中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

99 records (took 0.024 seconds)

    Substrates and optical systems and methods of use thereof
    22.
    发明专利
    Substrates and optical systems and methods of use thereof 未知

    公开(公告)号：AU2009292629A1

    公开(公告)日：2010-03-25

    申请号：AU2009292629

    申请日：2009-09-15

    Applicant: PACIFIC BIOSCIENCES CALIFORNIA

    Inventor： ZHONG CHENG FRANK ,  LUNDQUIST PAUL ,  FOQUET MATHIEU ,  KORLACH JONAS ,  BAYANDORIAN HOVIG

    IPC: G01N21/00 ,  G01B9/02 ,  G01N33/483

    Abstract: The present invention provides an integrated optical device (2300), comprising:a) a first component (2302) comprising a waveguide (2312) disposed upon or within a substrate and a plurality of nanometer-scale apertures (2308) comprising analyte regions (2310), wherein the analyte regions (2310) are disposed sufficiently proximal to a core of the waveguide (2312) to be illuminated by an evanescent field emanating from the core when optical energy is passed through the waveguide;b) a second component (2304) comprising a microlens array that collects optical energy signals from the analyte regions (2310) and directs the optical energy signals so collected to a detector (2320); andc) a third component (2306) comprising the detector (2320).

    Sequencing by cognate sampling
    23.
    发明专利
    Sequencing by cognate sampling 未知

    公开(公告)号：AU2009288696A1

    公开(公告)日：2010-03-11

    申请号：AU2009288696

    申请日：2009-09-04

    Applicant: PACIFIC BIOSCIENCES CALIFORNIA INC

    Inventor： PATEL PRANAV ,  KORLACH JONAS ,  BIBILLO ARKADIUSZ ,  BJORNSON KEITH ,  HANES JEREMIAH

    IPC: C12Q1/68 ,  C12N15/11 ,  C12Q1/25

    Abstract: Provided are methods for enhanced sequencing of nucleic acid templates. Also provided are reaction conditions that increase branching fractions during polymerization reactions. Also provided are compositions comprising modified recombinant polymerases that exhibit branching fractions that are higher than the branching fractions of the polymerases from which they were derived. Provided are compositions comprising modified recombinant polymerases that exhibit delayed translocation relative to the polymerases from which they were derived. Also provided are compositions comprising modified recombinant polymerases that exhibit increased nucleotide or nucleotide analog residence time at an active site of the polymerase. Provided are methods for generating polymerases with the aforementioned phenotypes and methods of using such polymerases to sequence a DNA template or make a DNA. Also provided are methods and nucleic acid sequencing systems for determining which labeled nucleotide is incorporated at a site during a template-dependent polymerization reaction.

    Labeled reactants and their uses
    24.
    发明专利
    Labeled reactants and their uses 未知

    公开(公告)号：AU2009223702A1

    公开(公告)日：2009-09-17

    申请号：AU2009223702

    申请日：2009-03-12

    Applicant: PACIFIC BIOSCIENCES CALIFORNIA

    Inventor： KORLACH JONAS ,  WEGENER JEFFREY

    IPC: G01N33/532 ,  C12Q1/68 ,  G01N33/53 ,  G01N33/533 ,  G01N33/535

    Abstract: Labeled reactant compositions, and particularly labeled nucleic acid reaction compositions that include structural components including double-stranded nucleic acids. In some embodiments, the structural components maintain potentially damaging labeling components sufficiently distal from the reactant portion of the molecule such that damaging effects of the label group on other reaction components, such as enzymes, are reduced, minimized and/or eliminated.

    REAL-TIME SEQUENCING METHODS AND SYSTEMS
    29.
    发明申请
    REAL-TIME SEQUENCING METHODS AND SYSTEMS 审中-公开
    实时测序方法和系统

    公开(公告)号：WO2010129019A3

    公开(公告)日：2011-03-31

    申请号：PCT/US2010001236

    申请日：2010-04-26

    Applicant: PACIFIC BIOSCIENCES CALIFORNIA ,  KORLACH JONAS ,  TURNER STEPHEN ,  SCHADT ERIC

    Inventor： KORLACH JONAS ,  TURNER STEPHEN ,  SCHADT ERIC

    IPC: C12Q1/68 ,  C12N15/10

    CPC classification number: C12Q1/6869 ,  C12Q1/702 ,  C12Q2565/518 ,  C12Q2547/101

    Abstract: The present invention is generally directed to compositions, methods, and systems for performing single-molecule, real-time analysis of a variety of different biological reactions. The ability to analyze such reactions provides an opportunity to study those reactions as well as to potentially identify factors and/or approaches for impacting such reactions, e.g., to either enhance or inhibit such reactions. In certain preferred embodiments, RNA templates are used in single-molecule real-time sequencing reactions.

    Abstract translation: 本发明一般涉及用于进行各种不同生物反应的单分子实时分析的组合物，方法和系统。 分析这些反应的能力提供了研究这些反应以及潜在鉴定影响这些反应的因素和/或方法的机会，例如增强或抑制这种反应。 在某些优选实施方案中，RNA模板用于单分子实时测序反应。

Patent Agency Ranking