公开(公告)号：DE19624607A1

公开(公告)日：1998-01-02

申请号：DE19624607

申请日：1996-06-20

Applicant: BASF AG

Inventor： BREITENBACH JOERG DR ,  ROSENBERG JOERG DR ,  NEUMANN JOERG DR ,  ZEIDLER JUERGEN DR ,  SIMON DIRK DR ,  DIENER RALPH DR

IPC: A61K31/19 ,  A61K9/16 ,  A61K31/00 ,  B01J19/00 ,  C07C51/41 ,  C07C57/30 ,  C07C229/26 ,  A61K31/195

Abstract: Preparation of a salt of a pharmaceutically active carboxylic acid compound comprises reacting the acid in an extruder with ≥ 1 stoichiometric equivalent of a base in melt form.

公开(公告)号：CZ340596A3

公开(公告)日：1997-06-11

申请号：CZ340596

申请日：1996-03-12

Applicant: BASF AG

Inventor： ROSENBERG JOERG DR ,  BREITENBACH JORG DR

IPC: A61K9/14 ,  A61K9/20 ,  B01J2/20

Abstract: PCT No. PCT/EP96/01047 Sec. 371 Date Nov. 21, 1996 Sec. 102(e) Date Nov. 21, 1996 PCT Filed Mar. 12, 1996 PCT Pub. No. WO96/29061 PCT Pub. Date Sep. 26, 1996A process for producing active substance compositions in the form of a solid solution of the active substance in a polymer matrix, which comprises melt extrusion of the active substance in nonionic form together with a polymer and a salt.

公开(公告)号：DE19536394A1

公开(公告)日：1997-04-03

申请号：DE19536394

申请日：1995-09-29

Applicant: BASF AG

Inventor： ZEIDLER JUERGEN DR ,  ROSENBERG JOERG DR ,  BREITENBACH JOERG DR ,  NEUMANN JOERG DR

IPC: A61K9/16 ,  A61K9/20 ,  A61K31/277 ,  A61K47/24 ,  A61K47/26 ,  A61K47/30 ,  A61K47/36 ,  A61K31/275 ,  A61J3/10

Abstract: The invention concerns solid medicaments obtained by extrusion with subsequent shaping of a solvent-free melt, containing in addition to one or a plurality of active substances: A) between 10 and 90 wt.% of a thermoplastically processable water-soluble polymer; B) between 5 and 85 wt.% isomalt; and C) between 0 and 5 wt.% lecithin, the total of all the contents equalling 100 wt.%.

公开(公告)号：DE19531277A1

公开(公告)日：1997-02-27

申请号：DE19531277

申请日：1995-08-25

Applicant: BASF AG

Inventor： ROSENBERG JOERG DR ,  BREITENBACH JOERG DR

IPC: A61K9/20 ,  A61K9/16

Abstract: Use of lipids as adjuvents in the production of solid medicinal forms by the melt extrusion process.

公开(公告)号：DE3810343A1

公开(公告)日：1989-10-05

申请号：DE3810343

申请日：1988-03-26

Applicant: BASF AG

Inventor： GOERTZ HANS-HELMUT DR ,  KLIMESCH ROGER DR ,  LANG SIEGFRIED DR ,  ROSENBERG JOERG DR ,  SANNER AXEL DR ,  SPENGLER REINHARD DR ,  SCHLEMMER LOTHAR

IPC: A61K9/20 ,  A61K9/22

Abstract: Process for the production of solid pharmaceutical sustained release forms which contain as binder a polymer which dissolves or disperses in water and gastric or intestinal fluid, wherein the pharmaceutical agent, the polymeric binder and, where appropriate, the pharmaceutical ancillary substances are mixed below the glass transition temperature of the binder, this mixture is compressed, above the glass transition temperature of the binder but below the decomposition temperature of the agent, to pharmaceutical forms, and the form is removed from the mould at a temperature below the glass transition temperature of the binder, and where the type and amount of the binder and ancillary substance are chosen so that the release of agent is sustained for a period of 3 to 24 hours.

公开(公告)号：CZ124298A3

公开(公告)日：1998-07-15

申请号：CZ124298

申请日：1996-10-23

Applicant: BASF AG

Inventor： BREITENBACH JORG DR ,  HARTL AXEL PAUL DR ,  HOFMANN JURGEN ,  ROSENBERG JOERG DR ,  SCHIESSL MICHAEL ,  ZETTLER HANS DIETER

IPC: A61J3/10 ,  A61K9/20 ,  A61K9/24 ,  A61K9/28 ,  A61K31/07 ,  A61K31/167 ,  A61K31/192 ,  A61K31/277 ,  A61K31/355 ,  A61K31/375 ,  A61K31/401 ,  A61K31/4422 ,  A61K31/52 ,  A61K31/522 ,  A61K31/60

Abstract: PCT No. PCT/EP96/04601 Sec. 371 Date Apr. 15, 1998 Sec. 102(e) Date Apr. 15, 1998 PCT Filed Oct. 23, 1996 PCT Pub. No. WO97/15293 PCT Pub. Date May 1, 1997The present invention relates to a process for producing multilayer, solid drug forms for oral or rectal administration, which comprises coextrusion of at least two compositions which in each case comprise a thermoplastic, pharmacologically acceptable polymeric binder which is soluble or swellable in a physiological environment, and at least one of which contains a pharmaceutical active ingredient, and shaping the coextruded multilayer material to the required drug form.

公开(公告)号：CZ9701852A3

公开(公告)日：1998-01-14

申请号：CZ185297

申请日：1995-12-22

Applicant: BASF AG

Inventor： ROSENBERG JOERG DR ,  MAIER WERNER ,  GRABOWSKI SVEN DR ,  BREITENBACH JORG DR

IPC: A61J1/03 ,  A61J3/00 ,  A61J3/10 ,  A61K9/20 ,  A61K9/28 ,  B30B11/16 ,  B65B9/04

CPC classification number: B30B11/34 ,  A61J1/035 ,  A61J3/005 ,  A61J3/10 ,  A61J2200/20 ,  A61K9/2072 ,  B30B11/16 ,  B65B9/04

公开(公告)号：CZ239497A3

公开(公告)日：1998-01-14

申请号：CZ239497

申请日：1996-02-01

Applicant: BASF AG

Inventor： GRABOWSKI SVEN DR ,  BREITENBACH JORG DR ,  ROSENBERG JOERG DR ,  SANNER AXEL DR

IPC: A61K9/22 ,  A61K9/20

Abstract: PCT No. PCT/EP96/00417 Sec. 371 Date Jul. 30, 1997 Sec. 102(e) Date Jul. 30, 1997 PCT Filed Feb. 1, 1996 PCT Pub. No. WO96/25151 PCT Pub. Date Aug. 22, 1996Solid preparations are obtainable by melt extrusion of A) at least one active compound, B) a mixture of B1) from 10 to 90% by weight of a water-soluble, thermoplastic polymer, and B2) from 10 to 90% by weight of a low-substituted hydroxypropylcellulose, and C) from 0 to 50% by weight, based on the total amount of the preparation, of customary pharmaceutical auxiliaries.

公开(公告)号：DE19602206A1

公开(公告)日：1997-07-24

申请号：DE19602206

申请日：1996-01-23

Applicant: BASF AG

Inventor： BREITENBACH JOERG DR ,  ROSENBERG JOERG DR

IPC: A61K47/04 ,  A61K9/20 ,  A61K31/00 ,  A61K31/19 ,  A61K31/192 ,  A61K45/00 ,  A61K47/32 ,  A61P25/00 ,  A61P29/00 ,  A61K9/22

Abstract: The invention concerns preparation of non-steroidal analgesics with antipyretic and antiphlogistic effect, obtained through extrusion and moulding of a melt containing in addition one or more substances in a mixture of: a) 40 to 99.5 wt% of a homopolymer of N -vinylpyrrolidone with a K value according to Fikentscher of 30; b) 0.25 to 59.75 wt% of a water-soluble copolymer of N-vinylpyrr olidone; and c) 0.25 to 10 wt% of one or more physiologically ac ceptable sodium or potassium salts, where the quantities refer to the total of the components a), b) and c).

公开(公告)号：DE19539363A1

公开(公告)日：1997-04-24

申请号：DE19539363

申请日：1995-10-23

Applicant: BASF AG

Inventor： BREITENBACH JOERG DR ,  HAERTL AXEL PAUL DR ,  ROSENBERG JOERG DR ,  SCHIESL MICHAEL ,  ZETTLER HANS DIETER

IPC: A61K9/20 ,  A61K9/22 ,  A61K9/16

Abstract: The invention concerns a method of producing medicaments in solid form by mixing and melting at least one pharmacologically acceptable polymer binder, at least one pharmaceutical active substance and optionally conventional pharmaceutical additives in the absence of a solvent to form a plastic mixture, and shaping the mixture to form the desired medicament, mixing and melting being carried out in separate stages. The method according to the invention enables high-quality medicaments to be produced in a simple and careful manner.