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公开(公告)号：AT401310T
公开(公告)日：2008-08-15
申请号：AT02714958
申请日：2002-01-17
Applicant: ABBOTT LAB
Inventor： ALTENBACH ROBERT J , BAI HAO , BRIONI JORGE , CARROL WILLIAM , GOPALAKRISHNAN MURALI , HOLLADAY MARK W , HUANG PEGGY , KINCAID JOHN , KORT MICHAEL , KYM PHILIP , LYNCH JOHN , PEREZ-MEDRANO ARTURO , ZHANG HENRY , GREGG ROBERT
IPC: C07D213/75 , A61K31/17 , A61K31/275 , A61K31/4164 , A61K31/4406 , A61K31/455 , A61K31/47 , A61K31/505 , A61P1/00 , A61P9/00 , A61P9/04 , A61P9/10 , A61P11/00 , A61P11/06 , A61P13/00 , A61P13/08 , A61P13/10 , A61P15/00 , A61P15/06 , A61P15/10 , A61P17/00 , A61P17/14 , A61P25/00 , A61P25/04 , A61P25/06 , A61P25/08 , A61P25/18 , A61P25/28 , A61P43/00 , C07C233/36 , C07C233/78 , C07C233/83 , C07C255/61 , C07C271/22 , C07C275/28 , C07C275/30 , C07C279/28 , C07C279/36 , C07C335/16 , C07C335/18 , C07C335/20 , C07D209/08 , C07D209/30 , C07D213/40 , C07D213/74 , C07D213/82 , C07D215/38 , C07D233/42 , C07D233/84 , C07D235/06 , C07D239/42 , C07D333/20 , C07D401/04 , C07D401/12 , C07D405/12 , C07D409/12
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公开(公告)号：DE60036476D1
公开(公告)日：2007-10-31
申请号：DE60036476
申请日：2000-08-02
Applicant: ABBOTT LAB
Inventor： ALTENBACH ROBERT J , BAI HAO , BRIONI JORGE D , CARROLL WILLIAM A , GOPALAKRISHNAN MURALI , GREGG ROBERT J , HOLLADAY MARK W , HUANG PEGGY P , KINCAID JOHN F , KORT MICHAEL E , KYM PHILIP R , LYNCH JOHN K , PEREZ-MEDRANO ARTURO , ZHANG HENRY Q
IPC: C07D213/74 , C07D249/18 , A61K31/166 , A61K31/17 , A61K31/417 , A61K31/4192 , A61K31/44 , A61K31/4406 , A61K31/47 , A61P1/00 , A61P9/00 , A61P9/10 , A61P11/06 , A61P13/02 , A61P13/08 , A61P13/10 , A61P15/00 , A61P15/10 , A61P17/14 , A61P25/00 , A61P25/02 , A61P25/06 , A61P25/08 , C07C233/78 , C07C233/83 , C07C271/22 , C07C275/28 , C07C275/30 , C07C275/54 , C07C279/22 , C07C279/28 , C07C279/30 , C07C279/36 , C07C335/16 , C07C335/18 , C07C335/26 , C07D209/08 , C07D213/75 , C07D215/38 , C07D233/02 , C07D233/42 , C07D235/06 , C07D239/42 , C07D401/04 , C07D401/12 , C07D405/12 , C07D407/12
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公开(公告)号：CA2628260A1
公开(公告)日：2007-05-18
申请号：CA2628260
申请日：2006-11-02
Applicant: ABBOTT LAB
Inventor： CARROLL WILLIAM A , PEREZ-MEDRANO ARTURO , LI TONGMEI
IPC: C07D231/38 , A61K31/415 , A61K31/416 , A61K31/4162 , A61K31/4439 , A61P29/00 , C07D231/54 , C07D401/12 , C07D495/04
Abstract: A compound having formula (I) wherein R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are defined in the description, is disclosed as an P2X 7 antagonist. Methods and compositions for treating disease or condition modulated by P2X 7 are also disclosed.
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公开(公告)号：MXPA06012595A
公开(公告)日：2007-05-09
申请号：MXPA06012595
申请日：2005-04-28
Applicant: ABBOTT LAB
Inventor： HIRST GAVIN C , LI TONGMEI , CARROLL WILLIAM A , PEREZ-MEDRANO ARTURO , FLORJANCIC ALAN S , NELSON DEREK W , PEDDI SRIDHAR , BUNNELLE ERIC M , LI BIQIN
IPC: C07D257/06 , A61K31/00 , A61K31/41 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14 , C07D487/04 , C07D491/04 , C07D491/18
Abstract: Se describe un compuesto que tiene la Formula (I) o Formula (II) como un antagonista de P2X7, en donde A, B, C, Y, Y, Z, m, v, R1, R2, R3, R4 y R5, son como se definen en la descripcion. Se describen metodos y composiciones para tratar enfermedad o condicion modulada por P2X7.
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公开(公告)号：CA2565211A1
公开(公告)日：2005-11-24
申请号：CA2565211
申请日：2005-04-28
Applicant: ABBOTT LAB
Inventor： HIRST GAVIN C , LI BIQIN , FLORJANCIC ALAN S , PEREZ-MEDRANO ARTURO , CARROLL WILLIAM A , BUNNELLE ERIC M , PEDDI SRIDHAR , NELSON DEREK W
IPC: C07D257/06 , A61K31/41 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14 , C07D487/04 , C07D491/04 , C07D491/18
Abstract: A compound having Formula (I) or Formula (II) is disclosed as an P2X7 antagonist, wherein A, B, C, Y, Y, Z, m, v, R1, R2, R3, R4, and R5, are as defined in the description. Methods and compositions for treating disease or condition modulated by P2X7 are also disclosed.
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Patent Agency Ranking
公开(公告)号：PE08042011A1
公开(公告)日：2011-11-30
申请号：PE0006262011
申请日：2009-09-16
Applicant: ABBOTT LAB
Inventor： CARROLL WILLIAM A , DART MICHAEL J , FROST JENNIFER M , LATSHAW STEVEN P , KOLASA TEODOZYJ , LI TONGMEI , PEDDI SRIDHAR , LIU BO , PEREZ-MEDRANO ARTURO , PATEL MEENA , WANG XUEQING , NELSON DEREK W
IPC: C07D231/40 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/12 , C07D413/14
CPC classification number: C07D405/12 , C07D231/40 , C07D285/135 , C07D403/12 , C07D405/14 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12
Abstract: SE REFIERE A UN COMPUESTO DE FORMULA (I) DONDE X4 ES O, S, S(O), N(Rbx); Rbx ES H, ALQUILO, -C(O)O(ALQUILO); A1 ES -(CR1aR1b)q1-A2, -(CR1aR1b)q1-G1c, ENTRE OTROS; R1a Y R1b SON CADA UNO H, HALOGENO, ALQUILO C1-C4, ALQUILO C1-C4, ENTRE OTROS q1 ES 1-4; G1c ES CICLOALQUENILO, HETEROCICLO, ARILO, HETEROARILO; A2 ES -CO, -SO2, ENTRE OTROS; A5 ES DE PREFERENCIA PIRAZOL, 1,3,4-TIADIAZOL, ENTRE OTROS; RX ES C1-C4 ALQUILO, HALOGENO, NO2, ENTRE OTROS; z ES 0-4. SON COMPUESTOS PREFERIDOS: N-{(3E)-5-TERT-BUTIL-1-METIL-2-[(2R)-TETRAHIDROFURAN-2-ILMETIL]-1,2-DIHIDRO-3H-PIRAZOL-3-ILIDEN}-2-[(2R)-TETRAHIDROFURAN-2-ILMETOXI]-5-(TRIFLUOROMETIL)BENZAMIDA; N-[(2Z)-3-BUTIL-5-TERT-BUTIL-1,3,4-TIADIAZOL-2(3H)-ILIDEN]-2-(2-HIDROXI-2-METILPROPOXI)-5-(TRIFLUOROMETIL)BENZAMIDA; ENTRE OTROS. REFERIDA TAMBIEN A UNA COMPOSICION FARMACEUTICA QUE PRESENTA UN BIODISPONIBILIDAD ORAL MAYOR O IGUAL A 30%. DICHOS COMPUESTOS SON LIGANDOS DE RECEPTORES DE CANNABINOIDES UTIL EN EL TRATAMIENTO DEL DOLOR
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公开(公告)号：CR20110170A
公开(公告)日：2011-06-22
申请号：CR20110170
申请日：2011-03-28
Applicant: ABBOTT LAB
Inventor： CARROLL WILLIAM A , DART MICHAEL J , FROST JENNIFER M , LATSHAW STEVEN P , KOLASA TEODOZYJ , LI TONGMEI , PEDDI SRIDHAR , LIU BO , PEREZ-MEDRANO ARTURO , PATEL MEENA , WANG XUEQING , NELSON DEREK W
IPC: C07D231/40 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/12 , C07D413/14
Abstract: Ligandos de receptores de canabinoides de la fórmula (I), en donde A1, A5, Rx, X4 y z son como se definen en la memoria descriptiva. Se divulgan asimismo composiciones que comprenden dichos compuestos y métodos para el tratamiento de condiciones y trastornos usando dichos compuestos y composiciones.
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公开(公告)号：CA2778266A1
公开(公告)日：2011-06-03
申请号：CA2778266
申请日：2010-11-18
Applicant: ABBOTT LAB
Inventor： BROWN BRIAN S , LI TONGMEI , PEREZ-MEDRANO ARTURO , PEDDI SRIDHAR
IPC: C07D237/24 , A61K31/502 , A61P29/00 , C07D401/12 , C07D405/04 , C07D471/04 , C07D495/04
Abstract: Disclosed herein are KCNQ potassium channels modulators of formula (I) wherein ring Z1, R1, p, R3, and R4 are as defined in the specification. Compositions comprising such compounds; and methods for treating conditions and disorders using such compounds and compositions are also described.
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公开(公告)号：ECSP11010974A
公开(公告)日：2011-05-31
申请号：ECSP11010974
申请日：2011-04-12
Applicant: ABBOTT LAB
Inventor： KOLASA TEODOZYJ , DART MICHAEL J , CARROLL WILLIAM A , FROST JENNIFER M , LI TONGMEL , NELSON DEREK W , PATEL MEENA V , PEDDI SRIDHAR , PEREZ-MEDRANO ARTURO , LATSHAW STEVEN P , LIU BO , WANG XUEQING
IPC: C07D231/40 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/12 , C07D413/14
Abstract: Ligandos de receptores de canabinoides de la fórmula (I) (consta diseño) en donde A1, A5, Rx, X4 y z son como se definen en la memoria descriptiva. Se divulgan asimismo composiciones que comprenden dichos compuestos y métodos para el tratamiento de condiciones y trastornos usando dichos compuestos y composiciones.
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公开(公告)号：MX2011001755A
公开(公告)日：2011-03-24
申请号：MX2011001755
申请日：2009-08-11
Applicant: ABBOTT LAB
Inventor： DART MICHAEL J , CARROLL WILLIAM A , LIU BO , KOLASA TEODOZYJ , FROST JENNIFER M , LATSHAW STEVEN P , PEREZ-MEDRANO ARTURO , PATEL MEENA V , WANG XUEQUING
IPC: C07D261/14 , A61K31/433 , A61P29/00 , C07D285/135 , C07D407/06 , C07D417/06
Abstract: Se describen ligandos de receptor canabinoide de la fórmula (I), en donde Y, X1, X2, X3, R1 y R2 son tal como se define en la especificación: También se describen composiciones que comprenden dichos compuestos, y métodos para tratar condiciones y trastornos utilizando dichos compuestos y composiciones.
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