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    24.
    发明专利
    未知

    公开(公告)号：DE3882589D1

    公开(公告)日：1993-09-02

    申请号：DE3882589

    申请日：1988-05-13

    Applicant: BASF AG

    Inventor： STEINER GERD DR ,  PFISTER JUERGEN DR ,  TESCHENDORF HANS-JUERGEN DR ,  UNGER LILIANE DR ,  BINDER RUDOLF DR

    IPC: A61K31/55 ,  A61P21/02 ,  A61P25/00 ,  A61P25/02 ,  A61P25/20 ,  C07D487/04

    Abstract: 4-Amino-10-cyanomethylene -pyrrolo (3,4-c) benz(b)azepine derivs. of formula (I) and their acid-addn. salts are new: In (I), R1 = H, halogen, 1-3C alkyl, CF3 or 1-3C alkoxy; R2 and R3 = H or halogen; R4 = H, 1-3C alkyl, or aryl (1-3C) alkyl opt. ring-substd. by halogen, 1-3C alkyl or OMe; A = NR3R6 or NHR7; NR5R6 is a satd. 5- to 7-membered ring opt. contg. O, NR or NR-O; R = H, 1-3C alkyl, 2-3C hydroxyalkyl, 2-3C alkoxyalkyl, 3-7C cycloalkyl, (3-7C cycloalkyl)methyl or 2-5C alkynyl; R7 = 2-7C aminoalkyl in which the amine N is opt. substd. by a 1-5C alkyl gp. or forms part of a satd. 5- to 7-membered ring opt. contg. O or NR"; R" = H, 1-3C alkyl or 2-3C hydroxyalkyl. 10-Cyanomethylene-4- (4-methyl-1-piperazinyl)- pyrrolo (3,4-c) benz(b)azepine and its 7-chloro deriv. are specifically claimed.

    New 2-substituted 1,2-benzisothiazole derivatives
    29.
    发明专利
    New 2-substituted 1,2-benzisothiazole derivatives 未知

    公开(公告)号：DE19746612A1

    公开(公告)日：1999-04-29

    申请号：DE19746612

    申请日：1997-10-22

    Applicant: BASF AG

    Inventor： LUBISCH WILFRIED DR ,  DULLWEBER UTA DR ,  STARCK DOROTHEA DR ,  STEINER GERD DR ,  BACH ALFRED DR ,  EMLING FRANZ DR ,  GARCIA-LADONA FRANCISCO JAVIER ,  TESCHENDORF HANS-JUERGEN DR ,  WIECKE KARSTEN DR

    IPC: A61K31/428 ,  A61P25/24 ,  A61P43/00 ,  C07D275/06 ,  C07D417/04 ,  C07D417/06 ,  C07D417/12 ,  C07D417/14 ,  A61K31/445 ,  A61K31/44 ,  A61K31/425

    Abstract: 2-Substituted 1,2-benzisothiazole derivatives (I) and their acid salts are new. 2-Substituted 1,2-benzisothiazole derivatives of formula (I) and their enantiomers, diastereomers, tautomers and acid salts are new. R , R = independently 1-6C alkyl; R , R = independently H, 1-6C alkyl, OH, 1-6C alkoxy, F, Cl, Br, I, CF3, NR R , CO2R , NO2, CN, pyrrolo, or phenyl-(1-4C alkyl), which may itself be ring-substituted by F, Cl, Br, I, 1-4C alkyl, 1-4C alkoxy, CF3, OH, NH2, CN or NO2; R , R = independently H, 1-6C alkyl, benzoyl, CO2-tert.-butyl, (1-4C alkyl)carbonyl or together form a 5- or 6-membered ring, which may contain a second N atom (e.g. piperazinyl); R = H or 1-6C alkyl; A = 1-10C alkylene or 2-10C alkylene containing one or more Z groups; Z = O, S, NR , cyclopropyl, CHOH, or a double or triple bond; B = 4-piperidine, 4-(1,2,3,6-tetrahydropyridine), 4-piperazine or one of these rings N-bound to A via a methylene group; Ar = phenyl (optionally substituted by 1-6C alkyl, 1-6C alkoxy, OH, F, Cl, Br, I, CF3, NR R , CO2R , CN or phenyl), tetralinyl, indanyl, other condensed aromatic moieties e.g. naphthalinyl (optionally substituted by 1-4C alkyl or 1-4C alkoxy), anthracenyl, or a 5- or 6-membered aromatic heterocycle with 1 or 2 O or N heteroatoms, which can be anellated with other aromatic groups.

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