公开(公告)号：AU9691198A

公开(公告)日：1999-04-27

申请号：AU9691198

申请日：1998-10-06

Applicant: BASF AG

Inventor： ARNOLD LEE D ,  XU YAJUN ,  BARLOZZARI TERESA

IPC: A61K31/416 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/4439 ,  A61P1/04 ,  A61P3/10 ,  A61P9/00 ,  A61P9/10 ,  A61P17/02 ,  A61P17/06 ,  A61P19/02 ,  A61P19/08 ,  A61P27/00 ,  A61P35/00 ,  A61P43/00 ,  C07D231/54 ,  C07D231/56 ,  C07D401/04 ,  C07D405/04 ,  C07D409/04 ,  A61K31/415 ,  A61K31/44

Abstract: Chemical compounds that are derivatives of indeno[1,2-c]-, naphtho[1,2-c]- and benzo[6,7]cyclohepta[1,2-c]pyrazole are inhibitors of tyrosine kinase activity. Several of the tyrosine kinases, whose activity is inhibited by these chemical compounds, are involved in hyperproliferative, angiogenic or in vascular hyperpermeability processes. Thus, these chemical compounds can ameliorate disease states where tumor formation, metastasis, angiogenesis, vascular hyperpermeability or endothelial cell proliferation is a factor.

公开(公告)号：CA2305688A1

公开(公告)日：1999-04-15

申请号：CA2305688

申请日：1998-09-24

Applicant: BASF AG

Inventor： BANERJEE SUBHASHIS ,  HAUPT ANDREAS ,  BARLOZZARI TERESA

IPC: A61K45/06 ,  A61K38/00 ,  A61K38/08 ,  A61K39/395 ,  A61P19/02 ,  A61P29/00 ,  C07K7/06 ,  A61K31/00

Abstract: The present invention provides compositions and methods for the treatment of rheumatoid arthritis in a subject wherein one or more compounds of Formula (I) as defined herein alone or in combination with one or more other antiarthritic drugs provide suppression of rheumatoid arthritis.

公开(公告)号：SK76798A3

公开(公告)日：1999-02-11

申请号：SK76798

申请日：1996-12-11

Applicant: BASF AG

Inventor： AMBERG WILHELM ,  BARLOZZARI TERESA ,  BERNARD HARALD ,  BUSCHMANN ERNST ,  HAUPT ANDREAS ,  HEGE HANS-GUENTHER ,  JANSSEN BERND ,  KLING ANDREAS ,  LIETZ HELMUT ,  RITTER KURT ,  ULLRICH MARTINA ,  WEYMANN JURGEN ,  ZIERKE THOMAS

IPC: A61K31/00 ,  A61K38/08 ,  A61P35/00 ,  A61K38/00 ,  A61P35/02 ,  C07K1/00 ,  C07K7/06

Abstract: Novel peptides of the formula R R N-CHX-CO-A-B-D-E-(G)s-K in which R , R , A, B, D, E, G, K, X, and s have the meanings stated in the description, and the preparation thereof are described. The novel peptides have an antineoplastic effect.

公开(公告)号：PL327175A1

公开(公告)日：1998-11-23

申请号：PL32717596

申请日：1996-12-11

Applicant: BASF AG

Inventor： AMBERG WILHELM ,  BARLOZZARI TERESA ,  BERNARD HARALD ,  BUSCHMANN ERNST ,  HAUPT ANDREAS ,  HEGE HANS-GUENTHER ,  JANSSEN BERND ,  KLING ANDREAS ,  LIETZ HELMUT ,  RITTER KURT ,  ULLRICH MARTINA ,  WEYMANN JUERGEN ,  ZIERKE THOMAS

IPC: A61K31/00 ,  A61K38/08 ,  A61P35/00 ,  A61K38/00 ,  A61P35/02 ,  C07K1/00 ,  C07K7/06

Abstract: Novel peptides of the formula R R N-CHX-CO-A-B-D-E-(G)s-K in which R , R , A, B, D, E, G, K, X, and s have the meanings stated in the description, and the preparation thereof are described. The novel peptides have an antineoplastic effect.

公开(公告)号：AU6694598A

公开(公告)日：1998-09-29

申请号：AU6694598

申请日：1998-03-09

Applicant: BASF AG ,  BASF BIORESEARCH CORP

Inventor： BARLOZZARI TERESA ,  HAUPT ANDREAS

IPC: A61K38/00 ,  A61K31/337 ,  A61K38/07 ,  A61K38/08 ,  A61K38/15 ,  A61P35/00 ,  C07K5/08 ,  C07K5/10 ,  C07K7/00 ,  A61K38/04

Abstract: The present invention provides compositions and methods for the treatment of cancer in a subject wherein compounds of Formula I as defined herein in combination with paclitaxel, taxotere or modified taxane or taxoid analogs provide enhanced anticancer effects over the effects achieved with the individual compounds.

公开(公告)号：CA2282720A1

公开(公告)日：1998-09-17

申请号：CA2282720

申请日：1998-03-09

Applicant: BASF AG

Inventor： BARLOZZARI TERESA ,  HAUPT ANDREAS

IPC: A61K38/00 ,  A61K31/337 ,  A61K38/07 ,  A61K38/08 ,  A61K38/15 ,  A61P35/00 ,  C07K5/08 ,  C07K5/10 ,  C07K7/00 ,  A61K38/04

Abstract: The present invention provides compositions and methods for the treatment of cancer in a subject wherein compounds of Formula (I) as defined herein in combination with paclitaxel, taxotere or modified taxane or taxoid analogs provide enhanced anticancer effects over the effects achieved with the individual compounds.

公开(公告)号：CZ9801846A3

公开(公告)日：1998-09-16

申请号：CZ184698

申请日：1996-12-11

Applicant: BASF AG

Inventor： AMBERG WILHELM DR ,  BARLOZZARI TERESA ,  BERNARD HARALD DR ,  BUSCHMANN ERNST DR ,  HAUPT ANDREAS DR ,  HEGE HANS-GUENTHER DR ,  JANSSEN BERND DR ,  KLING ANDREAS DR ,  LIETZ HELMUT ,  RITTER KURT DR ,  ULRICH MARTINA DR ,  WEYMANN JURGEN DR ,  ZIERKE THOMAS DR

IPC: A61K38/00 ,  A61K31/00 ,  A61K38/08 ,  A61P35/00 ,  A61P35/02 ,  C07K1/00 ,  C07K7/06

CPC classification number: A61K38/08

公开(公告)号：CZ139198A3

公开(公告)日：1998-09-16

申请号：CZ139198

申请日：1996-10-30

Applicant: BASF AG

Inventor： KLING ANDREAS ,  JANSSEN BERND ,  AMBERG WILHELM ,  HAUPT ANDREAS ,  RITTER KURT ,  BUSCHMANN ERNST ,  BERNARD HARALD ,  MULLER STEFAN ,  ZIERKE THOMAS ,  BARLOZZARI TERESA ,  DE ARRUDA MONIKA ,  ROBINSON SIMON

IPC: A61K38/00 ,  A61K31/00 ,  C07K7/06 ,  A61K38/08

Abstract: Novel peptides of the formulaA-B-D-E-F-L,wherein A, B, D, E, F, and L have the meanings stated in the specification, and their preparation are disclosed. The novel compounds are suitable for controlling diseases.

公开(公告)号：NZ258882A

公开(公告)日：1997-06-24

申请号：NZ25888293

申请日：1993-12-04

Applicant: BASF AG

Inventor： HAUPT ANDREAS ,  JANSSEN BERND ,  RITTER KURT ,  KLINGE DAGMAR ,  KEILHAUER GERHARD ,  ROMERDAHL CYNTHIA ,  BARLOZZARI TERESA ,  QIAN XIAO-DONG

IPC: A61K38/00 ,  A61K38/08 ,  A61P35/00 ,  C07K1/00 ,  C07K5/02 ,  C07K5/027 ,  C07K7/02 ,  C07K7/06 ,  A61K38/02

公开(公告)号：HRP931504A2

公开(公告)日：1997-02-28

申请号：HRP931504

申请日：1993-12-16

Applicant: BASF AG

Inventor： HAUPT ANDREAS ,  JANSSEN BERND ,  RITTER KURT ,  KLINGE DAGMAR ,  KEILHAUER GERHARD ,  ROMENDAHL CYNTHIA ,  BARLOZZARI TERESA ,  QUIAN XIAO-DONG

IPC: A61K38/00 ,  A61K38/08 ,  A61P35/00 ,  C07K1/00 ,  C07K5/02 ,  C07K5/027 ,  C07K7/02 ,  C07K7/06 ,  A61K38/03