公开(公告)号：DE3361181D1

公开(公告)日：1985-12-12

申请号：DE3361181

申请日：1983-11-17

Applicant: BASF AG

Inventor： SEITZ WERNER DR ,  TESCHENDORF HANS-JUERGEN DR ,  MICHEL ALFRED DR ,  TRAUT MARTIN DR ,  HOFMANN HANS PETER DR ,  KREISKOTT HORST PROF DR

IPC: C07C225/18 ,  A61K31/135 ,  A61K31/205 ,  A61K31/395 ,  A61P25/24 ,  A61P25/26 ,  C07D207/08 ,  C07D211/32 ,  C07D295/10 ,  C07D295/116 ,  C07D295/12 ,  C07D295/145 ,  C07C97/10

Abstract: 1-Oxo-2-phenyl-2-(2-alkylaminoethyl)-1,2,3,4-tetrahydronaphthalenes of the formula I I where R1 and R2 are identical or different and are each hydrogen, halogen, trifluoromethyl, C1-C4-alkyl or C1-C4-alkoxy, R3 is C1-C6-alkyl and R4 is hydrogen, C1-C6-alkyl or benzyl, or R3 and R4 together may furthermore be a C2-C5-alkylene chain, and their salts with physiologically tolerated acids, and their preparation, are described. The novel compounds are useful active compounds for treating disorders.

公开(公告)号：AT16180T

公开(公告)日：1985-11-15

申请号：AT83111353

申请日：1983-11-14

Applicant: BASF AG

Inventor： KUBINYI HUGO DR ,  TRAUT MARTIN DR ,  GRIES JOSEF DR

IPC: A61K31/455 ,  A61K31/185 ,  A61K38/00 ,  A61P9/12 ,  A61P25/04 ,  C07C67/00 ,  C07C325/00 ,  C07C327/20 ,  C07C327/32 ,  C07D205/04 ,  C07D207/16 ,  C07D209/20 ,  C07D209/26 ,  C07D211/60 ,  C07D217/26 ,  C07D277/06 ,  C07D333/24 ,  C07K5/062 ,  C07K5/065 ,  C07K5/078 ,  C07C153/07

公开(公告)号：DE3243370A1

公开(公告)日：1984-05-24

申请号：DE3243370

申请日：1982-11-24

Applicant: BASF AG

Inventor： KUBINYI HUGO DR ,  TRAUT MARTIN DR ,  GRIES JOSEF DR MED

IPC: A61K31/16 ,  A61K31/21 ,  A61K38/00 ,  A61K38/55 ,  A61P9/12 ,  A61P43/00 ,  C07C327/20 ,  C07D205/04 ,  C07D207/10 ,  C07D207/16 ,  C07D209/20 ,  C07D211/60 ,  C07D217/26 ,  C07D277/06 ,  C07K5/04 ,  C07K5/06 ,  C07K5/062 ,  C07K5/065 ,  C07K5/078 ,  C07K5/083 ,  C07K14/81 ,  C07C153/09 ,  C07C103/52 ,  A61K31/195 ,  A61K31/40

Abstract: Benzoylthio compounds of the formula I I CO(NR3CHR4CO)mOH where R1 and R3 are identical or different and are each hydrogen or C1-C4-alkyl, R2 and R4 are identical or different and are each hydrogen or C1-C6-alkyl which is unsubstituted or substituted by hydroxyl, mercapto, C1-C4-alkylthio, a carboxylic ester group, carboxamido or acylamino or are each an aryl, hetaryl, arylalkylene or hetarylalkylene radical which is unsubstituted or substituted in the aryl moiety by hydroxyl, C1-C4-alkoxy, arylalkoxy or halogen, R1 and R2 and/or R3 and R4 together may furthermore be a radical -(CH2)p- (p=2, 3, 4), -CH2-S-CH2- or -CH2-C6H4-CH2-(ortho), X is NH or sulfur, m and n are identical or different and are each 0 or 1, and q is 0 or 1 where X is S, and is 0 where X is NH, and their salts with physiologically tolerated bases, their preparation, drugs containing these compounds and the use of these drugs in treating disorders.

公开(公告)号：DE3243158A1

公开(公告)日：1984-05-24

申请号：DE3243158

申请日：1982-11-23

Applicant: BASF AG

Inventor： SCHLECKER RAINER DR ,  SCHMIDT PETER DR ,  THIEME PETER C DR ,  LENKE DIETER PROF DR ,  TESCHENDORF HANS-JUERGEN DR ME ,  TRAUT MARTIN DR ,  MUELLER CLAUS D DR MED ,  HOFMANN HANS PETER DR ,  KREISKOTT HORST PROF DR

IPC: A61K31/35 ,  A61K31/352 ,  A61K31/365 ,  A61K31/37 ,  A61P25/18 ,  A61P25/24 ,  A61P25/26 ,  A61P37/08 ,  A61P43/00 ,  C07D311/08 ,  C07D311/16 ,  C07D311/78 ,  C07D311/80

Abstract: Sulfonates of hydroxycoumarins of the formula I (I) where R1 and R2 are identical or different and are each hydrogen, halogen or alkyl of 1 to 5 carbon atoms which can be substituted by -NR4R5, -OR4 or -OC(O)R4, where R4 and R5 are identical or different and are each hydrogen or alkyl of 1 to 4 carbon atoms, or R1 and R2 are each a carboxylic acid group -OC(O)R4 or a carboxamido radical, with the proviso that R1 is not methyl when R2 is hydrogen, or R1 and R2 together form a -(CH2)n- chain where n is 3-5, and R3 is a straight-chain or branched alkyl radical of 1 to 8 carbon atoms or cycloalkyl of 3 to 8 carbon atoms, each of which can be substituted by halogen, -OR4, -NR4R5, -CN or phenyl, or R3 is a straight-chain or branched alkenyl radical of 3 to 8 carbon atoms, an amino group - NR4R5, or phenyl or naphthyl, each of which is unsubstituted or monosubstituted or polysubstituted by -OR4, -NR4R5, -NO2, halogen, -SR4, -S(O)R4, -OS(O)R4, -SCF3, -OS(O)CF3, -CN, -C(O)R4, -OC(O)R4, -NHC(O)R4, -CF3, C1-C4-alkyl or a combination of these substituents, a process for their preparation, drugs containing these compounds, and compounds of the formula I, in which R1 is methyl and R2 is hydrogen, for use as drugs.

公开(公告)号：DE3917232A1

公开(公告)日：1990-11-29

申请号：DE3917232

申请日：1989-05-26

Applicant: BASF AG

Inventor： GEISS KARL-HEINZ DR ,  RUEBSAMEN KLAUS DR ,  TRAUT MARTIN DR

IPC: C07D215/42

Abstract: 4-aminoquinoline derivs. of formula (I) and their salts are new, R1 = H, 1-4C alkyl, 1-4C hydroxyalkyl or (1-4C) alkoxy (1-4C)alkyl, R2 = 1-6C alkyl, R3 = naphthyl or a phenyl gp. of formula R13, R7 = H, 1-3C alkyl, 1-3C alkoxy, halogen, 1-3C alkylthio, CF3, NO2, or 2-4C alkoxycarbonyl, R8 = H, 1-3C alkyl, 1-3C alkoxy, or halogen, n = 1 or 2, R4 = H, 1-3C alkyl or CH2R3, R5 = H, 1-6C alkyl, 1-6C alkoxy, OPh phenyl (1-3C) alkoxy, CF3 or halogen, R6 = H, 1-3C alkyl, 1-3C alkoxy or halogen. USE - (I) are K+/H+ ATPase inhibitors and gastric acid secretion inhibitors useful for treating peptic ulcers, gastritis, oesophagal reflux, Zollinger-Ellison syndrome etc.

公开(公告)号：DE3762970D1

公开(公告)日：1990-07-05

申请号：DE3762970

申请日：1987-01-03

Applicant: BASF AG

Inventor： GEISS KARL-HEINZ DR ,  SCHMIED BERNHARD DR ,  KROPP RUDOLF ,  BALDINGER VERENA DR ,  GRIES JOSEF DR ,  LEHMANN HANS DIETER PROF DR ,  RUEBSAMEN KLAUS DR ,  TRAUT MARTIN DR

IPC: C07D237/00 ,  A61K31/50 ,  A61P1/04 ,  A61P7/02 ,  A61P9/04 ,  A61P9/12 ,  C07D403/04 ,  C07D403/10

公开(公告)号：DE3373655D1

公开(公告)日：1987-10-22

申请号：DE3373655

申请日：1983-11-12

Applicant: BASF AG

Inventor： SCHLECKER RAINER DR ,  SCHMIDT PETER DR ,  THIEME PETER C DR ,  LENKE DIETER PROF DR ,  TESCHENDORF HANS-JURGEN DR ,  TRAUT MARTIN DR ,  MUELLER CLAUS D DR ,  HOFMANN HANS PETER DR ,  KREISKOTT HORST PROF DR

IPC: A61K31/35 ,  A61K31/352 ,  A61K31/365 ,  A61K31/37 ,  A61P25/18 ,  A61P25/24 ,  A61P25/26 ,  A61P37/08 ,  A61P43/00 ,  C07D311/08 ,  C07D311/16 ,  C07D311/78 ,  C07D311/80

Abstract: Sulfonates of hydroxycoumarins of the formula I (I) where R1 and R2 are identical or different and are each hydrogen, halogen or alkyl of 1 to 5 carbon atoms which can be substituted by -NR4R5, -OR4 or -OC(O)R4, where R4 and R5 are identical or different and are each hydrogen or alkyl of 1 to 4 carbon atoms, or R1 and R2 are each a carboxylic acid group -OC(O)R4 or a carboxamido radical, with the proviso that R1 is not methyl when R2 is hydrogen, or R1 and R2 together form a -(CH2)n- chain where n is 3-5, and R3 is a straight-chain or branched alkyl radical of 1 to 8 carbon atoms or cycloalkyl of 3 to 8 carbon atoms, each of which can be substituted by halogen, -OR4, -NR4R5, -CN or phenyl, or R3 is a straight-chain or branched alkenyl radical of 3 to 8 carbon atoms, an amino group - NR4R5, or phenyl or naphthyl, each of which is unsubstituted or monosubstituted or polysubstituted by -OR4, -NR4R5, -NO2, halogen, -SR4, -S(O)R4, -OS(O)R4, -SCF3, -OS(O)CF3, -CN, -C(O)R4, -OC(O)R4, -NHC(O)R4, -CF3, C1-C4-alkyl or a combination of these substituents, a process for their preparation, drugs containing these compounds, and compounds of the formula I, in which R1 is methyl and R2 is hydrogen, for use as drugs.

公开(公告)号：AT29720T

公开(公告)日：1987-10-15

申请号：AT83111339

申请日：1983-11-12

Applicant: BASF AG

Inventor： SCHLECKER RAINER DR ,  SCHMIDT PETER DR ,  THIEME PETER C DR ,  LENKE DIETER PROF DR ,  TESCHENDORF HANS-JUERGEN DR ,  TRAUT MARTIN DR ,  MUELLER CLAUS D DR ,  HOFMANN HANS PETER DR ,  KREISKOTT HORST PROF DR

IPC: A61K31/35 ,  A61K31/352 ,  A61K31/365 ,  A61K31/37 ,  A61P25/18 ,  A61P25/24 ,  A61P25/26 ,  A61P37/08 ,  A61P43/00 ,  C07D311/08 ,  C07D311/16 ,  C07D311/78 ,  C07D311/80

公开(公告)号：DE3242923A1

公开(公告)日：1984-05-24

申请号：DE3242923

申请日：1982-11-20

Applicant: BASF AG

Inventor： TREIBER HANS JOERG DR ,  HOFMANN HANS PETER DR ,  KREISKOTT HORST PROF DR ,  TESCHENDORF HANS-JUERGEN DR ME ,  TRAUT MARTIN DR

IPC: A61K31/55 ,  A61P25/24 ,  A61P25/26 ,  C07D267/08 ,  C07D267/10

公开(公告)号：DE3144138A1

公开(公告)日：1983-05-19

申请号：DE3144138

申请日：1981-11-06

Applicant: BASF AG

Inventor： KROPP RUDOLF ,  THYES MARCO DR ,  SCHLECKER RAINER DR ,  FRANKE ALBRECHT DR ,  REICHENEDER FRANZ DR ,  AMANN AUGUST DR MED ,  TESCHENDORF HANS-JUERGEN DR ME ,  KRETZSCHMAR ROLF PROF DR MED ,  TRAUT MARTIN DR ,  GRIES JOSEF DR MED

IPC: A61K31/50 ,  A61P9/02 ,  A61P25/00 ,  A61P25/24 ,  A61P25/26 ,  C07D237/20 ,  C07D237/22