-17

Applicant: ABBOTT LAB

Inventor： FESIK STEPHEN W ,  HAJDUK PHILIP J ,  OLEJNICZAK EDWARD T

IPC: G01N24/00 ,  G01R33/32 ,  A61K45/00 ,  C07K14/705 ,  C12N9/00 ,  C12Q1/00 ,  C12Q1/68 ,  G01N24/08 ,  G01N33/00 ,  G01N33/15 ,  G01N33/50 ,  G01N33/53 ,  G01N33/68 ,  G01R33/44

Abstract: The present invention provides a process for identifying compounds, which bind to a specific target molecule. The process comprises the steps of: a) generating the first T2- or diffusion-filtered proton spectrum of one or a mixture of chemical compounds; b) exposing one or a mixture of chemical compounds to the target molecule; c) generating the second T2- or diffusion-filtered proton spectrum of one or a mixture of chemical compounds that has been exposed to the target molecule in step (b); and d) comparing said first and second T2- or diffusion-filtered proton spectra to determine differences between said first and said second spectra, the differences identifying the presence of one or more compounds that are ligands which have bound to the target molecule.

公开(公告)号：AT327510T

公开(公告)日：2006-06-15

申请号：AT00918228

申请日：2000-03-21

Applicant: ABBOTT LAB

Inventor： FESIK STEPHEN W ,  HAJDUK PHILIP J

IPC: G01N24/12 ,  B08B9/04 ,  C07K1/13 ,  E21B37/04 ,  G01N33/483 ,  G01N33/50 ,  G01N33/53 ,  G01N33/542 ,  G01N33/566 ,  G01N33/68 ,  G01N33/94 ,  G01R33/46 ,  G01R33/465 ,  C07B61/00 ,  G01N33/58